{"id":"https://openalex.org/W7224745188","doi":"https://doi.org/10.1002/advs.78567","title":"A UBE3A\u2010UTX Proteostasis\u2010Epigenetic Axis Governs Hypothalamic Energy Homeostasis","display_name":"A UBE3A\u2010UTX Proteostasis\u2010Epigenetic Axis Governs Hypothalamic Energy Homeostasis","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224745188","doi":"https://doi.org/10.1002/advs.78567","pmid":"https://pubmed.ncbi.nlm.nih.gov/42958748","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13720268"},"language":"en","primary_location":{"id":"doi:10.1002/advs.78567","doi":"https://doi.org/10.1002/advs.78567","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78567","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.78567","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025719317","display_name":"Junekyoung Lee","orcid":"https://orcid.org/0009-0003-4985-3696","observed_orcids":["https://orcid.org/0009-0003-4985-3696"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Junekyoung Lee","raw_affiliation_strings":["College of Pharmacy Seoul National University  Seoul Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0003-4985-3696","affiliations":[{"raw_affiliation_string":"College of Pharmacy Seoul National University  Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063399065","display_name":"Jaeyoung Yoo","orcid":"https://orcid.org/0009-0002-5740-5327","observed_orcids":["https://orcid.org/0009-0002-5740-5327","https://orcid.org/0000-0002-9874-9436"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaeyoung Yoo","raw_affiliation_strings":["College of Pharmacy Seoul National University  Seoul Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0002-5740-5327","affiliations":[{"raw_affiliation_string":"College of Pharmacy Seoul National University  Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160199890","display_name":"Young A. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young A. Kim","raw_affiliation_strings":["College of Pharmacy Seoul National University  Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy Seoul National University  Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079624522","display_name":"Zhuodu Wei","orcid":"https://orcid.org/0000-0003-4344-6427","observed_orcids":["https://orcid.org/0000-0003-4344-6427"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Zhuodu Wei","raw_affiliation_strings":["College of Pharmacy Seoul National University  Seoul Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-4344-6427","affiliations":[{"raw_affiliation_string":"College of Pharmacy Seoul National University  Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160236629","display_name":"Yunseo Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yunseo Lee","raw_affiliation_strings":["College of Pharmacy Seoul National University  Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy Seoul National University  Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034214708","display_name":"Woo-Jeong Shon","orcid":"https://orcid.org/0000-0002-5521-5768","observed_orcids":["https://orcid.org/0000-0002-5521-5768"]},"institutions":[{"id":"https://openalex.org/I22586776","display_name":"Cheongju University","ror":"https://ror.org/02tx4na66","country_code":"KR","type":"education","lineage":["https://openalex.org/I22586776"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo\u2010Jeong Shon","raw_affiliation_strings":["Department of Biopharmaceutical Sciences Cheongju University  Cheongju Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-5521-5768","affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutical Sciences Cheongju University  Cheongju Republic of Korea","institution_ids":["https://openalex.org/I22586776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067205978","display_name":"Seong Je Kyung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Je Kyung Seong","raw_affiliation_strings":["Korea Mouse Phenotyping Center Seoul National University  Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Mouse Phenotyping Center Seoul National University  Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100424969","display_name":"Seunghee Lee","orcid":"https://orcid.org/0000-0001-5483-0016","observed_orcids":["https://orcid.org/0000-0001-5483-0016"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seunghee Lee","raw_affiliation_strings":["College of Pharmacy Seoul National University  Seoul Republic of Korea","Research Institute of Pharmaceutical Sciences and Natural Products Research Institute Seoul National University  Seoul Republic of Korea","Seoul National University Energy Initiative Seoul National University  Seoul Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5483-0016","affiliations":[{"raw_affiliation_string":"College of Pharmacy