{"id":"https://openalex.org/W7224908518","doi":"https://doi.org/10.2147/ccid.s646149","title":"Exploring the Molecular Mechanisms of Yinxieping Tablets in Psoriasis Treatment Based on Network Pharmacology, Bioinformatics, and Experimental Validation","display_name":"Exploring the Molecular Mechanisms of Yinxieping Tablets in Psoriasis Treatment Based on Network Pharmacology, Bioinformatics, and Experimental Validation","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7224908518","doi":"https://doi.org/10.2147/ccid.s646149","pmid":"https://pubmed.ncbi.nlm.nih.gov/42985141","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13731869"},"language":"en","primary_location":{"id":"doi:10.2147/ccid.s646149","doi":"https://doi.org/10.2147/ccid.s646149","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ccid.s646149","pdf_url":"https://www.dovepress.com/article/download/121601","source":{"id":"https://openalex.org/S73516063","display_name":"Clinical Cosmetic and Investigational Dermatology","issn_l":"1178-7015","issn":["1178-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121601","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108328122","display_name":"Zhengjin Zhu","orcid":"https://orcid.org/0009-0001-5702-0809","observed_orcids":["https://orcid.org/0009-0001-5702-0809"]},"institutions":[{"id":"https://openalex.org/I4210147132","display_name":"Shaanxi Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/04kazdy71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengjin Zhu","raw_affiliation_strings":["Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0001-5702-0809","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, People's Republic of China","institution_ids":["https://openalex.org/I4210147132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160177061","display_name":"Ling Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147132","display_name":"Shaanxi Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/04kazdy71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Ma","raw_affiliation_strings":["Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, People's Republic of China","institution_ids":["https://openalex.org/I4210147132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160201406","display_name":"Dan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147132","display_name":"Shaanxi Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/04kazdy71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147132"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dan Sun","raw_affiliation_strings":["Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, People's Republic of China","institution_ids":["https://openalex.org/I4210147132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160206989","display_name":"Wenbin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147132","display_name":"Shaanxi Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/04kazdy71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147132"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenbin Li","raw_affiliation_strings":["Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, People's Republic of China","institution_ids":["https://openalex.org/I4210147132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081198167","display_name":"Jinfeng Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147132","display_name":"Shaanxi Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/04kazdy71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinfeng Zhao","raw_affiliation_strings":["Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, People's Republic of China","institution_ids":["https://openalex.org/I4210147132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5160201406","https://openalex.org/A5160206989"],"corresponding_institution_ids":["https://openalex.org/I4210147132"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76893029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 19","issue":null,"first_page":"1","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7940000295639038},{"id":"https://openalex.org/keywords/rosin","display_name":"rosin","score":0.7860000133514404},{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/imiquimod-induced-psoriasis-like-mouse-model","display_name":"imiquimod-induced psoriasis-like mouse model","score":0.9369999766349792},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8659999966621399},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8029999732971191},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7310000061988831},{"id":"https://openalex.org/keywords/lyn-kinase","display_name":"Lyn