{"id":"https://openalex.org/W7224815583","doi":"https://doi.org/10.20944/preprints202610.3024.v1","title":"Amygdalin and Cyanogenic Stress: Linking Plant Defense, Redox Signaling, and Xenochemical Toxicity","display_name":"Amygdalin and Cyanogenic Stress: Linking Plant Defense, Redox Signaling, and Xenochemical Toxicity","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224815583","doi":"https://doi.org/10.20944/preprints202610.3024.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202610.3024.v1","doi":"https://doi.org/10.20944/preprints202610.3024.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.3024.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202610.3024.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073774850","display_name":"Andrzej G\u00fcnther","orcid":"https://orcid.org/0000-0002-4492-6329","observed_orcids":["https://orcid.org/0000-0002-4492-6329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrzej G\u00fcnther","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087539124","display_name":"Rafa\u0142 Rakoczy","orcid":"https://orcid.org/0000-0002-5770-926X","observed_orcids":["https://orcid.org/0000-0002-5770-926X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafal Rakoczy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12305","display_name":"Cassava research and cyanide","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12305","display_name":"Cassava research and cyanide","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amygdalin","display_name":"amygdalin","score":1.0},{"id":"https://openalex.org/keywords/cyanogenic-glycosides","display_name":"cyanogenic glycosides","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cyanide","display_name":"cyanide","score":0.550000011920929},{"id":"https://openalex.org/keywords/mandelonitrile","display_name":"mandelonitrile","score":0.7879999876022339},{"id":"https://openalex.org/keywords/prunasin","display_name":"prunasin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/beta-glucosidase","display_name":"\u03b2-glucosidase","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cyanide-detoxification","display_name":"cyanide detoxification","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hydrogen-cyanide","display_name":"hydrogen cyanide","score":0.6460000276565552},{"id":"https://openalex.org/keywords/plant-defense","display_name":"plant defense","score":0.6949999928474426},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.8080000281333923},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8880000114440918},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/oral-exposure","display_name":"oral exposure","score":0.4869999885559082},{"id":"https://openalex.org/keywords/biotransformation","display_name":"biotransformation","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2781274105","wikidata":"https://www.wikidata.org/wiki/Q410215","display_name":"Amygdalin","level":3,"score":0.9904999732971191},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.8069999814033508},{"id":"https://openalex.org/C2781046861","wikidata":"https://www.wikidata.org/wiki/Q26075","display_name":"Hydrogen cyanide","level":2,"score":0.7329999804496765},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.6650000214576721},{"id":"https://openalex.org/C2778455166","wikidata":"https://www.wikidata.org/wiki/Q55076544","display_name":"Cyanide","level":2,"score":0.6628000140190125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6119999885559082},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5932999849319458},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.5406000018119812},{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.5241000056266785},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.49970000982284546},{"id":"https://openalex.org/C2781174152","wikidata":"https://www.wikidata.org/wiki/Q65772506","display_name":"Sinigrin","level":4,"score":0.48100000619888306},{"id":"https://openalex.org/C113850282","wikidata":"https://www.wikidata.org/wiki/Q416212","display_name":"Myrosinase","level":4,"score":0.4381999969482422},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.414900004863739},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4059999883174896},{"id":"https://openalex.org/C2779692420","wikidata":"https://www.wikidata.org/wiki/Q372524","display_name":"Benzaldehyde","level":3,"score":0.3955000042915344},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.36000001430511475},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3416000008583069},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3345000147819519},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28619998693466187},{"id":"https://openalex.org/C156203801","wikidata":"https://www.wikidata.org/wiki/Q1056194","display_name":"Plant cell","level":3,"score":0.26759999990463257},{"id":"https://openalex.org/C2779033446","wikidata":"https://www.wikidata.org/wiki/Q423139","display_name":"Rhodanese","level":3,"score":0.25870001316070557},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.25459998846054077}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202610.3024.v1","doi":"https://doi.org/10.20944/preprints202610.3024.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.3024.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202610.3024.v1","doi":"https://doi.org/10.20944/preprints202610.3024.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.3024.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2794628558","https://openalex.org/W1969802849","https://openalex.org/W2908365797","https://openalex.org/W97851747","https://openalex.org/W2801538837","https://openalex.org/W2090791864","https://openalex.org/W2041279505","https://openalex.org/W3110910307","https://openalex.org/W4304196341","https://openalex.org/W1564421441"],"abstract_inverted_index":{"Amygdalin":[0,43],"is":[1],"a":[2],"cyanogenic":[3,31,141],"diglycoside":[4],"whose":[5],"hydrolysis":[6,44],"links":[7],"plant":[8,29,95],"defense":[9],"with":[10,153,168],"cyanide":[11,54,73],"exposure":[12,83,100],"in":[13,94],"animals":[14],"and":[15,23,47,52,60,68,87,104,110,160,171,174],"humans.":[16],"This":[17],"review":[18],"examines":[19],"its":[20,154,161],"activation,":[21,65],"metabolism":[22],"associated":[24,152],"stress":[25,96],"responses.":[26],"In":[27],"intact":[28],"tissues,":[30],"glycosides":[32],"are":[33],"separated":[34],"from":[35,129,150],"hydrolytic":[36],"enzymes;":[37],"tissue":[38],"disruption":[39],"permits":[40],"substrate-enzyme":[41],"contact.":[42],"produces":[45],"prunasin":[46],"mandelonitrile,":[48],"followed":[49],"by":[50],"benzaldehyde":[51],"hydrogen":[53],"(HCN).":[55],"After":[56],"oral":[57,130],"exposure,":[58],"host":[59,67],"microbial":[61,70],"\u03b2-glucosidases":[62],"contribute":[63],"to":[64,107,143,146],"while":[66],"potentially":[69],"detoxification":[71,85],"modify":[72],"exposure.":[74],"The":[75],"biological":[76],"response":[77],"depends":[78],"on":[79],"dose,":[80],"release":[81],"rate,":[82],"route,":[84],"capacity":[86],"mitochondrial":[88,102,170],"susceptibility.":[89],"Localized":[90],"HCN":[91],"production":[92],"participates":[93],"signaling,":[97],"whereas":[98],"excessive":[99],"inhibits":[101],"respiration":[103],"may":[105],"lead":[106],"secondary":[108],"oxidative":[109],"inflammatory":[111],"injury.":[112],"Mammalian":[113],"cell":[114],"studies":[115],"have":[116],"reported":[117],"low-level":[118],"regulatory":[119],"effects,":[120],"but":[121],"these":[122],"findings":[123],"do":[124],"not":[125],"establish":[126],"therapeutic":[127],"benefit":[128],"amygdalin.":[131],"Reports":[132],"of":[133,140,158,163],"antioxidant":[134],"or":[135],"anti-inflammatory":[136],"activity":[137],"require":[138],"measurements":[139,157],"activation":[142],"distinguish":[144],"responses":[145],"the":[147],"parent":[148],"glycoside":[149],"those":[151],"degradation.":[155],"Time-resolved":[156],"amygdalin":[159],"products":[162],"biotransformation":[164],"should":[165],"be":[166],"paired":[167],"microbial,":[169],"redox":[172],"endpoints":[173],"appropriate":[175],"experimental":[176],"controls.":[177]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}