{"id":"https://openalex.org/W7224908420","doi":"https://doi.org/10.1093/cei/uxag070","title":"C5aR1 and C5aR2 deficiency confer different degrees of protection against imiquimod-induced psoriasiform dermatitis","display_name":"C5aR1 and C5aR2 deficiency confer different degrees of protection against imiquimod-induced psoriasiform dermatitis","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224908420","doi":"https://doi.org/10.1093/cei/uxag070","pmid":"https://pubmed.ncbi.nlm.nih.gov/42960665"},"language":"en","primary_location":{"id":"doi:10.1093/cei/uxag070","doi":"https://doi.org/10.1093/cei/uxag070","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cei/uxag070","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037363947","display_name":"Jeffrey J. Damman","orcid":"https://orcid.org/0000-0001-5997-7551","observed_orcids":["https://orcid.org/0000-0001-5997-7551","https://orcid.org/0000-0001-5070-6739"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jeffrey Damman","raw_affiliation_strings":["Department of Pathology, Erasmus Medical Center Rotterdam , Rotterdam ,"],"raw_orcid":"https://orcid.org/0000-0001-5997-7551","affiliations":[{"raw_affiliation_string":"Department of Pathology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025495315","display_name":"Koen Dudink","orcid":"https://orcid.org/0000-0003-4168-2311","observed_orcids":["https://orcid.org/0000-0003-4168-2311"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Koen Dudink","raw_affiliation_strings":["Department of Dermatology, Erasmus Medical Center Rotterdam , Rotterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108777905","display_name":"Anne-Marie C Mus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anne-Marie Mus","raw_affiliation_strings":["Department of Dermatology, Erasmus Medical Center Rotterdam , Rotterdam ,","Department of Rheumatology, Erasmus Medical Center Rotterdam , Rotterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Rheumatology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032184080","display_name":"Priyanka S Bangoer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Priyanka S Bangoer","raw_affiliation_strings":["Department of Dermatology, Erasmus Medical Center Rotterdam , Rotterdam ,","Department of Rheumatology, Erasmus Medical Center Rotterdam , Rotterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Rheumatology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036466163","display_name":"Thierry P. P. van den Bosch","orcid":"https://orcid.org/0000-0002-7223-4565","observed_orcids":["https://orcid.org/0000-0002-7223-4565"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Thierry P P van den Bosch","raw_affiliation_strings":["Department of Pathology, Erasmus Medical Center Rotterdam , Rotterdam ,"],"raw_orcid":"https://orcid.org/0000-0002-7223-4565","affiliations":[{"raw_affiliation_string":"Department of Pathology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076425940","display_name":"Antien L. Mooyaart","orcid":"https://orcid.org/0000-0001-9810-5780","observed_orcids":["https://orcid.org/0000-0001-9810-5780"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Antien L Mooyaart","raw_affiliation_strings":["Department of Pathology, Erasmus Medical Center Rotterdam , Rotterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025299489","display_name":"Felix Poppelaars","orcid":"https://orcid.org/0000-0002-5173-8078","observed_orcids":["https://orcid.org/0000-0002-5173-8078"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Felix Poppelaars","raw_affiliation_strings":["Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , Groningen ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , Groningen ,","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064550852","display_name":"Errol Prospero Prens","orcid":"https://orcid.org/0000-0002-8158-660X","observed_orcids":["https://orcid.org/0000-0002-8158-660X"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Errol P Prens","raw_affiliation_strings":["Department of Dermatology, Erasmus Medical Center Rotterdam , Rotterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017132626","display_name":"Marc A. Seelen","orcid":"https://orcid.org/0000-0003-2240-4682","observed_orcids":["https://orcid.org/0000-0003-2240-4682"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marc A Seelen","raw_affiliation_strings":["Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , Groningen ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , Groningen ,","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024916892","display_name":"Erik Lubberts","orcid":"https://orcid.org/0000-0002-3566-040X","observed_orcids":["https://orcid.org/0000-0002-3566-040X"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Erik Lubberts","raw_affiliation_strings":["Department of Dermatology, Erasmus Medical Center Rotterdam , Rotterdam ,","Department of Rheumatology, Erasmus Medical Center Rotterdam , Rotterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Rheumatology, Erasmus Medical Center Rotterdam , Rotterdam ,","institution_ids":["https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037363947"],"corresponding_institution_ids":["https://openalex.org/I2801952686"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80972016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/c5ar1","display_name":"C5aR1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/c5ar2","display_name":"C5aR2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.8130000233650208},{"id":"https://openalex.org/keywords/il-17f","display_name":"IL-17F","score":0.9909999966621399},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9350000023841858},{"id":"https://openalex.org/keywords/autoinflammation","display_name":"autoinflammation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/complement-inhibition","display_name":"complement