kinase","score":0.7490000128746033},{"id":"https://openalex.org/keywords/syk","display_name":"Syk","score":0.9890000224113464},{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.8240000009536743},{"id":"https://openalex.org/keywords/adrb2","display_name":"ADRB2","score":0.9340000152587891},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.8320000171661377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.724399983882904},{"id":"https://openalex.org/C2779112978","wikidata":"https://www.wikidata.org/wiki/Q423417","display_name":"Imiquimod","level":2,"score":0.6753000020980835},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.5978999733924866},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5759999752044678},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47929999232292175},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4465000033378601},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.43540000915527344},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4343000054359436},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43140000104904175},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4115000069141388},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36399999260902405},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.34540000557899475},{"id":"https://openalex.org/C126042315","wikidata":"https://www.wikidata.org/wiki/Q18033763","display_name":"SOCS3","level":4,"score":0.33629998564720154},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.33090001344680786},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.32429999113082886},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.3165999948978424},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.31060001254081726},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.31049999594688416},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.29089999198913574},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2867000102996826},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27889999747276306},{"id":"https://openalex.org/C1423137","wikidata":"https://www.wikidata.org/wiki/Q21113928","display_name":"CCR3","level":5,"score":0.27390000224113464},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2687000036239624},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2630999982357025},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.2565000057220459},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C2780439664","wikidata":"https://www.wikidata.org/wiki/Q7535376","display_name":"Skin biopsy","level":3,"score":0.2508000135421753}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ccid.s646149","doi":"https://doi.org/10.2147/ccid.s646149","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ccid.s646149","pdf_url":"https://www.dovepress.com/article/download/121601","source":{"id":"https://openalex.org/S73516063","display_name":"Clinical Cosmetic and Investigational Dermatology","issn_l":"1178-7015","issn":["1178-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology","raw_type":"journal-article"},{"id":"pmid:42985141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42985141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, cosmetic and investigational dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13731869","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13731869/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Cosmet Investig Dermatol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b3d07d3f63284f49830a6a0f792b08f4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b3d07d3f63284f49830a6a0f792b08f4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology, Vol Volume 19, Iss Issue 1, Pp 1-25 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/121601","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/exploring-the-molecular-mechanisms-of-yinxieping-tablets-in-psoriasis--peer-reviewed-fulltext-article-CCID","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ccid.s646149","doi":"https://doi.org/10.2147/ccid.s646149","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ccid.s646149","pdf_url":"https://www.dovepress.com/article/download/121601","source":{"id":"https://openalex.org/S73516063","display_name":"Clinical Cosmetic and Investigational Dermatology","issn_l":"1178-7015","issn":["1178-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8653734825","display_name":null,"funder_award_id":"82174386","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224908518.pdf","grobid_xml":"https://content.openalex.org/works/W7224908518.