{"id":"https://openalex.org/W7224928828","doi":"https://doi.org/10.1111/iwj.71081","title":"Multidimensional Wound Healing Outcomes in Chronic and Complex Wounds: A Real\u2010World Case Series With a Thermoreversible Wound Gel","display_name":"Multidimensional Wound Healing Outcomes in Chronic and Complex Wounds: A Real\u2010World Case Series With a Thermoreversible Wound Gel","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224928828","doi":"https://doi.org/10.1111/iwj.71081","pmid":"https://pubmed.ncbi.nlm.nih.gov/42958607","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13720227"},"language":"en","primary_location":{"id":"doi:10.1111/iwj.71081","doi":"https://doi.org/10.1111/iwj.71081","is_oa":true,"landing_page_url":"https://doi.org/10.1111/iwj.71081","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iwj.71081","source":{"id":"https://openalex.org/S118780703","display_name":"International Wound Journal","issn_l":"1742-4801","issn":["1742-4801","1742-481X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Wound Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iwj.71081","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030986423","display_name":"Iris Noland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iris Noland","raw_affiliation_strings":["Colborne Clinic  Colborne Ontario Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colborne Clinic  Colborne Ontario Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113696068","display_name":"Miloslav Sailer","orcid":"https://orcid.org/0009-0008-7208-5265","observed_orcids":["https://orcid.org/0009-0008-7208-5265"]},"institutions":[{"id":"https://openalex.org/I4210097323","display_name":"Kane Biotech (Canada)","ror":"https://ror.org/00w8fet54","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210097323"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Miloslav Sailer","raw_affiliation_strings":["Kane Biotech  Winnipeg Manitoba Canada"],"raw_orcid":"https://orcid.org/0009-0008-7208-5265","affiliations":[{"raw_affiliation_string":"Kane Biotech  Winnipeg Manitoba Canada","institution_ids":["https://openalex.org/I4210097323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053565309","display_name":"Jeyachchandran Visvalingam","orcid":"https://orcid.org/0000-0002-6099-409X","observed_orcids":["https://orcid.org/0000-0002-6099-409X"]},"institutions":[{"id":"https://openalex.org/I4210097323","display_name":"Kane Biotech (Canada)","ror":"https://ror.org/00w8fet54","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210097323"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeyachchandran Visvalingam","raw_affiliation_strings":["Kane Biotech  Winnipeg Manitoba Canada"],"raw_orcid":"https://orcid.org/0000-0002-6099-409X","affiliations":[{"raw_affiliation_string":"Kane Biotech  Winnipeg Manitoba Canada","institution_ids":["https://openalex.org/I4210097323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160211275","display_name":"Rohan Pointer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097323","display_name":"Kane Biotech (Canada)","ror":"https://ror.org/00w8fet54","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210097323"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rohan Pointer","raw_affiliation_strings":["Kane Biotech  Winnipeg Manitoba Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kane Biotech  Winnipeg Manitoba Canada","institution_ids":["https://openalex.org/I4210097323"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027167992","display_name":"Robert B. Huizinga","orcid":"https://orcid.org/0000-0001-8703-7655","observed_orcids":["https://orcid.org/0000-0001-8703-7655"]},"institutions":[{"id":"https://openalex.org/I4210097323","display_name":"Kane Biotech (Canada)","ror":"https://ror.org/00w8fet54","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210097323"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert B. Huizinga","raw_affiliation_strings":["Kane Biotech  Winnipeg Manitoba Canada"],"raw_orcid":"https://orcid.org/0000-0001-8703-7655","affiliations":[{"raw_affiliation_string":"Kane Biotech  Winnipeg Manitoba Canada","institution_ids":["https://openalex.org/I4210097323"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113696068"],"corresponding_institution_ids":["https://openalex.org/I4210097323"],"apc_list":{"value":3580,"currency":"USD","value_usd":3580},"apc_paid":{"value":3580,"currency":"USD","value_usd":3580},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86192367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.9879999756813049},{"id":"https://openalex.org/keywords/complex-wounds","display_name":"complex wounds","score":0.9789999723434448},{"id":"https://openalex.org/keywords/antimicrobial-wound-dressings","display_name":"antimicrobial dressings","score":0.7919999957084656},{"id":"https://openalex.org/keywords/wound-healing-outcomes","display_name":"wound healing outcomes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/wound-exudate","display_name":"wound exudate","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tissue-oxygenation","display_name":"tissue oxygenation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/wound-pain","display_name":"wound pain","score":0.7829999923706055},{"id":"https://openalex.org/keywords/biofilm","display_name":"biofilm","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9693999886512756},{"id":"https://openalex.org/C2778573061","wikidata":"https://www.wikidata.org/wiki/Q1139400","display_name":"Exudate","level":2,"score":0.6190000176429749},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6144000291824341},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5963000059127808},{"id":"https://openalex.org/C2781051411","wikidata":"https://www.wikidata.org/wiki/Q2078852","display_name":"Chronic