{"id":"https://openalex.org/W7224803771","doi":"https://doi.org/10.1186/s12916-026-05257-1","title":"BigpictureQC: multi-stain, multi-species artifact segmentation for whole-slide quality control","display_name":"BigpictureQC: multi-stain, multi-species artifact segmentation for whole-slide quality control","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224803771","doi":"https://doi.org/10.1186/s12916-026-05257-1"},"language":"en","primary_location":{"id":"doi:10.1186/s12916-026-05257-1","doi":"https://doi.org/10.1186/s12916-026-05257-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-026-05257-1","pdf_url":null,"source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12916-026-05257-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159916268","display_name":"Marina D'Amato","orcid":"https://orcid.org/0009-0002-2258-0715","observed_orcids":["https://orcid.org/0009-0002-2258-0715"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Marina D\u2019Amato","raw_affiliation_strings":["Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054363588","display_name":"H\u00f6lger Hoefling","orcid":"https://orcid.org/0000-0003-1209-8634","observed_orcids":["https://orcid.org/0000-0003-1209-8634"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Holger Hoefling","raw_affiliation_strings":["Biomedical Research, Novartis, Basel, CH-4056, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research, Novartis, Basel, CH-4056, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025115532","display_name":"Erio Barale-Thomas","orcid":"https://orcid.org/0000-0002-3799-5692","observed_orcids":["https://orcid.org/0000-0002-3799-5692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erio Barale-Thomas","raw_affiliation_strings":["Preclinical Sciences & Translational Safety, Johnson & Johnson Innovative Medicine, Beerse, 2340, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Sciences & Translational Safety, Johnson & Johnson Innovative Medicine, Beerse, 2340, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064058767","display_name":"Freya Molenberghs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Freya Molenberghs","raw_affiliation_strings":["Preclinical Sciences & Translational Safety, Johnson & Johnson Innovative Medicine, Beerse, 2340, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Sciences & Translational Safety, Johnson & Johnson Innovative Medicine, Beerse, 2340, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025170668","display_name":"Pieter Van Nuffel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pieter Van Nuffel","raw_affiliation_strings":["Preclinical Sciences & Translational Safety, Johnson & Johnson Innovative Medicine, Beerse, 2340, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Sciences & Translational Safety, Johnson & Johnson Innovative Medicine, Beerse, 2340, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076460061","display_name":"Anna Bod\u00e9n","orcid":"https://orcid.org/0000-0002-0128-870X","observed_orcids":["https://orcid.org/0000-0002-0128-870X"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]},{"id":"https://openalex.org/I4391767699","display_name":"Region \u00d6sterg\u00f6tland","ror":"https://ror.org/024emf479","country_code":"SE","type":"government","lineage":["https://openalex.org/I4391767699"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Bod\u00e9n","raw_affiliation_strings":["Center for Medical Image Science and Visualization (CMIV), Link\u00f6ping University, Link\u00f6ping, 581 83, Sweden","Clinical Department of Clinical Pathology, Region \u00d6sterg\u00f6tland, Link\u00f6ping, 581 91, Sweden","Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, 581 83, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Image Science and Visualization (CMIV), Link\u00f6ping University, Link\u00f6ping, 581 83, Sweden","institution_ids":["https://openalex.org/I102134673"]},{"raw_affiliation_string":"Clinical Department of Clinical Pathology, Region \u00d6sterg\u00f6tland, Link\u00f6ping, 581 91, Sweden","institution_ids":["https://openalex.org/I4391767699"]},{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, 581 83, Sweden","institution_ids":["https://openalex.org/I102134673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160159332","display_name":"Paul van Diest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paul van Diest","raw_affiliation_strings":["Department of Pathology, University Medical Center Utrecht, Utrecht, 3584, CX, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Medical Center Utrecht, Utrecht, 3584, CX, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160209096","display_name":"Nikolas Stathonikos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nikolas Stathonikos","raw_affiliation_strings":["Department of Pathology, University Medical Center Utrecht, Utrecht, 3584, CX, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Medical Center Utrecht, Utrecht, 3584, CX, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076207839","display_name":"Sara