{"id":"https://openalex.org/W7224824434","doi":"https://doi.org/10.1097/nr9.0000000000000132","title":"Metabolic abnormalities underlying symptom clusters in lung cancer patients: A weighted gene coexpression network analysis\u2013based metabolomic analysis","display_name":"Metabolic abnormalities underlying symptom clusters in lung cancer patients: A weighted gene coexpression network analysis\u2013based metabolomic analysis","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7224824434","doi":"https://doi.org/10.1097/nr9.0000000000000132"},"language":"en","primary_location":{"id":"doi:10.1097/nr9.0000000000000132","doi":"https://doi.org/10.1097/nr9.0000000000000132","is_oa":true,"landing_page_url":"https://doi.org/10.1097/nr9.0000000000000132","pdf_url":null,"source":{"id":"https://openalex.org/S4387285163","display_name":"Interdisciplinary Nursing Research","issn_l":"2832-918X","issn":["2832-918X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interdisciplinary Nursing Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1097/nr9.0000000000000132","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160199049","display_name":"Yanxuan Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanxuan Xiao","raw_affiliation_strings":["School of Nursing, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160163775","display_name":"Yuanyuan Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Luo","raw_affiliation_strings":["School of Nursing, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000495047","display_name":"Ruiyan Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiyan Bai","raw_affiliation_strings":["School of Nursing, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160180510","display_name":"Chang Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Gao","raw_affiliation_strings":["School of Nursing, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066351299","display_name":"Dongmei Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongmei Mao","raw_affiliation_strings":["Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101463154","display_name":"Le Zhang","orcid":"https://orcid.org/0000-0003-4622-5750","observed_orcids":["https://orcid.org/0000-0003-4622-5750"]},"institutions":[{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Zhang","raw_affiliation_strings":["Nursing Department, China-Japan Friendship Hospital, Beijing, China","School of Nursing, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nursing Department, China-Japan Friendship Hospital, Beijing, China","institution_ids":["https://openalex.org/I2801051648"]},{"raw_affiliation_string":"School of Nursing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143810548","display_name":"Zhihui Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihui Yang","raw_affiliation_strings":["School of Nursing, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160193051","display_name":"Yang Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhao","raw_affiliation_strings":["School of Nursing, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091596469","display_name":"Lili Zhang","orcid":"https://orcid.org/0000-0002-8935-5371","observed_orcids":["https://orcid.org/0000-0002-8935-5371"]},"institutions":[{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili Zhang","raw_affiliation_strings":["Nursing Department, China-Japan Friendship Hospital, Beijing, China","School of Nursing, Southern Medical University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-8935-5371","affiliations":[{"raw_affiliation_string":"Nursing Department, China-Japan Friendship Hospital, Beijing, China","institution_ids":["https://openalex.org/I2801051648"]},{"raw_affiliation_string":"School of Nursing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7187113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"3","first_page":"157","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.24480000138282776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemotherapy-induced-symptoms","display_name":"chemotherapy-induced symptoms","score":0.7020000219345093},{"id":"https://openalex.org/keywords/symptom-clusters","display_name":"symptom clusters","score":0.9940000176429749},{"id":"https://openalex.org/keywords/respiratory-symptoms","display_name":"respiratory