{"id":"https://openalex.org/W7224811449","doi":"https://doi.org/10.1371/journal.pone.0361575","title":"Frequencies of thyroid-related diagnoses and dyslipidemia among Japanese women with menstrual-related disorders aged under 40 years: A nationwide cross-sectional study using health insurance claims data","display_name":"Frequencies of thyroid-related diagnoses and dyslipidemia among Japanese women with menstrual-related disorders aged under 40 years: A nationwide cross-sectional study using health insurance claims data","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224811449","doi":"https://doi.org/10.1371/journal.pone.0361575","pmid":"https://pubmed.ncbi.nlm.nih.gov/42961921","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722161"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0361575","doi":"https://doi.org/10.1371/journal.pone.0361575","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361575","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361575&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361575&type=printable","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064550087","display_name":"Tatsuya Yoshihara","orcid":"https://orcid.org/0009-0001-2301-5075","observed_orcids":["https://orcid.org/0009-0001-2301-5075"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tatsuya Yoshihara","raw_affiliation_strings":["University of Yamanashi"],"raw_orcid":"https://orcid.org/0009-0001-2301-5075","affiliations":[{"raw_affiliation_string":"University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101994397","display_name":"Yosuke Ono","orcid":"https://orcid.org/0000-0001-5540-9434","observed_orcids":["https://orcid.org/0000-0001-5540-9434"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Ono","raw_affiliation_strings":["University of Yamanashi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113036210","display_name":"Harumasa Arita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123942","display_name":"Rohto Pharmaceutical (Japan)","ror":"https://ror.org/02y8ft411","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210123942"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Harumasa Arita","raw_affiliation_strings":["Rohto Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rohto Pharmaceutical Co., Ltd","institution_ids":["https://openalex.org/I4210123942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123664231","display_name":"Akiko Nakagomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Nakagomi","raw_affiliation_strings":["University of Yamanashi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106657000","display_name":"Dai Miyashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Dai Miyashita","raw_affiliation_strings":["University of Yamanashi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138700491","display_name":"Kota Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kota Tanaka","raw_affiliation_strings":["University of Yamanashi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116442182","display_name":"Satoko Sasatsu","orcid":"https://orcid.org/0009-0003-5096-0130","observed_orcids":["https://orcid.org/0009-0003-5096-0130"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoko Sasatsu","raw_affiliation_strings":["University of Yamanashi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035221784","display_name":"Osamu Yoshino","orcid":"https://orcid.org/0000-0001-6942-3018","observed_orcids":["https://orcid.org/0000-0001-6942-3018"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Yoshino","raw_affiliation_strings":["University of Yamanashi"],"raw_orcid":"https://orcid.org/0000-0001-6942-3018","affiliations":[{"raw_affiliation_string":"University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064550087"],"corresponding_institution_ids":["https://openalex.org/I66906201"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88593318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"10","first_page":"e0361575","last_page":"e0361575"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12054","display_name":"Menstrual Health and Disorders","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometriosis","display_name":"endometriosis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dysmenorrhea","display_name":"dysmenorrhea","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.878000020980835},{"id":"https://openalex.org/keywords/thyroid-disease","display_name":"thyroid dysfunction","score":0.8820000290870667},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6539999842643738},{"id":"https://openalex.org/keywords/dienogest","display_name":"dienogest","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hormonal-contraception","display_name":"hormonal