{"id":"https://openalex.org/W7224805874","doi":"https://doi.org/10.1161/jaha.126.050387","title":"Glucagon\u2010Like Peptide\u20101 Receptor Agonists in Obese Heart Failure With Preserved Ejection Fraction","display_name":"Glucagon\u2010Like Peptide\u20101 Receptor Agonists in Obese Heart Failure With Preserved Ejection Fraction","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224805874","doi":"https://doi.org/10.1161/jaha.126.050387","pmid":"https://pubmed.ncbi.nlm.nih.gov/42960821"},"language":"en","primary_location":{"id":"doi:10.1161/jaha.126.050387","doi":"https://doi.org/10.1161/jaha.126.050387","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.126.050387","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1161/jaha.126.050387","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088533595","display_name":"Padmini Selvaganesan","orcid":"https://orcid.org/0000-0003-2841-6334","observed_orcids":["https://orcid.org/0000-0003-2841-6334"]},"institutions":[{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Padmini Selvaganesan","raw_affiliation_strings":["Case Western Reserve University School of Medicine","Louis Stokes Cleveland Veterans Affairs Medical Center"],"raw_orcid":"https://orcid.org/0000-0003-2841-6334","affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Louis Stokes Cleveland Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I4210110978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037185347","display_name":"Mohamad Karnib","orcid":"https://orcid.org/0000-0001-8089-8073","observed_orcids":["https://orcid.org/0000-0001-8089-8073"]},"institutions":[{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamad Karnib","raw_affiliation_strings":["Case Western Reserve University School of Medicine","Louis Stokes Cleveland Veterans Affairs Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Louis Stokes Cleveland Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I4210110978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133917632","display_name":"Irfan Helmy","orcid":"https://orcid.org/0009-0004-7805-0654","observed_orcids":["https://orcid.org/0009-0004-7805-0654"]},"institutions":[{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irfan Helmy","raw_affiliation_strings":["Case Western Reserve University School of Medicine","Louis Stokes Cleveland Veterans Affairs Medical Center"],"raw_orcid":"https://orcid.org/0009-0004-7805-0654","affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Louis Stokes Cleveland Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I4210110978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029225376","display_name":"Rosita Zakeri","orcid":"https://orcid.org/0000-0002-4225-3693","observed_orcids":["https://orcid.org/0000-0002-4225-3693"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rosita Zakeri","raw_affiliation_strings":["King's College London"],"raw_orcid":"https://orcid.org/0000-0002-4225-3693","affiliations":[{"raw_affiliation_string":"King's College London","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108137627","display_name":"Yusef Babar Saeed","orcid":"https://orcid.org/0000-0003-4410-6125","observed_orcids":["https://orcid.org/0000-0003-4410-6125"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yusef Babar Saeed","raw_affiliation_strings":["Geriatric Research, Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center","Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center","Louis Stokes Cleveland Veterans Affairs Medical Center"],"raw_orcid":"https://orcid.org/0000-0003-4410-6125","affiliations":[{"raw_affiliation_string":"Geriatric Research, Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center","institution_ids":["https://openalex.org/I4210110978"]},{"raw_affiliation_string":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"raw_affiliation_string":"Louis Stokes Cleveland Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I4210110978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080364929","display_name":"Jayakumar Sahadevan","orcid":"https://orcid.org/0009-0007-1419-604X","observed_orcids":["https://orcid.org/0009-0007-1419-604X"]},"institutions":[{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayakumar Sahadevan","raw_affiliation_strings":["Case Western Reserve University School of Medicine","Louis Stokes Cleveland Veterans Affairs Medical Center"],"raw_orcid":"https://orcid.org/0009-0007-1419-604X","affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Louis Stokes Cleveland Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I4210110978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102873519","display_name":"Mohammed Najeeb Osman","orcid":"https://orcid.org/0000-0002-3205-6733","observed_orcids":["https://orcid.org/0000-0002-3205-6733"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed Najeeb Osman","raw_affiliation_strings":["Case Western Reserve University School of Medicine","Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center","Louis Stokes Cleveland Veterans Affairs Medical Center"],"raw_orcid":"https://orcid.org/0000-0002-3205-6733","affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"raw_affiliation_string":"Louis Stokes