{"id":"https://openalex.org/W7224745402","doi":"https://doi.org/10.1186/s43556-026-00634-x","title":"Syncytiotrophoblast differentiation defects drive ER stress and reprogram placental PSG1 glycosylation in preeclampsia","display_name":"Syncytiotrophoblast differentiation defects drive ER stress and reprogram placental PSG1 glycosylation in preeclampsia","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224745402","doi":"https://doi.org/10.1186/s43556-026-00634-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/42961606","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722672"},"language":"en","primary_location":{"id":"doi:10.1186/s43556-026-00634-x","doi":"https://doi.org/10.1186/s43556-026-00634-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43556-026-00634-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43556-026-00634-x.pdf","source":{"id":"https://openalex.org/S4210227457","display_name":"Molecular Biomedicine","issn_l":"2662-8651","issn":["2662-8651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s43556-026-00634-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014680232","display_name":"Charlotte Harms","orcid":"https://orcid.org/0000-0002-5105-4020","observed_orcids":["https://orcid.org/0000-0002-5105-4020"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Charlotte Harms","raw_affiliation_strings":["Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","Glyco-HAM, a Cooperation of Universit\u00e4t Hamburg, Technology Platform Mass Spectrometry and University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Glyco-HAM, a Cooperation of Universit\u00e4t Hamburg, Technology Platform Mass Spectrometry and University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055421632","display_name":"Yiru Wang","orcid":"https://orcid.org/0000-0001-7542-8392","observed_orcids":["https://orcid.org/0000-0001-7542-8392"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yiru Wang","raw_affiliation_strings":["Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101706114","display_name":"James Warren","orcid":"https://orcid.org/0000-0002-6290-2785","observed_orcids":["https://orcid.org/0000-0002-6290-2785"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Warren","raw_affiliation_strings":["Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20817, USA","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012408241","display_name":"Julia Baumeister","orcid":"https://orcid.org/0009-0002-8049-0566","observed_orcids":["https://orcid.org/0009-0002-8049-0566"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Baumeister","raw_affiliation_strings":["Global Development CMC Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an Der Riss, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Development CMC Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an Der Riss, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083377053","display_name":"Fabian Higel","orcid":"https://orcid.org/0009-0006-5966-1294","observed_orcids":["https://orcid.org/0009-0006-5966-1294"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Higel","raw_affiliation_strings":["Global Development CMC Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an Der Riss, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Development CMC Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an Der Riss, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082845707","display_name":"Cristina Antich","orcid":"https://orcid.org/0000-0001-7511-0480","observed_orcids":["https://orcid.org/0000-0001-7511-0480"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Antich","raw_affiliation_strings":["3D Tissue Bioprinting Laboratory, National Center for Advancing Translational Sciences, National Institute of Sciences, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3D Tissue Bioprinting Laboratory, National Center for Advancing Translational Sciences, National Institute of Sciences, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002699549","display_name":"Marc Ferrer","orcid":"https://orcid.org/0000-0003-4569-9137","observed_orcids":["https://orcid.org/0000-0003-4569-9137"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Ferrer","raw_affiliation_strings":["3D Tissue Bioprinting Laboratory, National Center for Advancing Translational Sciences, National Institute of Sciences, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3D Tissue Bioprinting Laboratory, National Center for Advancing Translational Sciences, National Institute of Sciences, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042897465","display_name":"Jennifer J. Hill","orcid":"https://orcid.org/0000-0002-5550-8173","observed_orcids":["https://orcid.org/0000-0002-5550-8173"]},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]},{"id":"https://openalex.org/I4401200393","display_name":"Ottawa Institute of Systems Biology","ror":"https://ror.org/047xz1e88","country_code":"CA","type":"facility","lineage":["https://openalex.org/I153718931","https://openalex.org/I4401200393"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jennifer J. Hill","raw_affiliation_strings":["Human Health Therapeutics, National Research Council Canada, Ottawa, ON, Canada","Ottawa Institute of Systems Biology, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Health Therapeutics, National Research Council Canada, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I4210159778"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I4401200393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160155018","display_name":"Mariana G. Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mariana G. Garcia","raw_affiliation_strings":["Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051627431","display_name":"Alexandra Gellhaus","orcid":"https://orcid.org/0000-0001-9506-4581","observed_orcids":["https://orcid.org/0000-0001-9506-4581"]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra Gellhaus","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005584876","display_name":"N\u00e1ndor G\u00e1bor Than","orcid":"https://orcid.org/0000-0001-9385-7019","observed_orcids":["https://orcid.org/0000-0001-9385-7019"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I4210151515","display_name":"Institute of Molecular Life Sciences","ror":"https://ror.org/04t4pws42","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210151515","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"N\u00e1ndor G\u00e1bor Than","raw_affiliation_strings":["Department of Obstetrics and Gynecology, School of Medicine, Semmelweis University, Budapest, Hungary","Genesis Theranostix Group, Budapest, Hungary","Maternity Private Clinic of Obstetrics and Gynecology, Budapest, Hungary","Systems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, School of Medicine, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Genesis Theranostix Group, Budapest, Hungary","institution_ids":[]},{"raw_affiliation_string":"Maternity Private Clinic of Obstetrics and Gynecology, Budapest, Hungary","institution_ids":[]},{"raw_affiliation_string":"Systems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary","institution_ids":["https://openalex.org/I4210151515","https://openalex.org/I80251312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044649936","display_name":"Florian Herse","orcid":"https://orcid.org/0000-0002-9305-8134","observed_orcids":["https://orcid.org/0000-0002-9305-8134"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Herse","raw_affiliation_strings":["Experimental and Clinical Research Center, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association and the Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany","Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental and Clinical Research Center, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association and the Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051045029","display_name":"Stefan Verlohren","orcid":"https://orcid.org/0000-0003-3507-8636","observed_orcids":["https://orcid.org/0000-0003-3507-8636"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Verlohren","raw_affiliation_strings":["Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020046699","display_name":"Gabriela S. Dveksler","orcid":"https://orcid.org/0000-0003-3037-1155","observed_orcids":["https://orcid.org/0000-0003-3037-1155"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gabriela S. Dveksler","raw_affiliation_strings":["Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20817, USA. gabriela.dveksler@usuhs.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20817, USA. gabriela.dveksler@usuhs.edu","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020314252","display_name":"Sandra M. Blois","orcid":"https://orcid.org/0000-0002-0434-2660","observed_orcids":["https://orcid.org/0000-0002-0434-2660"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sandra M. Blois","raw_affiliation_strings":["Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.blois@uke.de","Glyco-HAM, a Cooperation of Universit\u00e4t Hamburg, Technology Platform Mass Spectrometry and University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.blois@uke.de"],"raw_orcid":"https://orcid.org/0000-0002-0434-2660","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.blois@uke.de","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Glyco-HAM, a Cooperation of Universit\u00e4t Hamburg, Technology Platform Mass Spectrometry and University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.blois@uke.de","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5020046699","https://openalex.org/A5020314252"],"corresponding_institution_ids":["https://openalex.org/I148314036","https://openalex.org/I159176309","https://openalex.org/I4210108711"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88711044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/syncytiotrophoblast-differentiation","display_name":"syncytiotrophoblast differentiation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9559999704360962},{"id":"https://openalex.org/keywords/high-mannose-n-glycans","display_name":"high-mannose