contraception","score":0.47099998593330383},{"id":"https://openalex.org/keywords/japanese-women","display_name":"Japanese women","score":0.5059999823570251},{"id":"https://openalex.org/keywords/young-women","display_name":"young women","score":0.6150000095367432},{"id":"https://openalex.org/keywords/health-insurance-claims-data","display_name":"health insurance claims data","score":0.8069999814033508},{"id":"https://openalex.org/keywords/thyroiditis","display_name":"thyroiditis","score":0.3569999933242798},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nontoxic-goiter","display_name":"nontoxic goiter","score":0.8920000195503235},{"id":"https://openalex.org/keywords/metabolic-comorbidities","display_name":"metabolic comorbidities","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9223999977111816},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.6179999709129333},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.5422000288963318},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.4478999972343445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44200000166893005},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43880000710487366},{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.41679999232292175},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4023999869823456},{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.4004000127315521},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.3686999976634979},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3357999920845032},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.3181999921798706},{"id":"https://openalex.org/C2776254400","wikidata":"https://www.wikidata.org/wiki/Q165135","display_name":"Goiter","level":3,"score":0.3001999855041504},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.29589998722076416},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2906000018119812},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.28119999170303345},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.27730000019073486},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2757999897003174},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C2780176905","wikidata":"https://www.wikidata.org/wiki/Q6673122","display_name":"Thyroid disease","level":3,"score":0.2556999921798706},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.2529999911785126}],"mesh":[{"descriptor_ui":"D000095225","descriptor_name":"East Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004412","descriptor_name":"Dysmenorrhea","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007348","descriptor_name":"Insurance, Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008599","descriptor_name":"Menstruation Disturbances","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008599","descriptor_name":"Menstruation Disturbances","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D013959","descriptor_name":"Thyroid Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013959","descriptor_name":"Thyroid Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1371/journal.pone.0361575","doi":"https://doi.org/10.1371/journal.pone.0361575","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361575","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361575&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},{"id":"pmid:42961921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42961921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0361575","doi":"https://doi.org/10.1371/journal.pone.0361575","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361575","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361575&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224811449.pdf","grobid_xml":"https://content.openalex.org/works/W7224811449.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1966098682","https://openalex.org/W2012650501","https://openalex.org/W2041084308","https://openalex.org/W2078800104","https://openalex.org/W2118002087","https://openalex.org/W2127749649","https://openalex.org/W2151934245","https://openalex.org/W2581986521","https://openalex.org/W2754055756","https://openalex.org/W2949709696","https://openalex.org/W2951370690","https://openalex.org/W2954816350","https://openalex.org/W2980006395","https://openalex.org/W2991680466","https://openalex.org/W3003144693","https://openalex.org/W3085013744","https://openalex.org/W3087071746","https://openalex.org/W3134885188","https://openalex.org/W3165294846","https://openalex.org/W4220697912","https://openalex.org/W4220835311