{"id":"https://openalex.org/W7224744864","doi":"https://doi.org/10.1093/chemle/upag211","title":"Synthetic Studies on Leptolyngbyalides A\u2013C: Stereoselective Synthesis of the C16\u2013C27 Fragment","display_name":"Synthetic Studies on Leptolyngbyalides A\u2013C: Stereoselective Synthesis of the C16\u2013C27 Fragment","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224744864","doi":"https://doi.org/10.1093/chemle/upag211"},"language":"en","primary_location":{"id":"doi:10.1093/chemle/upag211","doi":"https://doi.org/10.1093/chemle/upag211","is_oa":true,"landing_page_url":"https://doi.org/10.1093/chemle/upag211","pdf_url":"https://academic.oup.com/chemlett/advance-article-pdf/doi/10.1093/chemle/upag211/72615462/upag211.pdf","source":{"id":"https://openalex.org/S90825563","display_name":"Chemistry Letters","issn_l":"0366-7022","issn":["0366-7022","1348-0715"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/chemlett/advance-article-pdf/doi/10.1093/chemle/upag211/72615462/upag211.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5149838006","display_name":"Yuuki OKAMURA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96679780","display_name":"Chuo University","ror":"https://ror.org/03qvqb743","country_code":"JP","type":"education","lineage":["https://openalex.org/I96679780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuuki Okamura","raw_affiliation_strings":["Department of Applied Chemistry, Graduate School of Science and Engineering, Chuo University , 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Graduate School of Science and Engineering, Chuo University , 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551","institution_ids":["https://openalex.org/I96679780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160235724","display_name":"Naoki Fukaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96679780","display_name":"Chuo University","ror":"https://ror.org/03qvqb743","country_code":"JP","type":"education","lineage":["https://openalex.org/I96679780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Fukaya","raw_affiliation_strings":["Department of Applied Chemistry, Graduate School of Science and Engineering, Chuo University , 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Graduate School of Science and Engineering, Chuo University , 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551","institution_ids":["https://openalex.org/I96679780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091119079","display_name":"Keisuke Murata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96679780","display_name":"Chuo University","ror":"https://ror.org/03qvqb743","country_code":"JP","type":"education","lineage":["https://openalex.org/I96679780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Murata","raw_affiliation_strings":["Department of Applied Chemistry, Graduate School of Science and Engineering, Chuo University , 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Graduate School of Science and Engineering, Chuo University , 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551","institution_ids":["https://openalex.org/I96679780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010628257","display_name":"Tomoki Tsuruta","orcid":"https://orcid.org/0009-0001-8269-1372","observed_orcids":["https://orcid.org/0009-0001-8269-1372"]},"institutions":[{"id":"https://openalex.org/I96679780","display_name":"Chuo University","ror":"https://ror.org/03qvqb743","country_code":"JP","type":"education","lineage":["https://openalex.org/I96679780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoki Tsuruta","raw_affiliation_strings":["School of Science and Engineering, Chuo University , 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science and Engineering, Chuo University , 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551","institution_ids":["https://openalex.org/I96679780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084478484","display_name":"Haruhiko Fuwa","orcid":"https://orcid.org/0000-0001-5343-9023","observed_orcids":["https://orcid.org/0000-0001-5343-9023"]},"institutions":[{"id":"https://openalex.org/I96679780","display_name":"Chuo University","ror":"https://ror.org/03qvqb743","country_code":"JP","type":"education","lineage":["https://openalex.org/I96679780"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Haruhiko Fuwa","raw_affiliation_strings":["School of Science and Engineering, Chuo University , 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science and Engineering, Chuo University , 