{"id":"https://openalex.org/W7224875835","doi":"https://doi.org/10.1016/j.adro.2026.102244","title":"Initial Clinical Experience with Upright Image-Guided Proton Therapy for Pediatric CNS, Pericranial, and Ocular Malignancies","display_name":"Initial Clinical Experience with Upright Image-Guided Proton Therapy for Pediatric CNS, Pericranial, and Ocular Malignancies","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7224875835","doi":"https://doi.org/10.1016/j.adro.2026.102244"},"language":"en","primary_location":{"id":"doi:10.1016/j.adro.2026.102244","doi":"https://doi.org/10.1016/j.adro.2026.102244","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.adro.2026.102244","pdf_url":"https://www.advancesradonc.org/article/S2452-1094(26)00250-2/pdf","source":{"id":"https://openalex.org/S2765008485","display_name":"Advances in Radiation Oncology","issn_l":"2452-1094","issn":["2452-1094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Radiation Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.advancesradonc.org/article/S2452-1094(26)00250-2/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089668902","display_name":"Philip A. Blumenfeld","orcid":"https://orcid.org/0000-0003-4672-6862","observed_orcids":["https://orcid.org/0000-0003-4672-6862"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Philip Blumenfeld","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028085896","display_name":"Alexander Pryanichnikov","orcid":"https://orcid.org/0000-0001-7959-1808","observed_orcids":["https://orcid.org/0000-0001-7959-1808"]},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Alexander Pryanichnikov","raw_affiliation_strings":["Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany","Institute of Biomedical Engineering (IBT), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Institute of Biomedical Engineering (IBT), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011899584","display_name":"Zelig A Tochner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zelig Tochner","raw_affiliation_strings":["Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077551024","display_name":"Marcel Fang","orcid":"https://orcid.org/0000-0001-8059-6913","observed_orcids":["https://orcid.org/0000-0001-8059-6913"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Marcel Fang","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073976405","display_name":"Ayman Salhab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ayman Salhab","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111119913","display_name":"Marc R. Wygoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Marc Wygoda","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026324242","display_name":"Yair Hillman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yair Hillman","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071721135","display_name":"Eduard Arbit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eduard Arbit","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107584615","display_name":"Ella Wajnryt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ella Wajnryt","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027402410","display_name":"Aviad Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Aviad Berger","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101610836","display_name":"Gal Goldstein","orcid":"https://orcid.org/0000-0002-1940-3286","observed_orcids":["https://orcid.org/0000-0002-1940-3286"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gal Goldstein","raw_affiliation_strings":["The Dyna and Fala Weinstock Department of Pediatric Hematology-Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dyna and Fala Weinstock Department of Pediatric Hematology-Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084402033","display_name":"Iris Fried","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801962034","display_name":"Shaare Zedek Medical Center","ror":"https://ror.org/04d0szq68","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801962034"]},{"id":"https://openalex.org/I2802879425","display_name":"Bikur Cholim Hospital","ror":"https://ror.org/03zpnb459","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2802879425"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Iris Fried","raw_affiliation_strings":["Pediatric Palliative Care Unit, Shaare Zedek Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Palliative Care Unit, Shaare Zedek Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2801962034","https://openalex.org/I2802879425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015744004","display_name":"Efrat Landau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Efrat Landau","raw_affiliation_strings":["Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151732687","display_name":"Jon Feldman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Jon Feldman","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021421185","display_name":"Aron Popovtzer","orcid":"https://orcid.org/0000-0003-4428-9232","observed_orcids":["https://orcid.org/0000-0003-4428-9232"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Aron Popovtzer","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5028085896"],"corresponding_institution_ids":["https://openalex.org/I102335020","https://openalex.org/I17937529"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87531393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"102244","last_page":"102244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/image-guided-radiotherapy","display_name":"image-guided radiotherapy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.746999979019165},{"id":"https://openalex.org/keywords/ocular-tumors","display_name":"ocular