{"id":"https://openalex.org/W7224737750","doi":"https://doi.org/10.3390/macromol6040106","title":"Ficin-Modified Chitosan Hydrogels: In Vitro Hemocompatibility and Hemostatic Performance","display_name":"Ficin-Modified Chitosan Hydrogels: In Vitro Hemocompatibility and Hemostatic Performance","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224737750","doi":"https://doi.org/10.3390/macromol6040106"},"language":"en","primary_location":{"id":"doi:10.3390/macromol6040106","doi":"https://doi.org/10.3390/macromol6040106","is_oa":true,"landing_page_url":"https://doi.org/10.3390/macromol6040106","pdf_url":null,"source":{"id":"https://openalex.org/S4210218005","display_name":"Macromol\u2014A Journal of Macromolecular Research","issn_l":"2673-6209","issn":["2673-6209"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromol","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/macromol6040106","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030290568","display_name":"Maria S. Lavlinskaya","orcid":"https://orcid.org/0000-0001-9058-027X","observed_orcids":["https://orcid.org/0000-0001-9058-027X"]},"institutions":[{"id":"https://openalex.org/I4405278832","display_name":"Sevastopol State University","ror":"https://ror.org/00m88tr89","country_code":"UA","type":"education","lineage":["https://openalex.org/I4405278832"]},{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU","UA"],"is_corresponding":false,"raw_author_name":"Maria S. Lavlinskaya","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","Institute for Advanced Studies, Sevastopol State University, 33 Universitetskaya Street, Sevastopol 299053, Russia"],"raw_orcid":"https://orcid.org/0000-0001-9058-027X","affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","institution_ids":["https://openalex.org/I71305448"]},{"raw_affiliation_string":"Institute for Advanced Studies, Sevastopol State University, 33 Universitetskaya Street, Sevastopol 299053, Russia","institution_ids":["https://openalex.org/I4405278832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082270519","display_name":"\u0410. \u0412. \u0421\u043e\u0440\u043e\u043a\u0438\u043d","orcid":"https://orcid.org/0000-0001-5268-9557","observed_orcids":["https://orcid.org/0000-0001-5268-9557"]},"institutions":[{"id":"https://openalex.org/I4405278832","display_name":"Sevastopol State University","ror":"https://ror.org/00m88tr89","country_code":"UA","type":"education","lineage":["https://openalex.org/I4405278832"]},{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU","UA"],"is_corresponding":false,"raw_author_name":"Andrey V. Sorokin","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","Institute for Advanced Studies, Sevastopol State University, 33 Universitetskaya Street, Sevastopol 299053, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","institution_ids":["https://openalex.org/I71305448"]},{"raw_affiliation_string":"Institute for Advanced Studies, Sevastopol State University, 33 Universitetskaya Street, Sevastopol 299053, Russia","institution_ids":["https://openalex.org/I4405278832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037107676","display_name":"Yu. A. Redko","orcid":"https://orcid.org/0009-0008-8318-8833","observed_orcids":["https://orcid.org/0009-0008-8318-8833"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yulia A. Redko","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093077001","display_name":"Anastasia N. Dubovitskaya","orcid":"https://orcid.org/0009-0009-1450-9549","observed_orcids":["https://orcid.org/0009-0009-1450-9549"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anastasia N. Dubovitskaya","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia"],"raw_orcid":"https://orcid.org/0009-0009-1450-9549","affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107049298","display_name":"Victoria A. Koroleva","orcid":"https://orcid.org/0000-0002-3583-8466","observed_orcids":["https://orcid.org/0000-0002-3583-8466","https://orcid.org/0000-0001-8571-8959"]},"institutions":[{"id":"https://openalex.org/I2800247874","display_name":"Voronezh State Medical Academy named after N.N. Burdenko","ror":"https://ror.org/05kce7016","country_code":"RU","type":"education","lineage":["https://openalex.org/I2800247874"]},{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Victoria A. Koroleva","raw_affiliation_strings":["Biology Department, N.N. Burdenko Voronezh State Medical University, 10 Studencheskaya Street, Voronezh 394036, Russia","Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia"],"raw_orcid":"https://orcid.org/0000-0002-3583-8466","affiliations":[{"raw_affiliation_string":"Biology Department, N.N. Burdenko Voronezh State Medical University, 10 Studencheskaya Street, Voronezh 394036, Russia","institution_ids":["https://openalex.org/I2800247874"]},{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011863519","display_name":"\u0421\u0432\u0435\u0442\u043b\u0430\u043d\u0430 \u0421\u0435\u0440\u0433\u0435\u0435\u0432\u043d\u0430 \u0413\u043e\u043d\u0447\u0430\u0440\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-3381-2008","observed_orcids":["https://orcid.org/0000-0003-3381-2008"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Svetlana S. Goncharova","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046260487","display_name":"Svetlana