{"id":"https://openalex.org/W7224767259","doi":"https://doi.org/10.5281/zenodo.23806055","title":"PHARMACOTOXICOLOGICAL AND ANTIDEPRESSANT ACTIVITY OF CISTANCHE MONGOLICA EXTRACT","display_name":"PHARMACOTOXICOLOGICAL AND ANTIDEPRESSANT ACTIVITY OF CISTANCHE MONGOLICA EXTRACT","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224767259","doi":"https://doi.org/10.5281/zenodo.23806055"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23806055","doi":"https://doi.org/10.5281/zenodo.23806055","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23806055","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23806055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160179056","display_name":"N.F. Rakhimova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rakhimova, N.F.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5160193227","display_name":"N.M. Mamatova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mamatova, N.M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.89864093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.9139999747276306},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.8809999823570251},{"id":"https://openalex.org/keywords/ld50","display_name":"LD50","score":0.765999972820282},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.7929999828338623},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.5239999890327454},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.906000018119812},{"id":"https://openalex.org/keywords/tail-suspension-test","display_name":"tail suspension test","score":0.9940000176429749},{"id":"https://openalex.org/keywords/catalepsy","display_name":"catalepsy","score":0.8640000224113464},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.4650000035762787},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.49300000071525574},{"id":"https://openalex.org/keywords/fergana-region","display_name":"Fergana region","score":0.671999990940094},{"id":"https://openalex.org/keywords/karakalpakstan","display_name":"Karakalpakstan","score":0.9559999704360962},{"id":"https://openalex.org/keywords/psychopharmacology","display_name":"psychopharmacology","score":0.6980000138282776},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.40700000524520874},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.45500001311302185},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.6816999912261963},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5932999849319458},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5152999758720398},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.5092999935150146},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5081999897956848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5078999996185303},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.5},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.48820000886917114},{"id":"https://openalex.org/C2780476085","wikidata":"https://www.wikidata.org/wiki/Q918193","display_name":"Catalepsy","level":4,"score":0.46459999680519104},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4456999897956848},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4171000123023987},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.3605000078678131},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.34790000319480896},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.2924000024795532},{"id":"https://openalex.org/C2781001258","wikidata":"https://www.wikidata.org/wiki/Q7676084","display_name":"Tail suspension test","level":5,"score":0.2919999957084656},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.28850001096725464},{"id":"https://openalex.org/C2779824472","wikidata":"https://www.wikidata.org/wiki/Q207123","display_name":"Herb","level":3,"score":0.2766999900341034},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.26570001244544983},{"id":"https://openalex.org/C3018223157","wikidata":"https://www.wikidata.org/wiki/Q7233257","display_name":"Positive control","level":2,"score":0.257999986410141}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23806055","doi":"https://doi.org/10.5281/zenodo.23806055","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23806055","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.23806056","doi":"https://doi.org/10.5281/zenodo.23806056","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23806056","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23806055","doi":"https://doi.org/10.5281/zenodo.23806055","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23806055","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390620697","https://openalex.org/W7224951471","https://openalex.org/W6911024881","https://openalex.org/W7222962822","https://openalex.org/W4386838264","https://openalex.org/W7216214308","https://openalex.org/W2416014572","https://openalex.org/W7220141318","https://openalex.org/W2728480441","https://openalex.org/W7217452630"],"abstract_inverted_index":{"Relevance.":[0],"According":[1],"to":[2,73,264,272,448,471],"the":[3,7,14,58,61,75,102,138,177,186,207,245,249,254,283,294,299,303,306,313,