{"id":"https://openalex.org/W7224808307","doi":"https://doi.org/10.1002/advs.78291","title":"HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer","display_name":"HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224808307","doi":"https://doi.org/10.1002/advs.78291","pmid":"https://pubmed.ncbi.nlm.nih.gov/42958722","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13720267"},"language":"en","primary_location":{"id":"doi:10.1002/advs.78291","doi":"https://doi.org/10.1002/advs.78291","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78291","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.78291","source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.78291","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020966873","display_name":"Maoxiao Feng","orcid":"https://orcid.org/0000-0002-3612-9792","observed_orcids":["https://orcid.org/0000-0002-3612-9792","https://orcid.org/0009-0004-3134-2836"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Maoxiao Feng","raw_affiliation_strings":["Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"],"raw_orcid":"https://orcid.org/0000-0002-3612-9792","affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038151884","display_name":"Qinlian Jiao","orcid":"https://orcid.org/0009-0000-5546-859X","observed_orcids":["https://orcid.org/0009-0000-5546-859X"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinlian Jiao","raw_affiliation_strings":["Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135824612","display_name":"Jiankang Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiankang Zhu","raw_affiliation_strings":["Department of General Surgery The First Affiliated Hospital of Shandong First Medical University  Jinan Shandong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery The First Affiliated Hospital of Shandong First Medical University  Jinan Shandong China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124970199","display_name":"Yidan Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yidan Ren","raw_affiliation_strings":["Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124930551","display_name":"Xiaoyu Teng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Teng","raw_affiliation_strings":["Department of Clinical Laboratory Shandong Provincial Hospital Shandong University  Jinan Shandong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Shandong Provincial Hospital Shandong University  Jinan Shandong China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101440399","display_name":"Xin Su","orcid":"https://orcid.org/0000-0001-5473-151X","observed_orcids":["https://orcid.org/0000-0001-5473-151X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Su","raw_affiliation_strings":["Department of Clinical Laboratory Cheeloo College of Medicine The Second Hospital of Shandong University Shandong University  Jinan Shandong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Cheeloo College of Medicine The Second Hospital of Shandong University Shandong University  Jinan Shandong China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008202055","display_name":"Zigan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zigan Li","raw_affiliation_strings":["Department of Clinical Laboratory Cheeloo College of Medicine The Second Hospital of Shandong University Shandong University  Jinan Shandong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Cheeloo College of Medicine The Second Hospital of Shandong University Shandong University  Jinan Shandong China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101535505","display_name":"Yuxuan Cai","orcid":"https://orcid.org/0000-0001-9250-6460","observed_orcids":["https://orcid.org/0000-0001-9250-6460","https://orcid.org/0009-0000-2581-2249"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxuan Cai","raw_affiliation_strings":["Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009317527","display_name":"Xiaoyan Liu","orcid":"https://orcid.org/0000-0002-8922-3766","observed_orcids":["https://orcid.org/0000-0002-8922-3766"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Liu","raw_affiliation_strings":["Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111875004","display_name":"Chuanxin Wang","orcid":"https://orcid.org/0000-0001-5234-8752","observed_orcids":["https://orcid.org/0000-0001-5234-8752","https://orcid.org/0009-0008-0754-9078"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunshan Wang","raw_affiliation_strings":["Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"],"raw_orcid":"https://orcid.org/0000-0001-5234-8752","affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027515470","display_name":"Guangyong Zhang","orcid":"https://orcid.org/0000-0001-5308-0129","observed_orcids":["https://orcid.org/0000-0001-5308-0129"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangyong Zhang","raw_affiliation_strings":["Department of General Surgery The First Affiliated Hospital of Shandong First Medical University  Jinan Shandong China"],"raw_orcid":"https://orcid.org/0000-0001-5308-0129","affiliations":[{"raw_affiliation_string":"Department of General Surgery The First Affiliated Hospital of Shandong First Medical University  Jinan Shandong China","institution_ids":["https://openalex.org/I4210163399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020966873","https://openalex.org/A5027515470","https://openalex.org/A5111875004"],"corresponding_institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82692308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.2468000054359436,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.08879999816417694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactylation","display_name":"lactylation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hadha","display_name":"HADHA","score":0.8560000061988831},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.8889999985694885},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.902999997138977},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hmgcr-inhibitors","display_name":"HMGCR