M. Pankova","orcid":"https://orcid.org/0000-0003-1510-119X","observed_orcids":["https://orcid.org/0000-0003-1510-119X"]},"institutions":[{"id":"https://openalex.org/I2800247874","display_name":"Voronezh State Medical Academy named after N.N. Burdenko","ror":"https://ror.org/05kce7016","country_code":"RU","type":"education","lineage":["https://openalex.org/I2800247874"]},{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Svetlana M. Pankova","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","Normal Physiology Department, N.N. Burdenko Voronezh State Medical University, 10 Studencheskaya Street, Voronezh 394036, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","institution_ids":["https://openalex.org/I71305448"]},{"raw_affiliation_string":"Normal Physiology Department, N.N. Burdenko Voronezh State Medical University, 10 Studencheskaya Street, Voronezh 394036, Russia","institution_ids":["https://openalex.org/I2800247874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160193143","display_name":"Elena V. Belousova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena V. Belousova","raw_affiliation_strings":["Laboratory Diagnostics Department, Voronezh Regional Blood Center, 56 Transportnaya Street, Voronezh 394024, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Diagnostics Department, Voronezh Regional Blood Center, 56 Transportnaya Street, Voronezh 394024, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046821470","display_name":"M. G. Holyavka","orcid":"https://orcid.org/0000-0002-1390-4119","observed_orcids":["https://orcid.org/0000-0002-1390-4119"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Marina G. Holyavka","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia"],"raw_orcid":"https://orcid.org/0000-0002-1390-4119","affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107049402","display_name":"Valeriy G. Artyukhov","orcid":"https://orcid.org/0000-0002-8264-3784","observed_orcids":["https://orcid.org/0000-0002-8264-3784"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Valeriy G. Artyukhov","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia"],"raw_orcid":"https://orcid.org/0000-0002-8264-3784","affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, Voronezh 394018, Russia","institution_ids":["https://openalex.org/I71305448"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046821470"],"corresponding_institution_ids":["https://openalex.org/I71305448"],"apc_list":{"value":1000,"currency":"CHF","value_usd":1207},"apc_paid":{"value":1000,"currency":"CHF","value_usd":1207},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85304784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"4","first_page":"106","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan-hydrogel","display_name":"chitosan hydrogel","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ficin","display_name":"ficin","score":0.996999979019165},{"id":"https://openalex.org/keywords/hemocompatibility","display_name":"hemocompatibility","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hemostatic-materials","display_name":"hemostatic materials","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cross-linking","display_name":"crosslinking","score":0.6869999766349792},{"id":"https://openalex.org/keywords/protein-immobilization","display_name":"protein immobilization","score":0.7689999938011169},{"id":"https://openalex.org/keywords/lymphocyte-viability","display_name":"lymphocyte viability","score":0.9589999914169312},{"id":"https://openalex.org/keywords/1-4-butanediol-diglycidyl-ether","display_name":"1,4-butanediol diglycidyl ether","score":0.8999999761581421},{"id":"https://openalex.org/keywords/colloidal-stability","display_name":"colloidal stability","score":0.734000027179718},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.8543999791145325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7318999767303467},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7178999781608582},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.49230000376701355},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.47999998927116394},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.4794999957084656},{"id":"https://openalex.org/C2910835652","wikidata":"https://www.wikidata.org/wiki/Q1642182","display_name":"Hemostatic Agent","level":3,"score":0.4142000079154968},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.3700999915599823},{"id":"https://openalex.org/C2776436638","wikidata":"https://www.wikidata.org/wiki/Q2108794","display_name":"Diglycidyl ether","level":4,"score":0.3303999900817871},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.32190001010894775},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.3109000027179718},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.3089999854564667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3027999997138977},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.2964000105857849},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.2937999963760376},{"id":"https://openalex.org/C2777664302","wikidata":"https://www.wikidata.org/wiki/Q4463725","display_name":"Thromboelastography","level":3,"score":0.28999999165534973},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2718000113964081},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.25780001282691956}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/macromol6040106","doi":"https://doi.org/10.3390/macromol6040106","is_oa":true,"landing_page_url":"https://doi.org/10.3390/macromol6040106","pdf_url":null,"source":{"id":"https://openalex.org/S4210218005","display_name":"Macromol\u2014A