{"id":"https://openalex.org/W7224914053","doi":"https://doi.org/10.1155/ianc/5522314","title":"An LC\u2010MS/MS Method for Quantitative Analysis of Regorafenib and Exploration of Its Intracellular Exposure in Colorectal Cancer Cells","display_name":"An LC\u2010MS/MS Method for Quantitative Analysis of Regorafenib and Exploration of Its Intracellular Exposure in Colorectal Cancer Cells","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7224914053","doi":"https://doi.org/10.1155/ianc/5522314","pmid":"https://pubmed.ncbi.nlm.nih.gov/42964553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13720225"},"language":"en","primary_location":{"id":"doi:10.1155/ianc/5522314","doi":"https://doi.org/10.1155/ianc/5522314","is_oa":true,"landing_page_url":"https://doi.org/10.1155/ianc/5522314","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/ianc/5522314","source":{"id":"https://openalex.org/S127888171","display_name":"International Journal of Analytical Chemistry","issn_l":"1687-8760","issn":["1687-8760","1687-8779"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/ianc/5522314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100458486","display_name":"Xinran Wang","orcid":"https://orcid.org/0000-0003-1120-8248","observed_orcids":["https://orcid.org/0000-0003-1120-8248","https://orcid.org/0009-0000-8541-1471"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinran Wang","raw_affiliation_strings":["Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China"],"raw_orcid":"https://orcid.org/0009-0000-8541-1471","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160228657","display_name":"Wenwen Cai","orcid":"https://orcid.org/0009-0000-3230-2618","observed_orcids":["https://orcid.org/0009-0000-3230-2618"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenwen Cai","raw_affiliation_strings":["Department of Hematology Myeloma &amp; Lymphoma Center Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 201203 China"],"raw_orcid":"https://orcid.org/0009-0000-3230-2618","affiliations":[{"raw_affiliation_string":"Department of Hematology Myeloma &amp; Lymphoma Center Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 201203 China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160236929","display_name":"Zhijun Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijun Liu","raw_affiliation_strings":["College of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China  shutcm.edu.cn","Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China  shutcm.edu.cn","institution_ids":["https://openalex.org/I4210098460"]},{"raw_affiliation_string":"Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101990739","display_name":"Jianguo Sun","orcid":"https://orcid.org/0000-0003-1011-7918","observed_orcids":["https://orcid.org/0000-0003-1011-7918","https://orcid.org/0000-0001-9463-8758"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianguo Sun","raw_affiliation_strings":["Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China"],"raw_orcid":"https://orcid.org/0000-0001-9463-8758","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160190677","display_name":"Zhenhui Jiang","orcid":"https://orcid.org/0009-0005-2592-8635","observed_orcids":["https://orcid.org/0009-0005-2592-8635"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenhui Jiang","raw_affiliation_strings":["Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China"],"raw_orcid":"https://orcid.org/0009-0005-2592-8635","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065982799","display_name":"Liya Ye","orcid":"https://orcid.org/0009-0007-2509-4794","observed_orcids":["https://orcid.org/0009-0007-2509-4794"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liya Ye","raw_affiliation_strings":["Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China"],"raw_orcid":"https://orcid.org/0009-0007-2509-4794","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036005181","display_name":"Zhengyan Liang","orcid":"https://orcid.org/0009-0009-6135-3372","observed_orcids":["https://orcid.org/0009-0009-6135-3372"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengyan Liang","raw_affiliation_strings":["Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China"],"raw_orcid":"https://orcid.org/0009-0009-6135-3372","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064248586","display_name":"Zhipeng Wang","orcid":"https://orcid.org/0000-0002-7964-9288","observed_orcids":["https://orcid.org/0000-0002-7964-9288"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhipeng Wang","raw_affiliation_strings":["Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China"],"raw_orcid":"https://orcid.org/0000-0002-7964-9288","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045557806","display_name":"Shouhong