glycans","score":0.9110000133514404},{"id":"https://openalex.org/keywords/sialylation","display_name":"sialylation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.6449999809265137},{"id":"https://openalex.org/keywords/asialoglycoprotein-receptor","display_name":"asialoglycoprotein receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/hepatic-clearance","display_name":"hepatic clearance","score":0.8420000076293945},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/single-nucleus-transcriptomics","display_name":"single-nucleus transcriptomics","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C2779315647","wikidata":"https://www.wikidata.org/wiki/Q2745412","display_name":"Syncytiotrophoblast","level":5,"score":0.9139999747276306},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.7088000178337097},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6829000115394592},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.6703000068664551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5968000292778015},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.5708000063896179},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.5587999820709229},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.548799991607666},{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.4932999908924103},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.45570001006126404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4392000138759613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43459999561309814},{"id":"https://openalex.org/C30324644","wikidata":"https://www.wikidata.org/wiki/Q3334151","display_name":"N-linked glycosylation","level":4,"score":0.38199999928474426},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38100001215934753},{"id":"https://openalex.org/C11569505","wikidata":"https://www.wikidata.org/wiki/Q727265","display_name":"Asialoglycoprotein receptor","level":4,"score":0.3531000018119812},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3521000146865845},{"id":"https://openalex.org/C130361206","wikidata":"https://www.wikidata.org/wiki/Q908443","display_name":"Calnexin","level":4,"score":0.34139999747276306},{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.31139999628067017},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.29089999198913574},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.28290000557899475},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2827000021934509},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2750000059604645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25369998812675476}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011268","descriptor_name":"Pregnancy-Specific beta 1-Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011268","descriptor_name":"Pregnancy-Specific beta 1-Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s43556-026-00634-x","doi":"https://doi.org/10.1186/s43556-026-00634-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43556-026-00634-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43556-026-00634-x.pdf","source":{"id":"https://openalex.org/S4210227457","display_name":"Molecular Biomedicine","issn_l":"2662-8651","issn":["2662-8651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722672","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722672/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722672/pdf/43556_2026_Article_634.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biomed","raw_type":"Text"},{"id":"pmid:42961606","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42961606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:05e18bfc2b484450a25f6fc2af9edc9e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/05e18bfc2b484450a25f6fc2af9edc9e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Biomedicine, Vol 7, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s43556-026-00634-x","doi":"https://doi.org/10.1186/s43556-026-00634-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43556-026-00634-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43556-026-00634-x.pdf","source":{"id":"https://openalex.org/S4210227457","display_name":"Molecular Biomedicine","issn_l":"2662-8651","issn":["2662-8651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320323381","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335908","display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","ror":null},{"id":"https://openalex.org/F4320335947","display_name":"Universit\u00e4tsklinikum Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35"},{"id":"https://openalex.org/F4320337353","display_name":"National Institute of Nursing Research","ror":"https://ror.org/01y3zfr79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224745402.pdf","grobid_xml":"https://content.openalex.org/works/W7224745402.