{"id":"https://openalex.org/W7224816025","doi":"https://doi.org/10.1039/d6ra06275j","title":"A GRPR-targeted near-infrared fluorescent probe for precise tumor imaging and intraoperative surgical navigation","display_name":"A GRPR-targeted near-infrared fluorescent probe for precise tumor imaging and intraoperative surgical navigation","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7224816025","doi":"https://doi.org/10.1039/d6ra06275j","pmid":"https://pubmed.ncbi.nlm.nih.gov/42965098","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13721913"},"language":"en","primary_location":{"id":"doi:10.1039/d6ra06275j","doi":"https://doi.org/10.1039/d6ra06275j","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra06275j","pdf_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra06275j/14981391/d6ra06275j.pdf","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra06275j/14981391/d6ra06275j.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130572778","display_name":"Huihui Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huihui Lu","raw_affiliation_strings":["School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China","The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an, Shaanxi, 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an, Shaanxi, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088040451","display_name":"Caiting Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caiting Deng","raw_affiliation_strings":["Institute of Medical Engineering, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China","School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Engineering, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130622467","display_name":"Jiayao Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayao Zhao","raw_affiliation_strings":["School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160155523","display_name":"Jingjing Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Zhang","raw_affiliation_strings":["School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160159405","display_name":"Anping Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anping Cao","raw_affiliation_strings":["School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075414128","display_name":"Feifei An","orcid":"https://orcid.org/0000-0001-7961-1709","observed_orcids":["https://orcid.org/0000-0001-7961-1709"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feifei An","raw_affiliation_strings":["School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China","State Key Laboratory of Molecular Engineering of Polymers (Fudan University), Shanghai, 200438, China"],"raw_orcid":"https://orcid.org/0000-0001-7961-1709","affiliations":[{"raw_affiliation_string":"School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Engineering of Polymers (Fudan University), Shanghai, 200438, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153484670","display_name":"Nandi Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152380","display_name":"Shenzhen Technology University","ror":"https://ror.org/04qzpec27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210152380"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Nandi Chen","raw_affiliation_strings":["Analysis and Testing Center, Shenzhen Technology University, Shenzhen, Guangdong, 518118, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analysis and Testing Center, Shenzhen Technology University, Shenzhen, Guangdong, 518118, China","institution_ids":["https://openalex.org/I4210152380"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103001766","display_name":"Yichao Chai","orcid":"https://orcid.org/0000-0002-0894-1062","observed_orcids":["https://orcid.org/0000-0002-0894-1062"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yichao Chai","raw_affiliation_strings":["The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an, Shaanxi, 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an, Shaanxi, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075414128","https://openalex.org/A5103001766","https://openalex.org/A5153484670"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210131893","https://openalex.org/I4210152380","https://openalex.org/I87445476"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71239422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.19850000739097595,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.16519999504089355,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastrin-releasing-peptide-receptor","display_name":"gastrin-releasing peptide receptor","score":0.8939999938011169},{"id":"https://openalex.org/keywords/near-infrared-fluorescent-probe","display_name":"near-infrared fluorescent probe","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.8320000171661377},{"id":"https://openalex.org/keywords/fluorescence-guided-surgery","display_name":"fluorescence-guided surgery","score":0.9850000143051147},{"id":"https://openalex.org/keywords/peptide-conjugation","display_name":"peptide conjugation","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6301000118255615},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.512499988079071},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.48510000109672546},{"id":"https://openalex.org/C2986637895","wikidata":"https://www.wikidata.org/wiki/Q953865","display_name":"Breast tumor","level":4,"score":0.4848000109195709},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.41350001096725464},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3928999900817871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3871999979019165},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.36419999599456787},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.32339999079704285},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.31529998779296875},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30720001459121704},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.28850001096725464},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C3017476499","wikidata":"https://www.wikidata.org/wiki/Q182925","display_name":"Fluorescent light","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.2648000121116638}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d6ra06275j","doi":"https://doi.org/10.1039/d6ra06275j","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra06275j","pdf_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra06275j/14981391/d6ra06275j.pdf","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13721913","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13721913/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13721913/pdf/RA-OLF-D6RA06275J.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmid:42965098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42965098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d6ra06275j","doi":"https://doi.org/10.1039/d6ra06275j","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra06275j","pdf_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra06275j/14981391/d6ra06275j.pdf","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1545819062","display_name":null,"funder_award_id":"2023-YBSF-270","funder_id":"https://openalex.org/F4320324173","funder_display_name":"Natural Science Foundation of Shaanxi Province"}],"funders":[{"id":"https://openalex.org/F4320319297","display_name":"Shenzhen Technology University","ror":"https://ror.org/04qzpec27"},{"id":"https://openalex.org/F4320324173","display_name":"Natural Science Foundation of Shaanxi Province","ror":null},{"id":"https://openalex.org/F4320328010","display_name":"Yakult Bio-Science Foundation","ror":"https://ror.org/051635438"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224816025.pdf","grobid_xml":"https://content.openalex.org/works/W7224816025.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W2199263403","https://openalex.org/W2412269568","https://openalex.org/W2508296036","https://openalex.org/W2887123655","https://openalex.org/W2956419372","https://openalex.org/W2969703787","https://openalex.org/W3080818483","https://openalex.org/W3125343722","https://openalex.org/W3174294541","https://openalex.org/W3210425536","https://openalex.org/W3214000599","https://openalex.org/W4205660011","https://openalex.org/W4283067182","https://openalex.org/W4295911509","https://openalex.org/W4296625127","https://openalex.org/W4318765086","https://openalex.org/W4319759410","https://openalex.org/W4319763451","https://openalex.org/W4377093627","https://openalex.org/W4377287007","https://openalex.org/W4382448901","https://openalex.org/W4385232636","https://openalex.org/W4392376294","https://openalex.org/W4396904912","https://openalex.org/W4400581611","https://openalex.org/W4407597501","https://openalex.org/W4408568277","https://openalex.org/W4409429994","https://openalex.org/W4410192700","https://openalex.org/W4410544931","https://openalex.org/W4410832237","https://openalex.org/W4412912735","https://openalex.org/W4415834997","https://openalex.org/W7143278064","https://openalex.org/W7146997464","https://openalex.org/W7162305643"],"related_works":["https://openalex.org/W7165658758","https://openalex.org/W2982947708","https://openalex.org/W4402829559","https://openalex.org/W4382448901","https://openalex.org/W2941475938","https://openalex.org/W4396801019","https://openalex.org/W7204210169","https://openalex.org/W4285305719","https://openalex.org/W4407562923","https://openalex.org/W3016299207"],"abstract_inverted_index":{"=":[0],"3).":[1],"Histological":[2],"and":[3,18,38],"fluorescence":[4,16],"microscopic":[5],"analyses":[6],"of":[7,27],"the":[8,13,25],"excised":[9],"tissues":[10],"further":[11],"supported":[12],"correspondence":[14],"between":[15],"signals":[17],"tumor-containing":[19],"specimens.":[20],"Overall,":[21],"these":[22],"findings":[23],"support":[24],"feasibility":[26],"IR783-BBN":[28],"as":[29],"a":[30],"BBN-conjugated":[31],"NIR":[32],"fluorescent":[33],"probe":[34],"for":[35],"tumor":[36],"imaging":[37],"fluorescence-guided":[39],"surgical":[40],"navigation.":[41]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-31T00:00:00"}