{"id":"https://openalex.org/W7224850279","doi":"https://doi.org/10.1002/1873-3468.70496","title":"Comparing the paths of Hedgehog release in artificial and natural settings","display_name":"Comparing the paths of Hedgehog release in artificial and natural settings","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224850279","doi":"https://doi.org/10.1002/1873-3468.70496","pmid":"https://pubmed.ncbi.nlm.nih.gov/42958968"},"language":"en","primary_location":{"id":"doi:10.1002/1873-3468.70496","doi":"https://doi.org/10.1002/1873-3468.70496","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.70496","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.70496","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.70496","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110974072","display_name":"Janna Puschmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janna Puschmann","raw_affiliation_strings":["Department of Cellular and Molecular Glycobiology, Institute of Physiological Chemistry and Pathobiochemistry University of M\u00fcnster  Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Glycobiology, Institute of Physiological Chemistry and Pathobiochemistry University of M\u00fcnster  Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041107408","display_name":"Kay Grobe","orcid":"https://orcid.org/0000-0002-8385-5877","observed_orcids":["https://orcid.org/0000-0002-8385-5877"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kay Grobe","raw_affiliation_strings":["Department of Cellular and Molecular Glycobiology, Institute of Physiological Chemistry and Pathobiochemistry University of M\u00fcnster  Germany"],"raw_orcid":"https://orcid.org/0000-0002-8385-5877","affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Glycobiology, Institute of Physiological Chemistry and Pathobiochemistry University of M\u00fcnster  Germany","institution_ids":["https://openalex.org/I22465464"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041107408"],"corresponding_institution_ids":["https://openalex.org/I22465464"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":{"value":3980,"currency":"USD","value_usd":3980},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74605131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lipidation","display_name":"lipid modification","score":0.6380000114440918},{"id":"https://openalex.org/keywords/scube2","display_name":"SCUBE2","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C193469717","wikidata":"https://www.wikidata.org/wiki/Q6556349","display_name":"Lipid-anchored protein","level":4,"score":0.776199996471405},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.7254999876022339},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.5745999813079834},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5504999756813049},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5461000204086304},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4984999895095825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42340001463890076},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38580000400543213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3434000015258789},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3264000117778778},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.32269999384880066},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.3208000063896179},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.319599986076355},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3098999857902527},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.30149999260902405},{"id":"https://openalex.org/C2988540567","wikidata":"https://www.wikidata.org/wiki/Q12070446","display_name":"Model system","level":2,"score":0.29589998722076416},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.2921999990940094},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.28999999165534973},{"id":"https://openalex.org/C4863142","wikidata":"https://www.wikidata.org/wiki/Q907920","display_name":"Solubilization","level":2,"score":0.27950000762939453},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2531999945640564}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/1873-3468.70496","doi":"https://doi.org/10.1002/1873-3468.70496","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.70496","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.70496","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:42958968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42958968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1873-3468.70496","doi":"https://doi.org/10.1002/1873-3468.70496","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.70496","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.70496","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7896716857","display_name":"SFB 1348: Dynamische zellul\u00e4re Grenzfl\u00e4chen: Bildung und Funktion","funder_award_id":"386797833","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7920248328","display_name":null,"funder_award_id":"GR1748/9-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G820177544","display_name":null,"funder_award_id":"SFB1348","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224850279.pdf","grobid_xml":"https://content.openalex.org/works/W7224850279.