{"id":"https://openalex.org/W7224926963","doi":"https://doi.org/10.1021/acs.analchem.6c05519","title":"Rapid and Controlled Single-Nanopore Insertion via Hydrogel-Confined Localized Delivery","display_name":"Rapid and Controlled Single-Nanopore Insertion via Hydrogel-Confined Localized Delivery","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224926963","doi":"https://doi.org/10.1021/acs.analchem.6c05519"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.6c05519","doi":"https://doi.org/10.1021/acs.analchem.6c05519","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.6c05519","pdf_url":"https://pubs.acs.org/ancham/article-pdf/doi/10.1021/acs.analchem.6c05519/69036491/ac6c05519.pdf","source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/ancham/article-pdf/doi/10.1021/acs.analchem.6c05519/69036491/ac6c05519.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012898417","display_name":"Xiang Hao","orcid":"https://orcid.org/0000-0001-6596-0529","observed_orcids":["https://orcid.org/0000-0001-6596-0529"]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Xiang Hao","raw_affiliation_strings":["University of Stuttgart , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Stuttgart , , ,","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015035453","display_name":"Tobias Ensslen","orcid":"https://orcid.org/0009-0000-1021-3964","observed_orcids":["https://orcid.org/0009-0000-1021-3964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Ensslen","raw_affiliation_strings":["Hahn-Schickard gGmbH , ,"],"raw_orcid":"https://orcid.org/0009-0000-1021-3964","affiliations":[{"raw_affiliation_string":"Hahn-Schickard gGmbH , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160189838","display_name":"Longjiang Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Longjiang Ding","raw_affiliation_strings":["University of Stuttgart , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Stuttgart , , ,","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160221564","display_name":"Sisi Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Sisi Fan","raw_affiliation_strings":["Chinese Academy of Sciences , , ,","University of Stuttgart , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences , , ,","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Stuttgart , , ,","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389730","display_name":"Na Liu","orcid":"https://orcid.org/0000-0001-5831-3382","observed_orcids":["https://orcid.org/0000-0001-5831-3382"]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Na Liu","raw_affiliation_strings":["University of Stuttgart , , ,"],"raw_orcid":"https://orcid.org/0000-0001-5831-3382","affiliations":[{"raw_affiliation_string":"University of Stuttgart , , ,","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003936492","display_name":"Jan Claas Behrends","orcid":"https://orcid.org/0000-0001-9686-7263","observed_orcids":["https://orcid.org/0000-0001-9686-7263","https://orcid.org/0009-0008-7362-0928"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan C. Behrends","raw_affiliation_strings":["University of Freiburg , , ,"],"raw_orcid":"https://orcid.org/0000-0001-9686-7263","affiliations":[{"raw_affiliation_string":"University of Freiburg , , ,","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055233748","display_name":"Stephan Nu\u00dfberger","orcid":"https://orcid.org/0000-0003-3619-4452","observed_orcids":["https://orcid.org/0000-0003-3619-4452"]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stephan Nussberger","raw_affiliation_strings":["University of Stuttgart , , ,"],"raw_orcid":"https://orcid.org/0000-0003-3619-4452","affiliations":[{"raw_affiliation_string":"University of Stuttgart , , ,","institution_ids":["https://openalex.org/I100066346"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055233748"],"corresponding_institution_ids":["https://openalex.org/I100066346"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72481145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10913","display_name":"Molecular Junctions and Nanostructures","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-bilayer-reconstitution","display_name":"lipid bilayer reconstitution","score":0.7620000243186951},{"id":"https://openalex.org/keywords/aerolysin","display_name":"aerolysin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tom-complex","display_name":"TOM complex","score":0.6190000176429749},{"id":"https://openalex.org/keywords/dna-nanopores","display_name":"DNA nanopores","score":0.9620000123977661},{"id":"https://openalex.org/keywords/single-channel-electrophysiology","display_name":"single-channel electrophysiology","score":0.9390000104904175},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8876000046730042},{"id":"https://openalex.org/C174319367","wikidata":"https://www.wikidata.org/wiki/Q67621537","display_name":"Aerolysin","level":4,"score":0.7865999937057495},{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.7757999897003174},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5245000123977661},{"id":"https://openalex.org/C126513998","wikidata":"https://www.wikidata.org/wiki/Q8973627","display_name":"Nanopore