{"id":"https://openalex.org/W7224901052","doi":"https://doi.org/10.1002/bco2.70294","title":"The impact of 5\u2010alpha reductase inhibitors on multiparametric MRI diagnostic performance and prostate\u2010specific antigen density triage: A systematic review","display_name":"The impact of 5\u2010alpha reductase inhibitors on multiparametric MRI diagnostic performance and prostate\u2010specific antigen density triage: A systematic review","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224901052","doi":"https://doi.org/10.1002/bco2.70294","pmid":"https://pubmed.ncbi.nlm.nih.gov/42966989","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722573"},"language":"en","primary_location":{"id":"doi:10.1002/bco2.70294","doi":"https://doi.org/10.1002/bco2.70294","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bco2.70294","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bco2.70294","source":{"id":"https://openalex.org/S4210190590","display_name":"BJUI Compass","issn_l":"2688-4526","issn":["2688-4526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJUI Compass","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bco2.70294","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052567866","display_name":"Gregory Harrison","orcid":"https://orcid.org/0000-0003-0838-067X","observed_orcids":["https://orcid.org/0000-0003-0838-067X"]},"institutions":[{"id":"https://openalex.org/I2802576581","display_name":"Whittington Hospital","ror":"https://ror.org/01ckbq028","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802576581","https://openalex.org/I4210129898"]},{"id":"https://openalex.org/I4210129898","display_name":"Whittington Health NHS Trust","ror":"https://ror.org/02vg92y09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210129898"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gregory Harrison","raw_affiliation_strings":["Department of Urology Whittington Health NHS Trust  London UK"],"raw_orcid":"https://orcid.org/0000-0003-0838-067X","affiliations":[{"raw_affiliation_string":"Department of Urology Whittington Health NHS Trust  London UK","institution_ids":["https://openalex.org/I2802576581","https://openalex.org/I4210129898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040934054","display_name":"Bogdan Toia","orcid":"https://orcid.org/0000-0002-1215-6585","observed_orcids":["https://orcid.org/0000-0002-1215-6585"]},"institutions":[{"id":"https://openalex.org/I1289784979","display_name":"University College Hospital","ror":"https://ror.org/00wrevg56","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1289784979","https://openalex.org/I1340918713"]},{"id":"https://openalex.org/I1340918713","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bogdan Toia","raw_affiliation_strings":["Department of Urology University College London Hospitals (UCLH) NHS Foundation Trust  London UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology University College London Hospitals (UCLH) NHS Foundation Trust  London UK","institution_ids":["https://openalex.org/I1289784979","https://openalex.org/I1340918713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075038130","display_name":"Anju Sahdev","orcid":"https://orcid.org/0000-0001-8520-3031","observed_orcids":["https://orcid.org/0000-0001-8520-3031"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I2802576581","display_name":"Whittington Hospital","ror":"https://ror.org/01ckbq028","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802576581","https://openalex.org/I4210129898"]},{"id":"https://openalex.org/I4210129898","display_name":"Whittington Health NHS Trust","ror":"https://ror.org/02vg92y09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210129898"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anju Sahdev","raw_affiliation_strings":["Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute Queen Mary University of London  London UK","Department of Urology Whittington Health NHS Trust  London UK"],"raw_orcid":"https://orcid.org/0000-0001-8520-3031","affiliations":[{"raw_affiliation_string":"Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute Queen Mary University of London  London UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]},{"raw_affiliation_string":"Department of Urology Whittington Health NHS Trust  London UK","institution_ids":["https://openalex.org/I2802576581","https://openalex.org/I4210129898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036775644","display_name":"Prabhakar Rajan","orcid":"https://orcid.org/0000-0001-8064-9878","observed_orcids":["https://orcid.org/0000-0001-8064-9878"]},"institutions":[{"id":"https://openalex.org/I1340918713","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Prabhakar Rajan","raw_affiliation_strings":["Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute Queen Mary University of London  London UK","Department of Urology Barts Health NHS Trust  London UK","Department of Urology University College London Hospitals NHS Foundation Trust  London UK"],"raw_orcid":"https://orcid.org/0000-0001-8064-9878","affiliations":[{"raw_affiliation_string":"Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute Queen Mary University of London  London UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]},{"raw_affiliation_string":"Department of Urology Barts Health NHS Trust  London UK","institution_ids":["https://openalex.org/I225661044"]},{"raw_affiliation_string":"Department of Urology University College London Hospitals NHS Foundation Trust  London UK","institution_ids":["https://openalex.org/I1340918713"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020739113","display_name":"Benjamin W. Lamb","orcid":"https://orcid.org/0000-0003-2220-893X","observed_orcids":["https://orcid.org/0000-0003-2220-893X","https://orcid.org/0000-0003-4391-5633"]},"institutions":[{"id":"https://openalex.org/I1340918713","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]},{"id":"https://openalex.org/I4210088881","display_name":"London