Gao","orcid":"https://orcid.org/0000-0002-8322-4637","observed_orcids":["https://orcid.org/0000-0002-8322-4637"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shouhong Gao","raw_affiliation_strings":["Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China"],"raw_orcid":"https://orcid.org/0000-0002-8322-4637","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033846884","display_name":"Wansheng Chen","orcid":"https://orcid.org/0000-0002-0025-1315","observed_orcids":["https://orcid.org/0000-0002-0025-1315"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wansheng Chen","raw_affiliation_strings":["Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China"],"raw_orcid":"https://orcid.org/0000-0002-0025-1315","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033846884","https://openalex.org/A5045557806","https://openalex.org/A5064248586"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"],"apc_list":{"value":1630,"currency":"USD","value_usd":1630},"apc_paid":{"value":1630,"currency":"USD","value_usd":1630},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71992379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2026","issue":"1","first_page":"5522314","last_page":"5522314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regorafenib","display_name":"regorafenib","score":1.0},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.8259999752044678},{"id":"https://openalex.org/keywords/subcellular-drug-distribution","display_name":"subcellular drug distribution","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sw480-cells","display_name":"SW480 cells","score":1.0},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.7960000038146973},{"id":"https://openalex.org/keywords/lc-ms-ms-method-validation","display_name":"LC-MS/MS method validation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/matrix-effects","display_name":"matrix effects","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C2776248978","wikidata":"https://www.wikidata.org/wiki/Q3891664","display_name":"Regorafenib","level":4,"score":0.8152999877929688},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6582000255584717},{"id":"https://openalex.org/C2777379063","wikidata":"https://www.wikidata.org/wiki/Q161233","display_name":"Formic acid","level":2,"score":0.6201000213623047},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.5652999877929688},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.525600016117096},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4643999934196472},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4269999861717224},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.3889000117778778},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3483999967575073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3131999969482422},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29649999737739563},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.2962000072002411},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28679999709129333},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.2867000102996826},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.2685000002384186},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25999999046325684},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.25290000438690186}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/ianc/5522314","doi":"https://doi.org/10.1155/ianc/5522314","is_oa":true,"landing_page_url":"https://doi.org/10.1155/ianc/5522314","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/ianc/5522314","source":{"id":"https://openalex.org/S127888171","display_name":"International Journal of Analytical Chemistry","issn_l":"1687-8760","issn":["1687-8760","1687-8779"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Analytical Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13720225","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720225/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720225/pdf/IANC-2026-5522314.