{"id":"https://openalex.org/W7224855843","doi":"https://doi.org/10.1186/s12905-026-05051-4","title":"Treatment of juvenile cystic adenomyoma through combined insertion of LNG-IUS and GyneFix\u00ae: a case report and literature review","display_name":"Treatment of juvenile cystic adenomyoma through combined insertion of LNG-IUS and GyneFix\u00ae: a case report and literature review","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7224855843","doi":"https://doi.org/10.1186/s12905-026-05051-4"},"language":"en","primary_location":{"id":"doi:10.1186/s12905-026-05051-4","doi":"https://doi.org/10.1186/s12905-026-05051-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12905-026-05051-4","pdf_url":null,"source":{"id":"https://openalex.org/S94788606","display_name":"BMC Women s Health","issn_l":"1472-6874","issn":["1472-6874"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Women's Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12905-026-05051-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037588320","display_name":"Caixia Han","orcid":"https://orcid.org/0000-0002-3638-2712","observed_orcids":["https://orcid.org/0000-0002-3638-2712"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caixia Han","raw_affiliation_strings":["Department of Gynecology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160033009","display_name":"Lekai Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lekai Nie","raw_affiliation_strings":["Department of Gynecology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029637163","display_name":"Peihai Zhang","orcid":"https://orcid.org/0000-0002-4836-9902","observed_orcids":["https://orcid.org/0000-0002-4836-9902"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peihai Zhang","raw_affiliation_strings":["Department of Gynecology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160190505","display_name":"Hongli Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongli Zou","raw_affiliation_strings":["Department of Gynecology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5160190505"],"corresponding_institution_ids":["https://openalex.org/I154099455"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86407916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10989","display_name":"Uterine Myomas and Treatments","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11589","display_name":"Gynecological conditions and treatments","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenomyosis","display_name":"adenomyosis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/levonorgestrel-releasing-intrauterine-system","display_name":"levonorgestrel-releasing intrauterine system","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gynefix","display_name":"GyneFix","score":0.8349999785423279},{"id":"https://openalex.org/keywords/dysmenorrhea","display_name":"dysmenorrhea","score":0.8930000066757202},{"id":"https://openalex.org/keywords/fertility-preservation","display_name":"fertility preservation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.6809999942779541},{"id":"https://openalex.org/keywords/iud-displacement","display_name":"IUD displacement","score":0.703000009059906},{"id":"https://openalex.org/keywords/minimally-invasive-treatment","display_name":"minimally invasive treatment","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9682000279426575},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6051999926567078},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4352000057697296},{"id":"https://openalex.org/C2776720265","wikidata":"https://www.wikidata.org/wiki/Q4682249","display_name":"Adenomyoma","level":3,"score":0.42340001463890076},{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.3828999996185303},{"id":"https://openalex.org/C2776210078","wikidata":"https://www.wikidata.org/wiki/Q351870","display_name":"Reproductive medicine","level":3,"score":0.3772999942302704},{"id":"https://openalex.org/C2780047204","wikidata":"https://www.wikidata.org/wiki/Q675754","display_name":"Laparoscopy","level":2,"score":0.36559998989105225},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.359499990940094},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.3531000018119812},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C3019396726","wikidata":"https://www.wikidata.org/wiki/Q25104748","display_name":"Conservative treatment","level":2,"score":0.33090001344680786},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.3292999863624573},{"id":"https://openalex.org/C2777904497","wikidata":"https://www.wikidata.org/wiki/Q5445580","display_name":"Fertility preservation","level":4,"score":0.31189998984336853},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.31139999628067017},{"id":"https://openalex.org/C3019796121","wikidata":"https://www.wikidata.org/wiki/Q5048356","display_name":"Case presentation","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.2896000146865845},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.28700000047683716},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C2994510025","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Medical