{"id":"https://openalex.org/W7224915004","doi":"https://doi.org/10.3389/frfst.2026.1974601","title":"Production and characterization of antidiabetic peptides from kefir-fermented goat milk with anti-inflammatory activity: an in silico, in vitro and molecular docking interactions","display_name":"Production and characterization of antidiabetic peptides from kefir-fermented goat milk with anti-inflammatory activity: an in silico, in vitro and molecular docking interactions","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224915004","doi":"https://doi.org/10.3389/frfst.2026.1974601"},"language":"en","primary_location":{"id":"doi:10.3389/frfst.2026.1974601","doi":"https://doi.org/10.3389/frfst.2026.1974601","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frfst.2026.1974601","pdf_url":"https://www.frontiersin.org/journals/food-science-and-technology/articles/10.3389/frfst.2026.1974601/pdf","source":{"id":"https://openalex.org/S4210221350","display_name":"Frontiers in Food Science and Technology","issn_l":"2674-1121","issn":["2674-1121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Food Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/food-science-and-technology/articles/10.3389/frfst.2026.1974601/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160204299","display_name":"Salvi Sunilkumar Tulsibhai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133099055","display_name":"Kamdhenu University","ror":"https://ror.org/02k3mav14","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133099055"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Salvi Sunilkumar Tulsibhai","raw_affiliation_strings":["Department of Dairy Microbiology, SMC College of Dairy Science, Kamdhenu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dairy Microbiology, SMC College of Dairy Science, Kamdhenu University","institution_ids":["https://openalex.org/I3133099055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160201666","display_name":"Kurmi Karankumar Prabhatsinh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133099055","display_name":"Kamdhenu University","ror":"https://ror.org/02k3mav14","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133099055"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kurmi Karankumar Prabhatsinh","raw_affiliation_strings":["Department of Dairy Microbiology, SMC College of Dairy Science, Kamdhenu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dairy Microbiology, SMC College of Dairy Science, Kamdhenu University","institution_ids":["https://openalex.org/I3133099055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013779970","display_name":"Pooja M. Mankad","orcid":"https://orcid.org/0000-0003-0679-6014","observed_orcids":["https://orcid.org/0000-0003-0679-6014"]},"institutions":[{"id":"https://openalex.org/I3133099055","display_name":"Kamdhenu University","ror":"https://ror.org/02k3mav14","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133099055"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pooja M. Mankad","raw_affiliation_strings":["Department of Veterinary Biotechnology, College of Veterinary Science and Animal Husbandry, Kamdhenu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biotechnology, College of Veterinary Science and Animal Husbandry, Kamdhenu University","institution_ids":["https://openalex.org/I3133099055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006395173","display_name":"Amar A. Sakure","orcid":"https://orcid.org/0000-0001-8805-0683","observed_orcids":["https://orcid.org/0000-0001-8805-0683"]},"institutions":[{"id":"https://openalex.org/I34750443","display_name":"Anand Agricultural University","ror":"https://ror.org/050qxn185","country_code":"IN","type":"education","lineage":["https://openalex.org/I34750443"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amar A. Sakure","raw_affiliation_strings":["Department of Agriculture Biotechnology, Anand Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agriculture Biotechnology, Anand Agricultural University","institution_ids":["https://openalex.org/I34750443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031500216","display_name":"Arka Bhattacharya","orcid":"https://orcid.org/0000-0002-0716-111X","observed_orcids":["https://orcid.org/0000-0002-0716-111X"]},"institutions":[{"id":"https://openalex.org/I4210164849","display_name":"BRIC-National Agri-Food and Biomanufacturing Institute","ror":"https://ror.org/05nnsek89","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210164849"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arka Bhattacharya","raw_affiliation_strings":["Healthy Gut Research Group, Food & Nutritional Biotechnology Division, National Agri-Food Biotechnology Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Healthy Gut Research Group, Food & Nutritional Biotechnology Division, National Agri-Food Biotechnology Institute","institution_ids":["https://openalex.org/I4210164849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061706236","display_name":"Kanthi Kiran Kondepudi","orcid":"https://orcid.org/0000-0001-8036-7555","observed_orcids":["https://orcid.org/0000-0001-8036-7555"]},"institutions":[{"id":"https://openalex.org/I4210164849","display_name":"BRIC-National