{"id":"https://openalex.org/W7224782138","doi":"https://doi.org/10.21203/rs.3.rs-11215949/v1","title":"Integrated RNA-seq and ATAC-seq profiling for assessing chemically induced inflammatory responses in human TK6 cells","display_name":"Integrated RNA-seq and ATAC-seq profiling for assessing chemically induced inflammatory responses in human TK6 cells","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224782138","doi":"https://doi.org/10.21203/rs.3.rs-11215949/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11215949/v1","doi":"https://doi.org/10.21203/rs.3.rs-11215949/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11215949/v1","pdf_url":"https://www.researchsquare.com/article/rs-11215949/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11215949/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115895908","display_name":"Keigo Yamakita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keigo Yamakita","raw_affiliation_strings":["Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004920141","display_name":"Manabu Yasui","orcid":"https://orcid.org/0000-0002-5243-8675","observed_orcids":["https://orcid.org/0000-0002-5243-8675"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manabu Yasui","raw_affiliation_strings":["National Institute of Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Health Sciences","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031891942","display_name":"Masamitsu Honma","orcid":"https://orcid.org/0000-0001-7805-3290","observed_orcids":["https://orcid.org/0000-0001-7805-3290"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masamitsu Honma","raw_affiliation_strings":["National Institute of Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Health Sciences","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032775705","display_name":"Kei\u2010ichi Sugiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei-ichi Sugiyama","raw_affiliation_strings":["National Institute of Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Health Sciences","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110022853","display_name":"Ryoji Fujiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoji Fujiki","raw_affiliation_strings":["Shimane University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shimane University","institution_ids":["https://openalex.org/I169016828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081519082","display_name":"Atsushi Kaneda","orcid":"https://orcid.org/0000-0002-6980-5515","observed_orcids":["https://orcid.org/0000-0002-6980-5515"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Kaneda","raw_affiliation_strings":["Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103745246","display_name":"Kiyoe Ura","orcid":"https://orcid.org/0000-0002-2424-2448","observed_orcids":["https://orcid.org/0000-0002-2424-2448"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoe Ura","raw_affiliation_strings":["Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059040888","display_name":"Akira Sassa","orcid":"https://orcid.org/0000-0003-2454-0223","observed_orcids":["https://orcid.org/0000-0003-2454-0223"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Sassa","raw_affiliation_strings":["Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiba University","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.09809999912977219,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.6769999861717224},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.800000011920929},{"id":"https://openalex.org/keywords/transcriptional-response","display_name":"transcriptional response","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.41600000858306885},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6549999713897705},{"id":"https://openalex.org/keywords/leukocyte-activation","display_name":"leukocyte activation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/non-genotoxic-carcinogens","display_name":"non-genotoxic carcinogens","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.9052000045776367},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6865000128746033},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5364999771118164},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5224000215530396},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49889999628067017},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4846999943256378},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.47940000891685486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4715999960899353},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.45080000162124634},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4316999912261963},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.41940000653266907},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4162999987602234},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3961000144481659},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.37950000166893005},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.36160001158714294},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.34380000829696655},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3395000100135803},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.3179999887943268},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.31130000948905945},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.29910001158714294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28600001335144043},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28519999980926514},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2827000021934509},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.2524999976158142},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.25200000405311584},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11215949/v1","doi":"https://doi.org/10.21203/rs.3.rs-11215949/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11215949/v1","pdf_url":"https://www.researchsquare.com/article/rs-11215949/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11215949/v1","doi":"https://doi.org/10.21203/rs.3.rs-11215949/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11215949/v1","pdf_url":"https://www.researchsquare.com/article/rs-11215949/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3910018688","display_name":null,"funder_award_id":"22H03748","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7389060321","display_name":"\u9999\u6599\u3092\u542b\u3080\u98df\u54c1\u6dfb\u52a0\u7269\u306e\u907a\u4f1d\u6bd2\u6027\u304b\u3089\u767a\u304c\u3093\u306b\u81f3\u308b\u6bd2\u6027\u8a55\u4fa1\u30b9\u30ad\u30fc\u30e0\u78ba\u7acb\u306b\u5411\u3051\u305f\u57fa\u76e4\u7684\u7814\u7a76","funder_award_id":"21KA1001","funder_id":"https://openalex.org/F4320321945","funder_display_name":"Ministry of Health, Labour and Welfare"}],"funders":[{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320325182","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224782138.pdf","grobid_xml":"https://content.openalex.org/works/W7224782138.