{"id":"https://openalex.org/W7224807479","doi":"https://doi.org/10.21203/rs.3.rs-11190555/v1","title":"Cell-specific Associations Between Ferroptosis-related Genes and the Risk of Subarachnoid Hemorrhage: A Mendelian Randomization Study Based on sc-eQTLs from 14 Immune Cell Types","display_name":"Cell-specific Associations Between Ferroptosis-related Genes and the Risk of Subarachnoid Hemorrhage: A Mendelian Randomization Study Based on sc-eQTLs from 14 Immune Cell Types","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224807479","doi":"https://doi.org/10.21203/rs.3.rs-11190555/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11190555/v1","doi":"https://doi.org/10.21203/rs.3.rs-11190555/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11190555/v1","pdf_url":"https://www.researchsquare.com/article/rs-11190555/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11190555/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136281347","display_name":"Xiaohan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohan Yang","raw_affiliation_strings":["Qingdao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao University","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111254765","display_name":"Dantong Han","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dantong Han","raw_affiliation_strings":["Shandong Medical and Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Medical and Pharmaceutical University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101302799","display_name":"Shaowan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaowan Yang","raw_affiliation_strings":["Yuhuangding Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuhuangding Hospital","institution_ids":["https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061203777","display_name":"Han Meng","orcid":"https://orcid.org/0000-0003-1650-6287","observed_orcids":["https://orcid.org/0000-0003-1650-6287"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Meng","raw_affiliation_strings":["Qingdao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao University","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140020576","display_name":"Xiaodi Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodi Chen","raw_affiliation_strings":["Yuhuangding Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuhuangding Hospital","institution_ids":["https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160178086","display_name":"Xiao Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Xiao","raw_affiliation_strings":["Yuhuangding Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuhuangding Hospital","institution_ids":["https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113406141","display_name":"Jiajia Yun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738115","display_name":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","ror":"https://ror.org/04n3e7v86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4392738115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Yun","raw_affiliation_strings":["The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","institution_ids":["https://openalex.org/I4392738115"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051779733","display_name":"Chao Ren","orcid":"https://orcid.org/0000-0002-5418-3354","observed_orcids":["https://orcid.org/0000-0002-5418-3354","https://orcid.org/0009-0003-7357-3619"]},"institutions":[{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Ren","raw_affiliation_strings":["Yuhuangding Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuhuangding Hospital","institution_ids":["https://openalex.org/I3018397418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.4390000104904175,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.4390000104904175,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.23849999904632568,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.1459999978542328,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subarachnoid-hemorrhage","display_name":"subarachnoid hemorrhage","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/ferroptosis-related-genes","display_name":"ferroptosis-related genes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cofilin-1","display_name":"cofilin-1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.8090000152587891},{"id":"https://openalex.org/keywords/single-cell-eqtl","display_name":"single-cell eQTL","score":0.871999979019165},{"id":"https://openalex.org/keywords/immune-cell-types","display_name":"immune cell types","score":0.7789999842643738},{"id":"https://openalex.org/keywords/genetic-risk","display_name":"genetic risk","score":0.38600000739097595},{"id":"https://openalex.org/keywords/causal-effects","display_name":"causal effects","score":0.3930000066757202},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.714900016784668},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.6851999759674072},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6729000210762024},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5260000228881836},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4993000030517578},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.49709999561309814},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4754999876022339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4722000062465668},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4571000039577484},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.42579999566078186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4163999855518341},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.41600000858306885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3878999948501587},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.3776000142097473},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3750999867916107},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.3610999882221222},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3499999940395355},