{"id":"https://openalex.org/W7224765230","doi":"https://doi.org/10.1097/cmr.0000000000001150","title":"BRAF wild-type metastatic melanoma arising in a congenital melanocytic nevus initially reported as melanoma in situ, 4 years after negative sentinel lymph node biopsy: a case report and literature review","display_name":"BRAF wild-type metastatic melanoma arising in a congenital melanocytic nevus initially reported as melanoma in situ, 4 years after negative sentinel lymph node biopsy: a case report and literature review","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224765230","doi":"https://doi.org/10.1097/cmr.0000000000001150","pmid":"https://pubmed.ncbi.nlm.nih.gov/42960497"},"language":"en","primary_location":{"id":"doi:10.1097/cmr.0000000000001150","doi":"https://doi.org/10.1097/cmr.0000000000001150","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cmr.0000000000001150","pdf_url":null,"source":{"id":"https://openalex.org/S3207524","display_name":"Melanoma Research","issn_l":"0960-8931","issn":["0960-8931","1473-5636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Melanoma Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160177115","display_name":"Hadi Khalil Abdulla Al-Ajmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145880","display_name":"Sultan Qaboos University Hospital","ror":"https://ror.org/049xx5c95","country_code":"OM","type":"healthcare","lineage":["https://openalex.org/I4210145880"]}],"countries":["OM"],"is_corresponding":false,"raw_author_name":"Hadi Khalil Abdulla Al-Ajmi","raw_affiliation_strings":["General Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman","institution_ids":["https://openalex.org/I4210145880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160229424","display_name":"Shady Sabry Salama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145880","display_name":"Sultan Qaboos University Hospital","ror":"https://ror.org/049xx5c95","country_code":"OM","type":"healthcare","lineage":["https://openalex.org/I4210145880"]}],"countries":["OM"],"is_corresponding":false,"raw_author_name":"Shady Sabry Salama","raw_affiliation_strings":["General Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman","institution_ids":["https://openalex.org/I4210145880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210145880"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81811809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-wild-type-melanoma","display_name":"BRAF wild-type melanoma","score":0.8199999928474426},{"id":"https://openalex.org/keywords/congenital-melanocytic-nevus","display_name":"congenital melanocytic nevus","score":0.9409999847412109},{"id":"https://openalex.org/keywords/melanoma-in-situ","display_name":"melanoma in situ","score":0.8190000057220459},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9049999713897705},{"id":"https://openalex.org/keywords/sentinel-lymph-node-biopsy","display_name":"sentinel lymph node biopsy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/distant-recurrence","display_name":"distant recurrence","score":0.6000000238418579},{"id":"https://openalex.org/keywords/spinal-metastases","display_name":"spinal metastases","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cauda-equina-compression","display_name":"cauda equina compression","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.8500000238418579},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9829999804496765},{"id":"https://openalex.org/keywords/palliative-radiotherapy","display_name":"palliative radiotherapy","score":0.7639999985694885},{"id":"https://openalex.org/keywords/hematogenous-spread","display_name":"hematogenous spread","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9560999870300293},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7167999744415283},{"id":"https://openalex.org/C2780212769","wikidata":"https://www.wikidata.org/wiki/Q776290","display_name":"Sentinel lymph node","level":4,"score":0.5396999716758728},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4693000018596649},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4578999876976013},{"id":"https://openalex.org/C2780352243","wikidata":"https://www.wikidata.org/wiki/Q5160447","display_name":"Congenital melanocytic nevus","level":4,"score":0.447299987077713},{"id":"https://openalex.org/C2781186586","wikidata":"https://www.wikidata.org/wiki/Q6931266","display_name":"Mucosal melanoma","level":3,"score":0.44029998779296875},{"id":"https://openalex.org/C2778303017","wikidata":"https://www.wikidata.org/wiki/Q7998643","display_name":"Wide local excision","level":2,"score":0.35510000586509705},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.3538999855518341},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.34139999747276306},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.328900009393692},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.3212999999523163},{"id":"https://openalex.org/C2779323059","wikidata":"https://www.wikidata.org/wiki/Q692077","display_name":"Nevus","level":3,"score":0.3190999925136566},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.31850001215934753},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3138999938964844},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.31299999356269836},{"id":"https://openalex.org/C200583388","wikidata":"https://www.wikidata.org/wiki/Q5630684","display_name":"HMB-45","level":3,"score":0.3019999861717224},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2791000008583069},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C2777734354","wikidata":"https://www.wikidata.org/wiki/Q7046751","display_name":"Nodular