{"id":"https://openalex.org/W7224754347","doi":"https://doi.org/10.1136/bjo-2026-330719","title":"Polygenic risk score for myopia prediction and risk stratification in Chinese children","display_name":"Polygenic risk score for myopia prediction and risk stratification in Chinese children","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224754347","doi":"https://doi.org/10.1136/bjo-2026-330719","pmid":"https://pubmed.ncbi.nlm.nih.gov/42963113"},"language":"en","primary_location":{"id":"doi:10.1136/bjo-2026-330719","doi":"https://doi.org/10.1136/bjo-2026-330719","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bjo-2026-330719","pdf_url":null,"source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092939553","display_name":"Bin Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Mao","raw_affiliation_strings":["School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111204875","display_name":"Tianyu Cheng","orcid":"https://orcid.org/0009-0005-7033-8140","observed_orcids":["https://orcid.org/0009-0005-7033-8140"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210092517","display_name":"Shanghai Eye Disease Prevention & Treatment Center","ror":"https://ror.org/0048a4976","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyu Cheng","raw_affiliation_strings":["National Clinical Research Center for Eye Diseases, Shanghai, China","School of Medicine, Shanghai Eye Disease Prevention and Treatment Center, Tongji University, Shanghai, China","Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Clinical Research Center for Eye Diseases, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, Shanghai Eye Disease Prevention and Treatment Center, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210092517"]},{"raw_affiliation_string":"Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065777425","display_name":"Dan\u2010Lin Li","orcid":"https://orcid.org/0000-0003-0800-4308","observed_orcids":["https://orcid.org/0000-0003-0800-4308"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danlin Li","raw_affiliation_strings":["School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-0800-4308","affiliations":[{"raw_affiliation_string":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451924","display_name":"Xun Xu","orcid":"https://orcid.org/0000-0002-4246-4343","observed_orcids":["https://orcid.org/0000-0002-4246-4343","https://orcid.org/0009-0005-0170-8339"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092517","display_name":"Shanghai Eye Disease Prevention & Treatment Center","ror":"https://ror.org/0048a4976","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092517"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]},{"id":"https://openalex.org/I4210157781","display_name":"Shanghai Clinical Research Center","ror":"https://ror.org/057tkkm33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157781"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xun Xu","raw_affiliation_strings":["Department of Ophthalmology, Shanghai General Hospital, Shanghai Clinical Research Center for Eye Diseases, Shanghai Key Clinical Specialty, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China","National Clinical Research Center for Eye Diseases, Shanghai, China","School of Medicine, Shanghai Eye Disease Prevention and Treatment Center, Tongji University, Shanghai, China","Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-4246-4343","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Clinical Research Center for Eye Diseases, Shanghai Key Clinical Specialty, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742","https://openalex.org/I4210157781"]},{"raw_affiliation_string":"National Clinical Research Center for Eye Diseases, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, Shanghai Eye Disease Prevention and Treatment Center, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210092517"]},{"raw_affiliation_string":"Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112321281","display_name":"Xiangui He","orcid":"https://orcid.org/0000-0002-8938-1879","observed_orcids":["https://orcid.org/0000-0002-8938-1879"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092517","display_name":"Shanghai Eye Disease Prevention & Treatment Center","ror":"https://ror.org/0048a4976","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092517"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]},{"id":"https://openalex.org/I4210157781","display_name":"Shanghai Clinical Research Center","ror":"https://ror.org/057tkkm33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157781"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangui He","raw_affiliation_strings":["Department of Ophthalmology, Shanghai General Hospital, Shanghai Clinical Research Center for Eye Diseases, Shanghai Key Clinical Specialty, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China","National Clinical Research Center for Eye Diseases, Shanghai, China","School of Medicine, Shanghai Eye Disease Prevention and Treatment Center, Tongji University, Shanghai, China","Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-8938-1879","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Clinical