wound","level":3,"score":0.5663999915122986},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5576000213623047},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4146000146865845},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.40290001034736633},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.33799999952316284},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.33640000224113464},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3167000114917755},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.31439998745918274},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.2946000099182129},{"id":"https://openalex.org/C2779899204","wikidata":"https://www.wikidata.org/wiki/Q7075718","display_name":"Occlusive dressing","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C2993807428","wikidata":"https://www.wikidata.org/wiki/Q25324087","display_name":"Wound care","level":2,"score":0.27970001101493835}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/iwj.71081","doi":"https://doi.org/10.1111/iwj.71081","is_oa":true,"landing_page_url":"https://doi.org/10.1111/iwj.71081","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iwj.71081","source":{"id":"https://openalex.org/S118780703","display_name":"International Wound Journal","issn_l":"1742-4801","issn":["1742-4801","1742-481X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Wound Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13720227","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720227/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720227/pdf/IWJ-23-e71081.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int Wound J","raw_type":"Text"},{"id":"pmid:42958607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42958607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International wound journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/iwj.71081","doi":"https://doi.org/10.1111/iwj.71081","is_oa":true,"landing_page_url":"https://doi.org/10.1111/iwj.71081","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iwj.71081","source":{"id":"https://openalex.org/S118780703","display_name":"International Wound Journal","issn_l":"1742-4801","issn":["1742-4801","1742-481X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Wound Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224928828.pdf","grobid_xml":"https://content.openalex.org/works/W7224928828.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2016738444","https://openalex.org/W2091651320","https://openalex.org/W2096131781","https://openalex.org/W2127535305","https://openalex.org/W2153323181","https://openalex.org/W2161344815","https://openalex.org/W2177519531","https://openalex.org/W2402202411","https://openalex.org/W2756826923","https://openalex.org/W2759665824","https://openalex.org/W3018267877","https://openalex.org/W4210835131","https://openalex.org/W4404769225","https://openalex.org/W4411849528","https://openalex.org/W4415823197","https://openalex.org/W7128957590","https://openalex.org/W7135080283"],"related_works":["https://openalex.org/W7128957590","https://openalex.org/W4400799909","https://openalex.org/W2984448198","https://openalex.org/W4386204172","https://openalex.org/W2897479667","https://openalex.org/W2108413073","https://openalex.org/W4416159733","https://openalex.org/W2884609601","https://openalex.org/W2522859671","https://openalex.org/W7159621679"],"abstract_inverted_index":{"Chronic":[0],"and":[1,14,77,88,180,183],"complex":[2,181],"wounds":[3,42,52,97,182],"frequently":[4],"exhibit":[5],"delayed":[6],"healing":[7],"associated":[8,25,165],"with":[9,26,40,139,150,166,178],"persistent":[10],"inflammation,":[11],"microbial":[12],"burden":[13],"biofilm":[15],"formation.":[16],"This":[17],"prospective":[18],"observational":[19],"case":[20],"series":[21],"describes":[22],"wound-healing":[23],"outcomes":[24,171],"adjunctive":[27,159],"use":[28,160],"of":[29,50,96,161,176],"a":[30,173],"thermo-reversible":[31],"antimicrobial":[32],"wound":[33,69,86],"gel":[34],"(TRG)":[35],"in":[36,44,145,172,187],"17":[37],"adult":[38],"patients":[39,138,177],"chronic":[41,179],"treated":[43],"an":[45],"outpatient":[46],"setting.":[47],"A":[48],"total":[49],"28":[51],"were":[53],"analysed":[54],"over":[55],"up":[56],"to":[57,104,112,121,132],"12":[58],"weeks":[59],"using":[60],"clinically":[61],"relevant":[62],"endpoints":[63],"including":[64],"percentage":[65],"area":[66],"reduction":[67],"(PAR),":[68],"bed":[70],"tissue":[71,75,100,108,141],"composition,":[72],"exudate":[73,115],"level,":[74],"oxygenation":[76,142,146],"patient-reported":[78],"pain.":[79],"Mean":[80,126],"PAR":[81,151],"was":[82,147,164],"43.9%":[83],"at":[84,90,119,123],"the":[85,91,162],"level":[87],"42.7%":[89],"patient":[92],"level.":[93],"The":[94],"proportion":[95],"demonstrating":[98],"epithelial":[99],"increased":[101,116],"from":[102,110,117,130],"25.0%":[103,111],"68.8%,":[105],"while":[106],"necrotic":[107],"decreased":[109,129],"12.5%.":[113],"Low":[114],"41.2%":[118],"baseline":[120],"64.7%":[122],"final":[124],"assessment.":[125],"pain":[127],"scores":[128],"4.76":[131],"2.18":[133],"(p":[134,152],"=":[135,153],"0.0125).":[136],"In":[137],"available":[140],"data,":[143],"change":[144],"positively":[148],"correlated":[149],"0.011).":[154],"These":[155],"findings":[156],"suggest":[157],"that":[158],"TRG":[163],"improvement":[167],"across":[168],"multiple":[169],"clinical":[170],"real-world":[174],"population":[175],"support":[184],"further":[185],"evaluation":[186],"controlled":[188],"studies.":[189]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}
