{"id":"https://openalex.org/W7224918254","doi":"https://doi.org/10.1080/14737167.2026.2752796","title":"Health-related quality of life in adult patients with moyamoya disease in Japan: a single-center study","display_name":"Health-related quality of life in adult patients with moyamoya disease in Japan: a single-center study","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224918254","doi":"https://doi.org/10.1080/14737167.2026.2752796","pmid":"https://pubmed.ncbi.nlm.nih.gov/42961279"},"language":"en","primary_location":{"id":"doi:10.1080/14737167.2026.2752796","doi":"https://doi.org/10.1080/14737167.2026.2752796","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14737167.2026.2752796","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/14737167.2026.2752796?needAccess=true","source":{"id":"https://openalex.org/S98544388","display_name":"Expert Review of Pharmacoeconomics & Outcomes Research","issn_l":"1473-7167","issn":["1473-7167","1744-8379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-c","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Pharmacoeconomics & Outcomes Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/14737167.2026.2752796?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006234979","display_name":"Honoka Tamori","orcid":"https://orcid.org/0000-0002-2196-2538","observed_orcids":["https://orcid.org/0000-0002-2196-2538"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Honoka Tamori","raw_affiliation_strings":["Hokkaido University","National Institute of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"National Institute of Public Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023182386","display_name":"Toshiya Osanai","orcid":"https://orcid.org/0000-0001-5570-1726","observed_orcids":["https://orcid.org/0000-0001-5570-1726"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshiya Osanai","raw_affiliation_strings":["Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063819703","display_name":"Haruto Uchino","orcid":"https://orcid.org/0000-0001-6567-8136","observed_orcids":["https://orcid.org/0000-0001-6567-8136"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruto Uchino","raw_affiliation_strings":["Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052472028","display_name":"Katsuhiko Ogasawara","orcid":"https://orcid.org/0000-0001-5474-7861","observed_orcids":["https://orcid.org/0000-0001-5474-7861"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuhiko Ogasawara","raw_affiliation_strings":["Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111262208","display_name":"Miki Fujimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miki Fujimura","raw_affiliation_strings":["Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023182386"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83214221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12747","display_name":"Moyamoya disease diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12747","display_name":"Moyamoya disease diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moyamoya-disease","display_name":"moyamoya disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":1.0},{"id":"https://openalex.org/keywords/japanese-adults","display_name":"Japanese adults","score":0.7440000176429749},{"id":"https://openalex.org/keywords/sf-36","display_name":"SF-36","score":0.7950000166893005},{"id":"https://openalex.org/keywords/eq-5d-5l","display_name":"EQ-5D-5L","score":0.9739999771118164},{"id":"https://openalex.org/keywords/modified-rankin-scale","display_name":"modified Rankin Scale","score":0.8889999985694885},{"id":"https://openalex.org/keywords/physical-health","display_name":"physical health","score":0.5370000004768372},{"id":"https://openalex.org/keywords/mental-health","display_name":"mental health","score":0.8809999823570251},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.7070000171661377},{"id":"https://openalex.org/keywords/functional-disability","display_name":"functional disability","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9190000295639038},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.7398999929428101},{"id":"https://openalex.org/C2776548475","wikidata":"https://www.wikidata.org/wiki/Q1951267","display_name":"Moyamoya disease","level":2,"score":0.6377999782562256},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.550599992275238},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5382000207901001},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.5365999937057495},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5270000100135803},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4952999949455261},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4498000144958496},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.4146000146865845},{"id":"https://openalex.org/C3018709324","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Population based study","level":3,"score":0.4072999954223633},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3885999917984009},{"id":"https://openalex.org/C2778464720","wikidata":"https://www.wikidata.org/wiki/Q19843151","display_name":"EQ-5D","level":4,"score":0.3871000111103058},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3637999892234802},{"id":"https://openalex.org/C2776237627","wikidata":"https://www.wikidata.org/wiki/Q133549","display_name":"SF-36","level":4,"score":0.33959999680519104},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.3296999931335449},{"id":"https://openalex.org/C3019006561","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Health related quality of life","level":3,"score":0.3206000030040741},{"id":"https://openalex.org/C79544238","wikidata":"https://www.wikidata.org/wiki/Q423243","display_name":"Activities of daily living","level":2,"score":0.3142000138759613},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.3009999990463257},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.27810001373291016},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.2766999900341034},{"id":"https://openalex.org/C2909321700","wikidata":"https://www.wikidata.org/wiki/Q181600","display_name":"Outpatient