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.3384999930858612},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.30880001187324524},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.3012000024318695},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.2856000065803528},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.27869999408721924},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2768000066280365},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.26919999718666077},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.2671000063419342},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.25519999861717224},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2531999945640564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11190555/v1","doi":"https://doi.org/10.21203/rs.3.rs-11190555/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11190555/v1","pdf_url":"https://www.researchsquare.com/article/rs-11190555/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11190555/v1","doi":"https://doi.org/10.21203/rs.3.rs-11190555/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11190555/v1","pdf_url":"https://www.researchsquare.com/article/rs-11190555/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5381471319","display_name":null,"funder_award_id":"RZ2300002690","funder_id":"https://openalex.org/F4320326964","funder_display_name":"Qingdao University"}],"funders":[{"id":"https://openalex.org/F4320326964","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224807479.pdf","grobid_xml":"https://content.openalex.org/works/W7224807479.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1905058580","https://openalex.org/W1968289383","https://openalex.org/W1993289560","https://openalex.org/W1997183854","https://openalex.org/W2031869158","https://openalex.org/W2113699335","https://openalex.org/W2149548233","https://openalex.org/W2166082348","https://openalex.org/W2324862792","https://openalex.org/W2499155228","https://openalex.org/W2581245397","https://openalex.org/W2613603864","https://openalex.org/W2770598799","https://openalex.org/W2803072880","https://openalex.org/W3013967177","https://openalex.org/W3042871645","https://openalex.org/W3134959125","https://openalex.org/W3164825503","https://openalex.org/W3183671483","https://openalex.org/W3205716919","https://openalex.org/W4280541700","https://openalex.org/W4292435983","https://openalex.org/W4376875538","https://openalex.org/W4377220857","https://openalex.org/W4387407123","https://openalex.org/W4388210739","https://openalex.org/W4388946406","https://openalex.org/W4391782579","https://openalex.org/W4400980361","https://openalex.org/W4407081607","https://openalex.org/W4412521268","https://openalex.org/W7152593063","https://openalex.org/W7155981113"],"related_works":["https://openalex.org/W7221805833","https://openalex.org/W7219614651","https://openalex.org/W7160693637","https://openalex.org/W4393153031","https://openalex.org/W7213919653","https://openalex.org/W4388646399","https://openalex.org/W4410055909","https://openalex.org/W4376875538","https://openalex.org/W4416862780","https://openalex.org/W4394811887"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,15,31,48,50,81,97,105,120],"Objectives":[3],"Subarachnoid":[4],"hemorrhage":[5],"(SAH)":[6],"involves":[7],"multiple":[8],"intertwined":[9],"pathological":[10],"processes,":[11],"among":[12],"which":[13],"ferroptosis":[14,218],"immune-inflammatory":[16],"responses":[17],"are":[18],"vital.":[19],"However,":[20],"the":[21,43,116,138,143,160],"genetic":[22,239],"causal":[23],"effects":[24],"of":[25,148],"ferroptosis-related":[26,46,66,150],"genes":[27,47,92,151],"on":[28,137],"SAH":[29,49,95,156,169,210,235],"risk":[30,96],"their":[32],"immunocellular":[33,52],"type":[34,53],"specificity":[35],"remain":[36],"unclear.":[37],"This":[38,56,171],"study":[39,57,71],"aimed":[40],"to":[41,90,130],"investigate":[42],"association":[44,70],"between":[45],"its":[51,223],"specificity.":[54],"Methods":[55],"integrated":[58],"expression":[59,108,146,164,177,184,201,225],"quantitative":[60],"trait":[61],"loci":[62],"(eQTL)":[63],"data":[64,72,126],"for":[65,73,241,246],"genes,":[67],"pooled":[68],"genome-wide":[69],"SAH,":[74],"Gene":[75],"Expression":[76],"Omnibus":[77],"(GEO)":[78],"transcriptomic":[79],"data,":[80],"single-cell":[82],"(sc)-eQTL":[83],"data.":[84],"We":[85],"used":[86,114,129],"Mendelian":[87],"randomization(MR)":[88],"analysis":[89,196],"identify":[91],"associated":[93,154,166,207,220,230],"with":[94,155,167,181,208,221,231],"validated":[98],"these":[99],"findings":[100],"using":[101,141],"independent":[102],"eQTL":[103],"datasets":[104],"GEO":[106,182],"differential":[107,183],"analysis.":[109],"The":[110],"inverse-variance-weighted":[111],"method":[112],"was":[113,165,173,187,205],"as":[115,189],"primary":[117],"analytical":[118],"approach,":[119],"sensitivity":[121],"analyses":[122],"assessed":[123],"robustness.":[124],"Sc-eQTL":[125],"were":[127,152],"further":[128],"explore":[131],"immune":[132],"cell-type-specific":[133],"associations.":[134],"Results":[135],"Based":[136],"initial":[139],"screening":[140],"eQTLGen,":[142],"genetically":[144],"predicted":[145],"levels":[147],"48":[149],"significantly":[153,206,233],"risk.":[157,170,211],"Among":[158],"them,":[159],"elevated":[161,224],"CFL1":[162,186,199,213],"gene":[163,200,219],"reduced":[168,209,234],"result":[172],"consistent":[174],"across":[175],"genotype-tissue":[176],"whole-blood":[178],"dataset.":[179],"Combined":[180],"results,":[185],"identified":[188],"a":[190,216,232],"key":[191,217],"candidate":[192],"gene.":[193],"Finally,":[194],"sc-eQTL":[195],"revealed":[197],"that":[198],"in":[202,226],"CD8NC":[203,227],"cells":[204,228],"Conclusion":[212],"may":[214],"be":[215],"SAH;":[222],"is":[229],"risk,":[236],"providing":[237],"new":[238],"evidence":[240],"exploring":[242],"potential":[243],"therapeutic":[244],"targets":[245],"SAH.":[247]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}