Agri-Food and Biomanufacturing Institute","ror":"https://ror.org/05nnsek89","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210164849"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kanthi Kiran Kondepudi","raw_affiliation_strings":["Healthy Gut Research Group, Food & Nutritional Biotechnology Division, National Agri-Food Biotechnology Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Healthy Gut Research Group, Food & Nutritional Biotechnology Division, National Agri-Food Biotechnology Institute","institution_ids":["https://openalex.org/I4210164849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065003224","display_name":"Bipransh Kumar Tiwary","orcid":"https://orcid.org/0000-0002-9479-8740","observed_orcids":["https://orcid.org/0000-0002-9479-8740"]},"institutions":[{"id":"https://openalex.org/I56090587","display_name":"North Bengal University","ror":"https://ror.org/039w8qr24","country_code":"IN","type":"education","lineage":["https://openalex.org/I56090587"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bipransh Kumar Tiwary","raw_affiliation_strings":["Department of Microbiology, North Bengal St. Xavier\u2019s College, North Bengal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, North Bengal St. Xavier\u2019s College, North Bengal University","institution_ids":["https://openalex.org/I56090587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078073566","display_name":"Preetam Sarkar","orcid":"https://orcid.org/0000-0002-6532-8408","observed_orcids":["https://orcid.org/0000-0002-6532-8408"]},"institutions":[{"id":"https://openalex.org/I4210107052","display_name":"Instituto Nacional de Tecnologia","ror":"https://ror.org/012ang229","country_code":"BR","type":"government","lineage":["https://openalex.org/I4210107052","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I4210120810","display_name":"National Institute of Technology","ror":"https://ror.org/02xqkcw08","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210120810"]},{"id":"https://openalex.org/I4210131302","display_name":"National Institute of Technology","ror":"https://ror.org/03bqt8z64","country_code":"NO","type":"company","lineage":["https://openalex.org/I4210131302"]}],"countries":["BR","JP","NO"],"is_corresponding":false,"raw_author_name":"Preetam Sarkar","raw_affiliation_strings":["Department of Food Process Engineering, National Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Process Engineering, National Institute of Technology","institution_ids":["https://openalex.org/I4210107052","https://openalex.org/I4210120810","https://openalex.org/I4210131302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029018421","display_name":"Subhash J. Jakhesara","orcid":"https://orcid.org/0000-0002-3246-8834","observed_orcids":["https://orcid.org/0000-0002-3246-8834"]},"institutions":[{"id":"https://openalex.org/I3133099055","display_name":"Kamdhenu University","ror":"https://ror.org/02k3mav14","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133099055"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhash J. Jakhesara","raw_affiliation_strings":["Department of Veterinary Biotechnology, College of Veterinary Science and Animal Husbandry, Kamdhenu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biotechnology, College of Veterinary Science and Animal Husbandry, Kamdhenu University","institution_ids":["https://openalex.org/I3133099055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031062126","display_name":"Subrota Hati","orcid":"https://orcid.org/0000-0002-4010-204X","observed_orcids":["https://orcid.org/0000-0002-4010-204X"]},"institutions":[{"id":"https://openalex.org/I3133099055","display_name":"Kamdhenu University","ror":"https://ror.org/02k3mav14","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133099055"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Subrota Hati","raw_affiliation_strings":["Department of Dairy Microbiology, SMC College of Dairy Science, Kamdhenu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dairy Microbiology, SMC College of Dairy Science, Kamdhenu University","institution_ids":["https://openalex.org/I3133099055"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5031062126"],"corresponding_institution_ids":["https://openalex.org/I3133099055"],"apc_list":{"value":1950,"currency":"CHF","value_usd":2353},"apc_paid":{"value":1950,"currency":"CHF","value_usd":2353},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74717014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antidiabetic-peptides","display_name":"antidiabetic peptides","score":0.9039999842643738},{"id":"https://openalex.org/keywords/kefir-fermentation","display_name":"kefir fermentation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/goat-milk","display_name":"goat milk","score":0.9810000061988831},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/digestive-enzyme-inhibition","display_name":"digestive enzyme