inhibition","score":0.45399999618530273},{"id":"https://openalex.org/keywords/epidermal-thickness","display_name":"epidermal thickness","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.8859999775886536},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8195000290870667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6617000102996826},{"id":"https://openalex.org/C2779499704","wikidata":"https://www.wikidata.org/wiki/Q5008266","display_name":"C5a receptor","level":4,"score":0.6363999843597412},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6017000079154968},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5702999830245972},{"id":"https://openalex.org/C2779112978","wikidata":"https://www.wikidata.org/wiki/Q423417","display_name":"Imiquimod","level":2,"score":0.5516999959945679},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48989999294281006},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4699999988079071},{"id":"https://openalex.org/C2777011040","wikidata":"https://www.wikidata.org/wiki/Q390643","display_name":"Psoriasis Area and Severity Index","level":3,"score":0.38199999928474426},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.35670000314712524},{"id":"https://openalex.org/C90582226","wikidata":"https://www.wikidata.org/wiki/Q424292","display_name":"Anaphylatoxin","level":4,"score":0.3409999907016754},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3140999972820282},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.29899999499320984},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.2946000099182129},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.28600001335144043},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C2778091633","wikidata":"https://www.wikidata.org/wiki/Q783903","display_name":"Contact dermatitis","level":3,"score":0.28049999475479126},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C2778750689","wikidata":"https://www.wikidata.org/wiki/Q1799146","display_name":"Irritant contact dermatitis","level":4,"score":0.2653999924659729},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25189998745918274}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/cei/uxag070","doi":"https://doi.org/10.1093/cei/uxag070","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cei/uxag070","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmid:42960665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42960665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3036475477","https://openalex.org/W3183338634","https://openalex.org/W2964208498","https://openalex.org/W6944181652","https://openalex.org/W4400107001","https://openalex.org/W2015354478","https://openalex.org/W2911246983","https://openalex.org/W4388178231","https://openalex.org/W4313379008","https://openalex.org/W2891275310"],"abstract_inverted_index":{"Psoriasis":[0,85],"pathogenesis":[1,20,195],"comprises":[2],"both":[3],"auto-immune":[4],"and":[5,28,33,55,87,94,129,137,148,173,178,201,208],"auto-inflammatory":[6],"aspects.":[7],"We":[8],"hypothesized":[9],"that":[10],"complement":[11],"anaphylatoxin":[12],"C5a":[13,24],"plays":[14],"an":[15],"important":[16],"role":[17,190],"in":[18,99,123,153,193,199,232],"the":[19,67,100,124,194,203,223,233],"of":[21,36,63,97,121,132,143,196,222,235],"psoriasis":[22],"via":[23],"receptor":[25],"(C5aR)":[26],"1":[27],"C5aR2":[29],"activation":[30],"on":[31,66,167],"neutrophils":[32],"through":[34],"regulation":[35],"C5aR":[37],"dependent":[38],"IL-17/IL-23-mediated":[39],"adaptive":[40],"immune":[41],"activation.":[42],"The":[43],"imiquimod":[44],"(IMQ)-induced":[45],"psoriasiform":[46,197,218],"dermatitis":[47,198],"mouse":[48,84],"model":[49],"was":[50,80,108],"used.":[51],"Wildtype":[52],"(WT),":[53],"C5ar1-/-":[54,115,154],"C5ar2-/-":[56,162,210],"mice":[57,116,155,163,200,211],"received":[58],"a":[59,188,228],"daily":[60],"topical":[61],"dose":[62],"IMQ":[64,144],"cream":[65],"shaved":[68],"back":[69],"for":[70,191],"three":[71,127,183],"or":[72],"up":[73],"to":[74,113,157],"five":[75,141,171],"consecutive":[76],"days.":[77,184],"Skin":[78],"inflammation":[79],"assessed":[81],"visually":[82],"(modified":[83],"Area":[86],"Severity":[88],"Index":[89],"(PASI)),":[90],"by":[91,104,110],"histology,":[92],"immunohistochemistry":[93],"gene":[95,119],"expression":[96,120],"cytokines":[98],"skin":[101,125],"were":[102,150],"measured":[103],"qPCR.":[105],"Serum":[106],"IL-17A":[107,139,180],"analyzed":[109],"ELISA.":[111],"Compared":[112],"WT,":[114],"demonstrated":[117,174],"lower":[118],"IL-1\u03b2":[122,207],"after":[126,140,170,182],"days":[128,142,172],"decreased":[130,152],"influx":[131],"neutrophils,":[133],"monocytes/macrophages,":[134],"C9":[135],"deposition":[136],"circulating":[138],"treatment.":[145],"Epidermal":[146],"thickness":[147],"PASI-scores":[149],"significantly":[151],"compared":[156],"WT":[158],"at":[159],"day":[160],"five.":[161],"showed":[164,212],"mild":[165],"protection":[166,215],"epidermal":[168],"thickening":[169],"higher":[175],"local":[176],"IL-17F":[177],"systemic":[179],"responses":[181],"This":[185],"study":[186],"shows":[187],"detrimental":[189],"C5aR1":[192],"confirms":[202],"link":[204],"between":[205],"C5a-C5aR1,":[206],"IL-17A.":[209],"only":[213],"modest":[214],"against":[216],"IMQ-induced":[217],"dermatitis.":[219],"Therefore,":[220],"inhibition":[221],"C5a-C5aR1":[224],"axis":[225],"might":[226],"be":[227],"promising":[229],"novel":[230],"approach":[231],"treatment":[234],"psoriasis.":[236]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}