Research Center for Eye Diseases, Shanghai Key Clinical Specialty, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742","https://openalex.org/I4210157781"]},{"raw_affiliation_string":"National Clinical Research Center for Eye Diseases, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, Shanghai Eye Disease Prevention and Treatment Center, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210092517"]},{"raw_affiliation_string":"Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052891820","display_name":"Jingjing Wang","orcid":"https://orcid.org/0000-0003-2279-9514","observed_orcids":["https://orcid.org/0000-0003-2279-9514"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210092517","display_name":"Shanghai Eye Disease Prevention & Treatment Center","ror":"https://ror.org/0048a4976","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Wang","raw_affiliation_strings":["National Clinical Research Center for Eye Diseases, Shanghai, China","School of Medicine, Shanghai Eye Disease Prevention and Treatment Center, Tongji University, Shanghai, China","Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0003-2279-9514","affiliations":[{"raw_affiliation_string":"National Clinical Research Center for Eye Diseases, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, Shanghai Eye Disease Prevention and Treatment Center, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210092517"]},{"raw_affiliation_string":"Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088371305","display_name":"Jinliuxing Yang","orcid":"https://orcid.org/0000-0002-4031-7040","observed_orcids":["https://orcid.org/0000-0002-4031-7040"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210092517","display_name":"Shanghai Eye Disease Prevention & Treatment Center","ror":"https://ror.org/0048a4976","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinliuxing Yang","raw_affiliation_strings":["National Clinical Research Center for Eye Diseases, Shanghai, China","School of Medicine, Shanghai Eye Disease Prevention and Treatment Center, Tongji University, Shanghai, China","Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-4031-7040","affiliations":[{"raw_affiliation_string":"National Clinical Research Center for Eye Diseases, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, Shanghai Eye Disease Prevention and Treatment Center, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210092517"]},{"raw_affiliation_string":"Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029981096","display_name":"Qiao Fan","orcid":"https://orcid.org/0000-0002-2762-8346","observed_orcids":["https://orcid.org/0000-0002-2762-8346","https://orcid.org/0009-0006-2434-335X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Qiao Fan","raw_affiliation_strings":["Centre for Biomedical Data Science, Duke-NUS Medical School, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-2762-8346","affiliations":[{"raw_affiliation_string":"Centre for Biomedical Data Science, Duke-NUS Medical School, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056240390","display_name":"Chen\u2010Wei Pan","orcid":"https://orcid.org/0000-0003-3362-4613","observed_orcids":["https://orcid.org/0000-0003-3362-4613"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chen-Wei Pan","raw_affiliation_strings":["School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-3362-4613","affiliations":[{"raw_affiliation_string":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5056240390"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85472619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"bjo","last_page":"2026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10381","display_name":"Ophthalmology and Visual Impairment Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10381","display_name":"Ophthalmology and Visual Impairment Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myopia","display_name":"myopia","score":0.9340000152587891},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myopia-prediction","display_name":"myopia prediction","score":0.7099999785423279},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9950000047683716},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7379999756813049},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.5920000076293945},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9103000164031982},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.8658999800682068},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.5034000277519226},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.43529999256134033},{"id":"https://openalex.org/C2910691881","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Multifactorial Inheritance","level":5,"score":0.3723999857902527},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.3671000003814697},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.34630000591278076},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3089999854564667},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.2989000082015991},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.29109999537467957},{"id":"https://openalex.org/C192943249","wikidata":"https://www.wikidata.org/wiki/Q1893382","display_name":"Stratification (seeds)","level":5,"score":0.26840001344680786},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.2646999955177307},{"id":"https://openalex.org/C2991661194","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Lifetime risk","level":3,"score":0.26440000534057617},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2583000063896179}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/bjo-2026-330719","doi":"https://doi.org/10.1136/bjo-2026-330719","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bjo-2026-330719","pdf_url":null,"source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:42963113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42963113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of ophthalmology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2042281393","https://openalex.org/W2042386803","https://openalex.org/W2062407610","https://openalex.org/W2133763585","https://openalex.org/W2136376873","https://openalex.org/W2263495255","https://openalex.org/W2804575948","https://openalex.org/W2889753319","https://openalex.org/W2891225014","https://openalex.org/W2897236295","https://openalex.org/W2903403247","https://openalex.org/W2926051075","https://openalex.org/W2982405120","https://openalex.org/W3001727806","https://openalex.org/W3013807235","https://openalex.org/W3019600791","https://openalex.org/W3024755257","https://openalex.org/W3026374036","https://openalex.org/W3089846215","https://openalex.org/W3144499889","https://openalex.org/W3183185663","https://openalex.org/W4206944815","https://openalex.org/W4221022051","https://openalex.org/W4364359588","https://openalex.org/W4400883286","https://openalex.org/W4402757343","https://openalex.org/W4408103636","https://openalex.org/W4415031410","https://openalex.org/W7141536053","https://openalex.org/W7155004670"],"related_works":["https://openalex.org/W2919541666","https://openalex.org/W3183185663","https://openalex.org/W3128731246","https://openalex.org/W4391610161","https://openalex.org/W2562027001","https://openalex.org/W2982405120","https://openalex.org/W2890332902","https://openalex.org/W3092032869","https://openalex.org/W4416297317","https://openalex.org/W3206853612"],"abstract_inverted_index":{"Aims":[0],"To":[1],"assess":[2],"a":[3,94],"polygenic":[4],"risk":[5,12,221],"score":[6],"(PRS)":[7],"for":[8,88,111,117,168],"myopia":[9,124,132,183],"prediction":[10],"and":[11,67,75,102,113,120,122,126,141,161,171,196,205,235,239],"stratification":[13],"in":[14,63,191,225],"Chinese":[15],"children.":[16],"Methods":[17],"This":[18],"study":[19,53],"included":[20],"4750":[21],"children":[22,218],"aged":[23],"6":[24],"to":[25,33,139,153,159,166,244],"9":[26],"years":[27,99],"from":[28,47],"the":[29,61,73,76,79,135,187,192,199],"Shanghai":[30],"Time":[31],"Outside":[32],"Reduce":[34],"Myopia":[35],"trial.":[36],"A":[37],"weighted":[38],"PRS":[39,118,129,180,200,214],"comprising":[40],"51":[41],"single":[42],"nucleotide":[43],"polymorphisms":[44],"was":[45],"constructed":[46],"East":[48],"Asian":[49],"ancestry":[50],"genome-wide":[51],"association":[52],"summary":[54],"statistics":[55],"(n=121":[56],"172).":[57],"Linear":[58],"regression":[59],"estimated":[60],"variance":[62],"spherical":[64],"equivalent":[65],"(SE)":[66],"axial":[68],"length":[69],"(AL),":[70],"explained":[71],"by":[72],"PRS,":[74],"area":[77],"under":[78],"receiver":[80],"operating":[81],"characteristic":[82],"curve":[83],"(AUC)":[84],"quantified":[85],"predictive":[86],"accuracy":[87],"myopia.":[89,105,229],"Results":[90],"The":[91,106,143],"participants":[92],"had":[93,104,202],"mean":[95],"age":[96],"of":[97,148,177,198,210,222],"7.26\u00b10.59":[98],"(boys,":[100],"52.8%),":[101],"8.2%":[103],"incremental":[107,136,231],"adjusted":[108,137],"R\u00b2":[109,138],"values":[110],"SE":[112],"AL":[114],"were":[115],"small":[116],"(1.7%":[119],"0.3%)":[121],"parental":[123,131,182,228],"(2.5%":[125],"0.5%).":[127],"Combining":[128],"with":[130,179,186,227],"modestly":[133],"increased":[134],"4.0%":[140],"0.8%.":[142],"combined":[144],"model":[145],"yielded":[146],"AUCs":[147],"0.719":[149],"(95%":[150,156,163],"CI,":[151,157,164],"0.694":[152],"0.744),":[154],"0.709":[155],"0.683":[158],"0.736)":[160],"0.861":[162],"0.791":[165],"0.930)":[167],"overall,":[169],"low":[170],"moderate":[172],"myopia,":[173,211,223],"respectively,":[174],"exceeding":[175],"those":[176,190],"models":[178],"or":[181],"alone.":[184],"Compared":[185],"remaining":[188],"children,":[189],"highest":[193],"25%,":[194],"10%":[195],"5%":[197],"distribution":[201],"1.52,":[203],"1.63":[204],"1.88":[206],"times":[207],"higher":[208],"odds":[209],"respectively.":[212],"Conclusions":[213],"may":[215],"help":[216],"identify":[217],"at":[219],"high":[220],"particularly":[224],"combination":[226],"Its":[230],"contribution":[232],"remains":[233],"limited,":[234],"further":[236],"longitudinal":[237],"studies":[238],"external":[240],"validation":[241],"are":[242],"needed":[243],"evaluate":[245],"its":[246],"clinical":[247],"value.":[248]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-31T00:00:00"}