{"id":"https://openalex.org/W7224899405","doi":"https://doi.org/10.26416/onhe.76.3.2026.11790","title":"Phase-related updates in the diagnosis and follow-up management of patients with chronic myeloid leukemia","display_name":"Phase-related updates in the diagnosis and follow-up management of patients with chronic myeloid leukemia","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7224899405","doi":"https://doi.org/10.26416/onhe.76.3.2026.11790"},"language":"en","primary_location":{"id":"doi:10.26416/onhe.76.3.2026.11790","doi":"https://doi.org/10.26416/onhe.76.3.2026.11790","is_oa":true,"landing_page_url":"https://doi.org/10.26416/onhe.76.3.2026.11790","pdf_url":"https://www.medichub.ro/mng/upload/1/Reviste/Oncolog-Hematolog/2026/3/PDFS/04-Phase-related%20updates%20in%20the%20diagnosis%20and%20follow-up%20management%20of%20patients%20with%20chronic%20m.pdf","source":{"id":"https://openalex.org/S4210202582","display_name":"Oncolog-Hematolog ro","issn_l":"2066-8260","issn":["2066-8260","2066-8716"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncolog-Hematolog.ro","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.medichub.ro/mng/upload/1/Reviste/Oncolog-Hematolog/2026/3/PDFS/04-Phase-related%20updates%20in%20the%20diagnosis%20and%20follow-up%20management%20of%20patients%20with%20chronic%20m.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160173345","display_name":"Vasile Mustea\u021b\u0103","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vasile Mustea\u021b\u0103","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075363352","display_name":"Valentina Stratan","orcid":"https://orcid.org/0000-0002-6490-9577","observed_orcids":["https://orcid.org/0000-0002-6490-9577","https://orcid.org/0000-0002-0614-6655"]},"institutions":[{"id":"https://openalex.org/I4210108897","display_name":"Institutul Oncologic din Republica Moldova","ror":"https://ror.org/01m92rg76","country_code":"MD","type":"healthcare","lineage":["https://openalex.org/I4210108897"]}],"countries":["MD"],"is_corresponding":false,"raw_author_name":"Valentina Stratan","raw_affiliation_strings":[". Institute of Oncology , Chi\u015fin\u0103u , Republic of Moldova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Institute of Oncology , Chi\u015fin\u0103u , Republic of Moldova","institution_ids":["https://openalex.org/I4210108897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059251853","display_name":"Daniel Coriu","orcid":"https://orcid.org/0000-0002-7251-6079","observed_orcids":["https://orcid.org/0000-0002-7251-6079"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Daniel Coriu","raw_affiliation_strings":[". \" Carol Davila\" University of Medicine and Pharmacy , Bucharest , Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". \" Carol Davila\" University of Medicine and Pharmacy , Bucharest , Romania","institution_ids":["https://openalex.org/I162051807"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5160173345"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85013213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"3","first_page":"20","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bcr-abl1-transcript","display_name":"BCR-ABL transcript","score":0.8859999775886536},{"id":"https://openalex.org/keywords/t315i-mutation","display_name":"T315I mutation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7329999804496765},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.5950000286102295},{"id":"https://openalex.org/keywords/molecular-monitoring","display_name":"molecular monitoring","score":0.35600000619888306},{"id":"https://openalex.org/keywords/biochemical-markers","display_name":"biochemical