{"id":"https://openalex.org/W7224827430","doi":"https://doi.org/10.64898/2026.10.29.762824","title":"Inhibition of Hippo signalling disrupts germinative cell-cycle progression and larval development in Echinococcus multilocularis","display_name":"Inhibition of Hippo signalling disrupts germinative cell-cycle progression and larval development in Echinococcus multilocularis","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224827430","doi":"https://doi.org/10.64898/2026.10.29.762824"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.29.762824","doi":"https://doi.org/10.64898/2026.10.29.762824","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.29.762824","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.29.762824.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.29.762824.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119647969","display_name":"Luisa Schiegl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luisa Schiegl","raw_affiliation_strings":["Consultant Laboratory for Echinococcosis, Institute of Hygiene and Microbiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Laboratory for Echinococcosis, Institute of Hygiene and Microbiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035574088","display_name":"Monika Bergmann","orcid":"https://orcid.org/0000-0003-2343-6467","observed_orcids":["https://orcid.org/0000-0003-2343-6467"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Monika Bergmann","raw_affiliation_strings":["Consultant Laboratory for Echinococcosis, Institute of Hygiene and Microbiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Laboratory for Echinococcosis, Institute of Hygiene and Microbiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031994978","display_name":"Klaus Brehm","orcid":"https://orcid.org/0000-0001-6768-824X","observed_orcids":["https://orcid.org/0000-0001-6768-824X"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Klaus Brehm","raw_affiliation_strings":["Consultant Laboratory for Echinococcosis, Institute of Hygiene and Microbiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6768-824X","affiliations":[{"raw_affiliation_string":"Consultant Laboratory for Echinococcosis, Institute of Hygiene and Microbiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031994978"],"corresponding_institution_ids":["https://openalex.org/I25974101"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.8930000066757202},{"id":"https://openalex.org/keywords/echinococcus-multilocularis","display_name":"Echinococcus multilocularis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/germinative-cells","display_name":"germinative cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/yorkie","display_name":"Yorkie","score":0.7310000061988831},{"id":"https://openalex.org/keywords/scalloped","display_name":"Scalloped","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tead-transcription-factors","display_name":"TEAD transcription factors","score":0.8019999861717224},{"id":"https://openalex.org/keywords/larval-development","display_name":"larval development","score":0.7990000247955322},{"id":"https://openalex.org/keywords/metacestodes","display_name":"metacestodes","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/giant-cell-formation","display_name":"giant cell formation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/multinucleation","display_name":"multinucleation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/xmu-mp-1","display_name":"XMU-MP-1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/aurora-kinase-inhibitors","display_name":"Aurora kinase inhibitors","score":0.6190000176429749},{"id":"https://openalex.org/keywords/mln8237","display_name":"MLN8237","score":0.8429999947547913},{"id":"https://openalex.org/keywords/histone-h3-phosphorylation","display_name":"histone H3 phosphorylation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/parasitic-flatworms","display_name":"parasitic flatworms","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tissue-homeostasis","display_name":"tissue homeostasis","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9204999804496765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6923999786376953},{"id":"https://openalex.org/C2780340127","wikidata":"https://www.wikidata.org/wiki/Q6822411","display_name":"Metacestode","level":4,"score":0.5805000066757202},{"id":"https://openalex.org/C2779752401","wikidata":"https://www.wikidata.org/wiki/Q669922","display_name":"Echinococcus multilocularis","level":3,"score":0.5523999929428101},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5130000114440918},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.4049000144004822},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.38420000672340393},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.37720000743865967},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.3686000108718872},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3610999882221222},{"id":"https://openalex.org/C172512520","wikidata":"https://www.wikidata.org/wiki/Q5768379","display_name":"Hippo signaling pathway","level":3,"score":0.34470000863075256},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.326200008392334},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30889999866485596},{"id":"https://openalex.org/C2780325390","wikidata":"https://www.wikidata.org/wiki/Q310391","display_name":"Triturus","level":2,"score":0.3052999973297119},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.25589999556541443},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.29.762824","doi":"https://doi.org/10.64898/2026.10.29.762824","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.29.762824","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.29.762824.