Rombouts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85722119","display_name":"UCB Pharma (Belgium)","ror":"https://ror.org/01n029866","country_code":"BE","type":"company","lineage":["https://openalex.org/I85722119"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sara Rombouts","raw_affiliation_strings":["Translational Pathology & In Vitro Safety, Non-clinical Safety Evaluation, UCB, Braine-l\u2019Alleud, 1420, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Pathology & In Vitro Safety, Non-clinical Safety Evaluation, UCB, Braine-l\u2019Alleud, 1420, Belgium","institution_ids":["https://openalex.org/I85722119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025767527","display_name":"Ilse Slootweg","orcid":"https://orcid.org/0000-0003-2514-0862","observed_orcids":["https://orcid.org/0000-0003-2514-0862"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ivan R. Slootweg","raw_affiliation_strings":["Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands","Oncode Institute, Utrecht, 3521, AL, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Oncode Institute, Utrecht, 3521, AL, The Netherlands","institution_ids":["https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055697525","display_name":"Geert J. S. Litjens","orcid":"https://orcid.org/0000-0003-1554-1291","observed_orcids":["https://orcid.org/0000-0003-1554-1291"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Geert Litjens","raw_affiliation_strings":["Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands","Oncode Institute, Utrecht, 3521, AL, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Oncode Institute, Utrecht, 3521, AL, The Netherlands","institution_ids":["https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081003438","display_name":"Jeroen A. W. M. van der Laak","orcid":"https://orcid.org/0000-0001-7982-0754","observed_orcids":["https://orcid.org/0000-0001-7982-0754"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen van der Laak","raw_affiliation_strings":["Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5135430833","display_name":"Francesco Ciompi","orcid":"https://orcid.org/0000-0001-8327-9606","observed_orcids":["https://orcid.org/0000-0001-8327-9606"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Francesco Ciompi","raw_affiliation_strings":["Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5159916268"],"corresponding_institution_ids":["https://openalex.org/I2802934949"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81474093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/whole-slide-images","display_name":"whole slide images","score":0.8510000109672546},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"digital pathology","score":0.8199999928474426},{"id":"https://openalex.org/keywords/artifact-detection","display_name":"artifact detection","score":0.6449999809265137},{"id":"https://openalex.org/keywords/image-quality-control","display_name":"image quality control","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pixel-wise-segmentation","display_name":"pixel-level segmentation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hematoxylin-and-eosin","display_name":"hematoxylin and eosin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/dermatopathology","display_name":"dermatopathology","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.798799991607666},{"id":"https://openalex.org/C2779010991","wikidata":"https://www.wikidata.org/wiki/Q2720909","display_name":"Artifact (error)","level":2,"score":0.7738000154495239},{"id":"https://openalex.org/C2779346075","wikidata":"https://www.wikidata.org/wiki/Q7268763","display_name":"Quality Score","level":3,"score":0.6930000185966492},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6126000285148621},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5906000137329102},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.5033000111579895},{"id":"https://openalex.org/C55020928","wikidata":"https://www.wikidata.org/wiki/Q3813865","display_name":"Image quality","level":3,"score":0.4875999987125397},{"id":"https://openalex.org/C159744936","wikidata":"https://www.wikidata.org/wiki/Q1126730","display_name":"Spearman's rank correlation coefficient","level":2,"score":0.4004000127315521},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3862999975681305},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3693999946117401},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.36230000853538513},{"id":"https://openalex.org/C3020001037","wikidata":"https://www.wikidata.org/wiki/Q836575","display_name":"Quality assessment","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2987000048160553},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C101601086","wikidata":"https://www.wikidata.org/wiki/Q3753228","display_name":"Rank correlation","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.2786000072956085},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2630000114440918},{"id":"https://openalex.org/C2779466056","wikidata":"https://www.wikidata.org/wiki/Q107630651","display_name":"Time