Seoul National University  Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences and Natural Products Research Institute Seoul National University  Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Seoul National University Energy Initiative Seoul National University  Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100424969"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79403875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ube3a","display_name":"UBE3A","score":0.9959999918937683},{"id":"https://openalex.org/keywords/kdm6a","display_name":"KDM6A","score":0.9110000133514404},{"id":"https://openalex.org/keywords/neuronal-proteostasis","display_name":"neuronal proteostasis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.8619999885559082},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/agrp-neurons","display_name":"AgRP neurons","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hyperphagia","display_name":"hyperphagia","score":0.871999979019165},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7850000262260437},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8880000114440918},{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gsk-j4","display_name":"GSK-J4","score":0.9309999942779541},{"id":"https://openalex.org/keywords/angelman-syndrome","display_name":"Angelman syndrome","score":0.7789999842643738},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.708899974822998},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.6312999725341797},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5873000025749207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5627999901771545},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5471000075340271},{"id":"https://openalex.org/C2777041782","wikidata":"https://www.wikidata.org/wiki/Q14878336","display_name":"UBE3A","level":5,"score":0.5278000235557556},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5210000276565552},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5109999775886536},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.48240000009536743},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.4819999933242798},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.429500013589859},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.426800012588501},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.4088999927043915},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.38449999690055847},{"id":"https://openalex.org/C2776667301","wikidata":"https://www.wikidata.org/wiki/Q18027324","display_name":"HSF1","level":5,"score":0.3720000088214874},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.33880001306533813},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.3109999895095825},{"id":"https://openalex.org/C2777767828","wikidata":"https://www.wikidata.org/wiki/Q2159860","display_name":"Palmitoylethanolamide","level":5,"score":0.30630001425743103},{"id":"https://openalex.org/C2781331208","wikidata":"https://www.wikidata.org/wiki/Q18032378","display_name":"XBP1","level":5,"score":0.3010999858379364},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.2989000082015991},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.29420000314712524},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.29330000281333923},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.28870001435279846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2815000116825104},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.27959999442100525},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.271699994802475},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2639999985694885},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.2630999982357025},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2597000002861023},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.2590999901294708},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2572999894618988}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/advs.78567","doi":"https://doi.org/10.1002/advs.78567","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78567","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmid:42958748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42958748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13720268","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720268/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/advs.78567","doi":"https://doi.org/10.1002/advs.78567","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78567","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1547961772","https://openalex.org/W1581958701","https://openalex.org/W1752412230","https://openalex.org/W1781960250","https://openalex.org/W1831618129","https://openalex.org/W1985567838","https://openalex.org/W2000251389","