{"id":"https://openalex.org/W7224810690","doi":"https://doi.org/10.35451/jfm.v9i1.3921","title":"Analgesic Activity of Moringa Leaf Ethanol Extract Nanogel in White Rats Using the Hot Plate Method","display_name":"Analgesic Activity of Moringa Leaf Ethanol Extract Nanogel in White Rats Using the Hot Plate Method","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224810690","doi":"https://doi.org/10.35451/jfm.v9i1.3921"},"language":"en","primary_location":{"id":"doi:10.35451/jfm.v9i1.3921","doi":"https://doi.org/10.35451/jfm.v9i1.3921","is_oa":true,"landing_page_url":"https://doi.org/10.35451/jfm.v9i1.3921","pdf_url":"https://ejournal.medistra.ac.id/index.php/JFM/article/download/3921/2180","source":{"id":"https://openalex.org/S4210213644","display_name":"JURNAL FARMASIMED (JFM)","issn_l":"2655-0814","issn":["2655-0814"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210164821","host_organization_name":"Institut Kesehatan Medistra Lubuk Pakam","host_organization_lineage":["https://openalex.org/I4210164821"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JURNAL FARMASIMED (JFM)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ejournal.medistra.ac.id/index.php/JFM/article/download/3921/2180","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158832865","display_name":"Miswati Furqani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263229","display_name":"Universitas Tjut Nyak Dhien","ror":"https://ror.org/045p92n89","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405263229"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Miswati Furqani","raw_affiliation_strings":["Universitas Tjut Nyak Dhien"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Tjut Nyak Dhien","institution_ids":["https://openalex.org/I4405263229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088662481","display_name":"Muflihah Fujiko","orcid":"https://orcid.org/0009-0000-5196-1045","observed_orcids":["https://orcid.org/0009-0000-5196-1045"]},"institutions":[{"id":"https://openalex.org/I4405263229","display_name":"Universitas Tjut Nyak Dhien","ror":"https://ror.org/045p92n89","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405263229"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muflihah Fujiko","raw_affiliation_strings":["Universitas Tjut Nyak Dhien"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Tjut Nyak Dhien","institution_ids":["https://openalex.org/I4405263229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051886686","display_name":"Siti Muliani Julianty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263229","display_name":"Universitas Tjut Nyak Dhien","ror":"https://ror.org/045p92n89","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405263229"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Siti Muliani Julianty","raw_affiliation_strings":["Universitas Tjut Nyak Dhien"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Tjut Nyak Dhien","institution_ids":["https://openalex.org/I4405263229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405263229"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"602","last_page":"608"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12721","display_name":"Moringa oleifera research and applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12721","display_name":"Moringa oleifera research and applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moringa-oleifera","display_name":"Moringa oleifera","score":0.9929999709129333},{"id":"https://openalex.org/keywords/analgesic-activity","display_name":"analgesic activity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/ethanolic-leaf-extract","display_name":"ethanolic leaf extract","score":0.7710000276565552},{"id":"https://openalex.org/keywords/nanogels","display_name":"nanogels","score":0.8539999723434448},{"id":"https://openalex.org/keywords/topical-pain-relief","display_name":"topical pain relief","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hot-plate-test","display_name":"hot plate test","score":0.6520000100135803},{"id":"https://openalex.org/keywords/paw-licking","display_name":"paw licking","score":0.8009999990463257},{"id":"https://openalex.org/keywords/natural-analgesics","display_name":"natural analgesics","score":0.5730000138282776},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2776836740","wikidata":"https://www.wikidata.org/wiki/Q310468","display_name":"Moringa","level":2,"score":0.9240000247955322},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.8852999806404114},{"id":"https://openalex.org/C134424308","wikidata":"https://www.wikidata.org/wiki/Q4119000","display_name":"Nanogel","level":3,"score":0.8734999895095825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5842999815940857},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5302000045776367},{"id":"https://openalex.org/C2993566434","wikidata":"https://www.wikidata.org/wiki/Q509869","display_name":"Hot plate","level":2,"score":0.5059000253677368},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4108999967575073},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.39340001344680786},{"id":"https://openalex.org/C197711040","wikidata":"https://www.wikidata.org/wiki/Q5910791","display_name":"Hot plate