inhibition","score":0.8610000014305115},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":0.8790000081062317},{"id":"https://openalex.org/keywords/alpha-amylase-inhibition","display_name":"\u03b1-amylase inhibition","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pancreatic-lipase-inhibition","display_name":"pancreatic lipase inhibition","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/macrophage-inflammatory-response","display_name":"macrophage inflammation","score":0.5929999947547913},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.8169999718666077},{"id":"https://openalex.org/keywords/milk-peptides","display_name":"milk peptides","score":0.6389999985694885},{"id":"https://openalex.org/keywords/peptide-bioactivity-prediction","display_name":"peptide bioactivity prediction","score":0.5210000276565552},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8379999995231628},{"id":"https://openalex.org/keywords/peptide-toxicity-prediction","display_name":"peptide toxicity prediction","score":0.5440000295639038},{"id":"https://openalex.org/keywords/ultrafiltration-fractionation","display_name":"ultrafiltration fractionation","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.7682999968528748},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.7001000046730042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6179999709129333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5817999839782715},{"id":"https://openalex.org/C2778072784","wikidata":"https://www.wikidata.org/wiki/Q185749","display_name":"Kefir","level":4,"score":0.5437999963760376},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.5396999716758728},{"id":"https://openalex.org/C2775992197","wikidata":"https://www.wikidata.org/wiki/Q513631","display_name":"Raw milk","level":2,"score":0.5026000142097473},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.46459999680519104},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4129999876022339},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.37619999051094055},{"id":"https://openalex.org/C2779853579","wikidata":"https://www.wikidata.org/wiki/Q3506176","display_name":"Fermented milk products","level":4,"score":0.34209999442100525},{"id":"https://openalex.org/C2777897731","wikidata":"https://www.wikidata.org/wiki/Q424430","display_name":"Whey protein","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C172353545","wikidata":"https://www.wikidata.org/wiki/Q2121926","display_name":"Ripening","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25209999084472656},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.25029999017715454}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/frfst.2026.1974601","doi":"https://doi.org/10.3389/frfst.2026.1974601","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frfst.2026.1974601","pdf_url":"https://www.frontiersin.org/journals/food-science-and-technology/articles/10.3389/frfst.2026.1974601/pdf","source":{"id":"https://openalex.org/S4210221350","display_name":"Frontiers in Food Science and Technology","issn_l":"2674-1121","issn":["2674-1121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Food Science and Technology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f4a6b72d88434fbbb3353a74a76d5264","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f4a6b72d88434fbbb3353a74a76d5264","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Food Science and Technology, Vol 6 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/frfst.2026.1974601","doi":"https://doi.org/10.3389/frfst.2026.1974601","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frfst.2026.1974601","pdf_url":"https://www.frontiersin.org/journals/food-science-and-technology/articles/10.3389/frfst.2026.1974601/pdf","source":{"id":"https://openalex.org/S4210221350","display_name":"Frontiers in Food Science and Technology","issn_l":"2674-1121","issn":["2674-1121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Food Science and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.5365999937057495,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224915004.pdf","grobid_xml":"https://content.openalex.org/works/W7224915004.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1656374382","https://openalex.org/W1869345845","https://openalex.org/W1881978711","https://openalex.org/W1914280947","https://openalex.org/W1966143107","https://openalex.org/W1972458261","https://openalex.org/W1977304530","https://openalex.org/W1985933988","https://openalex.org/W1994141928","https://openalex.org/W1998375228","https://openalex.org/W2017641546","https://openalex.org/W2020308329","https://openalex.org/W2025401975","https://openalex.org/W2036166876","https://openalex.org/W2062767224","https://openalex.org/W2065494411","https://openalex.org/W2072002605","https://openalex.org/W2082012892","https://openalex.org/W2086962493","https://openalex.org/W2090295712","https://openalex.org/W2100837269","https://openalex.org/W2105211035","https://openalex.org/W2126194460","https://openalex.org/W2127670645","https://openalex.org/W2149285811","https://openalex.org/W2154019529","https://openalex.org/W2184430240","https://openalex.org/W2196125147","https://openalex.org/W2519249650","https://openalex.org/W2