tumors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9733999967575073},{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.5898000001907349},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.47209998965263367},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28700000047683716},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2524000108242035},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.24449999630451202},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.24160000681877136},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.23569999635219574},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.22300000488758087}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.adro.2026.102244","doi":"https://doi.org/10.1016/j.adro.2026.102244","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.adro.2026.102244","pdf_url":"https://www.advancesradonc.org/article/S2452-1094(26)00250-2/pdf","source":{"id":"https://openalex.org/S2765008485","display_name":"Advances in Radiation Oncology","issn_l":"2452-1094","issn":["2452-1094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Radiation Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.adro.2026.102244","doi":"https://doi.org/10.1016/j.adro.2026.102244","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.adro.2026.102244","pdf_url":"https://www.advancesradonc.org/article/S2452-1094(26)00250-2/pdf","source":{"id":"https://openalex.org/S2765008485","display_name":"Advances in Radiation Oncology","issn_l":"2452-1094","issn":["2452-1094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Radiation Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224875835.pdf","grobid_xml":"https://content.openalex.org/works/W7224875835.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1496390158","https://openalex.org/W1999189079","https://openalex.org/W2015758016","https://openalex.org/W2067847570","https://openalex.org/W2110529088","https://openalex.org/W2113207830","https://openalex.org/W2151792543","https://openalex.org/W2167495216","https://openalex.org/W2177891002","https://openalex.org/W2203026646","https://openalex.org/W2263581080","https://openalex.org/W2265452267","https://openalex.org/W2799271863","https://openalex.org/W2906140292","https://openalex.org/W4293021298","https://openalex.org/W4296635562","https://openalex.org/W4308633897","https://openalex.org/W4376631049","https://openalex.org/W4386198484","https://openalex.org/W4391359140","https://openalex.org/W4403289646","https://openalex.org/W4404155270","https://openalex.org/W4413117183"],"related_works":["https://openalex.org/W7213347879","https://openalex.org/W4408481893","https://openalex.org/W4408481735","https://openalex.org/W7213319494","https://openalex.org/W4416593862","https://openalex.org/W2017454814","https://openalex.org/W7213362241","https://openalex.org/W4236183335","https://openalex.org/W4401447436","https://openalex.org/W7214276039"],"abstract_inverted_index":{"Purpose":[0],"To":[1],"report":[2],"early":[3,83,229],"clinical":[4,84,230],"experience":[5],"with":[6,20,37,48,66,145,148,196],"upright":[7,49],"image-guided":[8],"proton":[9],"therapy":[10],"(IGPT)":[11],"delivered":[12,59],"using":[13,60,96,108,213],"a":[14,61,214],"gantry-less":[15,215],"system":[16,23,216],"in":[17,160,167,192,202,208,219,232],"pediatric":[18,43,220],"patients":[19,44,117,204],"central":[21],"nervous":[22],"(CNS),":[24],"pericranial,":[25,235],"and":[26,30,54,70,82,90,111,130,138,163,205,227,236],"ocular":[27,237],"malignancies":[28],"Materials":[29],"methods":[31],"This":[32],"retrospective":[33],"observational":[34],"single-institution":[35],"study":[36],"data":[38],"taken":[39],"prospectively":[40],"included":[41],"ten":[42],"(\u226418":[45],"years)":[46],"treated":[47],"IGPT":[50,212],"between":[51],"January":[52],"2024":[53],"December":[55],"2025.":[56],"Treatments":[57],"were":[58,86,94,126],"fixed":[62],"horizontal":[63],"beamline":[64],"combined":[65],"robotic":[67],"six-degree-of-freedom":[68],"positioning":[69],"vertical":[71],"CT-based":[72],"image":[73,113],"guidance.":[74],"Feasibility,":[75],"setup":[76,124],"reproducibility,":[77],"acute":[78],"toxicity":[79],"(CTCAE":[80],"v5.0),":[81],"outcomes":[85,231],"evaluated.":[87],"Target":[88,141],"coverage":[89,142],"organ-at-risk":[91],"(OAR)":[92],"doses":[93,155,175],"assessed":[95],"dose\u2013volume":[97],"histogram":[98],"(DVH)":[99],"analysis":[100],"relative":[101,178],"to":[102,179],"prescription.":[103],"Positioning":[104],"accuracy":[105],"was":[106,143,190],"quantified":[107],"archived":[109],"3D/3D":[110],"2D/3D":[112],"registrations.":[114],"Results":[115],"All":[116],"completed":[118],"treatment":[119],"without":[120],"interruption.":[121],"Mean":[122],"translational":[123],"corrections":[125,132],"within":[127,133],"\u00b15":[128],"mm":[129],"rotational":[131],"\u00b12\u00b0":[134],"for":[135,170],"both":[136],"pre-irradiation":[137],"intra-irradiation":[139],"verification.":[140],"consistent":[144],"prescription":[146,180],"intent,":[147],"CTV":[149],"D":[150],"95%":[151],"closely":[152],"matching":[153],"prescribed":[154],"(45\u201370":[156],"Gy":[157],"RBE":[158],")":[159],"single-phase":[161],"treatments":[162],"appropriate":[164],"dose":[165],"escalation":[166],"boost":[168],"phases":[169],"multi-phase":[171],"treatments.":[172],"Serial":[173],"OAR":[174],"remained":[176],"constrained":[177],"across":[181],"all":[182,193],"cases.":[183],"At":[184],"three":[185],"months":[186],"post-treatment,":[187],"local":[188],"control":[189],"achieved":[191],"evaluable":[194],"patients,":[195,221],"complete":[197],"or":[198],"partial":[199],"metabolic":[200],"response":[201],"six":[203],"stable":[206],"disease":[207],"four.":[209],"Conclusions":[210],"Upright":[211],"is":[217],"feasible":[218],"providing":[222],"accurate":[223],"positioning,":[224],"prescription-compliant":[225],"dosimetry,":[226],"favorable":[228],"complex":[233],"CNS,":[234],"indications":[238]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-31T00:00:00"}