Journal of Macromolecular Research","issn_l":"2673-6209","issn":["2673-6209"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromol","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/macromol6040106","doi":"https://doi.org/10.3390/macromol6040106","is_oa":true,"landing_page_url":"https://doi.org/10.3390/macromol6040106","pdf_url":null,"source":{"id":"https://openalex.org/S4210218005","display_name":"Macromol\u2014A Journal of Macromolecular Research","issn_l":"2673-6209","issn":["2673-6209"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromol","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1980629206","https://openalex.org/W1985917720","https://openalex.org/W1990097426","https://openalex.org/W2035625148","https://openalex.org/W2045779927","https://openalex.org/W2086775219","https://openalex.org/W2131877642","https://openalex.org/W2154385453","https://openalex.org/W2466244506","https://openalex.org/W2491061507","https://openalex.org/W2750170631","https://openalex.org/W2768994987","https://openalex.org/W2884780408","https://openalex.org/W2885551485","https://openalex.org/W2912806406","https://openalex.org/W2938028646","https://openalex.org/W2982103792","https://openalex.org/W3036743573","https://openalex.org/W3036877536","https://openalex.org/W3037214938","https://openalex.org/W3041238645","https://openalex.org/W3084226867","https://openalex.org/W3143891767","https://openalex.org/W4281658979","https://openalex.org/W4290759902","https://openalex.org/W4293769873","https://openalex.org/W4312223641","https://openalex.org/W4317568876","https://openalex.org/W4319159815","https://openalex.org/W4320918999","https://openalex.org/W4364375357","https://openalex.org/W4381157927","https://openalex.org/W4382068872","https://openalex.org/W4385756714","https://openalex.org/W4386419079","https://openalex.org/W4388538316","https://openalex.org/W4389509661","https://openalex.org/W4399035873","https://openalex.org/W4399465919","https://openalex.org/W4400872010","https://openalex.org/W4404115032","https://openalex.org/W4404802033","https://openalex.org/W4405062108","https://openalex.org/W4406276858","https://openalex.org/W4407378391","https://openalex.org/W4407703509","https://openalex.org/W4408019740","https://openalex.org/W4413409506","https://openalex.org/W4413843719","https://openalex.org/W4414290666","https://openalex.org/W7140309883","https://openalex.org/W7160518473","https://openalex.org/W7161577802"],"related_works":["https://openalex.org/W7224084321","https://openalex.org/W4319084072","https://openalex.org/W3042641664","https://openalex.org/W4388736486","https://openalex.org/W3104345393","https://openalex.org/W3203409061","https://openalex.org/W3143769231","https://openalex.org/W3027596647","https://openalex.org/W2554837679","https://openalex.org/W4404734454"],"abstract_inverted_index":{"Bleeding":[0],"remains":[1],"a":[2,22,112],"leading":[3],"cause":[4],"of":[5,26,42,52,58,166],"death":[6],"in":[7,40],"trauma":[8],"and":[9,30,49,60,72,86,95,98,105,131,145,170],"surgery,":[10],"which":[11],"drives":[12],"the":[13,47,164,167],"search":[14],"for":[15],"effective":[16],"local":[17],"hemostatic":[18,32,50,99,176],"materials.":[19,177],"Chitosan":[20],"is":[21],"promising":[23],"candidate":[24],"because":[25],"its":[27],"biocompatibility,":[28],"biodegradability,":[29],"intrinsic":[31],"activity,":[33],"yet":[34],"chitosan":[35,53],"hydrogels":[36,54,110,169],"remain":[37],"poorly":[38],"characterized":[39,73],"terms":[41],"hemocompatibility.":[43],"This":[44],"study":[45],"assessed":[46,102],"hemocompatibility":[48],"activity":[51,147],"with":[55,63,158],"varying":[56],"degrees":[57],"crosslinking":[59],"their":[61,121,171],"complexes":[62,173],"ficin.":[64],"Hydrogels":[65],"were":[66,101],"synthesized":[67],"using":[68],"1,4-butanediol":[69],"diglycidyl":[70],"ether":[71],"by":[74,93],"\u03b6-potential":[75],"measurements.":[76],"Hemocompatibility":[77],"was":[78,91],"evaluated":[79],"through":[80],"hemolysis,":[81],"hemoglobin":[82,127],"spectroscopy,":[83],"erythrocyte":[84,129],"cytoarchitecture,":[85,130],"lymphocyte":[87,132],"viability":[88,133],"assays.":[89],"Ficin":[90],"immobilized":[92],"adsorption":[94],"covalent":[96,149],"binding,":[97],"properties":[100],"via":[103],"swelling":[104],"kinetic":[106],"blood":[107,155],"coagulation.":[108],"The":[109],"showed":[111,134],"statistically":[113,136],"significant":[114,137],"inverse":[115],"dose-dependent":[116],"hemolytic":[117],"effect,":[118],"attributed":[119],"to":[120],"low":[122],"colloidal":[123],"stability.":[124],"In":[125],"contrast,":[126],"spectra,":[128],"no":[135],"changes.":[138],"Adsorption":[139],"immobilization":[140],"provided":[141],"higher":[142],"protein":[143],"loading":[144],"proteolytic":[146],"than":[148],"binding.":[150],"Ficin-containing":[151],"compositions":[152],"significantly":[153],"accelerated":[154],"coagulation":[156],"compared":[157],"pristine":[159],"hydrogels.":[160],"These":[161],"findings":[162],"confirm":[163],"potential":[165],"developed":[168],"ficin":[172],"as":[174],"hemocompatible":[175]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}