{"id":"https://openalex.org/W7224829319","doi":"https://doi.org/10.1371/journal.pone.0361711","title":"Genome mining, antibacterial activity, and metabolomic profiling reveal the biosynthetic potential of Burkholderia glumae isolates from Thailand with activity against clinically important bacterial pathogens","display_name":"Genome mining, antibacterial activity, and metabolomic profiling reveal the biosynthetic potential of Burkholderia glumae isolates from Thailand with activity against clinically important bacterial pathogens","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224829319","doi":"https://doi.org/10.1371/journal.pone.0361711","pmid":"https://pubmed.ncbi.nlm.nih.gov/42961933","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722174"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0361711","doi":"https://doi.org/10.1371/journal.pone.0361711","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361711","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361711&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361711&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010712689","display_name":"Sujin Patarapuwadol","orcid":"https://orcid.org/0000-0002-8337-4096","observed_orcids":["https://orcid.org/0000-0002-8337-4096"]},"institutions":[{"id":"https://openalex.org/I198105771","display_name":"Kasetsart University","ror":"https://ror.org/05gzceg21","country_code":"TH","type":"education","lineage":["https://openalex.org/I198105771"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sujin Patarapuwadol","raw_affiliation_strings":["Kasetsart University Kamphaeng Saen Campus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kasetsart University Kamphaeng Saen Campus","institution_ids":["https://openalex.org/I198105771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160230413","display_name":"Panalee Oupaijit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255716","display_name":"Chulabhorn Royal Academy","ror":"https://ror.org/03b5p6e80","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405255716"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Panalee Oupaijit","raw_affiliation_strings":["Chulabhorn Royal Academy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chulabhorn Royal Academy","institution_ids":["https://openalex.org/I4405255716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092128571","display_name":"Pornpavee Nualnisachol","orcid":"https://orcid.org/0009-0006-2774-2663","observed_orcids":["https://orcid.org/0009-0006-2774-2663"]},"institutions":[{"id":"https://openalex.org/I4405255716","display_name":"Chulabhorn Royal Academy","ror":"https://ror.org/03b5p6e80","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405255716"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pornpavee Nualnisachol","raw_affiliation_strings":["Chulabhorn Royal Academy","Research Center on Clinical and System Microbiology (RCSyM), Chulabhorn Royal Academy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chulabhorn Royal Academy","institution_ids":["https://openalex.org/I4405255716"]},{"raw_affiliation_string":"Research Center on Clinical and System Microbiology (RCSyM), Chulabhorn Royal Academy","institution_ids":["https://openalex.org/I4405255716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046327119","display_name":"Peerut Chienwichai","orcid":"https://orcid.org/0000-0002-1088-9451","observed_orcids":["https://orcid.org/0000-0002-1088-9451"]},"institutions":[{"id":"https://openalex.org/I4405255716","display_name":"Chulabhorn Royal Academy","ror":"https://ror.org/03b5p6e80","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405255716"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Peerut Chienwichai","raw_affiliation_strings":["Chulabhorn Royal Academy","Research Center on Clinical and System Microbiology (RCSyM), Chulabhorn Royal Academy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chulabhorn Royal Academy","institution_ids":["https://openalex.org/I4405255716"]},{"raw_affiliation_string":"Research Center on Clinical and System Microbiology (RCSyM), Chulabhorn Royal Academy","institution_ids":["https://openalex.org/I4405255716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055092753","display_name":"Jiraphan Premsuriya","orcid":"https://orcid.org/0000-0003-0265-924X","observed_orcids":["https://orcid.org/0000-0003-0265-924X"]},"institutions":[{"id":"https://openalex.org/I4405255716","display_name":"Chulabhorn Royal Academy","ror":"https://ror.org/03b5p6e80","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405255716"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Jiraphan Premsuriya","raw_affiliation_strings":["Chulabhorn Royal Academy","Research Center on Clinical and System Microbiology (RCSyM), Chulabhorn Royal Academy"],"raw_orcid":"https://orcid.org/0000-0003-0265-924X","affiliations":[{"raw_affiliation_string":"Chulabhorn Royal Academy","institution_ids":["https://openalex.org/I4405255716"]},{"raw_affiliation_string":"Research Center on Clinical and System Microbiology (RCSyM), Chulabhorn Royal Academy","institution_ids":["https://openalex.org/I4405255716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055092753"],"corresponding_institution_ids":["https://openalex.org/I4405255716"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83732005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"10","first_page":"e0361711","last_page":"e0361711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12951","display_name":"Burkholderia