{"id":"https://openalex.org/W7224745194","doi":"https://doi.org/10.5281/zenodo.23818374","title":"Twenty-Nine Fundamental Problems in Quantum Protein Physics and a Unifying Experimental Methodology: Entangled Differential Tunneling Spectroscopy","display_name":"Twenty-Nine Fundamental Problems in Quantum Protein Physics and a Unifying Experimental Methodology: Entangled Differential Tunneling Spectroscopy","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224745194","doi":"https://doi.org/10.5281/zenodo.23818374"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23818374","doi":"https://doi.org/10.5281/zenodo.23818374","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23818374","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23818374","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136755863","display_name":"Bertrand Mercier des Rochettes","orcid":"https://orcid.org/0000-0002-1145-1881","observed_orcids":["https://orcid.org/0000-0002-1145-1881"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mercier des Rochettes, Bertrand","raw_affiliation_strings":["Mercier des Rochettes, Bertrand (Quantum Proteins AI, Cergy-Pontoise, France)"],"raw_orcid":"https://orcid.org/0000-0002-1145-1881","affiliations":[{"raw_affiliation_string":"Mercier des Rochettes, Bertrand (Quantum Proteins AI, Cergy-Pontoise, France)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5136755863"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10622","display_name":"Quantum Mechanics and Applications","score":0.23659999668598175,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10622","display_name":"Quantum Mechanics and Applications","score":0.23659999668598175,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13044","display_name":"Biofield Effects and Biophysics","score":0.17599999904632568,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":0.11180000007152557,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantum-path-integral","display_name":"quantum path integral","score":0.6899999976158142},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.5080000162124634},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9940000176429749},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hydrogen-transfer","display_name":"hydrogen transfer","score":0.6840000152587891},{"id":"https://openalex.org/keywords/quantum-biology","display_name":"quantum biology","score":0.5260000228881836},{"id":"https://openalex.org/keywords/hilbert-s-problems","display_name":"Hilbert's problems","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.6111999750137329},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.5231999754905701},{"id":"https://openalex.org/C120398109","wikidata":"https://www.wikidata.org/wiki/Q175751","display_name":"Quantum tunnelling","level":2,"score":0.49160000681877136},{"id":"https://openalex.org/C84114770","wikidata":"https://www.wikidata.org/wiki/Q46344","display_name":"Quantum","level":2,"score":0.47679999470710754},{"id":"https://openalex.org/C190463098","wikidata":"https://www.wikidata.org/wiki/Q2081419","display_name":"Quantum technology","level":4,"score":0.4480000138282776},{"id":"https://openalex.org/C190474826","wikidata":"https://www.wikidata.org/wiki/Q2495111","display_name":"Open quantum system","level":3,"score":0.4323999881744385},{"id":"https://openalex.org/C122527463","wikidata":"https://www.wikidata.org/wiki/Q578430","display_name":"Quantum decoherence","level":3,"score":0.42160001397132874},{"id":"https://openalex.org/C121040770","wikidata":"https://www.wikidata.org/wiki/Q215675","display_name":"Quantum entanglement","level":3,"score":0.3953999876976013},{"id":"https://openalex.org/C125198404","wikidata":"https://www.wikidata.org/wiki/Q1192916","display_name":"Instanton","level":2,"score":0.3871000111103058},{"id":"https://openalex.org/C71191651","wikidata":"https://www.wikidata.org/wiki/Q4218491","display_name":"Quantum nanoscience","level":5,"score":0.38429999351501465},{"id":"https://openalex.org/C58053490","wikidata":"https://www.wikidata.org/wiki/Q176555","display_name":"Quantum computer","level":3,"score":0.3806999921798706},{"id":"https://openalex.org/C95013731","wikidata":"https://www.wikidata.org/wiki/Q7269071","display_name":"Quantum metrology","level":5,"score":0.3806999921798706},{"id":"https://openalex.org/C169699857","wikidata":"https://www.wikidata.org/wiki/Q2122243","display_name":"Quantum information","level":3,"score":0.3555999994277954},{"id":"https://openalex.org/C33332235","wikidata":"https://www.wikidata.org/wiki/Q18362","display_name":"Theoretical physics","level":1,"score":0.3513000011444092},{"id":"https://openalex.org/C89143813","wikidata":"https://www.wikidata.org/wiki/Q17105423","display_name":"Quantum sensor","level":5,"score":0.3472000062465668},{"id":"https://openalex.org/C137019171","wikidata":"https://www.wikidata.org/wiki/Q2623817","display_name":"Quantum algorithm","level":3,"score":0.33570000529289246},{"id":"https://openalex.org/C194975256","wikidata":"https://www.wikidata.org/wiki/Q7269039","display_name":"Quantum dissipation","level":3,"score":0.3330000042915344},{"id":"https://openalex.org/C15706264","wikidata":"https://www.wikidata.org/wiki/Q230883","display_name":"Quantum state","level":3,"score":0.3314000070095062},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3287000060081482},{"id":"https://openalex.org/C15184713","wikidata":"https://www.wikidata.org/wiki/Q7269042","display_name":"Quantum dynamics","level":3,"score":0.32010000944137573},{"id":"https://openalex.org/C159317903","wikidata":"https://www.wikidata.org/wiki/Q3198","display_name":"Photon","level":2,"score":0.2962999939918518},{"id":"https://openalex.org/C5320026","wikidata":"https://www.wikidata.org/wiki/Q2122216","display_name":"Quantum