{"id":"https://openalex.org/W7224887249","doi":"https://doi.org/10.1016/j.heliyon.2026.e45637","title":"The prognostic value of TNFRSF4 in hepatocellular carcinoma using a two-zone CT imaging model","display_name":"The prognostic value of TNFRSF4 in hepatocellular carcinoma using a two-zone CT imaging model","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224887249","doi":"https://doi.org/10.1016/j.heliyon.2026.e45637"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2026.e45637","doi":"https://doi.org/10.1016/j.heliyon.2026.e45637","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2026.e45637","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.heliyon.2026.e45637","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041077471","display_name":"Ruifan Ye","orcid":"https://orcid.org/0009-0007-9491-6413","observed_orcids":["https://orcid.org/0009-0007-9491-6413"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruifan Ye","raw_affiliation_strings":["Department of Plastic and Aesthetic Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Aesthetic Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138704018","display_name":"Shengkai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengkai Wang","raw_affiliation_strings":["Department of Pathology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138736624","display_name":"Yujie Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujie Li","raw_affiliation_strings":["Radiology Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054173334","display_name":"Qikuan He","orcid":"https://orcid.org/0000-0002-7370-1428","observed_orcids":["https://orcid.org/0000-0002-7370-1428"]},"institutions":[{"id":"https://openalex.org/I4210101660","display_name":"Ningbo No. 2 Hospital","ror":"https://ror.org/01apc5d07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210101660","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qikuan He","raw_affiliation_strings":["Department of General Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China"],"raw_orcid":"https://orcid.org/0000-0002-7370-1428","affiliations":[{"raw_affiliation_string":"Department of General Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China","institution_ids":["https://openalex.org/I4210101660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054173334"],"corresponding_institution_ids":["https://openalex.org/I4210101660"],"apc_list":{"value":2270,"currency":"USD","value_usd":2270},"apc_paid":{"value":2270,"currency":"USD","value_usd":2270},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83719799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"16","first_page":"e45637","last_page":"e45637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ox40","display_name":"OX40","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/liver-cancer-prognosis","display_name":"liver cancer prognosis","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8230999708175659},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7416999936103821},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.6643999814987183},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5985999703407288},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.4440999925136566},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.36309999227523804},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3465999960899353},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C2993652001","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular cancer","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C3018130915","wikidata":"https://www.wikidata.org/wiki/Q1752284","display_name":"Neoplasm staging","level":3,"score":0.25609999895095825}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.heliyon.2026.e45637","doi":"https://doi.org/10.1016/j.heliyon.2026.e45637","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2026.e45637","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ee1f6d1cbc4f4b5fba65696e13a9d681","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ee1f6d1cbc4f4b5fba65696e13a9d681","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 12, Iss 16, Pp e45637- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2026.e45637","doi":"https://doi.org/10.1016/j.heliyon.2026.e45637","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2026.e45637","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1993506057","https://openalex.org/W2064251865","https://openalex.org/W2066372136","https://openalex.org/W2101181406","https://openalex.org/W2607211817","https://openalex.org/W2725702761","https://openalex.org/W2763355946","https://openalex.org/W2912289473","https://openalex.org/W2915597952","https://openalex.org/W2999826627","https://openalex.org/W3025022288","https://openalex.org/W3166753505","https://openalex.org/W3190437677","https://openalex.org/W3211548830","https://openalex.org/W4210955410","https://openalex.org/W4285099106","https://openalex.org/W4288074375","https://openalex.org/W4295885731","https://openalex.org/W4311282814","https://openalex.org/W4318821378","https://openalex.org/W4319015705","https://openalex.org/W4320712662","https://openalex.org/W4323043937","https://openalex.org/W4327616863","https://openalex.org/W4393433034","https://openalex.org/W4401612316","https://openalex.org/W4413391026"],"related_works":["https://openalex.org/W4205090365","https://openalex.org/W7162548236","https://openalex.org/W1973327558","https://openalex.org/W4401883075","https://openalex.org/W7162506021","https://openalex.org/W7213583377","https://openalex.org/W6887484431","https://openalex.org/W4309783299","https://openalex.org/W2164631148","https://openalex.org/W4253889215"],"abstract_inverted_index":{"Palbociclib":[0],"is":[1],"in":[2,6,42,56,60,65,118,125,148,151],"early-stage":[3],"clinical":[4],"testing":[5],"advanced":[7],"hepatocellular":[8],"carcinoma":[9],"(HCC).":[10],"Here,":[11],"we":[12,137],"investigated":[13],"whether":[14],"the":[15,22,52,66,87,112,140,155,158,161,165,179,182],"anti-tumor":[16],"activity":[17],"of":[18,25,99,110,122,142,164,167,171,181],"palbociclib,":[19],"which":[20],"prevents":[21],"CDK4/6-mediated":[23],"phosphorylation":[24,166],"RB1":[26,169],"but":[27,78,102],"simultaneously":[28],"activates":[29],"AKT":[30],"signaling,":[31],"could":[32],"be":[33,82],"improved":[34],"by":[35,84],"its":[36],"combination":[37,57,73,88,113,144,159,183],"with":[38,58,127],"a":[39,94,115,190],"PI3K/AKT/mTOR":[40],"inhibitor":[41],"liver":[43],"cancer":[44],"models.":[45],"The":[46,72],"selective":[47],"pan-AKT":[48],"inhibitor,":[49],"MK-2206,":[50],"or":[51,96,129,188],"microRNA-199a-3p":[53],"were":[54],"tested":[55],"palbociclib":[59,128],"HCC":[61,68],"cell":[62],"lines":[63],"and":[64,120,150,170],"TG221":[67],"transgenic":[69],"mouse":[70],"model.":[71],"palbociclib/MK-2206":[74],"was":[75,103],"highly":[76],"effective,":[77],"too":[79],"toxic":[80],"to":[81,193],"tolerated":[83],"mice.":[85],"Conversely,":[86],"miR-199a-3p":[89,130],"mimics/palbociclib":[90],"not":[91],"only":[92],"induced":[93],"complete":[95],"partial":[97],"regression":[98],"tumor":[100,123],"lesions,":[101],"also":[104,138],"well":[105],"tolerated.":[106],"After":[107],"3":[108],"weeks":[109],"treatment,":[111],"produced":[114],"significant":[116],"reduction":[117],"number":[119],"size":[121],"nodules":[124],"comparison":[126],"mimics":[131],"used":[132],"as":[133,185,189],"single":[134],"agents.":[135],"Moreover,":[136],"reported":[139],"efficacy":[141,180],"this":[143],"against":[145],"sorafenib-resistant":[146],"cells":[147],"vitro":[149],"vivo":[152],".":[153],"At":[154],"molecular":[156],"level,":[157],"caused":[160],"simultaneous":[162],"decrease":[163],"both":[168],"AKT.":[172],"Our":[173],"findings":[174],"provide":[175],"pre-clinical":[176],"evidence":[177],"for":[178],"miR-199a-3p/palbociclib":[184],"anti-HCC":[186],"treatment":[187],"new":[191],"approach":[192],"overcome":[194],"sorafenib":[195],"resistance.":[196]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-31T00:00:00"}
