{"id":"https://openalex.org/W7224898457","doi":"https://doi.org/10.64898/2026.10.29.762853","title":"Evolution of immune infiltration and immune triad formation across early melanoma progression","display_name":"Evolution of immune infiltration and immune triad formation across early melanoma progression","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224898457","doi":"https://doi.org/10.64898/2026.10.29.762853"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.29.762853","doi":"https://doi.org/10.64898/2026.10.29.762853","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.29.762853","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.29.762853.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.29.762853.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148173750","display_name":"Kayla Marks","orcid":"https://orcid.org/0009-0001-2585-6855","observed_orcids":["https://orcid.org/0009-0001-2585-6855"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayla A Marks","raw_affiliation_strings":["Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160168786","display_name":"Abigail Florell-Orton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail Florell-Orton","raw_affiliation_strings":["Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160172195","display_name":"Min Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Hu","raw_affiliation_strings":["Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA","Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160220085","display_name":"Burke Lawlor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Burke Lawlor","raw_affiliation_strings":["Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058952306","display_name":"Scott R. Florell","orcid":"https://orcid.org/0000-0002-9502-1386","observed_orcids":["https://orcid.org/0000-0002-9502-1386"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Florell","raw_affiliation_strings":["Department of Dermatology, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069706679","display_name":"Mitchell S. Stark","orcid":"https://orcid.org/0000-0002-4510-2161","observed_orcids":["https://orcid.org/0000-0002-4510-2161"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mitchell S Stark","raw_affiliation_strings":["Frazer Institute, The University of Queensland, Dermatology Research Centre, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frazer Institute, The University of Queensland, Dermatology Research Centre, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088574888","display_name":"Kathleen Janee Green","orcid":"https://orcid.org/0000-0001-7332-5867","observed_orcids":["https://orcid.org/0000-0001-7332-5867"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen J Green","raw_affiliation_strings":["Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA","Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076506932","display_name":"Dekker C. Deacon","orcid":"https://orcid.org/0000-0002-4160-5730","observed_orcids":["https://orcid.org/0000-0002-4160-5730"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dekker C Deacon","raw_affiliation_strings":["Department of Dermatology, University of Utah, Salt Lake City, UT, USA","Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025857523","display_name":"Frederick R. Adler","orcid":"https://orcid.org/0000-0002-9022-3157","observed_orcids":["https://orcid.org/0000-0002-9022-3157"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick R Adler","raw_affiliation_strings":["Department of Mathematics, University of Utah, Salt Lake City, UT, USA","Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA","School of Biological Sciences, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I2801159745"]},{"raw_affiliation_string":"School of Biological Sciences, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038106228","display_name":"Robert L. Judson\u2010Torres","orcid":"https://orcid.org/0000-0002-6559-0553","observed_orcids":["https://orcid.org/0000-0002-6559-0553"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L Judson-Torres","raw_affiliation_strings":["Department of Dermatology, University of Utah, Salt Lake City, UT, USA","Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA","Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015964712","display_name":"Melissa Quino Reeves","orcid":"https://orcid.org/0000-0002-4886-5164","observed_orcids":["https://orcid.org/0000-0002-4886-5164"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melissa Q Reeves","raw_affiliation_strings":["Department of Pathology, University of Utah, Salt Lake City, UT, USA","Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":"https://orcid.org/0000-0002-4886-5164","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I2801159745"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5015964712"],"corresponding_institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.18289999663829803,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/tumor-immune-infiltration","display_name":"tumor immune infiltration","score":0.5669999718666077},{"id":"https://openalex.org/keywords/melanoma-progression","display_name":"melanoma progression","score":0.8309999704360962},{"id":"https://openalex.org/keywords/melanoma-in-situ","display_name":"melanoma in