information science","level":4,"score":0.29159998893737793},{"id":"https://openalex.org/C2778926657","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum system","level":3,"score":0.27549999952316284},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27219998836517334},{"id":"https://openalex.org/C11255438","wikidata":"https://www.wikidata.org/wiki/Q7269085","display_name":"Quantum process","level":4,"score":0.26910001039505005},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.2624000012874603},{"id":"https://openalex.org/C28855332","wikidata":"https://www.wikidata.org/wiki/Q198099","display_name":"Quantization (signal processing)","level":2,"score":0.2578999996185303},{"id":"https://openalex.org/C104434177","wikidata":"https://www.wikidata.org/wiki/Q215675","display_name":"Photon entanglement","level":4,"score":0.25519999861717224},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.25200000405311584}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5281/zenodo.23818374","doi":"https://doi.org/10.5281/zenodo.23818374","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23818374","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.23818375","doi":"https://doi.org/10.5281/zenodo.23818375","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23818375","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.23819869","doi":"https://doi.org/10.5281/zenodo.23819869","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23819869","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23818374","doi":"https://doi.org/10.5281/zenodo.23818374","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23818374","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6903884163","https://openalex.org/W7106827733","https://openalex.org/W3173966181","https://openalex.org/W2310290398","https://openalex.org/W7125488861","https://openalex.org/W6903931369","https://openalex.org/W2965601612","https://openalex.org/W7201886394","https://openalex.org/W2990343095","https://openalex.org/W7095807631"],"abstract_inverted_index":{"We":[0,92],"present":[1],"twenty-nine":[2],"fundamental":[3],"problems":[4,25,117],"in":[5,22,39,142,205,222],"quantum":[6,29,43,52,71,86,143,220,244],"protein":[7,33,135],"physics,":[8],"organized":[9],"as":[10,102,105,248],"a":[11,80,106,112,186,250,255],"structured":[12],"research":[13,195],"program":[14],"inspired":[15],"by":[16,211],"Hilbert's":[17],"identification":[18],"of":[19,51,66,115,261],"transformative":[20],"challenges":[21],"mathematics.":[23],"These":[24],"span":[26],"eight":[27],"domains\u2014from":[28],"path":[30],"integrals":[31],"and":[32,37,47,59,169,254],"dynamics,":[34],"through":[35,240],"coherence":[36],"decoherence":[38],"biological":[40,223],"systems,":[41,136],"to":[42,118,128,140,150,154,180,225,243],"field":[44],"theory":[45],"unification":[46],"the":[48,63,176,191,197,213,226,258],"biomedical":[49],"implications":[50],"tunneling":[53,144,221],"for":[54,257],"cancer,":[55],"neurodegeneration,":[56],"demyelinating":[57],"disease,":[58],"chromosomal":[60],"nondisjunction\u2014and":[61],"address":[62],"central":[64,179],"question":[65],"whether":[67],"evolved":[68],"proteins":[69],"exploit":[70],"mechanical":[72],"effects":[73],"at":[74,196],"physiological":[75],"temperatures":[76],"(310":[77],"K)":[78],"with":[79],"sophistication":[81],"that":[82,110,209,216],"surpasses":[83],"current":[84],"engineered":[85],"systems":[87],"operating":[88],"near":[89],"absolute":[90],"zero.":[91],"then":[93],"introduce":[94],"Entangled":[95],"Differential":[96],"Tunneling":[97],"Spectroscopy":[98],"(EDTS),":[99],"formalized":[100],"here":[101],"Problem":[103,181],"#24,":[104],"unifying":[107],"experimental":[108,152],"methodology":[109,147],"connects":[111],"significant":[113],"subset":[114],"these":[116],"concrete":[119],"laboratory":[120],"protocols.":[121],"EDTS":[122],"exploits":[123],"time-energy":[124],"entangled":[125,228],"photon":[126],"pairs":[127],"perform":[129],"simultaneous":[130],"differential":[131],"measurements":[132],"on":[133,202],"related":[134],"achieving":[137],"Heisenberg-limited":[138],"sensitivity":[139],"differences":[141],"landscapes.":[145],"The":[146,183],"is":[148,246],"shown":[149],"provide":[151],"access":[153],"Problems":[155],"#1,":[156],"#5,":[157],"#7,":[158],"#10,":[159],"#12,":[160],"#15,":[161],"#18,":[162],"#19,":[163],"#22,":[164],"#25,":[165],"#26,":[166],"#27,":[167],"#28,":[168],"#29,":[170],"while":[171],"its":[172],"theoretical":[173],"framework":[174],"validates":[175],"instanton":[177],"description":[178],"#23.":[182],"paper":[184],"draws":[185],"direct":[187],"intellectual":[188],"lineage":[189],"from":[190,236],"author's":[192],"1985":[193],"doctoral":[194],"Institut":[198],"fran\u00e7ais":[199],"du":[200],"p\u00e9trole":[201],"hydrogen":[203],"transfer":[204],"conformationally-constrained":[206],"bicyclic":[207],"systems\u2014work":[208],"anticipated":[210],"decades":[212,235],"modern":[214],"understanding":[215],"geometric":[217],"constraints":[218],"modulate":[219],"contexts\u2014through":[224],"proposed":[227],"measurement":[229],"paradigm.":[230],"This":[231],"trajectory,":[232],"spanning":[233],"four":[234],"classical":[237],"catalytic":[238],"chemistry":[239],"computational":[241],"science":[242],"biology,":[245],"offered":[247],"both":[249],"personal":[251],"scientific":[252],"testament":[253],"roadmap":[256],"next":[259],"generation":[260],"researchers.":[262]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}