test","level":4,"score":0.329800009727478},{"id":"https://openalex.org/C2779252780","wikidata":"https://www.wikidata.org/wiki/Q582687","display_name":"Antipyretic","level":3,"score":0.3176000118255615},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.2994000017642975},{"id":"https://openalex.org/C2991691389","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Active compound","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.29330000281333923},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2892000079154968},{"id":"https://openalex.org/C52396799","wikidata":"https://www.wikidata.org/wiki/Q7676069","display_name":"Tail flick test","level":4,"score":0.26989999413490295},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2565999925136566},{"id":"https://openalex.org/C2909432430","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic agents","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.35451/jfm.v9i1.3921","doi":"https://doi.org/10.35451/jfm.v9i1.3921","is_oa":true,"landing_page_url":"https://doi.org/10.35451/jfm.v9i1.3921","pdf_url":"https://ejournal.medistra.ac.id/index.php/JFM/article/download/3921/2180","source":{"id":"https://openalex.org/S4210213644","display_name":"JURNAL FARMASIMED (JFM)","issn_l":"2655-0814","issn":["2655-0814"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210164821","host_organization_name":"Institut Kesehatan Medistra Lubuk Pakam","host_organization_lineage":["https://openalex.org/I4210164821"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JURNAL FARMASIMED (JFM)","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.35451/jfm.v9i1.3921","doi":"https://doi.org/10.35451/jfm.v9i1.3921","is_oa":true,"landing_page_url":"https://doi.org/10.35451/jfm.v9i1.3921","pdf_url":"https://ejournal.medistra.ac.id/index.php/JFM/article/download/3921/2180","source":{"id":"https://openalex.org/S4210213644","display_name":"JURNAL FARMASIMED (JFM)","issn_l":"2655-0814","issn":["2655-0814"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210164821","host_organization_name":"Institut Kesehatan Medistra Lubuk Pakam","host_organization_lineage":["https://openalex.org/I4210164821"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JURNAL FARMASIMED (JFM)","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224810690.pdf","grobid_xml":"https://content.openalex.org/works/W7224810690.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2980686739","https://openalex.org/W3078337028","https://openalex.org/W4299786179","https://openalex.org/W4319983239","https://openalex.org/W4386896835","https://openalex.org/W4389994227","https://openalex.org/W4390671544"],"related_works":["https://openalex.org/W2319249118","https://openalex.org/W4399463985","https://openalex.org/W1982147595","https://openalex.org/W7197035326","https://openalex.org/W4388595549","https://openalex.org/W6949208164","https://openalex.org/W7217673733","https://openalex.org/W4396747670","https://openalex.org/W7160731228","https://openalex.org/W3158474330"],"abstract_inverted_index":{"Pain":[0,108],"is":[1],"a":[2,60,209],"common":[3],"complaint,":[4],"as":[5,208],"it":[6],"hinders":[7],"daily":[8],"activities":[9],"and":[10,40,84,88,120,124,158,162,202],"reduces":[11],"overall":[12],"well-being.":[13],"While":[14],"synthetic":[15],"analgesics":[16],"are":[17],"effective":[18],"at":[19],"relieving":[20],"pain,":[21],"long-term":[22],"use":[23],"carries":[24],"the":[25,44,56,64,75,114,125,130,135,175,180,186,193],"risk":[26],"of":[27,59,67,116],"digestive":[28],"system":[29],"disorders.":[30],"Moringa":[31,68,194],"leaves":[32,69],"(Moringa":[33],"oleifera":[34],"Lam.)":[35],"contain":[36],"flavonoids,":[37],"tannins,":[38],"glycosides,":[39],"triterpenoids,":[41],"which":[42],"have":[43],"potential":[45,204],"to":[46,54,156],"produce":[47],"natural":[48,210],"analgesic":[49,57,94,183,200],"effects.":[50],"This":[51,189],"study":[52,190],"aimed":[53],"evaluate":[55],"activity":[58,201],"nanogel":[61,79,144,198],"formulated":[62],"from":[63,154],"ethanolic":[65,196],"extract":[66,197],"in":[70,98],"male":[71,100],"white":[72,101],"rats":[73,102],"using":[74,129],"hot-plate":[76],"method.":[77],"Four":[78],"concentrations":[80],"(0%,":[81],"2.5%,":[82],"5%,":[83],"7.5%)":[85],"were":[86,96,127],"prepared":[87],"tested":[89,187],"for":[90,205],"physical":[91,147],"quality;":[92],"their":[93],"effects":[95],"observed":[97],"30":[99],"divided":[103],"into":[104],"six":[105],"treatment":[106],"groups.":[107],"response":[109],"was":[110],"recorded":[111],"by":[112,134],"measuring":[113],"frequency":[115],"paw-licking":[117],"between":[118,160,171],"5":[119],"120":[121],"minutes":[122],"post-administration,":[123],"data":[126],"analyzed":[128],"Kruskal-Wallis":[131,166],"test":[132,167],"followed":[133],"Mann-Whitney":[136],"test.":[137],"The":[138,165],"results":[139],"showed":[140],"that":[141,192],"all":[142],"four":[143],"formulas":[145],"met":[146],"quality":[148],"standards,":[149],"with":[150,174],"pH":[151],"values":[152],"\u200b\u200branging":[153],"4.93":[155],"5.45":[157],"viscosities":[159],"5,480":[161],"9,990":[163],"mPa.s.":[164],"revealed":[168],"significant":[169],"differences":[170],"groups":[172],"(p=0.016),":[173],"7.5%":[176],"concentration":[177],"formula":[178],"demonstrating":[179],"most":[181],"superior":[182],"effect":[184],"among":[185],"nanogels.":[188],"demonstrates":[191],"leaf":[195],"possesses":[199],"holds":[203],"further":[206],"development":[207],"topical":[211],"pain-relief":[212],"product.":[213]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}