infections and melioidosis","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burkholderia-glumae","display_name":"Burkholderia glumae","score":1.0},{"id":"https://openalex.org/keywords/biosynthetic-gene-clusters","display_name":"biosynthetic gene clusters","score":0.9670000076293945},{"id":"https://openalex.org/keywords/antimicrobial-metabolites","display_name":"antimicrobial metabolites","score":0.6620000004768372},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.7020000219345093},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.7009999752044678},{"id":"https://openalex.org/keywords/plant-pathogenic-bacteria","display_name":"plant pathogenic bacteria","score":0.7360000014305115},{"id":"https://openalex.org/keywords/macrolactams","display_name":"macrocyclic lactams","score":0.8519999980926514},{"id":"https://openalex.org/keywords/triterpenoid-saponins","display_name":"triterpenoid saponins","score":0.9950000047683716},{"id":"https://openalex.org/keywords/polyketide-biosynthesis","display_name":"polyketide biosynthesis","score":0.6359999775886536},{"id":"https://openalex.org/keywords/nonribosomal-peptide-biosynthesis","display_name":"nonribosomal peptide biosynthesis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/acinetobacter-baumannii","display_name":"Acinetobacter baumannii","score":0.8389999866485596},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.953000009059906},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.996999979019165},{"id":"https://openalex.org/keywords/antimicrobial-natural-products","display_name":"antimicrobial natural products","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8456000089645386},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7217000126838684},{"id":"https://openalex.org/C2780855054","wikidata":"https://www.wikidata.org/wiki/Q135239","display_name":"Burkholderia","level":3,"score":0.7125999927520752},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5719000101089478},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5098000168800354},{"id":"https://openalex.org/C2778660310","wikidata":"https://www.wikidata.org/wiki/Q177998","display_name":"Agar","level":3,"score":0.487199991941452},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.43700000643730164},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4146000146865845},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.4115000069141388},{"id":"https://openalex.org/C62643968","wikidata":"https://www.wikidata.org/wiki/Q574816","display_name":"Agar plate","level":3,"score":0.39480000734329224},{"id":"https://openalex.org/C2777756538","wikidata":"https://www.wikidata.org/wiki/Q21401468","display_name":"Burkholderia cepacia complex","level":4,"score":0.37770000100135803},{"id":"https://openalex.org/C2778523567","wikidata":"https://www.wikidata.org/wiki/Q310457","display_name":"Acinetobacter","level":3,"score":0.3628999888896942},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.35499998927116394},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.34119999408721924},{"id":"https://openalex.org/C2776315533","wikidata":"https://www.wikidata.org/wiki/Q3241189","display_name":"Acinetobacter baumannii","level":4,"score":0.31619998812675476},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.30250000953674316},{"id":"https://openalex.org/C149453125","wikidata":"https://www.wikidata.org/wiki/Q5437094","display_name":"Fastidious organism","level":3,"score":0.29499998688697815},{"id":"https://openalex.org/C2780493024","wikidata":"https://www.wikidata.org/wiki/Q19903202","display_name":"Agar dilution","level":4,"score":0.287200003862381},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2750999927520752},{"id":"https://openalex.org/C11636898","wikidata":"https://www.wikidata.org/wiki/Q390585","display_name":"Agar diffusion test","level":4,"score":0.2736000120639801},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.25360000133514404}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013785","descriptor_name":"Thailand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019117","descriptor_name":"Burkholderia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019117","descriptor_name":"Burkholderia","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D019117","descriptor_name":"Burkholderia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0361711","doi":"https://doi.org/10.1371/journal.pone.0361711","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361711","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361711&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722174","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722174/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722174/pdf/pone.0361711.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:42961933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42961933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a41e714838bd4424831caf6d2b7879d5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a41e714838bd4424831caf6d2b7879d5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 21, Iss 10 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0361711","doi":"https://doi.org/10.1371/journal.pone.0361711","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361711","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361711&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316404","display_name":"Chulabhorn Royal Academy","ror":"https://ror.org/03b5p6e80"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224829319.pdf","grobid_xml":"https://content.openalex.org/works/W7224829319.