symptoms","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gastrointestinal-symptoms","display_name":"gastrointestinal symptoms","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plasma-metabolites","display_name":"plasma metabolites","score":0.8009999990463257},{"id":"https://openalex.org/keywords/harmine","display_name":"harmine","score":0.9139999747276306},{"id":"https://openalex.org/keywords/naproxen","display_name":"naproxen","score":0.8339999914169312},{"id":"https://openalex.org/keywords/essential-fatty-acid-metabolism","display_name":"essential fatty acid metabolism","score":0.8600000143051147},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.8240000009536743},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.4050000011920929},{"id":"https://openalex.org/keywords/weighted-gene-co-expression-network-analysis","display_name":"weighted gene co-expression network analysis","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.8568999767303467},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8345000147819519},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.4851999878883362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4262000024318695},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.3603000044822693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3582000136375427},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3560999929904938},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34549999237060547},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3384000062942505},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3330000042915344},{"id":"https://openalex.org/C2781450507","wikidata":"https://www.wikidata.org/wiki/Q128381","display_name":"Harmine","level":2,"score":0.30630001425743103},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.29429998993873596},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2919999957084656},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.2897000014781952},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.2890999913215637},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2856999933719635},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.26820001006126404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/nr9.0000000000000132","doi":"https://doi.org/10.1097/nr9.0000000000000132","is_oa":true,"landing_page_url":"https://doi.org/10.1097/nr9.0000000000000132","pdf_url":null,"source":{"id":"https://openalex.org/S4387285163","display_name":"Interdisciplinary Nursing Research","issn_l":"2832-918X","issn":["2832-918X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interdisciplinary Nursing Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1097/nr9.0000000000000132","doi":"https://doi.org/10.1097/nr9.0000000000000132","is_oa":true,"landing_page_url":"https://doi.org/10.1097/nr9.0000000000000132","pdf_url":null,"source":{"id":"https://openalex.org/S4387285163","display_name":"Interdisciplinary Nursing Research","issn_l":"2832-918X","issn":["2832-918X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interdisciplinary Nursing Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1530189959","https://openalex.org/W1590382336","https://openalex.org/W1773262993","https://openalex.org/W1892082417","https://openalex.org/W1966327575","https://openalex.org/W1968508379","https://openalex.org/W2004537227","https://openalex.org/W2046378210","https://openalex.org/W2075749315","https://openalex.org/W2078318384","https://openalex.org/W2082471133","https://openalex.org/W2109364152","https://openalex.org/W2112625260","https://openalex.org/W2300458685","https://openalex.org/W2539379962","https://openalex.org/W2552113437","https://openalex.org/W2552339890","https://openalex.org/W2582438818","https://openalex.org/W2596753368","https://openalex.org/W2614348652","https://openalex.org/W2783811473","https://openalex.org/W2792595120","https://openalex.org/W2895897802","https://openalex.org/W2921307754","https://openalex.org/W2956792925","https://openalex.org/W2965132120","https://openalex.org/W3000701029","https://openalex.org/W3009682272","https://openalex.org/W3010511947","https://openalex.org/W3021053184","https://openalex.org/W3021714211","https://openalex.org/W3088203083","https://openalex.org/W3135627827","https://openalex.org/W3158175214","https://openalex.org/W3163937536","https://openalex.org/W3164367120","https://openalex.