sequencing","level":4,"score":0.5163999795913696},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.48919999599456787},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.44190001487731934},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.43639999628067017},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.4284000098705292},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.391400009393692},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.31349998712539673},{"id":"https://openalex.org/C196806460","wikidata":"https://www.wikidata.org/wiki/Q188603","display_name":"Capillary action","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C2776363448","wikidata":"https://www.wikidata.org/wiki/Q12008238","display_name":"Microbead (research)","level":2,"score":0.2685999870300293}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.analchem.6c05519","doi":"https://doi.org/10.1021/acs.analchem.6c05519","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.6c05519","pdf_url":"https://pubs.acs.org/ancham/article-pdf/doi/10.1021/acs.analchem.6c05519/69036491/ac6c05519.pdf","source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/acs.analchem.6c05519","doi":"https://doi.org/10.1021/acs.analchem.6c05519","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.6c05519","pdf_url":"https://pubs.acs.org/ancham/article-pdf/doi/10.1021/acs.analchem.6c05519/69036491/ac6c05519.pdf","source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224926963.pdf","grobid_xml":"https://content.openalex.org/works/W7224926963.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1969454557","https://openalex.org/W1970286656","https://openalex.org/W1984545749","https://openalex.org/W1985204201","https://openalex.org/W1998913854","https://openalex.org/W1999319251","https://openalex.org/W1999877742","https://openalex.org/W2004863845","https://openalex.org/W2009025716","https://openalex.org/W2015701671","https://openalex.org/W2016776155","https://openalex.org/W2020097975","https://openalex.org/W2021793865","https://openalex.org/W2029375419","https://openalex.org/W2030683115","https://openalex.org/W2047723546","https://openalex.org/W2051999380","https://openalex.org/W2054260887","https://openalex.org/W2062882464","https://openalex.org/W2075569960","https://openalex.org/W2084401861","https://openalex.org/W2092212984","https://openalex.org/W2127407003","https://openalex.org/W2237123958","https://openalex.org/W2296071534","https://openalex.org/W2315037307","https://openalex.org/W2342925174","https://openalex.org/W2411648672","https://openalex.org/W2471671221","https://openalex.org/W2742457004","https://openalex.org/W2946655070","https://openalex.org/W2995162887","https://openalex.org/W3092789268","https://openalex.org/W3120739600","https://openalex.org/W3186609878","https://openalex.org/W3198767362","https://openalex.org/W4211132533","https://openalex.org/W4283642332","https://openalex.org/W4293056799","https://openalex.org/W4297243252","https://openalex.org/W4309657780","https://openalex.org/W4313224411","https://openalex.org/W4385802127","https://openalex.org/W4385803543","https://openalex.org/W4387012666","https://openalex.org/W4388895509","https://openalex.org/W4392470953","https://openalex.org/W4394874065","https://openalex.org/W4401728012","https://openalex.org/W4407342703","https://openalex.org/W4410287213","https://openalex.org/W4410512207","https://openalex.org/W4411376803","https://openalex.org/W4411411744","https://openalex.org/W4415397161","https://openalex.org/W4415749180","https://openalex.org/W7118193546","https://openalex.org/W7161234084","https://openalex.org/W7166579557","https://openalex.org/W7171854460"],"related_works":["https://openalex.org/W1999877742","https://openalex.org/W7038717911","https://openalex.org/W2982368487","https://openalex.org/W2902100919","https://openalex.org/W3086116809","https://openalex.org/W2932065144","https://openalex.org/W4377939782","https://openalex.org/W2767535465","https://openalex.org/W4393933041","https://openalex.org/W1863777741"],"abstract_inverted_index":{"Abstract":[0],"Controlled":[1],"insertion":[2,81,114],"of":[3,59,84],"a":[4,12,15,40,87,109],"single":[5],"protein":[6],"pore,":[7],"also":[8],"referred":[9],"to":[10,32,53,71,78,86],"as":[11],"nanopore,":[13,111],"into":[14],"free-standing":[16],"lipid":[17],"bilayer":[18],"underpins":[19],"high-resolution":[20],"single-channel":[21],"electrophysiology.":[22],"Hitherto,":[23],"conventional":[24],"bulk":[25],"reconstitution":[26],"is":[27],"stochastic,":[28],"slow,":[29],"and":[30,64,73,108,117],"prone":[31],"multiple":[33],"insertions.":[34],"To":[35],"overcome":[36],"this,":[37],"we":[38],"adapted":[39],"hydrogel-confined":[41],"delivery":[42],"strategy":[43],"in":[44],"which":[45],"an":[46],"agarose-filled":[47],"glass":[48],"capillary":[49],"delivers":[50],"nanopores":[51],"directly":[52],"the":[54,68,75,79,99,103],"bilayer.":[55],"An":[56],"optimal":[57],"window":[58],"agarose":[60],"concentration,":[61,63],"aerolysin":[62],"membrane":[65],"potential":[66],"raised":[67],"single-pore":[69],"yield":[70],">70%":[72],"shortened":[74],"waiting":[76],"time":[77],"first":[80],"from":[82],"tens":[83],"minutes":[85],"few":[88],"minutes,":[89],"without":[90],"altering":[91],"native":[92],"pore":[93],"conductance.":[94],"The":[95],"approach":[96],"generalizes":[97],"across":[98],"\u03b2-barrel":[100],"toxin":[101],"aerolysin,":[102],"mitochondrial":[104],"TOM":[105],"core":[106],"complex,":[107],"DNA":[110],"making":[112],"nanopore":[113],"rapid,":[115],"controlled,":[116],"reproducible.":[118]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}