https://openalex.org/W2007078899","https://openalex.org/W2012089320","https://openalex.org/W2032668395","https://openalex.org/W2043744435","https://openalex.org/W2044490269","https://openalex.org/W2045904517","https://openalex.org/W2047936342","https://openalex.org/W2056322726","https://openalex.org/W2060696630","https://openalex.org/W2077033935","https://openalex.org/W2082506514","https://openalex.org/W2085712839","https://openalex.org/W2096206804","https://openalex.org/W2096269769","https://openalex.org/W2101076088","https://openalex.org/W2139359479","https://openalex.org/W2143928516","https://openalex.org/W2152239989","https://openalex.org/W2154696002","https://openalex.org/W2157893447","https://openalex.org/W2167854759","https://openalex.org/W2169612876","https://openalex.org/W2170939558","https://openalex.org/W2177136124","https://openalex.org/W2435107391","https://openalex.org/W2562694348","https://openalex.org/W2586421092","https://openalex.org/W2588615952","https://openalex.org/W2623177225","https://openalex.org/W2729311324","https://openalex.org/W2793110535","https://openalex.org/W2801143887","https://openalex.org/W2892338303","https://openalex.org/W2897273152","https://openalex.org/W2897455519","https://openalex.org/W2906904130","https://openalex.org/W3016681824","https://openalex.org/W3120006232","https://openalex.org/W3160852293","https://openalex.org/W3185384160","https://openalex.org/W3203610562","https://openalex.org/W4221120070","https://openalex.org/W4246635138","https://openalex.org/W4284898859","https://openalex.org/W4301397878","https://openalex.org/W4323530529","https://openalex.org/W4324020764","https://openalex.org/W4390008621","https://openalex.org/W4401375094","https://openalex.org/W4402564875","https://openalex.org/W4402582097","https://openalex.org/W4402960500","https://openalex.org/W4404089168"],"related_works":["https://openalex.org/W1913481789","https://openalex.org/W2117498865","https://openalex.org/W4383620228","https://openalex.org/W2892338303","https://openalex.org/W1978761502","https://openalex.org/W2067507825","https://openalex.org/W4412535511","https://openalex.org/W2080204826","https://openalex.org/W7119273628","https://openalex.org/W2911788032"],"abstract_inverted_index":{"Energy":[0],"homeostasis":[1,57,173],"requires":[2],"integration":[3],"of":[4,15,28,47,131,149,178,181,190],"metabolic":[5,120,140,172,185],"and":[6,54,84,95,100,138,170,174],"stress":[7],"signals":[8],"within":[9],"hypothalamic":[10,135,150],"circuits,":[11],"yet":[12],"the":[13,26,119,146,179],"role":[14],"neuronal":[16,45,166],"proteostasis":[17],"remains":[18,122,156],"unclear.":[19],"Ubiquitin":[20],"protein":[21],"ligase":[22],"E3A":[23],"(UBE3A)":[24],"regulates":[25],"stability":[27],"lysine":[29,89],"demethylase":[30],"6A":[31],"(KDM6A),":[32],"also":[33],"known":[34],"as":[35],"ubiquitously":[36],"transcribed":[37],"tetratricopeptide":[38],"repeat":[39],"containing,":[40],"X":[41],"chromosome":[42],"(UTX).":[43],"Hypothalamic":[44],"deletion":[46,63],"Ube3a":[48],"results":[49],"in":[50,64,106,142,187],"hyperphagia,":[51],"obesity,":[52],"hyperleptinemia,":[53],"impaired":[55],"glucose":[56],"under":[58],"high-fat":[59],"diet":[60],"conditions;":[61],"selective":[62],"agouti-related":[65],"peptide":[66],"(AgRP)":[67],"neurons":[68],"is":[69],"sufficient":[70],"to":[71,118,123,153,157,184],"recapitulate":[72],"these":[73,154],"phenotypes.":[74],"UBE3A":[75,80],"promotes":[76],"UTX":[77,83,99,151],"degradation,":[78],"whereas":[79],"loss":[81],"stabilizes":[82],"decreases":[85],"repressive":[86],"histone":[87],"H3":[88],"27":[90],"trimethylation":[91],"(H3K27me3).":[92],"Integrated":[93],"transcriptomic":[94],"epigenomic":[96],"analyses":[97],"implicate":[98],"activating":[101],"transcription":[102],"factor":[103],"4":[104],"(ATF4)":[105],"altered":[107],"endoplasmic":[108],"reticulum":[109],"(ER)":[110],"stress-responsive":[111],"transcriptional":[112],"programs,":[113],"although":[114,145],"their":[115],"causal":[116],"contribution":[117,148],"phenotype":[121],"be":[124,158],"established.":[125,159],"Treatment":[126],"with":[127,192],"GSK-J4,":[128],"an":[129],"inhibitor":[130],"KDM6-family":[132],"demethylases,":[133],"increases":[134],"H3K27me3":[136],"levels":[137],"improves":[139],"outcomes":[141],"Ube3a-deficient":[143],"mice,":[144],"specific":[147],"inhibition":[152],"effects":[155],"These":[160],"findings":[161],"support":[162],"a":[163,188],"link":[164],"between":[165],"proteostasis,":[167],"chromatin":[168],"regulation,":[169],"systemic":[171],"warrant":[175],"further":[176],"investigation":[177],"relevance":[180],"UTX-associated":[182],"pathways":[183],"dysfunction":[186],"subset":[189],"individuals":[191],"Angelman":[193],"syndrome.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}