visits","level":3,"score":0.27630001306533813},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2646999955177307},{"id":"https://openalex.org/C2780664029","wikidata":"https://www.wikidata.org/wiki/Q5282120","display_name":"Disease burden","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C64332521","wikidata":"https://www.wikidata.org/wiki/Q614165","display_name":"Quality-adjusted life year","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.25429999828338623},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.2513999938964844},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2508000135421753},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/14737167.2026.2752796","doi":"https://doi.org/10.1080/14737167.2026.2752796","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14737167.2026.2752796","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/14737167.2026.2752796?needAccess=true","source":{"id":"https://openalex.org/S98544388","display_name":"Expert Review of Pharmacoeconomics & Outcomes Research","issn_l":"1473-7167","issn":["1473-7167","1744-8379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-c","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Pharmacoeconomics & Outcomes Research","raw_type":"journal-article"},{"id":"pmid:42961279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42961279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of pharmacoeconomics & outcomes research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/14737167.2026.2752796","doi":"https://doi.org/10.1080/14737167.2026.2752796","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14737167.2026.2752796","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/14737167.2026.2752796?needAccess=true","source":{"id":"https://openalex.org/S98544388","display_name":"Expert Review of Pharmacoeconomics & Outcomes Research","issn_l":"1473-7167","issn":["1473-7167","1744-8379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-c","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Pharmacoeconomics & Outcomes Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224918254.pdf","grobid_xml":"https://content.openalex.org/works/W7224918254.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W81110543","https://openalex.org/W1564375067","https://openalex.org/W1606583078","https://openalex.org/W1969661146","https://openalex.org/W1983284612","https://openalex.org/W1990166011","https://openalex.org/W1994517646","https://openalex.org/W2012380128","https://openalex.org/W2028398671","https://openalex.org/W2035121886","https://openalex.org/W2038163393","https://openalex.org/W2062461652","https://openalex.org/W2083066919","https://openalex.org/W2111521308","https://openalex.org/W2149672895","https://openalex.org/W2155524713","https://openalex.org/W2791479921","https://openalex.org/W2904387640","https://openalex.org/W2954993923","https://openalex.org/W3157544365","https://openalex.org/W3206535301","https://openalex.org/W4212945459","https://openalex.org/W4282941391","https://openalex.org/W4311791647","https://openalex.org/W4376133235","https://openalex.org/W4382630749","https://openalex.org/W4390545790","https://openalex.org/W4397031690","https://openalex.org/W4403910604","https://openalex.org/W4409376875","https://openalex.org/W7119515056"],"related_works":["https://openalex.org/W2357231484","https://openalex.org/W2062461652","https://openalex.org/W2474670073","https://openalex.org/W6908604375","https://openalex.org/W7221800498","https://openalex.org/W4390545790","https://openalex.org/W4409376875","https://openalex.org/W2092516806","https://openalex.org/W4308239226","https://openalex.org/W7103902600"],"abstract_inverted_index":{"BACKGROUND:":[0],"Moyamoya":[1],"disease":[2],"(MMD)":[3],"is":[4],"a":[5],"chronic":[6],"cerebrovascular":[7],"disorder":[8],"associated":[9,31,91,156],"with":[10,36,60,79,92,105,157,168],"stroke":[11],"and":[12,28,49,72,81,144],"functional":[13],"impairment":[14],"that":[15,174],"may":[16],"adversely":[17],"affect":[18],"health-related":[19],"quality":[20],"of":[21,175,193],"life":[22],"(HRQOL).":[23],"This":[24],"study":[25],"assessed":[26],"HRQOL":[27,75,154,164],"explored":[29],"its":[30],"factors":[32,90],"in":[33,165],"Japanese":[34,83,166],"adults":[35,59,167],"MMD.":[37],"RESEARCH":[38],"DESIGN":[39],"AND":[40],"METHODS:":[41],"The":[42],"36-Item":[43],"Short":[44],"Form":[45],"Health":[46],"Survey":[47],"(SF-36)":[48],"EuroQol":[50],"5-Dimension":[51],"5-Level":[52],"questionnaire":[53],"(EQ-5D-5":[54],"L)":[55],"were":[56,77,116],"mailed":[57],"to":[58,119,127,137,147,173,184],"MMD":[61,169],"attending":[62],"outpatient":[63],"clinics":[64],"at":[65],"Hokkaido":[66],"University":[67],"Hospital":[68],"between":[69],"January":[70],"2023":[71],"March":[73],"2025.":[74],"scores":[76,182],"compared":[78],"age-":[80],"sex-specific":[82],"population":[84,111],"norms.":[85],"Multivariable":[86],"regression":[87],"analyses":[88],"revealed":[89],"HRQOL.":[93],"RESULTS:":[94],"Of":[95],"213":[96],"eligible":[97],"patients,":[98],"140":[99],"provided":[100],"informed":[101],"consent.":[102],"Among":[103],"patients":[104],"self-reported":[106],"outcomes,":[107],"mean":[108],"differences":[109],"from":[110],"norms":[112],"(95%":[113],"confidence":[114],"intervals)":[115],"0.005":[117],"(-0.011":[118],"0.021)":[120],"for":[121,129,139,149],"EQ-5D":[122],"values,":[123],"-":[124],"-1.4":[125],"(-2.7":[126],"0.01)":[128],"the":[130,140,150,158,176,194],"SF-36":[131],"physical":[132,180],"component":[133,142,152],"summary,":[134,143],"4.4":[135],"(2.7":[136],"6.0)":[138],"mental":[141],"1.7":[145],"(0.1":[146],"3.3)":[148],"role/social":[151],"summary.":[153],"was":[155,170],"modified":[159],"Rankin":[160],"Scale":[161],"score.":[162],"CONCLUSIONS:":[163],"generally":[171],"comparable":[172],"general":[177],"population,":[178],"although":[179],"health":[181],"tended":[183],"be":[185],"lower.":[186],"These":[187],"findings":[188],"warrant":[189],"cautious":[190],"interpretation":[191],"because":[192],"study's":[195],"cross-sectional,":[196],"single-center":[197],"design.":[198]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}