point","level":2,"score":0.2574999928474426},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C2779751349","wikidata":"https://www.wikidata.org/wiki/Q1474480","display_name":"Scanner","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12916-026-05257-1","doi":"https://doi.org/10.1186/s12916-026-05257-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-026-05257-1","pdf_url":null,"source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12916-026-05257-1","doi":"https://doi.org/10.1186/s12916-026-05257-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-026-05257-1","pdf_url":null,"source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362593580","https://openalex.org/W7122618334","https://openalex.org/W7214235224","https://openalex.org/W4405419732","https://openalex.org/W6927143018","https://openalex.org/W4403899070","https://openalex.org/W7164321848","https://openalex.org/W7148316164","https://openalex.org/W4220668404","https://openalex.org/W7128057396"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Artifacts":[2],"in":[3,19,151,311],"digital":[4,289],"pathology":[5,21],"whole-slide":[6],"images":[7],"(WSIs)":[8],"cause":[9],"diagnostic":[10,157],"delay":[11],"and":[12,26,51,65,72,79,82,86,135,145,163,189,196,221,287,296,299,308,315,340],"quality":[13,16,39,128,139,214,236,263],"issues,":[14],"yet":[15],"control":[17,237],"(QC)":[18],"most":[20],"laboratories":[22],"remains":[23],"manual,":[24],"subjective,":[25],"difficult":[27],"to":[28,319],"scale.":[29],"We":[30],"present":[31],"BigpictureQC,":[32],"a":[33,152,164,177,206],"deep":[34],"learning":[35],"framework":[36,283],"for":[37,106,227],"WSI":[38],"assessment":[40],"based":[41],"on":[42,58,67,94,114,183],"per-class":[43],"pixel-level":[44,107],"segmentation":[45,91],"of":[46,118,155,167,181,210,225,240,256,327,334],"six":[47],"visually":[48],"distinct":[49],"artifact":[50,110,133,194,203],"marking":[52],"classes.":[53],"Methods":[54],"BigpictureQC":[55,175,275],"was":[56,92,112,130,149],"trained":[57,341],"268":[59],"WSIs":[60,69,96,121],"from":[61,97,132,171],"five":[62],"data":[63],"sources":[64],"evaluated":[66,93,136,150],">9,200":[68],"spanning":[70],"human":[71,286],"preclinical":[73,288],"samples,":[74],"diverse":[75,300],"tissue":[76,293],"types,":[77,294],"hematoxylin":[78],"eosin":[80],"(H&E)":[81],"immunohistochemical":[83],"(IHC)":[84],"stains,":[85,298],"multiple":[87,292],"scanner":[88,301],"models.":[89,302],"Patch-level":[90],"569":[95],"seven":[98],"independent":[99,116],"cohorts":[100],"using":[101,122,141],"the":[102,184,252,277,332],"Dice":[103,179],"similarity":[104],"coefficient":[105],"segmentation;":[108],"slide-level":[109,127],"detection":[111,204],"assessed":[113],"an":[115,223],"dataset":[117],"315":[119],"dermatopathology":[120],"F1":[123,208],"scores.":[124],"A":[125],"quantitative":[126],"score":[129,180,209,215],"derived":[131,213],"coverage":[134],"against":[137],"manual":[138,219,249,307],"ratings":[140,220],"Spearman":[142],"rank":[143],"correlation":[144],"AUC.":[146],"Clinical":[147],"impact":[148],"retrospective":[153],"cohort":[154,166],"3,686":[156],"slides":[158,170,257,330],"with":[159,218,244],"technician":[160],"rescan":[161],"decisions":[162],"prospective":[165],"4,426":[168],"unreviewed":[169],"routine":[172,248],"diagnostics.":[173],"Results":[174],"achieved":[176,222],"mean":[178],"0.93":[182],"evaluation":[185],"set,":[186],"outperforming":[187],"academic":[188],"commercial":[190],"baselines":[191],"across":[192,285],"all":[193,328],"classes":[195],"domains":[197],"(H&E,":[198],"IHC,":[199],"clinical,":[200],"preclinical).":[201],"Slide-level":[202],"yielded":[205],"micro-averaged":[207],"0.93.":[211],"The":[212,336],"strongly":[216],"correlated":[217],"AUC":[224],"0.978":[226],"identifying":[228],"poor-quality":[229,241,313],"slides.":[230],"In":[231,251],"clinical":[232],"workflow":[233],"analyses,":[234],"automated":[235,281,309],"identified":[238,259],"93%":[239],"slides,":[242,314],"compared":[243],"35%":[245],"detected":[246],"by":[247,323],"inspection.":[250],"prospective-style":[253],"cohort,":[254],"8.2%":[255],"were":[258],"as":[260],"having":[261],"substantial":[262],"issues":[264],"that":[265],"would":[266],"otherwise":[267],"have":[268],"reached":[269],"pathologists":[270],"without":[271],"prior":[272],"review.":[273],"Conclusions":[274],"provides":[276],"first":[278],"publicly":[279,345],"available":[280],"QC":[282],"validated":[284],"pathology,":[290],"encompassing":[291],"H&E":[295],"IHC":[297],"It":[303],"substantially":[304],"outperforms":[305],"existing":[306],"approaches":[310],"detecting":[312],"demonstrates":[316],"strong":[317],"potential":[318],"improve":[320],"laboratory":[321],"efficiency":[322],"enabling":[324],"systematic":[325],"pre-screening":[326],"digitized":[329],"at":[331],"point":[333],"scanning.":[335],"code,":[337],"inference":[338],"pipeline":[339],"model":[342],"weights":[343],"are":[344],"released.":[346]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}