markers","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.847599983215332},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.71670001745224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6984000205993652},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.6657000184059143},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6093999743461609},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.6003000140190125},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5008999705314636},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.453000009059906},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.42500001192092896},{"id":"https://openalex.org/C2777357209","wikidata":"https://www.wikidata.org/wiki/Q3595842","display_name":"Phlebotomy","level":2,"score":0.3944000005722046},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.36480000615119934},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33820000290870667},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.31060001254081726},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.2865000069141388},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28119999170303345},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25369998812675476}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.26416/onhe.76.3.2026.11790","doi":"https://doi.org/10.26416/onhe.76.3.2026.11790","is_oa":true,"landing_page_url":"https://doi.org/10.26416/onhe.76.3.2026.11790","pdf_url":"https://www.medichub.ro/mng/upload/1/Reviste/Oncolog-Hematolog/2026/3/PDFS/04-Phase-related%20updates%20in%20the%20diagnosis%20and%20follow-up%20management%20of%20patients%20with%20chronic%20m.pdf","source":{"id":"https://openalex.org/S4210202582","display_name":"Oncolog-Hematolog ro","issn_l":"2066-8260","issn":["2066-8260","2066-8716"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncolog-Hematolog.ro","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:fcb57b1d038d4255a676cea09d8111ed","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fcb57b1d038d4255a676cea09d8111ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncolog-Hematolog.ro, Vol 76, Iss 3, p 20 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.26416/onhe.76.3.2026.11790","doi":"https://doi.org/10.26416/onhe.76.3.2026.11790","is_oa":true,"landing_page_url":"https://doi.org/10.26416/onhe.76.3.2026.11790","pdf_url":"https://www.medichub.ro/mng/upload/1/Reviste/Oncolog-Hematolog/2026/3/PDFS/04-Phase-related%20updates%20in%20the%20diagnosis%20and%20follow-up%20management%20of%20patients%20with%20chronic%20m.pdf","source":{"id":"https://openalex.org/S4210202582","display_name":"Oncolog-Hematolog ro","issn_l":"2066-8260","issn":["2066-8260","2066-8716"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncolog-Hematolog.ro","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224899405.pdf","grobid_xml":"https://content.openalex.org/works/W7224899405.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4306989438"],"related_works":["https://openalex.org/W7204701626","https://openalex.org/W4414211505","https://openalex.org/W7037043769","https://openalex.org/W1836539244","https://openalex.org/W4386102497","https://openalex.org/W6888568640","https://openalex.org/W3181122946","https://openalex.org/W3131755082","https://openalex.org/W4281382826","https://openalex.org/W3196643062"],"abstract_inverted_index":{"Introduction.":[0],"The":[1,36,120,172,228,275,289,321,364,429,447,485],"increase":[2],"of":[3,15,39,49,75,100,111,118,148,151,164,175,202,209,226,293,332,378,422,431,456],"lactate":[4],"dehydrogenase":[5],"(LDH)":[6],"level":[7],"is":[8],"regarded":[9],"as":[10,26,57,510],"a":[11,511],"common":[12,283],"biochemical":[13,71,138,166],"marker":[14],"neoplastic":[16],"proliferation":[17],"and":[18,21,33,41,47,68,72,79,82,86,92,105,145,161,168,182,188,237,246,257,310,352,395,418,450,458,470,482,488],"anaerobic":[19],"metabolism,":[20],"it":[22],"has":[23],"been":[24],"asserted":[25],"an":[27],"unfavorable":[28],"prognostic":[29,513],"factor":[30],"in":[31,107,155,213,223,249,260,327,375,409,419,443,495],"leu\u00adke\u00admias":[32],"malignant":[34],"lymphomas.":[35],"regular":[37],"de\u00adter\u00admi\u00adna\u00adtion":[38],"LDH":[40,210,238,297,330,416,451,483,500,508],"BCR::ABL1":[42,153,270,433,479],"transcripts":[43,480],"during":[44,437],"the":[45,70,108,112,152,159,189,199,206,214,219,250,261,269,281,376,432,438,444,454,465,507],"diag\u00adno\u00adsis":[46,78],"monitoring":[48],"chronic":[50,97,128],"myeloid":[51],"leukemia":[52],"(CML)":[53],"subjects":[54,267],"could":[55],"deem":[56],"markers":[58],"for":[59,135,463],"treatment":[60],"con\u00adti\u00adnua\u00adtion.":[61],"Objective.":[62],"This":[63],"research":[64],"aimed":[65],"to":[66,157,234,254,279,324,371,492],"