","https://openalex.org/W4229052466","https://openalex.org/W4234160457","https://openalex.org/W4283451643","https://openalex.org/W4290779939","https://openalex.org/W4379798330","https://openalex.org/W4387904762","https://openalex.org/W4389553825","https://openalex.org/W4391536419","https://openalex.org/W4392885417","https://openalex.org/W4399202410","https://openalex.org/W4400330691","https://openalex.org/W4405621165","https://openalex.org/W4406588815","https://openalex.org/W4406605720","https://openalex.org/W4413049769","https://openalex.org/W7120128865"],"related_works":["https://openalex.org/W2065072281","https://openalex.org/W7120128865","https://openalex.org/W4389553825","https://openalex.org/W2127749649","https://openalex.org/W4306412167","https://openalex.org/W7160272741","https://openalex.org/W4220905539","https://openalex.org/W2617826945","https://openalex.org/W2032343447","https://openalex.org/W4387391075"],"abstract_inverted_index":{"Women":[0,54],"with":[1,55,138,151,187,242,258,276,292],"endometriosis":[2,59,175,205],"and":[3,20,106,111,286,298],"dysmenorrhea":[4,63],"are":[5],"increasingly":[6],"recognized":[7],"as":[8,69],"having":[9],"systemic":[10],"comorbidities":[11,22],"beyond":[12],"pelvic":[13],"disease,":[14],"but":[15],"large-scale":[16],"data":[17],"on":[18],"endocrine":[19],"metabolic":[21],"across":[23,228],"a":[24,41],"broad":[25],"menstrual-related":[26,71,139,152,188,243,277],"disorders":[27,72,109,140,153,189,278],"population":[28],"remain":[29],"limited.":[30],"Using":[31],"the":[32,70,82,92,165,174,209,222,307],"Japan":[33],"Medical":[34],"Data":[35],"Center":[36],"Claims":[37],"Database,":[38],"we":[39],"conducted":[40],"nationwide":[42],"cross-sectional":[43,308],"study":[44],"of":[45,58,94,149,156,185,192,283,306],"women":[46,137,150,186,241,275],"aged":[47],"under":[48],"40":[49],"years":[50],"enrolled":[51],"in":[52,147,173,183,249,256],"2023.":[53],"confirmed":[56],"diagnoses":[57,80,96,131,285],"(ICD-10:":[60],"N80)":[61],"and/or":[62],"(N94.4":[64],"or":[65,126],"N94.6)":[66],"were":[67,81,91,116,132,234,264],"classified":[68],"group":[73,84],"(n":[74,85,177],"=":[75,86,178],"257,897);":[76],"those":[77,250,257,291],"without":[78,251],"such":[79],"control":[83],"3,183,032).":[87],"The":[88,204],"primary":[89],"outcomes":[90],"frequencies":[93,263,282],"thyroid-related":[95,130,284],"(hypothyroidism":[97],"[E03],":[98],"non-toxic":[99],"goiter":[100],"[E04],":[101],"hyperthyroidism":[102],"[E05],":[103],"thyroiditis":[104],"[E06],":[105],"other":[107],"thyroid":[108],"[E07])":[110],"dyslipidemia":[112,262,287],"(E78).":[113],"Stratified":[114],"analyses":[115],"performed":[117],"according":[118],"to":[119],"prescription":[120],"for":[121,219],"low-dose":[122],"estrogen-progestin":[123],"preparations":[124],"(LEP)":[125],"dienogest":[127],"(DNG).":[128],"All":[129],"recorded":[133,182],"more":[134,247],"frequently":[135],"among":[136,142],"than":[141,237,255,288],"controls.":[143],"Hypothyroidism":[144],"was":[145,168,181,246],"identified":[146],"2.1%":[148],"versus":[154,190],"0.8%":[155],"controls":[157,193],"(prevalence":[158],"ratio":[159],"[PR]":[160],"2.46;":[161],"95%":[162,196],"CI":[163,171,197],"2.39-2.54);":[164],"corresponding":[166],"PR":[167,226],"3.11":[169],"(95%":[170],"2.99-3.24)":[172],"subgroup":[176,206],"96,863).":[179],"Dyslipidemia":[180],"5.2%":[184],"1.4%":[191],"(PR":[194],"3.73;":[195],"3.66-3.80;":[198],"prevalence":[199],"difference":[200],"+3.78":[201],"percentage":[202],"points).":[203],"consistently":[207,235],"showed":[208],"highest":[210],"frequencies.":[211],"These":[212,269],"associations":[213],"remained":[214],"statistically":[215],"significant":[216],"after":[217],"adjustment":[218],"age":[220,296],"using":[221],"Mantel-Haenszel":[223],"method":[224],"(adjusted":[225],"1.45-3.02":[227],"all":[229],"comparisons),":[230],"although":[231],"adjusted":[232],"estimates":[233],"lower":[236],"crude":[238],"estimates.":[239],"Among":[240],"disorders,":[244],"hypothyroidism":[245],"frequent":[248],"LEP/DNG":[252],"prescriptions":[253,259],"(3.4%)":[254],"(1.5%),":[260],"whereas":[261],"similar":[265],"(5.2%":[266],"vs.":[267],"5.1%).":[268],"findings":[270],"indicate":[271],"that":[272],"young":[273],"Japanese":[274],"have":[279],"substantially":[280],"higher":[281],"controls,":[289],"particularly":[290],"endometriosis.":[293],"Surveillance":[294],"bias,":[295],"confounding,":[297],"confounding":[299],"by":[300],"indication":[301],"cannot":[302],"be":[303],"excluded":[304],"because":[305],"claims-based":[309],"design.":[310]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-31T00:00:00"}