Cleveland Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I4210110978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102809851","display_name":"Anirban Mondal","orcid":"https://orcid.org/0000-0002-4100-2366","observed_orcids":["https://orcid.org/0000-0002-4100-2366"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anirban Mondal","raw_affiliation_strings":["Case Western Reserve University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060390548","display_name":"Sharon LaForest","orcid":"https://orcid.org/0000-0003-4076-186X","observed_orcids":["https://orcid.org/0000-0003-4076-186X"]},"institutions":[{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherry Milfred\u2010LaForest","raw_affiliation_strings":["Louis Stokes Cleveland Veterans Affairs Medical Center"],"raw_orcid":"https://orcid.org/0000-0003-4076-186X","affiliations":[{"raw_affiliation_string":"Louis Stokes Cleveland Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I4210110978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026740203","display_name":"James Chen-Tson Fang","orcid":"https://orcid.org/0000-0003-2427-9504","observed_orcids":["https://orcid.org/0000-0003-2427-9504","https://orcid.org/0009-0008-5394-5610"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Fang","raw_affiliation_strings":["University of Utah"],"raw_orcid":"https://orcid.org/0000-0003-2427-9504","affiliations":[{"raw_affiliation_string":"University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031317277","display_name":"Yogesh N.V. Reddy","orcid":"https://orcid.org/0000-0001-5322-0902","observed_orcids":["https://orcid.org/0000-0001-5322-0902"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yogesh N.V. Reddy","raw_affiliation_strings":["Mayo Clinic"],"raw_orcid":"https://orcid.org/0000-0001-5322-0902","affiliations":[{"raw_affiliation_string":"Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012701510","display_name":"Varun Sundaram","orcid":"https://orcid.org/0000-0001-6543-8482","observed_orcids":["https://orcid.org/0000-0001-6543-8482"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Varun Sundaram","raw_affiliation_strings":["Case Western Reserve University School of Medicine","Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center","Louis Stokes Cleveland Veterans Affairs Medical Center","University Hospitals Research and Education Institute"],"raw_orcid":"https://orcid.org/0000-0001-6543-8482","affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"raw_affiliation_string":"Louis Stokes Cleveland Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I4210110978"]},{"raw_affiliation_string":"University Hospitals Research and Education Institute","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012701510"],"corresponding_institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4210110978","https://openalex.org/I58956616"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":{"value":3810,"currency":"USD","value_usd":3810},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85348837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"21","first_page":"e050387","last_page":"e050387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.47510001063346863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9750000238418579},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9850000143051147},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.996999979019165},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.925000011920929},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.9990000128746033},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.984000027179718},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.9980000257492065},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9539999961853027},{"id":"https://openalex.org/keywords/veterans","display_name":"veterans","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9531000256538391},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8841000199317932},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.791700005531311},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.7820000052452087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6916999816894531},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6751000285148621},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5149999856948853},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5105000138282776},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.41690000891685486},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3930000066757202},{"id":"https://openalex.org/C2781223611","wikidata":"https://www.wikidata.org/wiki/Q357496","display_name":"Obesity paradox","level":4,"score":0.382099986076355},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.33869999647140503},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.33709999918937683},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.32670000195503235},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.3203999996185303},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.3059000074863434},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.3012999892234802},{"id":"https://openalex.org/C2779781611","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Diastolic heart