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551","institution_ids":["https://openalex.org/I96679780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084478484"],"corresponding_institution_ids":["https://openalex.org/I96679780"],"apc_list":{"value":150000,"currency":"JPY","value_usd":1003},"apc_paid":{"value":150000,"currency":"JPY","value_usd":1003},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73635031,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.195700004696846,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stereoselective-synthesis","display_name":"stereoselective synthesis","score":0.777999997138977},{"id":"https://openalex.org/keywords/mukaiyama-aldol-reaction","display_name":"Mukaiyama aldol reaction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leptolyngbya","display_name":"Leptolyngbya","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cyanobacterial-natural-products","display_name":"cyanobacterial natural products","score":0.8510000109672546},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9721999764442444},{"id":"https://openalex.org/C134195300","wikidata":"https://www.wikidata.org/wiki/Q902071","display_name":"Stereocenter","level":4,"score":0.8914999961853027},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.8828999996185303},{"id":"https://openalex.org/C61156836","wikidata":"https://www.wikidata.org/wiki/Q494392","display_name":"Aldol reaction","level":3,"score":0.8616999983787537},{"id":"https://openalex.org/C2776235265","wikidata":"https://www.wikidata.org/wiki/Q18392052","display_name":"Fragment (logic)","level":2,"score":0.7688000202178955},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.7627999782562256},{"id":"https://openalex.org/C2781171952","wikidata":"https://www.wikidata.org/wiki/Q415812","display_name":"Polyol","level":3,"score":0.6852999925613403},{"id":"https://openalex.org/C18616679","wikidata":"https://www.wikidata.org/wiki/Q1027170","display_name":"Aldol condensation","level":3,"score":0.29829999804496765},{"id":"https://openalex.org/C180000673","wikidata":"https://www.wikidata.org/wiki/Q899268","display_name":"Isostere","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.2816999852657318},{"id":"https://openalex.org/C2991667435","wikidata":"https://www.wikidata.org/wiki/Q334951","display_name":"Carbon chain","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.257099986076355},{"id":"https://openalex.org/C2780407432","wikidata":"https://www.wikidata.org/wiki/Q103230","display_name":"Ether","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C35753019","wikidata":"https://www.wikidata.org/wiki/Q644785","display_name":"Total synthesis","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/chemle/upag211","doi":"https://doi.org/10.1093/chemle/upag211","is_oa":true,"landing_page_url":"https://doi.org/10.1093/chemle/upag211","pdf_url":"https://academic.oup.com/chemlett/advance-article-pdf/doi/10.1093/chemle/upag211/72615462/upag211.pdf","source":{"id":"https://openalex.org/S90825563","display_name":"Chemistry Letters","issn_l":"0366-7022","issn":["0366-7022","1348-0715"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry Letters","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/chemle/upag211","doi":"https://doi.org/10.1093/chemle/upag211","is_oa":true,"landing_page_url":"https://doi.org/10.1093/chemle/upag211","pdf_url":"https://academic.oup.com/chemlett/advance-article-pdf/doi/10.1093/chemle/upag211/72615462/upag211.pdf","source":{"id":"https://openalex.org/S90825563","display_name":"Chemistry Letters","issn_l":"0366-7022","issn":["0366-7022","1348-0715"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224744864.pdf","grobid_xml":"https://content.openalex.org/works/W7224744864.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7172295398","https://openalex.org/W1510320319","https://openalex.org/W2605941591","https://openalex.org/W4407108730","https://openalex.org/W4240684438","https://openalex.org/W2174940329","https://openalex.org/W2315478834","https://openalex.org/W2477242720","https://openalex.org/W2131431439","https://openalex.org/W1964783335"],"abstract_inverted_index":{"Abstract":[0],"Leptolyngbyalides":[1],"A\u2013C,":[2],"isolated":[3],"from":[4],"the":[5,31,53,60],"cyanobacterium":[6],"Leptolyngbya":[7],"sp.":[8],"PCC":[9],"7375,":[10],"are":[11,16],"complex":[12],"polyol":[13],"macrolides,":[14],"which":[15,36],"structurally":[17],"relevant":[18],"to":[19,51],"oscillariolide":[20],"and":[21,46],"phormidolides":[22],"A\u2013C.":[23],"We":[24],"describe":[25],"herein":[26],"a":[27,42,47],"stereoselective":[28],"synthesis":[29],"of":[30,34,59],"C16\u2013C27":[32],"fragment":[33],"leptolyngbyalides,":[35],"involved":[37],"an":[38],"Evans":[39],"syn-aldol":[40],"reaction,":[41,45],"Kiyooka":[43],"aldol":[44,49],"Mukaiyama":[48],"reaction":[50],"construct":[52],"carbon":[54],"chain":[55],"with":[56,63],"simultaneous":[57],"generation":[58],"stereogenic":[61],"centers":[62],"full":[64],"stereocontrol.":[65]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}