{"id":"https://openalex.org/W7224829357","doi":"https://doi.org/10.20944/preprints202610.3066.v1","title":"Ventral Tegmental Dopamine Adaptations in Alcohol Use Disorder: A Narrative Review of Mechanisms and Prevention Implications","display_name":"Ventral Tegmental Dopamine Adaptations in Alcohol Use Disorder: A Narrative Review of Mechanisms and Prevention Implications","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224829357","doi":"https://doi.org/10.20944/preprints202610.3066.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202610.3066.v1","doi":"https://doi.org/10.20944/preprints202610.3066.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.3066.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202610.3066.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160234426","display_name":"Jiang-Hong Ye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jiang-Hong Ye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5160185209","display_name":"Wanhong Zuo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wanhong Zuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5160234426"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9819999933242798},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.7149999737739563},{"id":"https://openalex.org/keywords/alcohol-reward","display_name":"alcohol reward","score":0.46000000834465027},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.7070000171661377},{"id":"https://openalex.org/keywords/withdrawal","display_name":"withdrawal","score":0.35499998927116394},{"id":"https://openalex.org/keywords/dopamine-receptor-signaling","display_name":"dopamine receptor signaling","score":0.5419999957084656},{"id":"https://openalex.org/keywords/alcohol-cue-reactivity","display_name":"alcohol cue reactivity","score":0.46399998664855957},{"id":"https://openalex.org/keywords/alcohol-relapse","display_name":"alcohol relapse","score":0.4749999940395355},{"id":"https://openalex.org/keywords/alcohol-prevention","display_name":"alcohol prevention","score":0.5230000019073486},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.703000009059906},{"id":"https://openalex.org/keywords/hormonal-status","display_name":"hormonal status","score":0.7990000247955322},{"id":"https://openalex.org/keywords/motivation","display_name":"motivation","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2780948874","wikidata":"https://www.wikidata.org/wiki/Q640562","display_name":"Ventral tegmental area","level":4,"score":0.883400022983551},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.8378000259399414},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6600000262260437},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.5759000182151794},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5465999841690063},{"id":"https://openalex.org/C143661069","wikidata":"https://www.wikidata.org/wiki/Q670713","display_name":"Reward system","level":2,"score":0.5379999876022339},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.5001999735832214},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.39910000562667847},{"id":"https://openalex.org/C2779442783","wikidata":"https://www.wikidata.org/wiki/Q15326","display_name":"Alcohol use disorder","level":3,"score":0.38519999384880066},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.3806999921798706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3801000118255615},{"id":"https://openalex.org/C2777650357","wikidata":"https://www.wikidata.org/wiki/Q1569460","display_name":"Mesolimbic pathway","level":5,"score":0.35830000042915344},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.3172999918460846},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C2779992327","wikidata":"https://www.wikidata.org/wiki/Q337668","display_name":"Acamprosate","level":5,"score":0.287200003862381},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C64948172","wikidata":"https://www.wikidata.org/wiki/Q1653277","display_name":"Brain stimulation reward","level":4,"score":0.2637999951839447},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.2599000036716461}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202610.3066.v1","doi":"https://doi.org/10.20944/preprints202610.3066.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.3066.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202610.3066.v1","doi":"https://doi.org/10.20944/preprints202610.3066.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.3066.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4413403054","https://openalex.org/W3033917781","https://openalex.org/W7028056409","https://openalex.org/W2889729606","https://openalex.org/W7165381458","https://openalex.org/W7063918380","https://openalex.org/W7083288296","https://openalex.org/W3004122899","https://openalex.org/W2312686135","https://openalex.org/W2012139294"],"abstract_inverted_index":{"Alcohol":[0],"use":[1,166],"disorder":[2],"involves":[3],"persistent":[4,165],"changes":[5],"in":[6,14],"motivation":[7],"that":[8,42,77,89,160],"a":[9,65,94,204,209,213,217,221],"uniform":[10],"increase":[11],"or":[12,52,150,220],"decrease":[13],"dopamine":[15,28,48,122,210],"activity":[16],"cannot":[17],"explain.":[18],"This":[19],"narrative":[20],"review":[21],"examines":[22],"how":[23],"alcohol":[24,56],"alters":[25],"ventral":[26],"tegmental":[27],"circuits":[29],"through":[30],"membrane":[31],"conductances,":[32],"excitatory":[33],"and":[34,37,57,109,121,124,167,189,192],"inhibitory":[35,107],"inputs,":[36],"synaptic":[38,111],"plasticity.":[39],"We":[40],"propose":[41],"repeated":[43],"exposure":[44],"can":[45],"reduce":[46],"baseline":[47],"output":[49,61],"while":[50],"preserving":[51],"enhancing":[53],"responses":[54],"to":[55,98,147,164],"its":[58],"cues.":[59],"Baseline":[60],"is":[62,72,83,203,212],"defined":[63,95,183],"as":[64],"prespecified":[66],"measurement":[67],"before":[68],"an":[69],"event;":[70],"recruitment":[71],"the":[73,86],"event-evoked":[74],"increment":[75],"above":[76],"baseline.":[78],"Evidence":[79],"for":[80,206],"individual":[81],"adaptations":[82],"distinguished":[84],"from":[85],"unproven":[87],"prediction":[88],"their":[90],"joint":[91],"change":[92],"within":[93,182],"projection":[96],"contributes":[97],"renewed":[99],"seeking.":[100],"Withdrawal-related":[101],"reward":[102,188],"deficits,":[103],"stress":[104],"recruitment,":[105],"receptor-specific":[106],"signaling,":[108],"selective":[110,193],"recovery":[112],"provide":[113],"complementary":[114],"mechanisms.":[115],"Projection":[116],"identity,":[117],"sex,":[118],"hormonal":[119],"state,":[120],"release":[123],"clearance":[125],"at":[126],"terminals":[127],"help":[128],"explain":[129],"differences":[130],"across":[131],"studies.":[132],"Regional":[133],"rescue":[134,195],"experiments":[135],"strengthen":[136],"causal":[137],"inference,":[138],"but":[139],"most":[140],"mechanisms":[141],"have":[142],"not":[143,173],"been":[144],"linked":[145],"selectively":[146],"relief-driven":[148],"drinking":[149],"recurrence.":[151],"For":[152],"prevention":[153],"research,":[154],"these":[155],"findings":[156],"identify":[157],"candidate":[158],"processes":[159],"may":[161],"support":[162],"progression":[163],"vulnerability":[168],"after":[169],"cessation;":[170],"they":[171],"do":[172],"establish":[174],"clinical":[175],"preventive":[176],"efficacy.":[177],"Priorities":[178],"include":[179],"longitudinal":[180],"measurements":[181],"circuits,":[184],"independent":[185],"tests":[186],"of":[187,215,223],"relief":[190],"motivation,":[191],"physiological":[194],"with":[196],"appropriate":[197],"behavioral":[198],"controls.":[199],"The":[200],"practical":[201],"contribution":[202],"framework":[205],"evaluating":[207],"when":[208],"adaptation":[211],"cause":[214],"vulnerability,":[216],"compensatory":[218],"response,":[219],"marker":[222],"exposure.":[224]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}