org/W3188319015","https://openalex.org/W3196105990","https://openalex.org/W3201094218","https://openalex.org/W4280496068","https://openalex.org/W4281253145","https://openalex.org/W4283650536","https://openalex.org/W4293113423","https://openalex.org/W4307125854","https://openalex.org/W4312117502","https://openalex.org/W4372330756","https://openalex.org/W4375841182","https://openalex.org/W4390545131","https://openalex.org/W4392195561","https://openalex.org/W4395004260","https://openalex.org/W4402312414","https://openalex.org/W4402518098","https://openalex.org/W4404773906","https://openalex.org/W4405012089","https://openalex.org/W4405365257","https://openalex.org/W4416185296"],"related_works":["https://openalex.org/W4416185296","https://openalex.org/W2917605200","https://openalex.org/W2917105999","https://openalex.org/W1995349263","https://openalex.org/W2756990177","https://openalex.org/W2409953849","https://openalex.org/W3197822291","https://openalex.org/W4281721564","https://openalex.org/W2767238220","https://openalex.org/W2887589291"],"abstract_inverted_index":{"Abstract":[0],"Objectives:":[1],"To":[2],"investigate":[3],"the":[4,42,87,185,222,230],"metabolic":[5,246],"underpinnings":[6],"of":[7,105,142,173,225],"three":[8],"major":[9],"symptom":[10],"clusters":[11],"(SCs):":[12],"somato-psychological,":[13],"respiratory,":[14],"and":[15,49,73,82,127,132,158,163,202,212,248,260],"gastrointestinal":[16,182],"SCs":[17,238],"in":[18,239,257],"lung":[19],"cancer":[20],"(LC)":[21],"patients":[22,30,241],"undergoing":[23,242],"chemotherapy.":[24],"Methods:":[25],"Plasma":[26],"from":[27],"100":[28],"LC":[29,50,240],"receiving":[31],"chemotherapy":[32],"was":[33,59,116,147,178],"analyzed":[34],"through":[35,111],"untargeted":[36],"metabolomics.":[37],"Symptoms":[38],"were":[39,78,92,204],"assessed":[40],"using":[41,86],"M.D.":[43],"Anderson":[44],"Symptom":[45],"Inventory-Chinese":[46],"version":[47],"(MDASI-C)":[48],"module":[51,115,146,177,187],"scales.":[52],"Weighted":[53],"gene":[54],"coexpression":[55],"network":[56],"analysis":[57,72],"(WGCNA)":[58],"performed":[60],"to":[61,95,130,161,207,233,236],"identify":[62],"metabolite":[63,75,137,168,217],"modules":[64,110],"associated":[65],"with":[66,119,122,150,153,181],"SCs,":[67],"followed":[68],"by":[69],"biological":[70],"enrichment":[71],"core":[74],"screening.":[76],"Patients":[77],"categorized":[79],"into":[80],"positive":[81,190],"negative":[83],"SC":[84],"groups":[85],"75th":[88],"percentile.":[89],"Core":[90],"metabolites":[91,123,154],"then":[93],"used":[94],"evaluate":[96],"their":[97],"combined":[98],"effect":[99],"on":[100],"SCs.":[101],"Results:":[102],"Hierarchical":[103],"clustering":[104],"96":[106],"samples":[107],"identified":[108],"12":[109],"WGCNA.":[112],"The":[113,135,144,166,175,215],"black":[114],"negatively":[117,148,179],"correlated":[118,149,180],"somato-psychological":[120],"SC,":[121,152,183],"such":[124,155],"as":[125,156],"harmine":[126],"dihydroketoprofen":[128],"linked":[129,206],"neuromodulation":[131],"other":[133],"pathways.":[134,165],"corresponding":[136,167,216],"panel":[138,169,218],"yielded":[139,170,219],"an":[140,171],"AUC":[141,172],"0.649.":[143],"blue":[145],"respiratory":[151],"Ala-Pro":[157],"naproxen":[159],"related":[160],"metabolism":[162,211],"synthesis":[164],"0.706.":[174],"brown":[176],"whereas":[184],"magenta":[186],"showed":[188],"a":[189],"correlation.":[191],"Key":[192],"metabolites,":[193],"including":[194],"alpha-linolenic":[195],"acid,":[196,200],"acyclovir,":[197],"diphenylmethylphosphine,":[198],"DL-glutamic":[199],"phenylacetyl-L-glutamine,":[201],"acetylcysteine,":[203],"primarily":[205],"essential":[208],"fatty":[209],"acid":[210],"microbe-host":[213],"interactions.":[214],"anarea":[220],"under":[221],"curve":[223],"(AUC)":[224],"0.749.":[226],"Conclusions:":[227],"This":[228],"is":[229],"first":[231],"study":[232],"apply":[234],"metabolomics":[235],"multiple":[237],"chemotherapy,":[243],"identifying":[244],"key":[245],"alterations":[247],"discriminatory":[249],"metabolites.":[250],"Future":[251],"studies":[252],"should":[253],"validate":[254],"these":[255],"findings":[256],"larger":[258],"cohorts":[259],"explore":[261],"mechanistic":[262],"pathways":[263],"for":[264],"biomarker":[265],"development.":[266]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}