failure","level":4,"score":0.29089999198913574},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.2630999982357025}],"mesh":[{"descriptor_ui":"D000097789","descriptor_name":"Glucagon-Like Peptide-1 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1161/jaha.126.050387","doi":"https://doi.org/10.1161/jaha.126.050387","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.126.050387","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},{"id":"pmid:42960821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42960821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/jaha.126.050387","doi":"https://doi.org/10.1161/jaha.126.050387","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.126.050387","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1849521086","https://openalex.org/W1964098393","https://openalex.org/W2064130493","https://openalex.org/W2130025776","https://openalex.org/W2137097374","https://openalex.org/W2154746519","https://openalex.org/W2605401289","https://openalex.org/W2809966205","https://openalex.org/W2995420665","https://openalex.org/W2998791565","https://openalex.org/W3026172159","https://openalex.org/W3040190199","https://openalex.org/W3164477560","https://openalex.org/W3193297191","https://openalex.org/W3206335847","https://openalex.org/W4372214811","https://openalex.org/W4386154055","https://openalex.org/W4388609165","https://openalex.org/W4393255879","https://openalex.org/W4394061375","https://openalex.org/W4398781461","https://openalex.org/W4399985802","https://openalex.org/W4400588785","https://openalex.org/W4400691617","https://openalex.org/W4402066678","https://openalex.org/W4404437149","https://openalex.org/W4407853982","https://openalex.org/W4414129013"],"related_works":["https://openalex.org/W7128788779","https://openalex.org/W4408357300","https://openalex.org/W7223571158","https://openalex.org/W4407265345","https://openalex.org/W4405237049","https://openalex.org/W7223549912","https://openalex.org/W4414160046","https://openalex.org/W4415791209","https://openalex.org/W4415681582","https://openalex.org/W4394917777"],"abstract_inverted_index":{"Background":[0],"To":[1],"evaluate":[2],"whether":[3],"GLP\u20101":[4],"(glucagon\u2010like":[5],"peptide\u20101)":[6],"receptor":[7],"agonists":[8],"(GLP\u20101RAs),":[9],"compared":[10,229,265],"with":[11,20,30,39,79,99,102,171,179,205,227,230,239,243,255,266],"DPP4":[12,128,188,231],"(dipeptidyl":[13],"peptidase\u20104)":[14],"inhibitors":[15],"or":[16,24,146,261],"sulfonylureas,":[17],"are":[18],"associated":[19,204,254],"reduced":[21],"all\u2010cause":[22,144],"mortality":[23,145],"heart":[25,37,100,147,177,241,262],"failure":[26,38,101,148,178,242,263],"hospitalizations":[27],"in":[28,49],"patients":[29,170,238],"obesity":[31],"and":[32,36,87,106,176,186,247],"type":[33,80,172,248],"2":[34,81,113,173,249],"diabetes,":[35,174,250],"preserved":[40,103,180,244],"ejection":[41,104,181,245],"fraction.":[42],"Methods":[43],"PRAISE\u2010HFpEF":[44],"(Glucagon\u2010Like":[45],"Peptide\u20101":[46],"Receptor":[47],"Agonist":[48],"Obese":[50],"Heart":[51],"Failure":[52],"With":[53],"Preserved":[54],"Ejection":[55],"Fraction)":[56],"was":[57,122,141,160,203,224,253],"a":[58,64,107,117,125,195,206,256],"nationwide":[59],"multicenter":[60],"cohort":[61],"study":[62],"using":[63,116],"new\u2010user,":[65],"active\u2010comparator":[66],"design":[67],"within":[68],"the":[69,157,210],"national":[70],"Veterans":[71],"Affairs":[72],"Health":[73],"System":[74],"(170":[75],"US":[76],"hospitals).":[77],"Adults":[78],"diabetes":[82],"between":[83],"January":[84,131],"1,":[85,132],"2000":[86],"December":[88,135],"31,":[89,136],"2021,":[90],"were":[91,114],"identified":[92],"from":[93,130],"centralized":[94],"electronic":[95],"health":[96],"records.":[97],"Patients":[98],"fraction":[105,246],"body":[108],"mass":[109],"index":[110],"\u226530":[111],"kg/m":[112],"selected":[115],"validated":[118],"diagnostic":[119],"algorithm.":[120],"Exposure":[121],"initiation":[123,252],"of":[124,152,198,209,259],"GLP\u20101RA":[126,184,201,251],"versus":[127,234],"inhibitors/sulfonylurea":[129,189,232],"2015":[133],"to":[134,143,162],"2021.":[137],"The":[138],"primary":[139,211],"outcome":[140,212],"time":[142],"hospitalization.":[149],"Inverse":[150],"probability":[151],"treatment":[153],"weighting":[154],"based":[155],"on":[156],"propensity":[158],"score":[159],"used":[161],"balanced":[163],"baseline":[164],"characteristics.":[165],"Results":[166],"Among":[167,237],"179":[168],"288":[169],"obesity,":[175],"fraction,":[182],"1024":[183],"users":[185,190],"796":[187],"met":[191],"inclusion":[192],"criteria.":[193],"Over":[194],"median":[196],"follow\u2010up":[197],"1.5":[199],"years,":[200],"use":[202],"lower":[207,257],"risk":[208],"(adjusted":[213],"hazard":[214],"ratio,":[215],"0.78":[216],"[95%":[217],"CI,":[218],"0.64\u20130.95],":[219],"P":[220],"=0.01).":[221],"Weight":[222],"loss":[223],"modestly":[225],"greater":[226],"GLP\u20101RAs":[228],"(\u221212.9%":[233],"\u221210.1%).":[235],"Conclusions":[236],"obese":[240],"incidence":[258],"death":[260],"hospitalization":[264],"alternative":[267],"oral":[268],"agents.":[269]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-31T00:00:00"}