{"id":"https://openalex.org/W7224820612","doi":"https://doi.org/10.3389/fgene.2026.1895948","title":"Study on copy number variant detection results of 472 fetuses with non-structural ultrasound abnormalities in non-advanced age pregnant women and the correlation with adverse obstetric history","display_name":"Study on copy number variant detection results of 472 fetuses with non-structural ultrasound abnormalities in non-advanced age pregnant women and the correlation with adverse obstetric history","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224820612","doi":"https://doi.org/10.3389/fgene.2026.1895948"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2026.1895948","doi":"https://doi.org/10.3389/fgene.2026.1895948","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1895948","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1895948/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1895948/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100960705","display_name":"Lifang Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086600","display_name":"Meizhou City People's Hospital","ror":"https://ror.org/0026mdx79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086600"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifang Lin","raw_affiliation_strings":["Department of Prenatal Diagnostic Center, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prenatal Diagnostic Center, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]},{"raw_affiliation_string":"Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153023879","display_name":"Heming Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086600","display_name":"Meizhou City People's Hospital","ror":"https://ror.org/0026mdx79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086600"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heming Wu","raw_affiliation_strings":["Department of Prenatal Diagnostic Center, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prenatal Diagnostic Center, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]},{"raw_affiliation_string":"Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160222997","display_name":"Zhiyuan Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086600","display_name":"Meizhou City People's Hospital","ror":"https://ror.org/0026mdx79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086600"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyuan Zheng","raw_affiliation_strings":["Department of Prenatal Diagnostic Center, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prenatal Diagnostic Center, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]},{"raw_affiliation_string":"Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160173822","display_name":"Ping Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086600","display_name":"Meizhou City People's Hospital","ror":"https://ror.org/0026mdx79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086600"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Chen","raw_affiliation_strings":["Department of Ultrasound, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]},{"raw_affiliation_string":"Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153022095","display_name":"Jianwen Lian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086600","display_name":"Meizhou City People's Hospital","ror":"https://ror.org/0026mdx79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086600"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwen Lian","raw_affiliation_strings":["Department of Prenatal Diagnostic Center, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prenatal Diagnostic Center, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]},{"raw_affiliation_string":"Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102548703","display_name":"Shuxian Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086600","display_name":"Meizhou City People's Hospital","ror":"https://ror.org/0026mdx79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086600"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuxian Huang","raw_affiliation_strings":["Department of Ultrasound, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]},{"raw_affiliation_string":"Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053946200","display_name":"Liubing Lan","orcid":"https://orcid.org/0009-0003-8610-896X","observed_orcids":["https://orcid.org/0009-0003-8610-896X"]},"institutions":[{"id":"https://openalex.org/I4210086600","display_name":"Meizhou City People's Hospital","ror":"https://ror.org/0026mdx79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086600"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liubing Lan","raw_affiliation_strings":["Department of Obstetrics, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","Department of Prenatal Diagnostic Center, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]},{"raw_affiliation_string":"Department of Prenatal Diagnostic Center, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]},{"raw_affiliation_string":"Meizhou Municipal Engineering and Technology Research Center for Molecular Diagnostics of Major Genetic Disorders, Meizhou People\u2019s Hospital, Meizhou Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210086600"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053946200"],"corresponding_institution_ids":["https://openalex.org/I4210086600"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88216933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/variants-of-uncertain-significance","display_name":"variants of uncertain significance","score":0.9340000152587891},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.7509999871253967},{"id":"https://openalex.org/keywords/amniotic-fluid-volume","display_name":"amniotic fluid volume","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tricuspid-regurgitation","display_name":"tricuspid regurgitation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/persistent-right-umbilical-vein","display_name":"persistent right umbilical vein","score":0.8830000162124634},{"id":"https://openalex.org/keywords/persistent-left-superior-vena-cava","display_name":"persistent left superior vena cava","score":0.9470000267028809},{"id":"https://openalex.org/keywords/prenatal-genetic-testing","display_name":"prenatal genetic testing","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.804099977016449},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.7800999879837036},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.7218999862670898},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.6974999904632568},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5903000235557556},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.5737000107765198},{"id":"https://openalex.org/C2778194526","wikidata":"https://www.wikidata.org/wiki/Q901674","display_name":"Amniotic