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1486333022","https://openalex.org/W2037219928","https://openalex.org/W2096301496","https://openalex.org/W2128156351","https://openalex.org/W2323531720","https://openalex.org/W2573502983","https://openalex.org/W2596228045","https://openalex.org/W2604286787","https://openalex.org/W2792688302","https://openalex.org/W2803795060","https://openalex.org/W2897063798","https://openalex.org/W2924895007","https://openalex.org/W2971801381","https://openalex.org/W3097912707","https://openalex.org/W3124008657","https://openalex.org/W3130062571","https://openalex.org/W4200402944","https://openalex.org/W4206739528","https://openalex.org/W4223889031","https://openalex.org/W4291015237","https://openalex.org/W4307358260","https://openalex.org/W4309402738","https://openalex.org/W4320035465","https://openalex.org/W4380368096","https://openalex.org/W4386221007","https://openalex.org/W4387016555","https://openalex.org/W4388097798","https://openalex.org/W4390665850","https://openalex.org/W4390711247","https://openalex.org/W4393317407","https://openalex.org/W4394984893","https://openalex.org/W4399553302","https://openalex.org/W4400733926","https://openalex.org/W4401503742","https://openalex.org/W4406228487","https://openalex.org/W4409534252","https://openalex.org/W4410058782","https://openalex.org/W4410587130","https://openalex.org/W4411474910","https://openalex.org/W4412493515","https://openalex.org/W4413365597","https://openalex.org/W4413855628","https://openalex.org/W4413890487","https://openalex.org/W4414410975"],"related_works":["https://openalex.org/W4399907956","https://openalex.org/W4412415204","https://openalex.org/W7162118644","https://openalex.org/W4324087525","https://openalex.org/W4386640628","https://openalex.org/W4409204515","https://openalex.org/W4401548383","https://openalex.org/W7204477142","https://openalex.org/W4412075202","https://openalex.org/W7166084613"],"abstract_inverted_index":{"Introduction:":[0],"Psoriasis":[1],"is":[2],"a":[3,11,25,95,222],"prevalent":[4],"immune-mediated":[5],"chronic":[6],"inflammatory":[7],"skin":[8,104,196],"disease,":[9],"with":[10,109,139,146],"pathology":[12],"defined":[13],"by":[14,89,204],"abnormal":[15],"keratinocyte":[16],"proliferation":[17],"and":[18,62,68,81,92,106,114,137,156,165,173,175,183,208,213,231],"immune":[19],"cell":[20],"infiltration.":[21],"Yinxieping":[22],"Tablets":[23],"(YXPT),":[24],"traditional":[26],"Chinese":[27],"medicine":[28],"formula":[29],"consisting":[30],"solely":[31],"of":[32,46,70,154,169,178],"rosin,":[33],"have":[34],"been":[35],"clinically":[36],"used":[37],"to":[38,49,233,238],"alleviate":[39],"psoriatic":[40],"symptoms.":[41],"However,":[42],"their":[43],"underlying":[44],"mechanisms":[45],"action":[47],"remain":[48,237],"be":[50,239],"fully":[51],"elucidated.":[52],"Methods:":[53],"We":[54],"established":[55],"an":[56],"imiquimod":[57],"(IMQ)-induced":[58],"psoriasis-like":[59,96,195],"mouse":[60,97,201],"model":[61],"systematically":[63],"screened":[64],"the":[65,123,143,189,199,234],"potential":[66],"targets":[67],"pathways":[69],"YXPT":[71,100,120,160,193],"using":[72],"integrated":[73],"network":[74],"pharmacology,":[75],"bioinformatics,":[76],"machine":[77],"learning,":[78],"transcriptome":[79],"sequencing,":[80],"molecular":[82],"docking.":[83],"Key":[84],"findings":[85,218],"were":[86,185],"experimentally":[87],"validated":[88],"Western":[90],"blot":[91],"qPCR":[93],"in":[94,188,198,210],"model.":[98],"Results:":[99],"treatment":[101],"improved":[102],"psoriasiform":[103],"lesions":[105,197],"was":[107],"associated":[108],"lower":[110,186,205],"lesional":[111,162],"Ki67":[112],"expression":[113,207],"serum":[115],"pro-inflammatory":[116],"cytokine":[117],"levels;":[118],"high-dose":[119],"also":[121],"reduced":[122],"spleen":[124],"index.":[125],"Integrated":[126],"analyses":[127],"identified":[128],"six":[129],"candidate":[130,223],"genes":[131],"(BCL2,":[132],"LYN,":[133],"SYK,":[134],"CCR2,":[135],"AURKA,":[136],"ADRB2),":[138],"CCR2":[140,163,206,220],"emerging":[141],"as":[142,221],"sole":[144],"overlap":[145],"RNA-seq-derived":[147],"genes.":[148],"CCR2-based":[149],"gene-set":[150],"analysis":[151],"showed":[152],"enrichment":[153],"PI3K/Akt-":[155],"NF-\u03baB-related":[157],"pathways.":[158],"Following":[159],"treatment,":[161],"protein":[164],"mRNA":[166,176],"levels,":[167],"phosphorylation":[168],"PI3K,":[170,179],"Akt,":[171,180],"p38,":[172,181],"p65,":[174],"levels":[177],"ERK1/2,":[182],"p65":[184],"than":[187],"IMQ":[190,200],"group.":[191],"Conclusion:":[192],"ameliorated":[194],"model,":[202],"accompanied":[203],"changes":[209,236],"PI3K/Akt,":[211],"MAPK,":[212],"NF-\u03baB":[214],"pathway":[215],"components.":[216],"These":[217],"nominate":[219],"for":[224],"further":[225],"study,":[226],"while":[227],"its":[228],"causal":[229],"role":[230],"relationship":[232],"signaling":[235],"established.":[240]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-31T00:00:00"}
