{"id":"https://openalex.org/W7224822198","doi":"https://doi.org/10.1097/rc9.0000000000001100","title":"Hepatic eosinophilic granuloma without peripheral eosinophilia diagnosed by laparoscopic liver resection: a case report","display_name":"Hepatic eosinophilic granuloma without peripheral eosinophilia diagnosed by laparoscopic liver resection: a case report","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7224822198","doi":"https://doi.org/10.1097/rc9.0000000000001100","pmid":"https://pubmed.ncbi.nlm.nih.gov/43006051","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13747425"},"language":"en","primary_location":{"id":"doi:10.1097/rc9.0000000000001100","doi":"https://doi.org/10.1097/rc9.0000000000001100","is_oa":true,"landing_page_url":"https://doi.org/10.1097/rc9.0000000000001100","pdf_url":null,"source":{"id":"https://openalex.org/S5398819","display_name":"International Journal of Surgery Case Reports","issn_l":"2210-2612","issn":["2210-2612"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/rc9.0000000000001100","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055679788","display_name":"Takao Tayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Tayama","raw_affiliation_strings":["Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054203101","display_name":"Tomoyuki Abe","orcid":"https://orcid.org/0000-0001-6859-7614","observed_orcids":["https://orcid.org/0000-0001-6859-7614","https://orcid.org/0009-0000-6816-6187"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tomoyuki Abe","raw_affiliation_strings":["Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6859-7614","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089533787","display_name":"Hiroki Kitagawa","orcid":"https://orcid.org/0000-0003-1651-0091","observed_orcids":["https://orcid.org/0000-0003-1651-0091"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Kitagawa","raw_affiliation_strings":["Department of Infectious Disease, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015251653","display_name":"\u525b \u5c0f\u6797","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Kobayashi","raw_affiliation_strings":["Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085033780","display_name":"Susumu Tazuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284852","display_name":"Hiroshima Prefectural Hospital Organization","ror":"https://ror.org/04a8m9s75","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284852"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Tazuma","raw_affiliation_strings":["Department of Gastroenterology, Hiroshima Prefectural Hospital Organization Futabanosato Prefectural Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hiroshima Prefectural Hospital Organization Futabanosato Prefectural Hospital, Hiroshima, Japan","institution_ids":["https://openalex.org/I4405284852"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091464981","display_name":"Hideki Ohdan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Ohdan","raw_affiliation_strings":["Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054203101"],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":{"value":2090,"currency":"USD","value_usd":2090},"apc_paid":{"value":2090,"currency":"USD","value_usd":2090},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"11","first_page":"5056","last_page":"5060"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.6401000022888184,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.6401000022888184,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":0.1444000005722046,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12538","display_name":"Eosinophilic Esophagitis","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laparoscopic-liver-resection","display_name":"laparoscopic liver resection","score":0.8100000023841858},{"id":"https://openalex.org/keywords/preoperative-diagnosis","display_name":"preoperative diagnosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/eosinophilic-granulomatous-inflammation","display_name":"eosinophilic granulomatous inflammation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/parasitic-infection","display_name":"parasitic infection","score":0.515999972820282},{"id":"https://openalex.org/keywords/lymph-node-dissection","display_name":"lymph node dissection","score":0.621999979019165},{"id":"https://openalex.org/keywords/coagulative-necrosis","display_name":"coagulative necrosis","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9204000234603882},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.7764999866485596},{"id":"https://openalex.org/C2779849941","wikidata":"https://www.wikidata.org/wiki/Q16882760","display_name":"Inflammatory pseudotumor","level":3,"score":0.6456000208854675},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.64410001039505},{"id":"https://openalex.org/C2780140890","wikidata":"https://www.wikidata.org/wiki/Q1129338","display_name":"Granuloma","level":2,"score":0.6352999806404114},{"id":"https://openalex.org/C2777210190","wikidata":"https://www.wikidata.org/wiki/Q655982","display_name":"Eosinophilic granuloma","level":2,"score":0.6051999926567078},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.49410000443458557},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.4569000005722046},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.3912999927997589},{"id":"https://openalex.org/C2775862295","wikidata":"https://www.wikidata.org/wiki/Q2660911","display_name":"Dissection (medical)","level":2,"score":0.3352000117301941},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.3156000077724457},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.29789999127388},{"id":"https://openalex.org/C2779690883","wikidata":"https://www.wikidata.org/wiki/Q1811092","display_name":"Liver abscess","level":3,"score":0.27730000019073486},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2718000113964081},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.27090001106262207},{"id":"https://openalex.org/C2779681694","wikidata":"https://www.wikidata.org/wiki/Q8034532","display_name":"Work-up","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.2535000145435333},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/rc9.0000000000001100","doi":"https://doi.org/10.1097/rc9.0000000000001100","is_oa":true,"landing_page_url":"https://doi.org/10.1097/rc9.0000000000001100","pdf_url":null,"source":{"id":"https://openalex.org/S5398819","display_name":"International Journal of Surgery Case Reports","issn_l":"2210-2612","issn":["2210-2612"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery Case Reports","raw_type":"journal-article"},{"id":"pmid:43006051","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43006051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of surgery case reports","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1097/rc9.0000000000001100","doi":"https://doi.org/10.1097/rc9.0000000000001100","is_oa":true,"landing_page_url":"https://doi.org/10.1097/rc9.0000000000001100","pdf_url":null,"source":{"id":"https://openalex.org/S5398819","display_name":"International Journal of Surgery Case Reports","issn_l":"2210-2612","issn":["2210-2612"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1984821508","https://openalex.org/W2014205004","https://openalex.org/W2047845566","https://openalex.org/W2052619624","https://openalex.org/W2180670745","https://openalex.org/W3023802258","https://openalex.org/W3160352483","https://openalex.org/W4386273823","https://openalex.org/W4410344885"],"related_works":["https://openalex.org/W2180670745","https://openalex.org/W3030899129","https://openalex.org/W7162795622","https://openalex.org/W2103081192","https://openalex.org/W3000671910","https://openalex.org/W1984821508","https://openalex.org/W3028917081","https://openalex.org/W2317729186","https://openalex.org/W1974228407","https://openalex.org/W2360800806"],"abstract_inverted_index":{"Introduction":[0],"and":[1,14,31,94,117,130,143,153,253],"importance:":[2],"Eosinophilic":[3],"granuloma":[4,24,138],"is":[5,15,26,32,197,246],"a":[6,17,41,49,54,74,137,216,247],"histopathological":[7],"condition":[8],"characterized":[9],"by":[10,59,81],"eosinophil-rich":[11],"granulomatous":[12],"inflammation":[13],"considered":[16,223],"manifestation":[18],"of":[19,43,73,114,160,169,180,187,192,208,228,236],"allergic":[20],"reactions.":[21],"Hepatic":[22],"eosinophilic":[23,141],"(HEG)":[25],"an":[27,104],"extremely":[28],"rare":[29],"entity":[30],"most":[33,198],"commonly":[34],"associated":[35,200],"with":[36,53,139,201],"parasitic":[37,51,155,161,193,202,238],"infections.":[38,203],"We":[39],"report":[40],"case":[42],"HEG":[44,170,196,210,220],"without":[45],"peripheral":[46,188,241],"eosinophilia":[47,189],"or":[48,107,190,240],"confirmed":[50,237],"infection,":[52],"difficult":[55],"preoperative":[56,206],"diagnosis,":[57],"treated":[58],"laparoscopic":[60],"liver":[61,75],"resection.":[62],"Case":[63],"presentation:":[64],"A":[65],"67-year-old":[66],"woman":[67],"was":[68,110,163],"referred":[69],"for":[70,85,128,148],"further":[71,96],"evaluation":[72],"tumor":[76],"in":[77,184,224,233],"segment":[78,115],"3":[79],"detected":[80],"computed":[82],"tomography":[83],"performed":[84,127],"unexplained":[86],"abdominal":[87],"pain.":[88],"Tumor":[89],"markers":[90],"were":[91,126,151],"not":[92,100],"elevated,":[93],"although":[95],"imaging":[97],"studies":[98],"did":[99],"exclude":[101],"hepatic":[102,124,181,230],"malignancy,":[103],"inflammatory":[105],"pseudotumor":[106],"intrahepatic":[108],"cholangiocarcinoma":[109],"suspected.":[111],"Laparoscopic":[112,213],"sub-segmentectomy":[113],"3,":[116],"lymph":[118],"node":[119],"dissection":[120],"around":[121],"the":[122,185,225,234],"common":[123],"artery,":[125],"diagnostic":[129,254],"therapeutic":[131,252],"purposes,":[132],"respectively.":[133],"Histopathological":[134],"examination":[135],"revealed":[136],"marked":[140],"infiltration":[142],"central":[144],"coagulative":[145],"necrosis.":[146],"Tests":[147],"mycobacterial":[149],"infection":[150,162],"negative,":[152],"neither":[154],"organisms":[156],"nor":[157],"serological":[158],"evidence":[159,191],"identified.":[164],"Clinical":[165],"discussion:":[166],"Preoperative":[167],"diagnosis":[168,207,227],"remains":[171,211],"challenging":[172],"because":[173],"its":[174],"radiological":[175],"findings":[176],"often":[177],"resemble":[178],"those":[179],"malignancies,":[182],"particularly":[183],"absence":[186,235],"infection.":[194],"Conclusion:":[195],"frequently":[199],"However,":[204],"precise":[205],"nonparasitic":[209],"challenging.":[212],"resection":[214],"enabled":[215],"definitive":[217],"diagnosis.":[218],"Therefore,":[219],"should":[221],"be":[222],"differential":[226],"primary":[229],"tumors,":[231],"even":[232],"infections":[239],"eosinophilia.":[242],"Minimally":[243],"invasive":[244],"surgery":[245],"reasonable":[248],"option":[249],"from":[250],"both":[251],"perspectives.":[255]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-10-31T00:00:00"}