assess":[67],"update":[69],"molecular-genetic":[73,146],"profile":[74],"CML":[76,101,124,176,203,439],"at":[77,299,335,467,502],"follow-up.":[80],"Materials":[81],"method.":[83],"Our":[84],"ana\u00adly\u00adti\u00adcal":[85],"cohort":[87,174],"study":[88],"included":[89],"193":[90],"prospective":[91],"re\u00adtro\u00adspec\u00adtive":[93],"cases":[94,125,204,285,328,412,424],"with":[95,126,186,295,329,380,413,425,498],"late":[96,262],"phase":[98,466],"(CPh)":[99],"trea\u00adted":[102],"between":[103,478],"2016":[104],"2025":[106],"Hematology":[109],"Division":[110],"Oncology":[113],"Institute":[114],"from":[115,243],"Chi\u015fin\u0103u,":[116],"Republic":[117],"Moldova.":[119],"control":[121],"group":[122,377],"comprised":[123,178],"early":[127,251],"phase.":[129],"Peri\u00adphe\u00adral":[130],"blood":[131,216],"samples":[132],"were":[133,211,476],"collected":[134],"quantitative":[136],"RT-PCR,":[137],"tests":[139],"(alkaline":[140],"phosphatase":[141],"\u2013":[142,340,345,350,356,388,393,399],"ALP,":[143],"LDH)":[144],"detection":[147],"T315I":[149,426],"mutation":[150],"gene,":[154],"order":[156],"assert":[158],"diagnostic":[160],"prog\u00adnos\u00adtic":[162],"significance":[163],"these":[165],"parameters":[167],"molecular":[169],"aberration.":[170],"Results.":[171],"researched":[173],"patients":[177,294,379,497],"104":[179],"(53.9%)":[180],"males":[181],"89":[183],"(46.1%)":[184],"females":[185],"CPh,":[187,263],"average":[190],"age":[191],"was":[192,232,301],"47.5":[193],"years":[194,309,314,344,349,355,392,398],"old":[195],"(m=1.02;":[196],"F=0.251).":[197],"In":[198,265],"overwhelming":[200],"majority":[201],"(151/78.2%),":[205],"elevated":[207,415],"levels":[208,221,298,331,382],"found":[212],"venous":[215],"samples,":[217],"while":[218],"ALP":[220,235,381,449],"in\u00adcreased":[222],"48":[224],"(30%)":[225],"cases.":[227],"statistically":[229],"significant":[230],"ele\u00adva\u00adtion":[231,436],"assigned":[233],"(p<0.05)":[236],"(p<0.01)":[239],"va\u00adlues,":[240],"which":[241],"rose":[242],"207.5":[244],"U/L":[245,256,259,334],"460.07":[247],"U/l":[248],"CPh":[252],"up":[253],"1516":[255],"2509":[258],"cor\u00adres\u00adpon\u00addingly.":[264],"most":[266,282],"(71.8%),":[268],"trans\u00adcripts":[271,434],"expression":[272,430],"surpassed":[273],"65%.":[274],"b3a2":[276],"transcript":[277],"proved":[278,323,491],"be":[280,325,372,461,493],"(65":[284],"or":[286,441],"53.3%;":[287],"p<0.001).":[288],"global":[290],"survival":[291,366,487],"(GS)":[292],"normal":[296],"diagnosis":[300,468,503],"100%":[302],"within":[303,307,312],"one":[304,338,386],"year,":[305],"93.7%":[306],"five":[308,348,391],"84.4%":[311],"10":[313,354,397],"(M=221.090":[315],"months;":[316,359,402],"95%":[317,360,403],"Confidence":[318,361,404],"Interval;":[319,362,405],"187.788-254.392).":[320],"GS":[322],"inferior":[326],"1001-1250":[333],"diagnosis:":[336],"over":[337,342,347,353,385,390,396],"year":[339,387],"100%;":[341],"three":[343],"66.7%;":[346],"55.6%;":[351],"0%":[357],"(M=110.977":[358],"79.915-142.039).":[363],"disease-free":[365,489],"(DFS)":[367],"indices":[368],"turned":[369],"out":[370],"much":[373],"higher":[374,494],"\u2264270":[383],"U/L:":[384],"91.3%;":[389],"81.6%;":[394],"75%":[400],"(M=167.507":[401],"148.185-186.828).":[406],"Relapses":[407],"emerged":[408],"18":[410],"(62.1%)":[411],"initially":[414],"levels,":[417],"nine":[420],"(64.3%)":[421],"14":[423],"mu\u00adta\u00adtion.":[427],"Conclusions.":[428],"exhibits":[435],"recurrence":[440],"trans\u00adfor\u00admation":[442],"advanced":[445],"phases.":[446],"increased":[448],"values":[452],"de\u00admon\u00adstrate":[453],"activity":[455],"CML,":[457],"they":[459],"may":[460],"used":[462],"asserting":[464],"con\u00adfir\u00adma\u00adtion":[469],"mo\u00adni\u00adto\u00adring":[471],"under":[472],"treatment.":[473],"Positive":[474],"cor\u00adre\u00adla\u00adtions":[475],"ob\u00adserved":[477],"ex\u00adpres\u00adsion":[481],"values.":[484],"general":[486],"sur\u00advi\u00adval":[490],"CPh-CML":[496],"lower":[499],"va\u00adlues":[501],"and,":[504],"thus,":[505],"certified":[506],"value":[509],"pro\u00admi\u00adsing":[512],"factor.":[514]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}