inhibitors","score":0.8080000281333923},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.503000020980835},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.875}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6477000117301941},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.635699987411499},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6337000131607056},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.572700023651123},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.539900004863739},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5239999890327454},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.43689998984336853},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.4260999858379364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4205000102519989},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4072999954223633},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4041999876499176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.388700008392334},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.38510000705718994},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.34599998593330383},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.3154999911785126},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.30219998955726624},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2809000015258789},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2621999979019165},{"id":"https://openalex.org/C2910680157","wikidata":"https://www.wikidata.org/wiki/Q18028499","display_name":"Lactate dehydrogenase A","level":4,"score":0.26030001044273376},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2583000063896179}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/advs.78291","doi":"https://doi.org/10.1002/advs.78291","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78291","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.78291","source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13720267","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720267/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720267/pdf/ADVS-9999-e78291.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"},{"id":"pmid:42958722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42958722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/advs.78291","doi":"https://doi.org/10.1002/advs.78291","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78291","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.78291","source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320328999","display_name":"Shandong First Medical University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224808307.pdf","grobid_xml":"https://content.openalex.org/works/W7224808307.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1493846190","https://openalex.org/W1957108698","https://openalex.org/W1969630360","https://openalex.org/W1973789394","https://openalex.org/W2034688612","https://openalex.org/W2047207059","https://openalex.org/W2055671617","https://openalex.org/W2082216460","https://openalex.org/W2101061654","https://openalex.org/W2131124395","https://openalex.org/W2168921982","https://openalex.org/W2309904337","https://openalex.org/W2339808165","https://openalex.org/W2343796589","https://openalex.org/W2519020116","https://openalex.org/W2520747151","https://openalex.org/W2567232760","https://openalex.org/W2606614539","https://openalex.org/W2606914681","https://openalex.org/W2607257154","https://openalex.org/W2770246164","https://openalex.org/W2888074414","https://openalex.org/W2890397692","https://openalex.org/W2896380324","https://openalex.org/W2909486828","https://openalex.org/W2941036215","https://openalex.org/W2949498852","https://openalex.org/W2966019641","https://openalex.org/W3031000287","https://openalex.org/W3033366394","https://openalex.org/W3041063691","https://openalex.org/W3049617439","https://openalex.org/W3070105802","https://openalex.org/W3134008684","https://openalex.org/W3134906771","https://openalex.org/W3160973971","https://openalex.org/W3173318634","https://openalex.org/W3195406213","https://openalex.org/W4210361469","https://openalex.org/W4220769687","https://openalex.org/W4223515782","https://openalex.org/W4224321569","https://openalex.org/W4283749492","https://openalex.org/W4293574586","https://openalex.org/W4294786592","https://openalex.org/W4307502381","https://openalex.org/W4308292556","https://openalex.org/W4308515288","https://openalex.org/W4312038111","https://openalex.org/W4365810337","https://openalex.org/W4375955115","https://openalex.org/W4383876657","https://openalex.org/W4388336785","https://openalex.org/W4398216156"],"related_works":["https://openalex.org/W7163587926","https://openalex.org/W7214108036","https://openalex.org/W7161840781","https://openalex.org/W4415900276","https://openalex.org/W4323045532","https://openalex.org/W4414422247","https://openalex.org/W7167824775","https://openalex.org/W4417144083","https://openalex.org/W4404833645","https://openalex.org/W7162036454"],"abstract_inverted_index":{"ABSTRACT":[0],"Gastric":[1],"cancer":[2],"(GC)":[3],"represents":[4],"a":[5,27,140,178],"substantial":[6],"global":[7],"health":[8],"challenge":[9],"and":[10,16,40,107,153],"is":[11],"among":[12],"the":[13,31,37,66,89,117,128,148],"most":[14],"prevalent":[15],"deadly":[17],"malignancies":[18],"worldwide.":[19],"Emerging":[20],"evidence":[21],"suggests":[22],"that":[23,162],"protein":[24,44],"lactylation":[25,45,64,81,87,113],"plays":[26],"pivotal":[28],"role":[29],"in":[30,46,60,76,125,132],"progression":[32,101,167],"of":[33,43,69],"various":[34],"cancers.":[35],"However,":[36],"specific":[38],"levels":[39,59],"regulatory":[41],"mechanisms":[42],"GC":[47,61,77,84,100,152,166,182],"remain":[48],"poorly":[49],"understood.":[50],"In":[51,157],"this":[52,159],"study,":[53],"we":[54],"detected":[55],"elevated":[56],"pan\u2010lactylation":[57],"modification":[58,82],"tissues.":[62,78],"Notably,":[63],"at":[65,88],"K406":[67,91,112],"site":[68,92],"hydroxyacyl\u2010CoA":[70],"dehydrogenase":[71,142],"(HADHA)":[72],"was":[73],"significantly":[74],"upregulated":[75],"This":[79],"site\u2010specific":[80],"enhanced":[83,147],"progression.":[85,156],"Disrupting":[86],"HADHA":[90,111,163],"markedly":[93],"reduced":[94],"its":[95,169,175],"enzymatic":[96],"activity,":[97],"thereby":[98],"mitigating":[99],"by":[102],"impairing":[103],"fatty":[104],"acid":[105],"\u03b2\u2010oxidation":[106],"glycolysis.":[108],"Furthermore,":[109],"inhibiting":[110],"(HADHA":[114],"K406la)":[115],"suppressed":[116],"HMG\u2010CoA":[118],"reductase":[119],"(HMGCR)\u2010mediated":[120],"cholesterol":[121],"synthesis":[122],"pathway,":[123],"which,":[124],"turn,":[126],"improved":[127],"immunosuppressive":[129],"tumor":[130,155],"microenvironment":[131],"GC.":[133],"Finally,":[134],"combining":[135],"an":[136],"HMGCR":[137],"inhibitor":[138,145],"with":[139],"lactate":[141],"A":[143],"(LDHA)":[144],"effectively":[146],"immune":[149],"response":[150],"against":[151],"inhibited":[154],"conclusion,":[158],"study":[160],"demonstrated":[161],"K406la":[164],"regulates":[165],"through":[168],"impact":[170],"on":[171],"metabolic":[172],"pathways,":[173],"suggesting":[174],"potential":[176],"as":[177],"therapeutic":[179],"target":[180],"for":[181],"treatment.":[183]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-10-31T00:00:00"}