situ","score":0.718999981880188},{"id":"https://openalex.org/keywords/nevi","display_name":"nevi","score":0.890999972820282},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/skin-invasion","display_name":"dermal invasion","score":0.5609999895095825},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8385000228881836},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7792999744415283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4925999939441681},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4235999882221222},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4099999964237213},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.38830000162124634},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37220001220703125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3677000105381012},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.364300012588501},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.357699990272522},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3495999872684479},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3154999911785126},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2583000063896179},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.2574000060558319}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.29.762853","doi":"https://doi.org/10.64898/2026.10.29.762853","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.29.762853","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.29.762853.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.29.762853","doi":"https://doi.org/10.64898/2026.10.29.762853","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.29.762853","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.29.762853.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2689323976","display_name":null,"funder_award_id":"P30CA040214","funder_id":"https://openalex.org/F4320312218","funder_display_name":"Huntsman Cancer Institute"},{"id":"https://openalex.org/G7555868500","display_name":"FUNCTIONAL CHARACTERIZATION OF ISOLATED PDGF RECEPTOR","funder_award_id":"R01CA040214","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320312217","display_name":"Huntsman Cancer Foundation","ror":"https://ror.org/03v7tx966"},{"id":"https://openalex.org/F4320312218","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224898457.pdf","grobid_xml":"https://content.openalex.org/works/W7224898457.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7028946116","https://openalex.org/W2908784791","https://openalex.org/W2159707304","https://openalex.org/W4392286120","https://openalex.org/W1980740370","https://openalex.org/W1999912819","https://openalex.org/W2395322526","https://openalex.org/W4309477021","https://openalex.org/W2380863500","https://openalex.org/W2754648032"],"abstract_inverted_index":{"Abstract":[0],"Tumor-infiltrating":[1,209],"lymphocytes":[2,210],"(TIL)":[3],"in":[4,88,100,163,204,217,252],"melanoma":[5,34,68,84,94,140,195,199,213,228,246],"are":[6,13,86,161],"a":[7,44,179,188],"clinically":[8],"important":[9],"prognostic":[10],"marker":[11],"and":[12,28,43,63,75,80,103,116,141,223,254],"routinely":[14],"used":[15],"to":[16,83,97,153,166,187],"inform":[17],"patient":[18,214],"care.":[19],"However,":[20],"when":[21,224],"immune":[22,65,137,175,191,225,243],"recognition":[23,138,176,197,226],"of":[24,47,53,90,126,139,181,193,198,227,237],"transformed":[25],"melanocytes":[26],"begins":[27],"how":[29,222],"it":[30],"evolves":[31],"during":[32,67],"early":[33,54,218],"progression":[35,149,239],"is":[36,120,177,229],"not":[37,121,178],"well":[38],"understood.":[39,233],"Using":[40,234],"spatial":[41,132],"transcriptomics":[42],"unique":[45],"cohort":[46],"patient-matched":[48,235],"lesions":[49,102,236],"representing":[50],"multiple":[51,238],"stages":[52],"evolution,":[55],"we":[56,106,171,241],"investigate":[57],"T":[58,73,114],"cells,":[59],"dendritic":[60],"cells":[61,85],"(DCs)":[62],"multi-cell":[64],"\u201ctriads\u201d":[66],"initiation.":[69],"We":[70,134],"find":[71,107,242],"that":[72,108,136,160,202],"cell":[74,115,128],"DC":[76,117],"density,":[77,79,118],"triad":[78,81,109],"proximity":[82],"elevated":[87],"regions":[89],"Stage":[91,98,151,154,167,205,250,255],"I":[92,155,168,206,256],"invasive":[93,169,194,257],"as":[95],"compared":[96],"0":[99,152,251],"situ":[101,253],"nevi.":[104],"Further,":[105,157],"abundance":[110],"correlates":[111],"with":[112,143,148,245],"both":[113],"but":[119,221],"predicted":[122],"by":[123],"clustering":[124],"patterns":[125],"these":[127],"types":[129],"over":[130],"larger":[131],"scales.":[133],"conclude":[135],"engagement":[142,192,244],"the":[144,164],"lesion":[145],"significantly":[146],"increases":[147,248],"from":[150],"disease.":[156,207,258],"using":[158],"nevi":[159],"depth-matched":[162],"dermis":[165],"lesions,":[170],"demonstrate":[172],"this":[173],"increased":[174],"consequence":[180],"dermal":[182],"invasion":[183],"alone.":[184],"This":[185],"points":[186],"paradigm":[189],"where":[190],"reflects":[196],"cell-intrinsic":[200],"changes":[201],"emerge":[203],"Significance":[208],"predict":[211],"better":[212],"outcomes":[215],"even":[216],"stage":[219],"disease,":[220],"initiated":[230],"remains":[231],"poorly":[232],"stages,":[240],"strongly":[247],"between":[249]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-31T00:00:00"}