327,330,338,348,355,375,388,397,412,421,453,476,487],"WHO,":[4],"3.8%":[5],"of":[6,16,52,60,81,101,107,131,206,225,238,285,396,411,450,468,489],"world":[8],"population":[9],"suffers":[10],"from":[11,39],"depression,":[12],"and":[13,28,35,64,78,93,104,119,134,137,145,156,176,185,271,341,344,357,437,460],"number":[15],"patients":[17],"exceeds":[18],"300":[19],"million.":[20],"Current":[21],"synthetic":[22],"antidepressants":[23],"often":[24],"cause":[25],"adverse":[26],"effects":[27],"have":[29,66],"relatively":[30],"high":[31,473],"toxicity.":[32],"Developing":[33],"effective":[34,393],"safe":[36],"herbal":[37,484],"medicines":[38],"local":[40],"plant":[41],"raw":[42],"materials":[43],"is":[44,281,430,445,478],"therefore":[45],"an":[46,99],"urgent":[47],"task.":[48],"The":[49,95,124,148,203,223,260,351,363,391,408],"psychopharmacological":[50],"properties":[51],"Cistanche":[53,82,427],"mongolica,":[54],"which":[55],"grows":[56],"in":[57,85,88,209,217,253,337,368,387,465],"deserts":[59],"Fergana":[62],"region":[63],"Karakalpakstan,":[65],"not":[67,446],"been":[68],"studied":[69],"before.":[70],"Aim":[71],"\u2013":[72],"evaluate":[74],"acute":[76,153],"toxicity":[77,154,218],"antidepressant":[79,443],"activity":[80,359,367,444],"mongolica":[83,428],"extract":[84,100,125,208,261,304,349,352,364,398,413,422,429,477],"experimental":[86],"animals":[87],"comparison":[89],"with":[90,312,347,403,452],"fluoxetine.":[91,407],"Materials":[92],"methods.":[94],"study":[96],"object":[97],"was":[98,126,227,257,324,334,382,399],"aerial":[103],"underground":[105],"parts":[106],"C.":[108],"mongolica.":[109],"Experiments":[110],"were":[111,151,191,199],"performed":[112],"on":[113],"male":[114],"white":[115,120,210],"mice":[116,211],"(18\u201324":[117],"g)":[118],"rats":[121],"(180\u2013220":[122],"g).":[123],"administered":[127],"orally":[128],"at":[129,142,197,267,275,287,316,456],"doses":[130,318],"50,":[132],"100":[133,276,400,457],"200":[135,292],"mg/kg,":[136,174,214,401],"reference":[139],"drug":[140],"fluoxetine":[141,226,286],"10,":[143],"20":[144,404],"30":[146],"mg/kg.":[147,458],"following":[149],"methods":[150],"used:":[152],"(LD\u2085\u2080)":[155],"a":[157,479,483],"28-day":[158],"cumulation":[159],"test;":[160,180],"forced":[161,246],"swim":[162,247],"test":[163,168],"(Porsolt":[164],"R.);":[165],"tail":[166,300],"suspension":[167,301],"(Steru":[169],"L.);":[170],"reserpine-induced":[171],"blepharoptosis":[172],"(2.5":[173],"s.c.)":[175],"open":[178],"field":[179],"haloperidol-induced":[181,369],"catalepsy":[182,370],"(1.0":[183],"mg/kg)":[184,436],"light\u2013dark":[187,376],"box":[188,377],"test.":[189],"Data":[190],"analysed":[192],"using":[193],"Student's":[194],"t-test;":[195],"differences":[196],"p\u22640.05":[198],"considered":[200],"significant.":[201],"Results.":[202],"oral":[204],"LD\u2085\u2080":[205,224],"exceeded":[212,414],"10,000":[213,435],"placing":[215],"it":[216,263],"class":[219],"V":[220],"(practically":[221],"non-toxic).":[222],"360":[228],"mg/kg":[229,269,277,289,293,405],"(class":[230],"III).":[231],"No":[232],"deaths":[233],"occurred":[234],"during":[235],"28":[236],"days":[237],"administration":[239],"(total":[240],"dose":[241,394],"127,200":[242],"mg/kg).":[243],"In":[244,298,326,374],"test,":[248,302,378],"active":[250],"swimming":[251],"period":[252,308],"control":[255,314,339,389],"group":[256,315,340],"233.2\u00b143.5":[258],"s.":[259],"increased":[262,305],"265.0\u00b146.7":[265],"s":[266,274],"50":[268],"(+25.1%)":[270],"294.6\u00b157.2":[273],"(+48.4%;":[278],"p\u22640.05).":[279],"This":[280],"twice":[282],"effect":[284,295,381,455],"10":[288],"(+24%).":[290],"At":[291],"declined":[296],"(+5.2%).":[297],"mobility":[307],"by":[309,361],"21\u201326%":[310],"compared":[311,402],"all":[317],"(p\u22640.05).":[319,350],"For":[320],"fluoxetine,":[321,419,451],"this":[322],"value":[323],"13\u201331.5%.":[325],"reserpine":[328],"model,":[329],"palpebral":[331],"fissure":[332],"width":[333],"2.1\u00b10.1":[335],"mm":[336,346],"3.4\u00b10.4,":[342],"4.0\u00b10.3":[343],"3.8\u00b10.4":[345],"also":[353],"restored":[354],"locomotor":[356],"exploratory":[358],"suppressed":[360],"reserpine.":[362],"showed":[365],"dopamine-positive":[366],"over":[371],"5":[372],"hours.":[373],"its":[379,466,472],"anxiolytic":[380],"4.3\u20135.2":[383],"times":[384,424],"greater":[385],"than":[386],"group.":[390],"mean":[392],"(ED\u2085\u2080)":[395],"for":[406,418,482,486],"therapeutic":[409,474],"index":[410],"100,":[415],"versus":[416],"18":[417],"making":[420],"5.56":[423],"safer.":[425],"Conclusion.":[426],"practically":[431],"non-toxic":[432],"(LD\u2085\u2080":[433],">":[434],"has":[438],"no":[439],"cumulative":[440],"properties.":[441],"Its":[442],"inferior":[447],"that":[449],"maximum":[454],"Serotonergic":[459],"dopaminergic":[461],"systems":[462],"are":[463],"involved":[464],"mechanism":[467],"action.":[469],"Owing":[470],"index,":[475],"promising":[480],"candidate":[481],"medicine":[485],"treatment":[488],"depressive":[490],"states.":[491]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-31T00:00:00"}