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1543068333","https://openalex.org/W1991619286","https://openalex.org/W2016136656","https://openalex.org/W2052371137","https://openalex.org/W2082062788","https://openalex.org/W2158696212","https://openalex.org/W2165191800","https://openalex.org/W2166986886","https://openalex.org/W2185564569","https://openalex.org/W2289359230","https://openalex.org/W2408798126","https://openalex.org/W2619035265","https://openalex.org/W2756935148","https://openalex.org/W2856866728","https://openalex.org/W2944759895","https://openalex.org/W2956606079","https://openalex.org/W2958017797","https://openalex.org/W2967688728","https://openalex.org/W2996508375","https://openalex.org/W3025082178","https://openalex.org/W3089529641","https://openalex.org/W3125227012","https://openalex.org/W3129038928","https://openalex.org/W3162707924","https://openalex.org/W3196903026","https://openalex.org/W3201399631","https://openalex.org/W3201476781","https://openalex.org/W4206677002","https://openalex.org/W4293796952","https://openalex.org/W4319763946","https://openalex.org/W4368358469","https://openalex.org/W4387140301","https://openalex.org/W4390909937","https://openalex.org/W4394578957","https://openalex.org/W4399180654","https://openalex.org/W4402557213","https://openalex.org/W4408190138","https://openalex.org/W4411536029","https://openalex.org/W4414905414","https://openalex.org/W7117671410","https://openalex.org/W7128311316","https://openalex.org/W7160548496"],"related_works":["https://openalex.org/W2563406556","https://openalex.org/W4415898914","https://openalex.org/W3211916742","https://openalex.org/W3215414234","https://openalex.org/W3188325071","https://openalex.org/W3115150751","https://openalex.org/W4310230617","https://openalex.org/W2344090272","https://openalex.org/W4306145869","https://openalex.org/W3093245418"],"abstract_inverted_index":{"The":[0],"increasing":[1],"prevalence":[2],"of":[3,15,23,30,52,152,275,281],"antimicrobial":[4,12,24,288],"resistance":[5],"has":[6],"underscored":[7],"the":[8,16,27,44,139,177,207,217,273],"need":[9],"for":[10,145,247,284],"novel":[11],"agents.":[13],"Members":[14],"genus":[17],"Burkholderia":[18,31],"produce":[19],"a":[20,33,279],"diverse":[21,191,261],"array":[22],"metabolites;":[25],"however,":[26],"biosynthetic":[28,45,70,262],"potential":[29,274],"glumae,":[32],"plant":[34],"pathogen,":[35],"remains":[36],"relatively":[37],"underexplored.":[38],"In":[39],"this":[40],"study,":[41],"we":[42],"investigated":[43],"potential,":[46],"antibacterial":[47,104,121,141,265],"activity,":[48],"and":[49,64,68,89,133,156,172,202,230,264],"metabolomic":[50,147],"profiles":[51],"16":[53,118],"B.":[54,255],"glumae":[55,256],"isolates":[56,119,137,171,257,277],"collected":[57],"from":[58,154,238,258],"Thailand.":[59],"Genome":[60],"mining":[61],"using":[62,108],"antiSMASH":[63],"DeepBGC":[65,93],"identified":[66,161],"14-17":[67],"40-51":[69],"gene":[71],"clusters":[72],"(BGCs)":[73],"per":[74,99],"genome,":[75],"respectively.":[76],"Multiple":[77],"conserved":[78],"BGC":[79],"classes":[80],"were":[81,101,143,233],"detected":[82,210,235],"across":[83],"all":[84,117,169],"isolates,":[85],"including":[86,128,194],"terpene-,":[87],"polyketide-,":[88],"nonribosomal":[90],"peptide-associated":[91],"clusters.":[92],"further":[94,146],"predicted":[95],"that":[96,116,254],"22-32":[97],"BGCs":[98],"isolate":[100],"associated":[102],"with":[103],"activity.":[105],"Phenotypic":[106],"screening":[107],"soft-agar":[109],"overlay":[110],"assays":[111],"on":[112,241],"LB":[113,158,223,242],"agar":[114,159,224,243],"demonstrated":[115],"displayed":[120],"activity":[122,142,266],"against":[123,267],"clinically":[124,268],"important":[125,269],"bacterial":[126,226,270],"pathogens,":[127,271],"Acinetobacter":[129],"baumannii,":[130],"Escherichia":[131],"coli,":[132],"Staphylococcus":[134],"aureus.":[135],"Four":[136],"exhibiting":[138],"strongest":[140],"selected":[144],"analysis.":[148],"Untargeted":[149],"LC-MS/MS":[150],"profiling":[151],"extracts":[153,237],"inoculated":[155],"uninoculated":[157,178],"plates":[160],"68":[162],"putatively":[163],"annotated":[164],"antimicrobial-related":[165],"metabolites":[166,188,283],"shared":[167],"among":[168],"four":[170],"significantly":[173],"enriched":[174],"relative":[175,220],"to":[176,190,221],"controls":[179],"(fold":[180],"change":[181],">":[182],"2,":[183],"p":[184],"<":[185],"0.05).":[186],"These":[187,250],"belonged":[189],"chemical":[192],"classes,":[193],"macrolactams,":[195],"triterpene":[196,214],"saponins,":[197],"triterpenoids,":[198],"hydroxyquinolones,":[199],"phenolic":[200],"glycosides,":[201],"cyclic":[203],"depsipeptides.":[204],"Macrolactams":[205],"represented":[206],"most":[208],"frequently":[209],"metabolite":[211],"class,":[212],"whereas":[213],"saponins":[215],"exhibited":[216],"highest":[218],"enrichment":[219],"control":[222],"without":[225],"inoculation.":[227],"Toxoflavin,":[228],"reumycin,":[229],"bactobolin":[231],"A":[232],"not":[234],"in":[236,287],"cultures":[239],"grown":[240],"at":[244],"37":[245],"\u00b0C":[246],"24":[248],"h.":[249],"findings,":[251],"which":[252],"demonstrate":[253],"Thailand":[259],"possess":[260],"capabilities":[263],"highlight":[272],"these":[276],"as":[278],"source":[280],"bioactive":[282],"future":[285],"efforts":[286],"agent":[289],"discovery.":[290]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-31T00:00:00"}