{"id":"https://openalex.org/W7224919623","doi":"https://doi.org/10.1039/d6ra08265c","title":"An efficient hypochlorous acid fluorescence imaging strategy based on toehold-mediated strand displacement for distinguishing cancer cells from normal cells","display_name":"An efficient hypochlorous acid fluorescence imaging strategy based on toehold-mediated strand displacement for distinguishing cancer cells from normal cells","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7224919623","doi":"https://doi.org/10.1039/d6ra08265c","pmid":"https://pubmed.ncbi.nlm.nih.gov/42964600","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13720905"},"language":"en","primary_location":{"id":"doi:10.1039/d6ra08265c","doi":"https://doi.org/10.1039/d6ra08265c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra08265c","pdf_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra08265c/14974840/d6ra08265c.pdf","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra08265c/14974840/d6ra08265c.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101475067","display_name":"Qianqian Duan","orcid":"https://orcid.org/0000-0003-4010-4202","observed_orcids":["https://orcid.org/0000-0003-4010-4202","https://orcid.org/0009-0004-0751-6648"]},"institutions":[{"id":"https://openalex.org/I4210152095","display_name":"Xinxiang Central Hospital","ror":"https://ror.org/006zn6z18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152095"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianqian Duan","raw_affiliation_strings":["Department of Clinical Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China"],"raw_orcid":"https://orcid.org/0009-0004-0751-6648","affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China","institution_ids":["https://openalex.org/I4210152095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160165592","display_name":"Aihua Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210152095","display_name":"Xinxiang Central Hospital","ror":"https://ror.org/006zn6z18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152095"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aihua Xu","raw_affiliation_strings":["Department of Clinical Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China","School of Life Sciences, Central South University, 410013, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China","institution_ids":["https://openalex.org/I4210152095"]},{"raw_affiliation_string":"School of Life Sciences, Central South University, 410013, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160163783","display_name":"Ruobing Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152095","display_name":"Xinxiang Central Hospital","ror":"https://ror.org/006zn6z18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152095"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruobing Han","raw_affiliation_strings":["Central Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China","institution_ids":["https://openalex.org/I4210152095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160173372","display_name":"Guochao Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152095","display_name":"Xinxiang Central Hospital","ror":"https://ror.org/006zn6z18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152095"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guochao Xu","raw_affiliation_strings":["Department of Clinical Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China","institution_ids":["https://openalex.org/I4210152095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160231655","display_name":"Qianqing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152095","display_name":"Xinxiang Central Hospital","ror":"https://ror.org/006zn6z18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152095"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qianqing Wang","raw_affiliation_strings":["Central Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China","Department of Gynecology Oncology, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China","institution_ids":["https://openalex.org/I4210152095"]},{"raw_affiliation_string":"Department of Gynecology Oncology, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China","institution_ids":["https://openalex.org/I4210152095"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043917319","display_name":"Changbei Ma","orcid":"https://orcid.org/0000-0002-9973-0366","observed_orcids":["https://orcid.org/0000-0002-9973-0366"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changbei Ma","raw_affiliation_strings":["School of Life Sciences, Central South University, 410013, Changsha, Hunan, China"],"raw_orcid":"https://orcid.org/0000-0002-9973-0366","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Central South University, 410013, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043917319","https://openalex.org/A5160231655"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210152095"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71162591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypochlorous-acid-detection","display_name":"hypochlorous acid detection","score":0.9539999961853027},{"id":"https://openalex.org/keywords/toehold-mediated-strand-displacement","display_name":"toehold-mediated strand displacement","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dna-biosensor","display_name":"DNA biosensor","score":0.5849999785423279},{"id":"https://openalex.org/keywords/fluorescence-imaging","display_name":"fluorescence imaging","score":0.703000009059906},{"id":"https://openalex.org/keywords/cancer-cell-discrimination","display_name":"cancer cell discrimination","score":0.6970000267028809},{"id":"https://openalex.org/keywords/intracellular-reactive-oxygen-species","display_name":"intracellular reactive oxygen species","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dna-hairpin","display_name":"DNA hairpins","score":0.6269999742507935},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2780908991","wikidata":"https://www.wikidata.org/wiki/Q407318","display_name":"Hypochlorous acid","level":2,"score":0.9800000190734863},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.765999972820282},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6891000270843506},{"id":"https://openalex.org/C107551265","wikidata":"https://www.wikidata.org/wiki/Q1458245","display_name":"Displacement (psychology)","level":2,"score":0.6308000087738037},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.602400004863739},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5529999732971191},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5277000069618225},{"id":"https://openalex.org/C2994114330","wikidata":"https://www.wikidata.org/wiki/Q5031437","display_name":"Cancer imaging","level":3,"score":0.5210000276565552},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.40459999442100525},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37400001287460327},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.31859999895095825},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.3174999952316284},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3089999854564667}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d6ra08265c","doi":"https://doi.org/10.1039/d6ra08265c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra08265c","pdf_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra08265c/14974840/d6ra08265c.pdf","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13720905","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720905/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720905/pdf/RA-OLF-D6RA08265C.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmid:42964600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42964600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d6ra08265c","doi":"https://doi.org/10.1039/d6ra08265c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra08265c","pdf_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra08265c/14974840/d6ra08265c.pdf","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224919623.pdf","grobid_xml":"https://content.openalex.org/works/W7224919623.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W2780750565","https://openalex.org/W3023752815","https://openalex.org/W3086590916","https://openalex.org/W3128053495","https://openalex.org/W4200623032","https://openalex.org/W4210498051","https://openalex.org/W4221023698","https://openalex.org/W4223440490","https://openalex.org/W4224215508","https://openalex.org/W4229006573","https://openalex.org/W4281936047","https://openalex.org/W4283691835","https://openalex.org/W4309775982","https://openalex.org/W4311279859","https://openalex.org/W4312082559","https://openalex.org/W4312179686","https://openalex.org/W4312220173","https://openalex.org/W4318927412","https://openalex.org/W4321793552","https://openalex.org/W4323314841","https://openalex.org/W4324326514","https://openalex.org/W4378952453","https://openalex.org/W4386306755","https://openalex.org/W4386495800","https://openalex.org/W4389440988","https://openalex.org/W4398664756","https://openalex.org/W4399697703","https://openalex.org/W4400245757","https://openalex.org/W4400859848","https://openalex.org/W4401160971","https://openalex.org/W4402649622","https://openalex.org/W4403229886","https://openalex.org/W4403612072","https://openalex.org/W4403980991","https://openalex.org/W4406550022","https://openalex.org/W4407149901","https://openalex.org/W4407260930","https://openalex.org/W4408018468","https://openalex.org/W4408989485","https://openalex.org/W4409986279","https://openalex.org/W4416373524","https://openalex.org/W7125204089"],"related_works":["https://openalex.org/W2548858264","https://openalex.org/W2549265405","https://openalex.org/W2954839616","https://openalex.org/W2088036173","https://openalex.org/W4385973417","https://openalex.org/W4377992516","https://openalex.org/W2071300070","https://openalex.org/W2936920755","https://openalex.org/W7223183995","https://openalex.org/W2303815386"],"abstract_inverted_index":{"Cancer":[0],"is":[1,27,105],"among":[2],"the":[3,55,95,99,116,121,158],"most":[4],"significant":[5,113],"diseases":[6],"endangering":[7],"global":[8],"public":[9],"health.":[10],"Early":[11],"detection":[12,49,126,130,181],"has":[13],"been":[14],"demonstrated":[15],"to":[16,72],"markedly":[17],"improve":[18],"prognoses":[19],"and":[20,46,78,146,154,189],"increase":[21,114],"cure":[22],"rates.":[23],"Hypochlorous":[24],"acid":[25],"(HClO)":[26],"a":[28,41,63,74,80,85,112,129],"pivotal":[29],"reactive":[30],"oxygen":[31],"species,":[32],"frequently":[33],"manifesting":[34],"elevated":[35],"levels":[36],"in":[37,111,115,198],"cancer":[38,168],"cells.":[39,172],"Herein,":[40],"highly":[42,44],"sensitive,":[43],"specific,":[45],"efficient":[47],"HClO":[48,125],"method":[50,61,122,159,175],"was":[51],"established":[52],"based":[53],"on":[54],"toehold-mediated":[56],"strand":[57],"displacement":[58],"(TMSD).":[59],"This":[60],"employs":[62],"duplex":[64],"complex":[65],"(TN)":[66],"formed":[67],"from":[68,108,170],"three":[69],"single-stranded":[70],"DNAs":[71],"carry":[73],"fluorescent":[75],"group":[76,104],"(FAM),":[77],"introduces":[79],"hairpin":[81],"DNA":[82],"(HP)":[83],"with":[84,128],"phosphorothioate":[86],"(PS)-modified":[87],"site":[88],"for":[89,196],"specific":[90],"recognition":[91],"of":[92,97,132,139,162,187,201],"HClO.":[93],"Under":[94],"action":[96],"HClO,":[98,164],"short":[100],"fragment":[101],"bearing":[102],"FAM":[103],"eventually":[106],"released":[107],"TN,":[109],"resulting":[110],"system":[117],"fluorescence.":[118],"After":[119],"optimization,":[120],"achieves":[123],"excellent":[124,180],"performance,":[127,182],"range":[131],"0.01-7":[133],"\u00b5M":[134],"(LOD:":[135],"12.9":[136],"nM).":[137],"Analysis":[138],"real":[140],"samples,":[141],"including":[142,179],"tap":[143],"water,":[144],"serum":[145],"cell":[147],"lysate,":[148],"also":[149],"confirms":[150],"its":[151],"good":[152],"stability":[153],"accuracy.":[155],"Most":[156],"importantly,":[157],"enables":[160],"imaging":[161],"intracellular":[163],"thereby":[165],"effectively":[166],"distinguishing":[167],"cells":[169],"normal":[171],"Overall,":[173],"this":[174],"offers":[176],"various":[177],"advantages,":[178],"fast":[183],"response":[184],"times,":[185],"ease":[186],"use,":[188],"readily":[190],"available":[191],"materials,":[192],"making":[193],"it":[194],"promising":[195],"application":[197],"early":[199],"diagnosis":[200],"cancer.":[202]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-31T00:00:00"}