therapy","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C115961737","wikidata":"https://www.wikidata.org/wiki/Q1516282","display_name":"Juvenile","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C2776141087","wikidata":"https://www.wikidata.org/wiki/Q2161551","display_name":"Watchful waiting","level":4,"score":0.2671000063419342},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2538999915122986},{"id":"https://openalex.org/C2982822547","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Medical treatment","level":2,"score":0.2531999945640564},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2524999976158142},{"id":"https://openalex.org/C2779231881","wikidata":"https://www.wikidata.org/wiki/Q5977147","display_name":"Medical literature","level":2,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12905-026-05051-4","doi":"https://doi.org/10.1186/s12905-026-05051-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12905-026-05051-4","pdf_url":null,"source":{"id":"https://openalex.org/S94788606","display_name":"BMC Women s Health","issn_l":"1472-6874","issn":["1472-6874"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Women's Health","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12905-026-05051-4","doi":"https://doi.org/10.1186/s12905-026-05051-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12905-026-05051-4","pdf_url":null,"source":{"id":"https://openalex.org/S94788606","display_name":"BMC Women s Health","issn_l":"1472-6874","issn":["1472-6874"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Women's Health","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3200521797","https://openalex.org/W3096626081","https://openalex.org/W2072464153","https://openalex.org/W4220678664","https://openalex.org/W1982954443","https://openalex.org/W3195052935","https://openalex.org/W4323869151","https://openalex.org/W2955230878","https://openalex.org/W3127396981","https://openalex.org/W4221014631"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Juvenile":[2],"cystic":[3],"adenomyoma":[4],"(JCA)":[5],"is":[6,26,48],"an":[7],"uncommon":[8],"form":[9],"of":[10,36,67,103,116,126,218],"adenomyosis.":[11],"No":[12],"consensus":[13,117],"exists":[14],"regarding":[15],"its":[16],"optimal":[17],"treatment.":[18],"Despite":[19],"the":[20,27,33,52,65,123,161,178,216],"potential":[21,148,155],"long-term":[22,166],"complications,":[23],"lesion":[24,137],"resection":[25],"radical":[28],"therapy":[29,206],"for":[30,54,136,169,195],"JCA.":[31],"Given":[32],"dual":[34],"goals":[35],"symptom":[37,167,201],"control":[38,202],"and":[39,60,121,154,181,190],"fertility":[40],"preservation":[41],"in":[42],"such":[43,131],"young":[44],"adolescents,":[45],"treatment":[46,78,120,192],"selection":[47],"often":[49,143],"challenging,":[50],"highlighting":[51],"need":[53],"alternative":[55,227],"therapeutic":[56],"choices.":[57],"Case":[58],"presentation":[59],"literature":[61],"review":[62,102],"We":[63],"report":[64],"case":[66],"a":[68,84,91,114,186,225],"14-year-old":[69],"nulliparous":[70],"female":[71],"with":[72,83,147,176,203],"severe":[73],"dysmenorrhoea":[74],"refractory":[75],"to":[76,90,98,228,235],"medical":[77],"who":[79,197],"was":[80],"successfully":[81],"managed":[82],"levonorgestrel-releasing":[85],"intrauterine":[86,95],"system":[87],"(LNG-IUS)":[88],"fixed":[89],"GyneFix":[92,182],"\u00ae":[93,183,205],"frameless":[94],"device":[96,209,219],"(IUD)":[97],"prevent":[99],"re-displacement.":[100],"A":[101],"14":[104],"published":[105],"articles":[106],"(covering":[107],"19":[108],"reported":[109],"cases)":[110],"on":[111,118],"JCA":[112],"revealed":[113],"lack":[115],"standardized":[119],"highlighted":[122],"frequent":[124],"use":[125],"more":[127,229],"invasive":[128,230],"surgical":[129,140,231],"procedures,":[130],"as":[132],"laparoscopy":[133],"or":[134,211],"laparotomy,":[135],"resection.":[138],"These":[139],"approaches,":[141],"while":[142,233],"effective,":[144],"are":[145],"associated":[146],"risks,":[149],"including":[150],"uterine":[151],"wall":[152],"injury":[153],"future":[156],"fertility-related":[157],"complications.":[158],"In":[159],"contrast,":[160],"combined":[162,179,222],"IUD":[163],"approach":[164,223],"achieved":[165,199],"relief":[168],">":[170],"16":[171],"months.":[172],"Conclusion":[173],"For":[174],"adolescents":[175],"JCA,":[177],"LNG-IUS":[180],"technique":[184],"represents":[185],"promising,":[187],"minimally":[188],"invasive,":[189],"fertility-preserving":[191],"strategy,":[193],"particularly":[194],"patients":[196],"previously":[198],"satisfactory":[200],"Mirena":[204],"but":[207],"experienced":[208],"expulsion":[210],"displacement.":[212],"By":[213],"effectively":[214],"reducing":[215],"risk":[217],"expulsion,":[220],"this":[221],"offers":[224],"conservative":[226],"intervention":[232],"aiming":[234],"preserve":[236],"fertility.":[237]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-31T00:00:00"}