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.29.762824","doi":"https://doi.org/10.64898/2026.10.29.762824","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.29.762824","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.29.762824.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224827430.pdf","grobid_xml":"https://content.openalex.org/works/W7224827430.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W61229286","https://openalex.org/W1567765448","https://openalex.org/W1978746441","https://openalex.org/W1995160678","https://openalex.org/W2006778392","https://openalex.org/W2014177763","https://openalex.org/W2027029609","https://openalex.org/W2027150010","https://openalex.org/W2036155808","https://openalex.org/W2044171436","https://openalex.org/W2046633882","https://openalex.org/W2058819379","https://openalex.org/W2097192405","https://openalex.org/W2099709490","https://openalex.org/W2106740149","https://openalex.org/W2107277218","https://openalex.org/W2117981064","https://openalex.org/W2123018407","https://openalex.org/W2124059822","https://openalex.org/W2130787389","https://openalex.org/W2131418202","https://openalex.org/W2136550480","https://openalex.org/W2148056172","https://openalex.org/W2167978765","https://openalex.org/W2289331890","https://openalex.org/W2289739009","https://openalex.org/W2512544075","https://openalex.org/W2554510445","https://openalex.org/W2594847274","https://openalex.org/W2784346805","https://openalex.org/W2891780076","https://openalex.org/W2905097208","https://openalex.org/W2911324006","https://openalex.org/W2946718979","https://openalex.org/W2951665402","https://openalex.org/W2963554762","https://openalex.org/W4229046432","https://openalex.org/W4391226572","https://openalex.org/W4396690261","https://openalex.org/W4396761084","https://openalex.org/W7140120327","https://openalex.org/W7204150862","https://openalex.org/W7213451848"],"related_works":["https://openalex.org/W2594847274","https://openalex.org/W4289731321","https://openalex.org/W4200139160","https://openalex.org/W2014177763","https://openalex.org/W7130644750","https://openalex.org/W4405760489","https://openalex.org/W2130787389","https://openalex.org/W4391226572","https://openalex.org/W3160514143","https://openalex.org/W7204150862"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"metacestode":[2,131],"larval":[3,216],"stage":[4],"of":[5,56,64,79,162,166,177,197,212,222,234],"Echinococcus":[6],"multilocularis":[7,72],"exhibits":[8],"a":[9,61,84,135,210],"remarkable":[10],"capacity":[11,170],"for":[12,171,209],"sustained,":[13],"infiltrative":[14],"growth,":[15],"driven":[16],"by":[17],"germinative":[18,109,163],"cells,":[19,119,164],"the":[20,57,76,80,96,142,169,175,184,192,231],"parasite\u2019s":[21],"only":[22],"mitotically":[23],"active":[24],"cell":[25,34,124],"population.":[26],"Yet,":[27],"despite":[28,174],"this":[29,238],"seemingly":[30],"unlimited":[31],"growth":[32,66],"potential,":[33],"proliferation":[35],"and":[36,46,52,67,89,95,103,111,117,160,194,200,218,227],"differentiation":[37],"must":[38],"remain":[39],"tightly":[40],"coordinated":[41],"to":[42],"maintain":[43],"tissue":[44,68],"organization":[45],"parasite":[47],"development.":[48],"Here,":[49],"we":[50],"identify":[51],"functionally":[53],"investigate":[54],"components":[55,78],"Hippo":[58],"signaling":[59,236],"pathway,":[60,82],"conserved":[62],"regulator":[63],"cellular":[65],"homeostasis,":[69],"in":[70,107,112,138,191,214,237],"E.":[71],".":[73],"We":[74],"identified":[75],"principal":[77],"canonical":[81],"including":[83],"highly":[85],"divergent":[86],"Yorkie":[87],"ortholog,":[88],"demonstrated":[90],"an":[91,149],"interaction":[92],"between":[93],"EmYorkie":[94,213],"TEAD-family":[97],"transcription":[98],"factor":[99],"EmScalloped.":[100],"Both":[101],"emhippo":[102],"emyorkie":[104,129],"are":[105],"expressed":[106],"proliferating":[108],"cells":[110],"association":[113],"with":[114,147,183],"differentiated":[115],"neural":[116],"muscle":[118],"suggesting":[120],"functions":[121],"beyond":[122],"stem":[123],"regulation.":[125],"RNA":[126],"interference":[127],"targeting":[128],"enhanced":[130],"vesicle":[132],"formation":[133,199],"without":[134],"detectable":[136,178],"increase":[137],"EdU":[139],"incorporation":[140],"at":[141],"time":[143],"point":[144],"examined.":[145],"Treatment":[146],"XMU-MP-1,":[148],"inhibitor":[150,187],"originally":[151],"developed":[152],"against":[153],"mammalian":[154],"MST1/2":[155],"kinases,":[156],"induced":[157],"pronounced":[158,220],"enlargement":[159],"multinucleation":[161],"some":[165],"which":[167],"retained":[168],"DNA":[172],"synthesis":[173],"absence":[176],"phospho-histone":[179],"H3":[180,202],"staining.":[181,203],"Comparison":[182],"Aurora":[185],"kinase":[186],"MLN8237":[188],"revealed":[189],"differences":[190],"magnitude":[193],"concentration":[195],"dependence":[196],"giant-cell":[198],"phosphor-histone":[201],"Together,":[204],"our":[205],"findings":[206],"provide":[207],"evidence":[208],"role":[211],"early":[215],"development":[217],"reveal":[219],"effects":[221],"XMU-MP-1":[223],"on":[224],"germinative-cell":[225],"morphology":[226],"cell-cycle-associated":[228],"processes,":[229],"highlighting":[230],"potential":[232],"importance":[233],"Hippo-associated":[235],"parasitic":[239],"flatworm.":[240]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}