Cancer","ror":"https://ror.org/005kpb876","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210088881"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Benjamin W. Lamb","raw_affiliation_strings":["Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute Queen Mary University of London  London UK","Department of Urology Barts Health NHS Trust  London UK","Department of Urology University College London Hospitals NHS Foundation Trust  London UK","North East London Cancer Alliance NHS North East London  London UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute Queen Mary University of London  London UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]},{"raw_affiliation_string":"Department of Urology Barts Health NHS Trust  London UK","institution_ids":["https://openalex.org/I225661044"]},{"raw_affiliation_string":"Department of Urology University College London Hospitals NHS Foundation Trust  London UK","institution_ids":["https://openalex.org/I1340918713"]},{"raw_affiliation_string":"North East London Cancer Alliance NHS North East London  London UK","institution_ids":["https://openalex.org/I4210088881"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5020739113"],"corresponding_institution_ids":["https://openalex.org/I1340918713","https://openalex.org/I166337079","https://openalex.org/I225661044","https://openalex.org/I4210088881","https://openalex.org/I4405264518"],"apc_list":{"value":2770,"currency":"USD","value_usd":2770},"apc_paid":{"value":2770,"currency":"USD","value_usd":2770},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69799093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"11","first_page":"e70294","last_page":"e70294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5alpha-reductase-inhibitors","display_name":"5-alpha reductase inhibitors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/multiparametric-mri","display_name":"multiparametric MRI","score":0.9660000205039978},{"id":"https://openalex.org/keywords/clinically-significant-prostate-cancer","display_name":"clinically significant prostate cancer","score":0.9049999713897705},{"id":"https://openalex.org/keywords/psa-density","display_name":"PSA density","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pi-rads","display_name":"PI-RADS","score":0.7710000276565552},{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.8809999823570251},{"id":"https://openalex.org/keywords/prostate-cancer-detection","display_name":"prostate cancer detection","score":0.5640000104904175},{"id":"https://openalex.org/keywords/peripheral-zone-lesions","display_name":"peripheral zone lesions","score":0.628000020980835},{"id":"https://openalex.org/keywords/prostate-cancer-screening","display_name":"prostate cancer screening","score":0.4480000138282776},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.4169999957084656},{"id":"https://openalex.org/keywords/conspicuity","display_name":"conspicuity","score":0.3720000088214874},{"id":"https://openalex.org/keywords/isup-grade-group","display_name":"ISUP grade group","score":0.49300000071525574},{"id":"https://openalex.org/keywords/prostate-cancer-risk-stratification","display_name":"prostate cancer risk stratification","score":0.375},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9071000218391418},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5579000115394592},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5174000263214111},{"id":"https://openalex.org/C2910607126","wikidata":"https://www.wikidata.org/wiki/Q48790829","display_name":"Multiparametric MRI","level":4,"score":0.4514999985694885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42010000348091125},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4163999855518341},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.3817000091075897},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3700000047683716},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3659999966621399},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.3587000072002411},{"id":"https://openalex.org/C3017906399","wikidata":"https://www.wikidata.org/wiki/Q48973845","display_name":"Pooled analysis","level":3,"score":0.35190001130104065},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.3402999937534332},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.33489999175071716},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3346000015735626},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.3089999854564667},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3086000084877014},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2971999943256378},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.29339998960494995},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.28999999165534973},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2890999913215637},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.28769999742507935},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2842000126838684},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2587999999523163},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.25099998712539673},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.25029999017715454}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/bco2.70294","doi":"https://doi.org/10.1002/bco2.70294","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bco2.70294","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bco2.70294","source":{"id":"https://openalex.org/S4210190590","display_name":"BJUI Compass","issn_l":"2688-4526","issn":["2688-4526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJUI Compass","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722573","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722573/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722573/pdf/BCO2-7-e70294.