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W152075184","https://openalex.org/W1502422762","https://openalex.org/W1508831423","https://openalex.org/W1555380614","https://openalex.org/W1566448969","https://openalex.org/W1960701554","https://openalex.org/W1965550615","https://openalex.org/W1967429840","https://openalex.org/W1969608698","https://openalex.org/W1970846696","https://openalex.org/W1974518572","https://openalex.org/W1976551834","https://openalex.org/W1982824007","https://openalex.org/W1983921526","https://openalex.org/W1990633759","https://openalex.org/W1994303245","https://openalex.org/W1996218285","https://openalex.org/W2013492079","https://openalex.org/W2017204222","https://openalex.org/W2018886211","https://openalex.org/W2026905611","https://openalex.org/W2029042594","https://openalex.org/W2030943228","https://openalex.org/W2031065774","https://openalex.org/W2031380343","https://openalex.org/W2032935853","https://openalex.org/W2034842916","https://openalex.org/W2042774795","https://openalex.org/W2045100304","https://openalex.org/W2047181007","https://openalex.org/W2047659079","https://openalex.org/W2053698830","https://openalex.org/W2055019393","https://openalex.org/W2059790042","https://openalex.org/W2059921810","https://openalex.org/W2062518278","https://openalex.org/W2062930347","https://openalex.org/W2066090767","https://openalex.org/W2066915390","https://openalex.org/W2069528220","https://openalex.org/W2078267991","https://openalex.org/W2082372465","https://openalex.org/W2086023112","https://openalex.org/W2086751240","https://openalex.org/W2089749296","https://openalex.org/W2090146362","https://openalex.org/W2090663837","https://openalex.org/W2093395445","https://openalex.org/W2101902403","https://openalex.org/W2108184622","https://openalex.org/W2109976541","https://openalex.org/W2110022036","https://openalex.org/W2112613176","https://openalex.org/W2124711584","https://openalex.org/W2142112187","https://openalex.org/W2146712325","https://openalex.org/W2152821878","https://openalex.org/W2157175723","https://openalex.org/W2157227019","https://openalex.org/W2164677099","https://openalex.org/W2165562833","https://openalex.org/W2166715625","https://openalex.org/W2166841567","https://openalex.org/W2169542532","https://openalex.org/W2260997035","https://openalex.org/W2403309779","https://openalex.org/W2556830543","https://openalex.org/W2745184208","https://openalex.org/W2752440393","https://openalex.org/W2773278063","https://openalex.org/W2791918584","https://openalex.org/W2792277372","https://openalex.org/W2809141540","https://openalex.org/W2811347531","https://openalex.org/W2859185793","https://openalex.org/W2888579822","https://openalex.org/W2890577735","https://openalex.org/W2974791834","https://openalex.org/W3082842604","https://openalex.org/W3092269333","https://openalex.org/W3111429537","https://openalex.org/W3127136969","https://openalex.org/W3128326787","https://openalex.org/W3153740745","https://openalex.org/W3187216062","https://openalex.org/W3188703238","https://openalex.org/W4210300460","https://openalex.org/W4214493999","https://openalex.org/W4319951256","https://openalex.org/W4321497378","https://openalex.org/W4376139767","https://openalex.org/W4390499167","https://openalex.org/W4400143179","https://openalex.org/W4401910572","https://openalex.org/W4413960444","https://openalex.org/W7119012904","https://openalex.org/W7161263418"],"related_works":["https://openalex.org/W2790727236","https://openalex.org/W2921246668","https://openalex.org/W7161819221","https://openalex.org/W3210551176","https://openalex.org/W3199024572","https://openalex.org/W2042524126","https://openalex.org/W4402643343","https://openalex.org/W3202598562","https://openalex.org/W2062930347","https://openalex.org/W2047181007"],"abstract_inverted_index":{"The":[0],"Hedgehog":[1],"(Hh)":[2],"family":[3],"is":[4],"a":[5,106],"central":[6],"model":[7],"for":[8,51,112],"signaling":[9],"gradient":[10],"formation":[11],"despite":[12],"its":[13],"members":[14],"undergoing":[15],"dual":[16],"N-":[17],"and":[18,66,80,102],"C-terminal":[19],"lipidation":[20],"during":[21],"biogenesis.":[22],"This":[23,82],"process":[24],"strongly":[25],"binds":[26],"Hh":[27,45,64,76,115],"proteins":[28,46],"to":[29,85,97,103,105],"the":[30,34,58,75,91,110],"plasma":[31],"membrane":[32],"of":[33,94,109],"cells":[35],"that":[36],"produce":[37],"them,":[38],"preventing":[39],"their":[40,52],"spontaneous":[41],"solubilization.":[42],"Therefore,":[43],"lipidated":[44],"require":[47],"specific":[48],"molecular":[49],"mechanisms":[50,72],"controlled":[53],"release.":[54],"Here,":[55],"we":[56],"synthesize":[57],"available":[59],"in":[60],"vivo":[61],"data":[62],"on":[63,69,74,90],"solubilization":[65],"dispersion,":[67],"focusing":[68],"three":[70],"proposed":[71],"centered":[73],"release":[77],"enhancers":[78],"Dispatched":[79],"Scube2.":[81],"approach":[83],"aims":[84],"reconcile":[86],"conflicting":[87],"experimental":[88],"findings":[89],"mechanistic":[92],"functions":[93],"these":[95],"enhancers,":[96],"clarify":[98],"previous":[99],"conceptual":[100],"inconsistencies,":[101],"contribute":[104],"unified":[107],"understanding":[108],"prerequisites":[111],"forming":[113],"precise":[114],"gradients.":[116]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}