{"id":"https://openalex.org/W7224820115","doi":"https://doi.org/10.1055/a-2988-1455","title":"Sepsis-Induced Coagulopathy (SIC) Update 2026: Simplifying the Diagnosis and Dynamic Monitoring of Sepsis-Associated DIC","display_name":"Sepsis-Induced Coagulopathy (SIC) Update 2026: Simplifying the Diagnosis and Dynamic Monitoring of Sepsis-Associated DIC","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224820115","doi":"https://doi.org/10.1055/a-2988-1455","pmid":"https://pubmed.ncbi.nlm.nih.gov/42962682"},"language":"en","primary_location":{"id":"doi:10.1055/a-2988-1455","doi":"https://doi.org/10.1055/a-2988-1455","is_oa":false,"landing_page_url":"https://doi.org/10.1055/a-2988-1455","pdf_url":null,"source":{"id":"https://openalex.org/S96726197","display_name":"Seminars in Thrombosis and Hemostasis","issn_l":"0094-6176","issn":["0094-6176","1098-9064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Thrombosis and Hemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022890528","display_name":"Toshiaki Iba","orcid":"https://orcid.org/0000-0002-0255-4088","observed_orcids":["https://orcid.org/0000-0002-0255-4088"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Iba","raw_affiliation_strings":["Juntendo University Graduate School of Medicine, Tokyo, Japan","Juntendo University, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0255-4088","affiliations":[{"raw_affiliation_string":"Juntendo University Graduate School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Juntendo University, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053864173","display_name":"Jerrold H. Levy","orcid":"https://orcid.org/0000-0003-3766-4962","observed_orcids":["https://orcid.org/0000-0003-3766-4962"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerrold H. Levy","raw_affiliation_strings":["School of Medicine, Duke University, North Carolina, United States"],"raw_orcid":"https://orcid.org/0000-0003-3766-4962","affiliations":[{"raw_affiliation_string":"School of Medicine, Duke University, North Carolina, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038678186","display_name":"Marcel M Levi","orcid":"https://orcid.org/0000-0002-2212-5299","observed_orcids":["https://orcid.org/0000-0002-2212-5299"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marcel Levi","raw_affiliation_strings":["Amsterdam University Medical Centres, Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2212-5299","affiliations":[{"raw_affiliation_string":"Amsterdam University Medical Centres, Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85580621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis-induced-coagulopathy","display_name":"sepsis-induced coagulopathy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/coagulation-monitoring","display_name":"coagulation monitoring","score":0.7749999761581421},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.8849999904632568},{"id":"https://openalex.org/keywords/pt-inr","display_name":"PT-INR","score":0.9290000200271606},{"id":"https://openalex.org/keywords/sofa-score","display_name":"SOFA score","score":0.9390000104904175},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8669999837875366},{"id":"https://openalex.org/keywords/sepsis-pathophysiology","display_name":"sepsis pathophysiology","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C2779936836","wikidata":"https://www.wikidata.org/wiki/Q890200","display_name":"Coagulopathy","level":2,"score":0.8256000280380249},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8080000281333923},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7645999789237976},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6341999769210815},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.5679000020027161},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.47859999537467957},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.41429999470710754},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.39899998903274536},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.37529999017715454},{"id":"https://openalex.org/C16124881","wikidata":"https://www.wikidata.org/wiki/Q5363933","display_name":"Coagulation testing","level":3,"score":0.3221000134944916},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3000999987125397},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.29840001463890076},{"id":"https://openalex.org/C2780434524","wikidata":"https://www.wikidata.org/wiki/Q1144385","display_name":"Prothrombin time","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C2993316766","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant therapy","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.2563999891281128},{"id":"https://openalex.org/C2777914111","wikidata":"https://www.wikidata.org/wiki/Q1064904","display_name":"Major trauma","level":2,"score":0.25450000166893005},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1055/a-2988-1455","doi":"https://doi.org/10.1055/a-2988-1455","is_oa":false,"landing_page_url":"https://doi.org/10.1055/a-2988-1455","pdf_url":null,"source":{"id":"https://openalex.org/S96726197","display_name":"Seminars in Thrombosis and Hemostasis","issn_l":"0094-6176","issn":["0094-6176","1098-9064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Thrombosis and Hemostasis","raw_type":"journal-article"},{"id":"pmid:42962682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42962682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in thrombosis and hemostasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1713440487","https://openalex.org/W2293727557","https://openalex.org/W2745119542","https://openalex.org/W2799655571","https://openalex.org/W2907889533","https://openalex.org/W2963387556","https://openalex.org/W2986750072","https://openalex.org/W3119622488","https://openalex.org/W4362561278","https://openalex.org/W4391697259","https://openalex.org/W4392381448","https://openalex.org/W4399977249","https://openalex.org/W4406310295","https://openalex.org/W4409290495","https://openalex.org/W7117870541","https://openalex.org/W7137910561","https://openalex.org/W7152444126","https://openalex.org/W7170617266"],"related_works":["https://openalex.org/W7170617266","https://openalex.org/W3002680671","https://openalex.org/W4402694619","https://openalex.org/W3193174180","https://openalex.org/W7203835847","https://openalex.org/W4318479024","https://openalex.org/W4377822943","https://openalex.org/W7203831867","https://openalex.org/W2799655571","https://openalex.org/W4291141296"],"abstract_inverted_index":{"Abstract:":[0],"Coagulation":[1],"abnormalities":[2,91],"are":[3],"a":[4,36,41,61],"fundamental":[5],"component":[6,103],"of":[7,63,74,136,157,182,209],"sepsis":[8,149],"pathophysiology":[9],"and":[10,16,32,49,85,92,104,110,120,204],"contribute":[11],"directly":[12],"to":[13,52,131,172,202],"organ":[14],"dysfunction":[15],"mortality.":[17],"The":[18,96],"sepsis-induced":[19],"coagulopathy":[20,48],"(SIC)":[21],"criteria,":[22],"introduced":[23],"in":[24,166,212],"2017":[25],"by":[26,39],"the":[27,75,87,101,129,179,195,198,206],"International":[28],"Society":[29],"on":[30,107],"Thrombosis":[31],"Haemostasis":[33],"(ISTH),":[34],"represented":[35],"major":[37],"advance":[38],"providing":[40],"practical":[42],"framework":[43],"for":[44,148],"identifying":[45],"early":[46],"sepsis-associated":[47,213],"predicting":[50],"progression":[51],"overt":[53],"disseminated":[54],"intravascular":[55],"coagulation":[56,158,210],"(DIC).":[57],"However,":[58],"after":[59],"nearly":[60],"decade":[62],"clinical":[64],"experience,":[65],"several":[66],"limitations":[67],"have":[68],"become":[69],"apparent.":[70],"In":[71],"particular,":[72],"incorporation":[73],"Sequential":[76],"Organ":[77],"Failure":[78],"Assessment":[79],"(SOFA)":[80],"score":[81],"complicates":[82],"bedside":[83],"application":[84],"blurs":[86],"distinction":[88],"between":[89],"coagulation-specific":[90],"global":[93],"illness":[94],"severity.":[95],"newly":[97],"proposed":[98],"SIC-2":[99,127,167,203],"removes":[100],"SOFA":[102],"relies":[105],"exclusively":[106],"platelet":[108],"count":[109],"prothrombin":[111],"time-international":[112],"normalized":[113],"ratio":[114],"(PT-INR),":[115],"thereby":[116],"preserving":[117],"conceptual":[118],"clarity":[119],"improving":[121],"feasibility.":[122],"Emerging":[123],"evidence":[124],"suggests":[125],"that":[126,188],"maintains":[128],"ability":[130],"identify":[132,169],"patients":[133,170],"at":[134],"risk":[135,162],"developing":[137],"DIC":[138],"while":[139],"simplifying":[140],"serial":[141,155],"monitoring.":[142],"Although":[143],"an":[144,185],"effective":[145],"anticoagulant":[146,175],"therapy":[147,176],"has":[150],"not":[151],"yet":[152],"been":[153],"established,":[154],"assessment":[156],"trajectories":[159],"may":[160],"facilitate":[161],"stratification.":[163],"Whether":[164],"changes":[165],"can":[168],"likely":[171],"benefit":[173],"from":[174,197],"or":[177],"determine":[178],"optimal":[180],"timing":[181],"treatment":[183],"remains":[184],"important":[186],"hypothesis":[187],"requires":[189],"prospective":[190],"validation.":[191],"This":[192],"perspective":[193],"discusses":[194],"evolution":[196],"original":[199],"SIC":[200],"criteria":[201],"considers":[205],"future":[207],"role":[208],"monitoring":[211],"DIC.":[214]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-31T00:00:00"}