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Anal Chem","raw_type":"Text"},{"id":"pmid:42964553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42964553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e0e8a31a7cf64b50b9ae703df11542d7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e0e8a31a7cf64b50b9ae703df11542d7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Analytical Chemistry, Vol 2026 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/ianc/5522314","doi":"https://doi.org/10.1155/ianc/5522314","is_oa":true,"landing_page_url":"https://doi.org/10.1155/ianc/5522314","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/ianc/5522314","source":{"id":"https://openalex.org/S127888171","display_name":"International Journal of Analytical Chemistry","issn_l":"1687-8760","issn":["1687-8760","1687-8779"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Analytical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3337028234","display_name":null,"funder_award_id":"82530119","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7756944838","display_name":null,"funder_award_id":"82204819","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224914053.pdf","grobid_xml":"https://content.openalex.org/works/W7224914053.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2087543162","https://openalex.org/W2115721706","https://openalex.org/W2147834058","https://openalex.org/W2517515570","https://openalex.org/W2906686817","https://openalex.org/W3006728494","https://openalex.org/W3151818686","https://openalex.org/W3178723556","https://openalex.org/W4205143379","https://openalex.org/W4226413102","https://openalex.org/W4255291191","https://openalex.org/W4313680819","https://openalex.org/W4324148732","https://openalex.org/W4379537172","https://openalex.org/W4388033330"],"related_works":["https://openalex.org/W7130689952","https://openalex.org/W3204546574","https://openalex.org/W2774538128","https://openalex.org/W2170961867","https://openalex.org/W3028484194","https://openalex.org/W2611767388","https://openalex.org/W4392631775","https://openalex.org/W2319736389","https://openalex.org/W2954831934","https://openalex.org/W2735362862"],"abstract_inverted_index":{"Objective:":[0],"Regorafenib":[1],"(Reg)":[2],"is":[3],"a":[4,132,179],"multikinase":[5],"inhibitor":[6],"for":[7,32,110],"treating":[8],"metastatic":[9],"colorectal":[10],"cancer":[11],"(CRC);":[12],"however,":[13],"plasma":[14],"concentrations":[15,109],"may":[16,227,234],"not":[17],"fully":[18],"predict":[19],"clinical":[20],"response.":[21],"This":[22],"study":[23],"aimed":[24],"to":[25,39,164],"develop":[26],"and":[27,38,44,51,76,98,114,117,123,131,149,166,184,205,213,223,233],"validate":[28],"an":[29,59,92],"LC-MS/MS":[30],"method":[31,202],"quantifying":[33],"Reg":[34,50,104,118,172,209,225],"in":[35,86,120,174,178,210,221],"CRC":[36,195,211],"cells":[37,100,212],"preliminarily":[40],"characterize":[41],"its":[42],"temporal":[43,190,219],"spatial":[45],"distribution.":[46],"Methods:":[47],"Separation":[48],"of":[49,135,137,208],"the":[52,156,193],"internal":[53],"standard":[54],"(selinexor)":[55],"was":[56,84,126],"achieved":[57],"using":[58,74,91],"Agilent":[60,93],"Poroshell":[61],"120":[62],"EC-C18":[63],"column":[64],"(3.0":[65],"\u00d7":[66],"100":[67],"mm,":[68],"2.7":[69],"\u03bcm)":[70],"with":[71,103,230],"isocratic":[72],"elution":[73],"acetonitrile":[75],"0.1%":[77],"aqueous":[78],"formic":[79],"acid":[80],"(70:30,":[81],"v/v).":[82],"Detection":[83],"performed":[85],"multiple":[87],"reaction":[88],"monitoring":[89],"mode":[90],"1260-6460":[94],"UHPLC-MS/MS":[95,201],"system.":[96],"HCT116":[97],"SW480":[99],"were":[101,154,170],"treated":[102],"at":[105],"their":[106],"respective":[107],"IC50":[108],"12,":[111],"24,":[112],"36,":[113],"48":[115],"h,":[116],"exposure":[119,173,226],"whole-cell,":[121],"nuclear,":[122],"mitochondrial":[124,185],"fractions":[125],"measured.":[127],"Results:":[128],">":[129],"0.99)":[130],"lower":[133],"limit":[134],"quantification":[136,207],"1.0":[138],"ng/mL.":[139],"Precision":[140],"(intraday":[141],"RSD%":[142,146],"<":[143,147],"11.39%;":[144],"interday":[145],"9.11%)":[148],"accuracy":[150],"(RE%":[151],"within":[152,155],"\u00b16.80%)":[153],"acceptance":[157],"criteria.":[158],"The":[159,199,217],"recovery":[160],"ranged":[161],"from":[162],"86.03%":[163],"106.41%,":[165],"consistent":[167],"matrix":[168],"effects":[169],"observed.":[171],"whole-cell":[175],"samples":[176],"increased":[177],"time-dependent":[180],"manner,":[181],"while":[182],"nuclear":[183],"fraction-associated":[186,224],"exposures":[187],"showed":[188],"distinct":[189],"patterns":[191],"between":[192],"two":[194],"cell":[196],"lines.":[197],"Conclusion:":[198],"validated":[200],"enables":[203],"sensitive":[204],"reliable":[206],"isolated":[214],"subcellular":[215],"fractions.":[216],"observed":[218],"differences":[220],"intracellular":[222],"be":[228],"associated":[229],"cellular":[231],"response":[232],"support":[235],"future":[236],"exposure-response":[237],"assessments":[238],"beyond":[239],"plasma-based":[240],"pharmacokinetics.":[241]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-31T00:00:00"}