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJUI Compass","raw_type":"Text"},{"id":"pmid:42966989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42966989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJUI compass","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/bco2.70294","doi":"https://doi.org/10.1002/bco2.70294","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bco2.70294","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bco2.70294","source":{"id":"https://openalex.org/S4210190590","display_name":"BJUI Compass","issn_l":"2688-4526","issn":["2688-4526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJUI Compass","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224901052.pdf","grobid_xml":"https://content.openalex.org/works/W7224901052.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1769725882","https://openalex.org/W1827911007","https://openalex.org/W1967315019","https://openalex.org/W2012608816","https://openalex.org/W2053552044","https://openalex.org/W2091362934","https://openalex.org/W2107638293","https://openalex.org/W2129302529","https://openalex.org/W2133929387","https://openalex.org/W2155530804","https://openalex.org/W2531269403","https://openalex.org/W2551730987","https://openalex.org/W2577453388","https://openalex.org/W2615565368","https://openalex.org/W2793905111","https://openalex.org/W2922071185","https://openalex.org/W2990668952","https://openalex.org/W3118615836","https://openalex.org/W4365813379","https://openalex.org/W4366987732","https://openalex.org/W4387296791","https://openalex.org/W4391541813","https://openalex.org/W4394787252","https://openalex.org/W4404052178","https://openalex.org/W4404416576","https://openalex.org/W4415912406"],"related_works":["https://openalex.org/W4387296791","https://openalex.org/W4404052178","https://openalex.org/W4391541813","https://openalex.org/W2990668952","https://openalex.org/W4414620939","https://openalex.org/W4415912406","https://openalex.org/W4394801371","https://openalex.org/W4404416576","https://openalex.org/W7160980297","https://openalex.org/W4365813379"],"abstract_inverted_index":{"Abstract":[0],"Objectives":[1],"To":[2],"evaluate":[3],"the":[4,54,199,255],"impact":[5],"of":[6,93,151,205,212,216],"5\u2010alpha":[7],"reductase":[8],"inhibitor":[9],"(5\u2010ARI)":[10],"exposure":[11,78,144],"on":[12],"multiparametric":[13],"MRI":[14],"(mpMRI)":[15],"diagnostic":[16,113],"performance":[17,235],"for":[18,236],"clinically":[19],"significant":[20],"prostate":[21],"cancer":[22],"(csPCa)":[23],"and":[24,41,53,86,99,142,224,250],"to":[25,62,198],"assess":[26],"whether":[27],"standard":[28],"prostate\u2010specific":[29],"antigen":[30],"density":[31],"(PSAD)\u2010gated":[32],"biopsy":[33,209],"thresholds":[34],"remain":[35],"safe":[36],"in":[37,126,130,163,210,222,241,254],"this":[38,246],"population.":[39],"Subjects/patients":[40],"methods":[42],"A":[43,202],"systematic":[44],"review":[45],"followed":[46],"PRISMA":[47],"2020":[48],"(PROSPERO:":[49],"CRD420251050507).":[50],"PubMed/MEDLINE,":[51],"EMBASE":[52],"Cochrane":[55],"Library":[56],"were":[57],"searched":[58],"from":[59],"January":[60],"2015":[61],"December":[63],"2024.":[64],"Eligible":[65],"studies":[66,107],"reported":[67,187],"PI\u2010RADS,":[68],"PSAD":[69,203],"or":[70],"lesion\u2010level":[71],"apparent":[72],"diffusion":[73],"coefficient":[74],"(ADC)":[75],"data":[76],"by":[77,264],"status,":[79],"biopsy\u2010verified":[80],"csPCa":[81,112,133,221,237],"(ISUP":[82],"grade":[83],"group":[84],"\u22652)":[85],"an":[87,147],"unexposed":[88,131,217],"comparator":[89],"(\u2265100":[90],"patients).":[91],"Risk":[92],"bias":[94],"was":[95,115,124,135,145,161,251],"assessed":[96],"using":[97],"QUADAS\u20102":[98],"ROBINS\u2010I;":[100],"heterogeneity":[101],"precluded":[102],"meta\u2010analysis.":[103],"Results":[104],"Seven":[105],"comparative":[106],"met":[108],"inclusion":[109],"criteria.":[110],"Patient\u2010level":[111],"accuracy":[114],"largely":[116,239],"maintained:":[117],"Sensitivity":[118],"at":[119],"a":[120,265],"PI\u2010RADS":[121],"\u22653":[122],"threshold":[123,204],"93.8%":[125],"exposed":[127,164,213],"versus":[128,137,214],"96.1%":[129],"men,":[132,218],"detection":[134],"39.1%":[136],"39.3%":[138],"(p":[139],"=":[140,173,182],"0.9),":[141],"5\u2010ARI":[143],"not":[146,252],"independent":[148],"negative":[149],"predictor":[150],"detection.":[152],"On":[153],"blinded":[154],"matched":[155],"review,":[156],"peripheral":[157,200],"zone":[158],"lesion":[159],"ADC":[160],"higher":[162],"men":[165,242],"(869":[166],"vs.":[167,179],"765":[168],"mm":[169],"2":[170],"/s,":[171],"p":[172,181],"0.04)":[174],"with":[175,219],"lower":[176,188],"conspicuity":[177],"(1.59":[178],"1.78,":[180],"0.03);":[183],"that":[184],"cohort":[185],"also":[186],"adjusted":[189],"per\u2010lesion":[190],"yield":[191],"(OR":[192],"0.32,":[193],"95%":[194],"CI":[195],"0.18\u20130.57),":[196],"confined":[197],"zone.":[201],">0.15":[206],"ng/ml/cc":[207],"avoided":[208],"37.0%":[211],"30.3%":[215],"missed":[220],"12.3%":[223],"11.0%,":[225],"respectively.":[226],"Conclusion":[227],"Across":[228],"seven":[229],"heterogeneous":[230],"observational":[231],"studies,":[232],"patient\u2010level":[233],"mpMRI":[234],"appears":[238],"preserved":[240],"receiving":[243],"5\u2010ARIs,":[244],"though":[245],"lacks":[247],"pooled":[248],"support":[249],"reproduced":[253],"one":[256],"lesion\u2010level,":[257],"zone\u2010stratified":[258],"analysis.":[259],"Standard":[260],"PSAD\u2010gated":[261],"thresholds,":[262],"evidenced":[263],"single":[266],"cohort,":[267],"may":[268],"perform":[269],"comparably":[270],"across":[271],"populations.":[272],"Prospective":[273],"validation":[274],"is":[275],"required.":[276]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-31T00:00:00"}