731242593","https://openalex.org/W2763713850","https://openalex.org/W2768549104","https://openalex.org/W2800282691","https://openalex.org/W2806757837","https://openalex.org/W2900966921","https://openalex.org/W2944444090","https://openalex.org/W2950200056","https://openalex.org/W2966588906","https://openalex.org/W2990894737","https://openalex.org/W3000743710","https://openalex.org/W3008924797","https://openalex.org/W3176585824","https://openalex.org/W3195409988","https://openalex.org/W4200276747","https://openalex.org/W4318203861","https://openalex.org/W4367722861","https://openalex.org/W4382458996","https://openalex.org/W4396517685","https://openalex.org/W4401802047","https://openalex.org/W4402097680","https://openalex.org/W4409922334","https://openalex.org/W7127284285","https://openalex.org/W7134195404","https://openalex.org/W7134842471","https://openalex.org/W7161401574","https://openalex.org/W7169856643"],"related_works":["https://openalex.org/W2946248261","https://openalex.org/W7164037059","https://openalex.org/W4405316086","https://openalex.org/W7202162425","https://openalex.org/W7163040179","https://openalex.org/W4387010372","https://openalex.org/W4389703038","https://openalex.org/W4396517685","https://openalex.org/W2793751845","https://openalex.org/W1881978711"],"abstract_inverted_index":{"Introduction":[0],"Kefir":[1,253],"fermentation":[2,152,254],"may":[3],"promote":[4],"proteolysis":[5,23,259],"of":[6,132,225,248,264,293],"goat":[7,38,276,295],"milk":[8,39,47,161,277,296],"proteins":[9],"and":[10,24,32,54,61,73,77,88,92,109,117,126,135,141,171,184,189,220,230,234,238,246,260,274,281,297,305],"generate":[11],"peptide-containing":[12,30,299],"fractions":[13,31,102,269,300],"with":[14,50,155,227,257,270],"measurable":[15,261],"in-vitro":[16,42,55,262],"bioactivity.":[17],"This":[18],"study":[19],"investigated":[20],"changes":[21],"in":[22,40,97,115,284],"digestive-enzyme":[25],"inhibition":[26,131,202,263],"during":[27],"fermentation,":[28],"characterized":[29,104],"evaluated":[33,96],"cellular":[34],"responses":[35,94],"to":[36,84,148,180,310],"fermented":[37,49,275],"an":[41],"macrophage":[43],"model.":[44],"Methods":[45],"Goat":[46],"was":[48,119,153,178,255],"kefir":[51,158],"culture.":[52],"Proteolysis":[53],"inhibitory":[56,272],"activities":[57,273],"against":[58],"\u03b1-amylase,":[59,133],"\u03b1-glucosidase":[60,134,201],"pancreatic":[62,136],"lipase":[63,137],"were":[64,68,82,95,103,113],"assessed.":[65],"Fermentation":[66],"conditions":[67],"compared":[69],"across":[70],"culture":[71],"concentrations":[72],"time":[74],"points.":[75],"FTIR":[76,170],"dynamic":[78],"light":[79],"scattering":[80],"(DLS)":[81],"used":[83],"characterize":[85],"spectral":[86],"features":[87],"particle-size":[89],"distributions.":[90],"Cytotoxicity":[91],"inflammatory":[93,280],"RAW":[98,181,285],"264.7":[99,182,286],"macrophages.":[100],"Peptide-containing":[101],"by":[105],"ultrafiltration,":[106],"RP-HPLC,":[107],"electrophoresis":[108],"RP-LC/MS.":[110],"Candidate":[111],"peptides":[112,219],"screened":[114],"silico":[116],"SCQDQPTTLAR":[118,226],"selected":[120,279],"for":[121,162],"exploratory":[122],"molecular":[123],"docking.":[124],"Results":[125],"Discussion":[127],"After":[128],"48":[129,163],"h,":[130,164],"reached":[138],"68.87%,":[139],"70.21%":[140],"61.40%,":[142],"respectively,":[143],"while":[144],"proteolytic":[145,168,212],"activity":[146,213],"increased":[147,258],"5.523":[149],"mg/mL.":[150,193],"Optimal":[151],"obtained":[154],"4.8\u20136.8":[156],"mg":[157],"culture/100":[159],"mL":[160],"producing":[165],"5.93":[166],"mg/mL":[167],"activity.":[169],"DLS":[172],"indicated":[173,223],"fermentation-associated":[174],"structural":[175],"changes.":[176],"GMK":[177],"non-cytotoxic":[179],"cells":[183],"decreased":[185],"TNF-\u03b1,":[186],"IL-6,":[187],"IL-1\u03b2":[188],"ROS":[190],"at":[191],"1":[192],"The":[194],"3":[195],"kDa":[196,207],"permeate":[197],"exhibited":[198],"the":[199,205,210,243,249],"greatest":[200],"(75.20%),":[203],"whereas":[204],"10":[206],"retentate":[208],"showed":[209],"highest":[211],"(6.35":[214],"mg/mL).":[215],"RP-LC/MS":[216],"identified":[217,250],"milk-derived":[218],"docking":[221],"analysis":[222],"interactions":[224],"hBAL,":[228],"hMGA":[229],"hPAM,":[231],"involving":[232],"His435":[233],"Asp300.":[235],"BIOPEP-UWM,":[236],"PeptideRanker":[237],"toxicity":[239],"prediction":[240],"further":[241,291,306],"supported":[242],"potential":[244,302],"bioactivity":[245],"safety":[247],"peptides.":[251],"Conclusion":[252],"associated":[256],"digestive":[265],"enzymes.":[266],"Ultrafiltration":[267],"produced":[268],"differing":[271],"altered":[278],"ROS-related":[282],"readouts":[283],"cells.":[287],"These":[288],"findings":[289],"support":[290],"investigation":[292],"kefir-fermented":[294],"its":[298],"as":[301],"functional-food":[303],"ingredients":[304],"studies":[307],"are":[308],"required":[309],"establish":[311],"clinical":[312],"antidiabetic":[313],"efficacy":[314],"or":[315],"product":[316],"shelf":[317],"life.":[318]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-31T00:00:00"}