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W73372657","https://openalex.org/W1500181036","https://openalex.org/W1554187365","https://openalex.org/W1971997894","https://openalex.org/W1972766975","https://openalex.org/W1982325304","https://openalex.org/W2001772098","https://openalex.org/W2004070580","https://openalex.org/W2012402693","https://openalex.org/W2029273918","https://openalex.org/W2064551554","https://openalex.org/W2065955846","https://openalex.org/W2067074405","https://openalex.org/W2078420687","https://openalex.org/W2081508441","https://openalex.org/W2087586279","https://openalex.org/W2099632503","https://openalex.org/W2113357723","https://openalex.org/W2182552855","https://openalex.org/W2346794004","https://openalex.org/W2379025285","https://openalex.org/W2607310450","https://openalex.org/W2615203596","https://openalex.org/W2850708907","https://openalex.org/W2895883334","https://openalex.org/W2915010378","https://openalex.org/W2946525881","https://openalex.org/W2982612901","https://openalex.org/W2987440653","https://openalex.org/W2993787099","https://openalex.org/W3011052015","https://openalex.org/W3015249881","https://openalex.org/W3028352551","https://openalex.org/W3081360923","https://openalex.org/W3082375444","https://openalex.org/W3088028695","https://openalex.org/W3090230755","https://openalex.org/W3104349756","https://openalex.org/W3207420069","https://openalex.org/W4205973432","https://openalex.org/W4210269450","https://openalex.org/W4308156712","https://openalex.org/W4309506674","https://openalex.org/W4313334298","https://openalex.org/W4315786089","https://openalex.org/W4368377032","https://openalex.org/W4388464011","https://openalex.org/W4391539784","https://openalex.org/W4392296554","https://openalex.org/W4399772022","https://openalex.org/W4401424982","https://openalex.org/W4402380504","https://openalex.org/W4403691884","https://openalex.org/W4410067409","https://openalex.org/W7134202876","https://openalex.org/W7140106656","https://openalex.org/W7152469358"],"related_works":["https://openalex.org/W4313334298","https://openalex.org/W4315786089","https://openalex.org/W1975869519","https://openalex.org/W4386688708","https://openalex.org/W2063144575","https://openalex.org/W4389635948","https://openalex.org/W2066031844","https://openalex.org/W2182552855","https://openalex.org/W2993787099","https://openalex.org/W4415419133"],"abstract_inverted_index":{"During":[0],"pregnancy,":[1],"placenta-derived":[2],"proteins":[3,201],"such":[4],"as":[5,160,187],"pregnancy-specific":[6],"glycoprotein":[7,142,181],"1":[8],"(PSG1)":[9],"enter":[10],"the":[11,119],"maternal":[12],"circulation,":[13],"providing":[14],"a":[15,30,100,128,161,188,191],"window":[16],"into":[17],"placental":[18,200],"health":[19],"and":[20,77,106,123,150,153,183,210],"enabling":[21],"liquid":[22,67,212],"biopsy":[23,213],"strategies":[24],"for":[25,164],"monitoring":[26],"pregnancy":[27],"disorders.":[28],"PSG1,":[29],"highly":[31],"glycosylated":[32],"protein":[33,207],"secreted":[34],"by":[35,66],"syncytiotrophoblast":[36],"(STB)":[37],"cells,":[38],"reflects":[39],"trophoblast":[40],"differentiation":[41,178],"status.":[42],"Circulating":[43],"PSG1":[44,54,73,97,167,185],"levels":[45,168,208],"are":[46],"reduced":[47,107,129,165],"in":[48,58,85,89,115,135,169,194],"early-onset":[49,78],"preeclampsia":[50],"(PE),":[51],"but":[52],"how":[53],"glycosylation":[55,120,186],"is":[56],"altered":[57,118,180],"this":[59],"condition":[60],"remains":[61],"unclear.":[62],"Here,":[63],"we":[64],"show":[65],"chromatography-tandem":[68],"mass":[69],"spectrometry":[70],"that":[71],"native":[72],"purified":[74],"from":[75],"healthy":[76],"PE":[79],"pregnancies":[80],"carries":[81],"an":[82,139],"O-linked":[83],"glycan":[84],"its":[86],"N":[87],"domain":[88],"addition":[90],"to":[91,148,179],"diverse":[92],"N-linked":[93],"glycans.":[94],"In":[95],"PE,":[96,136],"N-glycans":[98],"displayed":[99],"shift":[101],"toward":[102],"increased":[103,146],"oligomannose":[104],"structures":[105],"sialylation.":[108],"Induction":[109],"of":[110,131,190,198],"endoplasmic":[111],"reticulum":[112],"(ER)":[113],"stress":[114,175],"primary":[116],"STBs":[117],"enzyme":[121],"machinery,":[122],"single-nucleus":[124],"transcriptomic":[125],"data":[126,172],"indicated":[127],"contribution":[130],"mature":[132],"STB":[133,177,193],"populations":[134],"consistent":[137],"with":[138],"immature":[140],"STB-like":[141],"signature.":[143],"Altered":[144],"N-glycosylation":[145],"binding":[147],"mannose":[149],"asialoglycoprotein":[151],"receptors":[152],"cellular":[154],"uptake,":[155],"suggesting":[156],"enhanced":[157],"hepatic":[158],"clearance":[159],"possible":[162],"explanation":[163],"circulating":[166,199],"PE.":[170,195],"Our":[171],"link":[173],"ER":[174],"during":[176],"maturation":[182],"identify":[184],"readout":[189],"stress-impaired":[192],"Glycan":[196],"features":[197],"could":[202],"therefore":[203],"provide":[204],"information":[205],"beyond":[206],"alone":[209],"complement":[211],"approaches.":[214]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-31T00:00:00"}