fluid","level":4,"score":0.4551999866962433},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.40959998965263367},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.4020000100135803},{"id":"https://openalex.org/C2778780700","wikidata":"https://www.wikidata.org/wiki/Q1671598","display_name":"Intrauterine growth restriction","level":4,"score":0.3978999853134155},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C2776352029","wikidata":"https://www.wikidata.org/wiki/Q4686351","display_name":"Advanced maternal age","level":4,"score":0.3131999969482422},{"id":"https://openalex.org/C10885799","wikidata":"https://www.wikidata.org/wiki/Q80015","display_name":"Obstetrics and gynaecology","level":3,"score":0.30970001220703125},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3000999987125397},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.29840001463890076},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.2879999876022339},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2786000072956085},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.27219998836517334},{"id":"https://openalex.org/C2777202286","wikidata":"https://www.wikidata.org/wiki/Q9609","display_name":"Vein","level":2,"score":0.26010000705718994}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fgene.2026.1895948","doi":"https://doi.org/10.3389/fgene.2026.1895948","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1895948","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1895948/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2e171c6d704347e0a8672c049987bf7e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2e171c6d704347e0a8672c049987bf7e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2026.1895948","doi":"https://doi.org/10.3389/fgene.2026.1895948","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1895948","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1895948/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224820612.pdf","grobid_xml":"https://content.openalex.org/works/W7224820612.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W2592746645","https://openalex.org/W2883271054","https://openalex.org/W2974857756","https://openalex.org/W2983742483","https://openalex.org/W3043875487","https://openalex.org/W3087639870","https://openalex.org/W3096210402","https://openalex.org/W3103661483","https://openalex.org/W3134108396","https://openalex.org/W3153229240","https://openalex.org/W3161593288","https://openalex.org/W3175803896","https://openalex.org/W3193789192","https://openalex.org/W3206439107","https://openalex.org/W4213124257","https://openalex.org/W4296328654","https://openalex.org/W4309365916","https://openalex.org/W4309448442","https://openalex.org/W4318068460","https://openalex.org/W4377038145","https://openalex.org/W4382700950","https://openalex.org/W4385684400","https://openalex.org/W4388869810","https://openalex.org/W4389507000","https://openalex.org/W4391722780","https://openalex.org/W4394998078","https://openalex.org/W4396826556","https://openalex.org/W4399121239","https://openalex.org/W4401622352","https://openalex.org/W4403403430","https://openalex.org/W4404121025","https://openalex.org/W4406222427","https://openalex.org/W4408816789","https://openalex.org/W4409114316","https://openalex.org/W4411324458","https://openalex.org/W4413486635","https://openalex.org/W4414254482","https://openalex.org/W4414853690","https://openalex.org/W4415024125","https://openalex.org/W4415625797","https://openalex.org/W7116755911","https://openalex.org/W7118158739","https://openalex.org/W7124460980","https://openalex.org/W7139032881","https://openalex.org/W7140193141"],"related_works":["https://openalex.org/W7214534745","https://openalex.org/W7213719973","https://openalex.org/W3087639870","https://openalex.org/W4387208559","https://openalex.org/W4407818453","https://openalex.org/W2806064452","https://openalex.org/W4388813812","https://openalex.org/W3021976883","https://openalex.org/W4391722780","https://openalex.org/W6957734544"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"copy":[3],"number":[4],"variant":[5],"(CNV)":[6],"results":[7],"in":[8,153,170,214],"472":[9,44],"fetuses":[10,154],"with":[11,50,64,155,194,225,240],"non-structural":[12,52,75,242],"ultrasound":[13,53,76,111,172,191,243,255],"abnormalities":[14,54,244],"among":[15,185],"pregnant":[16,45,238],"women":[17,46,224,239],"under":[18],"35":[19],"years,":[20],"and":[21,29,34,81,88,90,125,140,182,201,218,226,252,272],"analyze":[22],"the":[23,72,79,162,269],"association":[24],"between":[25,93,223],"adverse":[26,67,228],"obstetric":[27,68,264],"history":[28,230,265],"pathogenic/likely":[30],"pathogenic":[31],"(P/LP)":[32],"CNVs":[33,87,139,150,251,271],"variants":[35],"of":[36,43,74,85,117,148,166,180,188,249],"uncertain":[37],"significance":[38],"(VUS).":[39],"Methods":[40],"A":[41],"total":[42],"aged":[47],"<35":[48],"years":[49],"fetal":[51,121,241],"were":[55,60,135,221],"retrospectively":[56],"enrolled.":[57],"All":[58],"participants":[59],"divided":[61],"into":[62],"groups":[63],"or":[65],"without":[66,227],"history.":[69,109],"We":[70],"summarized":[71],"distribution":[73],"abnormalities,":[77],"calculated":[78],"overall":[80,132,215],"stratified":[82],"detection":[83,133,146,164,178,209,261,274],"rates":[84,134,220],"P/LP":[86,138,149,181,216,250,270],"VUS,":[89],"compared":[91],"differences":[92,213],"groups.":[94],"Results":[95],"The":[96,131,144,176],"mean":[97],"maternal":[98],"age":[99,237],"was":[100,151,168],"28.73":[101],"\u00b1":[102],"3.59":[103],"years;":[104],"22.0%":[105],"had":[106],"a":[107,246],"positive":[108],"Abnormal":[110],"soft":[112,173,192,256],"markers":[113,174,257],"accounted":[114],"for":[115,137,142],"82.6%":[116],"cases,":[118],"followed":[119],"by":[120],"growth":[122],"restriction":[123],"(12.3%)":[124],"abnormal":[126,156,171,190],"amniotic":[127,157],"fluid":[128,158],"volume":[129,159],"(4.0%).":[130],"5.7%":[136],"9.1%":[141],"VUS.":[143,253],"highest":[145,163],"rate":[147,165,179],"observed":[152],"(10.5%),":[160],"while":[161],"VUS":[167,183,219,273],"seen":[169],"(9.2%).":[175],"combined":[177],"differed":[184],"different":[186],"types":[187],"isolated":[189],"markers,":[193],"tricuspid":[195],"regurgitation,":[196],"persistent":[197,202],"right":[198],"umbilical":[199],"vein":[200],"left":[203],"superior":[204],"vena":[205],"cava":[206],"showing":[207],"higher":[208],"rates.":[210,262],"No":[211],"significant":[212],"CNV":[217,260],"found":[222],"pregnancy":[229],"(":[231],"p":[232],">":[233],"0.05).":[234],"Conclusion":[235],"Non-advanced":[236],"carry":[245],"non-negligible":[247],"risk":[248],"Different":[254],"present":[258],"distinct":[259],"Adverse":[263],"does":[266],"not":[267],"alter":[268],"rate.":[275]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}