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1538575383","https://openalex.org/W1965037168","https://openalex.org/W1971708895","https://openalex.org/W1974319034","https://openalex.org/W1974987314","https://openalex.org/W1977308882","https://openalex.org/W1979689648","https://openalex.org/W1982754708","https://openalex.org/W1987496015","https://openalex.org/W1999964048","https://openalex.org/W2009164208","https://openalex.org/W2035010201","https://openalex.org/W2035276787","https://openalex.org/W2042433863","https://openalex.org/W2056198580","https://openalex.org/W2076110140","https://openalex.org/W2086667809","https://openalex.org/W2090602346","https://openalex.org/W2102619694","https://openalex.org/W2104005232","https://openalex.org/W2107018762","https://openalex.org/W2114104545","https://openalex.org/W2117202998","https://openalex.org/W2119180969","https://openalex.org/W2129155846","https://openalex.org/W2131271579","https://openalex.org/W2147494386","https://openalex.org/W2149233112","https://openalex.org/W2163617266","https://openalex.org/W2170551349","https://openalex.org/W2170830174","https://openalex.org/W2171808845","https://openalex.org/W2184655932","https://openalex.org/W2210414257","https://openalex.org/W2314739834","https://openalex.org/W2341539131","https://openalex.org/W2510875395","https://openalex.org/W2606232917","https://openalex.org/W2911555896","https://openalex.org/W2960349018","https://openalex.org/W2964849163","https://openalex.org/W2977079874","https://openalex.org/W2999376753","https://openalex.org/W3009920944","https://openalex.org/W3024191006","https://openalex.org/W3025060722","https://openalex.org/W3135249861","https://openalex.org/W3178877420","https://openalex.org/W4211054359","https://openalex.org/W4388494121","https://openalex.org/W4408216071","https://openalex.org/W7147113943"],"related_works":["https://openalex.org/W3192774811","https://openalex.org/W3045916200","https://openalex.org/W4389304038","https://openalex.org/W7117142223","https://openalex.org/W2066520295","https://openalex.org/W4294916217","https://openalex.org/W2477912252","https://openalex.org/W2755761104","https://openalex.org/W3163637615","https://openalex.org/W2039752918"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Chemical":[2],"exposure":[3,195],"can":[4],"exert":[5],"biological":[6],"effects":[7],"not":[8,310],"only":[9],"through":[10,41],"genetic":[11],"alterations":[12],"but":[13],"also":[14],"by":[15,131,219],"changing":[16],"gene":[17,39],"regulation":[18],"and":[19,32,37,48,78,135,160,165,168,198,203,208,231,236,256,275,286,298,334],"chromatin":[20,43,67,79,139,174,221,287],"states.":[21],"Inflammation":[22],"is":[23],"a":[24,84],"key":[25,52],"cellular":[26],"response":[27],"to":[28,113,121,125,196,229,251,269,291],"diverse":[29],"chemical":[30,152,294],"stresses,":[31],"immune":[33],"cells":[34],"control":[35],"activation":[36,167],"inflammatory":[38,91,319,333],"programs":[40],"dynamic":[42],"remodeling;":[44],"moreover,":[45],"chronic":[46],"inflammation":[47],"immunosuppression":[49],"are":[50,62],"recognized":[51],"characteristics":[53],"of":[54,186,215,330],"carcinogens.":[55],"However,":[56],"how":[57],"chemically":[58,89,331],"induced":[59,90,145,332],"transcriptional":[60,147,285],"responses":[61,304],"coordinated":[63,302],"with":[64,267],"changes":[65,148,262],"in":[66,105,158],"accessibility":[68,80,222],"remains":[69],"incompletely":[70],"understood.":[71],"Here,":[72],"we":[73],"investigated":[74],"whether":[75],"integrating":[76],"transcriptomic":[77,306],"profiling":[81,300],"could":[82],"provide":[83,322],"molecular":[85,303,324],"framework":[86],"for":[87,111,123,137,326],"assessing":[88],"responses.":[92],"To":[93],"do":[94],"so,":[95],"human":[96,270],"TK6":[97],"cells,":[98],"an":[99],"immune-lineage":[100],"cell":[101],"line":[102],"widely":[103],"used":[104],"regulatory":[106],"genotoxicity":[107],"testing,":[108],"were":[109,156],"exposed":[110],"24h":[112],"the":[114,180,183,213],"non-genotoxic":[115,335],"tumor":[116],"promoter":[117],"12-O-tetradecanoylphorbol-13-acetate":[118],"(TPA),":[119],"allowed":[120],"recover":[122],"up":[124],"7":[126],"days":[127],"before":[128],"being":[129],"analyzed":[130],"RNA":[132],"sequencing":[133,141],"(RNA-seq)":[134],"assay":[136],"transposase-accessible":[138],"using":[140],"(ATAC-seq).":[142],"Results":[143],"TPA":[144,282],"time-dependent":[146],"that":[149,176,212,281,289,305],"persisted":[150],"after":[151,194,293],"removal.":[153,295],"Upregulated":[154],"genes":[155,217,242,265],"enriched":[157],"immune-":[159],"inflammation-related":[161,264],"processes,":[162],"including":[163,272],"leukocyte":[164],"lymphocyte":[166],"cytokine":[169],"production.":[170],"ATAC-seq":[171,209,299],"revealed":[172],"extensive":[173],"remodeling":[175],"increased":[177,220,243],"progressively":[178],"during":[179],"post-exposure":[181],"period:":[182],"total":[184],"number":[185],"differentially":[187],"accessible":[188],"regions":[189],"rose":[190,223],"from":[191,224,246],"6,488":[192],"immediately":[193],"11,364":[197],"12,710":[199],"on":[200,226,233,248,253,258],"Days":[201,234],"3":[202,235,255],"7,":[204,237],"respectively.":[205,238],"Integrated":[206,296],"RNA-seq":[207,297],"analysis":[210,307],"showed":[211],"proportion":[214],"upregulated":[216],"accompanied":[218],"32.7%":[225],"Day":[227,249,254,259],"0":[228,250],"50.1%":[230],"46.3%":[232],"Concordance":[239],"among":[240],"downregulated":[241],"more":[244],"markedly,":[245],"8.7%":[247],"26.1%":[252],"39.6%":[257],"7.":[260],"Concordant":[261],"included":[263],"associated":[266],"susceptibility":[268],"disease,":[271],"TNFSF4,":[273],"CSF2,":[274],"SELL.":[276],"Conclusions":[277],"These":[278,312],"findings":[279],"show":[280],"induces":[283],"sustained":[284],"states":[288],"continue":[290],"remodel":[292],"identifies":[301],"alone":[308],"does":[309],"capture.":[311],"concordant":[313],"RNA\u2013ATAC":[314],"changes,":[315],"particularly":[316],"at":[317],"disease-associated":[318],"genes,":[320],"may":[321],"candidate":[323],"indicators":[325],"mechanistically":[327],"informed":[328],"assessment":[329],"effects.":[336]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-10-31T00:00:00"}