melanoma","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C2778123414","wikidata":"https://www.wikidata.org/wiki/Q2779635","display_name":"Micrometastasis","level":4,"score":0.25279998779296875},{"id":"https://openalex.org/C2776294769","wikidata":"https://www.wikidata.org/wiki/Q377568","display_name":"Melanocytic nevus","level":4,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/cmr.0000000000001150","doi":"https://doi.org/10.1097/cmr.0000000000001150","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cmr.0000000000001150","pdf_url":null,"source":{"id":"https://openalex.org/S3207524","display_name":"Melanoma Research","issn_l":"0960-8931","issn":["0960-8931","1473-5636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Melanoma Research","raw_type":"journal-article"},{"id":"pmid:42960497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42960497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Melanoma research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1865896695","https://openalex.org/W1977874158","https://openalex.org/W2006488964","https://openalex.org/W2015748004","https://openalex.org/W2036676617","https://openalex.org/W2041959121","https://openalex.org/W2060162388","https://openalex.org/W2110383815","https://openalex.org/W2112642558","https://openalex.org/W2135925159","https://openalex.org/W2164857025","https://openalex.org/W2206673145","https://openalex.org/W2511177373","https://openalex.org/W2753432434","https://openalex.org/W2771421095","https://openalex.org/W2800104500","https://openalex.org/W2943211708","https://openalex.org/W3085502726","https://openalex.org/W3213947909","https://openalex.org/W4200479769","https://openalex.org/W4311861992","https://openalex.org/W4402552706"],"related_works":["https://openalex.org/W4403441307","https://openalex.org/W4310055264","https://openalex.org/W2035769808","https://openalex.org/W2801609329","https://openalex.org/W4413055604","https://openalex.org/W4406080004","https://openalex.org/W2825045062","https://openalex.org/W1969616159","https://openalex.org/W2521778678","https://openalex.org/W2901653166"],"abstract_inverted_index":{"Melanoma":[0],"arising":[1],"in":[2,29,51,83,171,198,227],"a":[3,14,19,39,54,132,158,193,235],"congenital":[4,41],"melanocytic":[5],"nevus":[6,43],"is":[7,26],"uncommon,":[8],"and":[9,18,69,90,106,129,139,157,176,178],"distant":[10],"relapse":[11],"years":[12,77,95],"after":[13,96,234],"thin":[15,55],"primary":[16],"tumor":[17,160],"negative":[20,82,211],"sentinel":[21],"lymph":[22],"node":[23],"biopsy":[24],"(SLNB)":[25],"rarely":[27],"documented":[28],"detail.":[30],"A":[31,210],"34-year-old":[32],"man":[33],"underwent":[34],"wide":[35],"local":[36],"excision":[37],"of":[38,44,150],"bleeding":[40],"hairy":[42],"the":[45,91,200,204],"sacral":[46],"skin.":[47],"Histopathology":[48],"showed":[49],"melanoma":[50,197,228],"situ":[52],"with":[53,101,113,126,135],"invasive":[56,201],"component":[57,116],"(<0.8":[58],"mm,":[59],"nonulcerated,":[60],"mitotic":[61],"rate":[62],"7/10":[63],"high-power":[64],"fields;":[65],"recorded":[66],"as":[67,196],"pT1b),":[68],"BRAF":[70,187],"testing":[71],"was":[72,81],"negative.":[73],"After":[74],"referral":[75],"2":[76],"later,":[78],"lymphoscintigraphy-guided":[79],"SLNB":[80,212],"all":[84],"eight":[85],"nodes":[86],"from":[87,109],"both":[88],"groins":[89],"right":[92],"axilla.":[93],"Four":[94],"nodal":[97,217],"staging,":[98],"he":[99],"presented":[100],"back":[102],"pain,":[103],"lower-limb":[104],"weakness,":[105],"urinary":[107],"retention":[108],"multiple":[110],"vertebral":[111,140],"metastases":[112],"an":[114,182],"epidural":[115],"at":[117],"L3,":[118],"raising":[119],"concern":[120],"for":[121,186],"cauda":[122],"equina":[123],"compression,":[124],"together":[125],"solitary":[127],"hepatic":[128],"pulmonary":[130],"lesions,":[131],"pattern":[133],"consistent":[134],"hematogenous":[136,220],"dissemination.":[137,221],"Liver":[138],"biopsies":[141],"confirmed":[142],"metastatic":[143,208],"melanoma.":[144],"Next-generation":[145],"sequencing":[146],"identified":[147],"no":[148],"variant":[149],"therapeutic":[151],"or":[152,219,224],"prognostic":[153],"significance":[154],"(BRAF":[155],"wild-type)":[156],"low":[159],"mutational":[161],"burden":[162],"(2.84":[163],"mutations/Mb).":[164],"Palliative":[165],"radiotherapy":[166],"to":[167],"L1-L4":[168],"(20":[169],"Gy":[170],"five":[172],"fractions)":[173],"restored":[174],"ambulation,":[175],"denosumab":[177],"ipilimumab":[179],"plus":[180],"nivolumab,":[181],"accepted":[183],"first-line":[184],"option":[185],"wild-type":[188],"melanoma,":[189],"were":[190],"started.":[191],"In":[192],"lesion":[194],"reported":[195],"situ,":[199],"component,":[202,206],"not":[203,214],"in-situ":[205],"confers":[207],"potential.":[209],"does":[213],"exclude":[215],"occult":[216],"disease":[218],"New":[222],"skeletal":[223],"neurological":[225],"symptoms":[226],"survivors":[229],"warrant":[230],"prompt":[231],"imaging,":[232],"even":[233],"prolonged":[236],"disease-free":[237],"interval.":[238]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}