{"id":"https://openalex.org/W7224677614","doi":"https://doi.org/10.20944/preprints202610.2902.v1","title":"Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and C-Reactive Protein as Risk Markers in Thyroid Autoimmunity, Hypothyroidism, and Hyperthyroidism: A Cross-Sectional Study","display_name":"Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and C-Reactive Protein as Risk Markers in Thyroid Autoimmunity, Hypothyroidism, and Hyperthyroidism: A Cross-Sectional Study","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224677614","doi":"https://doi.org/10.20944/preprints202610.2902.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202610.2902.v1","doi":"https://doi.org/10.20944/preprints202610.2902.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.2902.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202610.2902.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091150762","display_name":"Hernando Vargas\u2010Uricoechea","orcid":"https://orcid.org/0000-0001-6573-7378","observed_orcids":["https://orcid.org/0000-0001-6573-7378"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hernando Vargas-Uricoechea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079464907","display_name":"Alejandro Castellanos-Pinedo","orcid":"https://orcid.org/0000-0002-8822-6770","observed_orcids":["https://orcid.org/0000-0002-8822-6770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alejandro Castellanos-Pinedo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061404440","display_name":"Hernando David Vargas-Sierra","orcid":"https://orcid.org/0000-0001-6342-1556","observed_orcids":["https://orcid.org/0000-0001-6342-1556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hernando D. Vargas-Sierra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060515594","display_name":"Ivonne Alejandra Meza-Cabrera","orcid":"https://orcid.org/0000-0003-0738-8530","observed_orcids":["https://orcid.org/0000-0003-0738-8530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivonne A. Meza-Cabrera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103090627","display_name":"Mar\u00eda Virginia Pinz\u00f3n Fern\u00e1ndez","orcid":"https://orcid.org/0000-0003-4701-551X","observed_orcids":["https://orcid.org/0000-0003-4701-551X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda V. Pinz\u00f3n-Fern\u00e1ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091150762"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.18960000574588776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9879999756813049},{"id":"https://openalex.org/keywords/platelet-to-lymphocyte-ratio","display_name":"platelet-to-lymphocyte ratio","score":1.0},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/thyroid-autoimmunity","display_name":"thyroid autoimmunity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":1.0},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/thyroid-autoantibodies","display_name":"thyroid autoantibodies","score":0.7630000114440918},{"id":"https://openalex.org/keywords/risk-indicators","display_name":"risk indicators","score":0.6129999756813049},{"id":"https://openalex.org/keywords/thyroid-disease","display_name":"thyroid dysfunction","score":0.5509999990463257},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8300999999046326},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.728600025177002},{"id":"https://openalex.org/C2994032529","wikidata":"https://www.wikidata.org/wiki/Q6673122","display_name":"Thyroid dysfunction","level":3,"score":0.6403999924659729},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6312000155448914},{"id":"https://openalex.org/C2780176905","wikidata":"https://www.wikidata.org/wiki/Q6673122","display_name":"Thyroid disease","level":3,"score":0.5397999882698059},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5325999855995178},{"id":"https://openalex.org/C50181227","wikidata":"https://www.wikidata.org/wiki/Q1943709","display_name":"Anti-thyroid autoantibodies","level":4,"score":0.5156000256538391},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.3716000020503998},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3686000108718872},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3628000020980835},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3571999967098236},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.3490000069141388},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.3474999964237213},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34450000524520874},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3244999945163727},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.28060001134872437},{"id":"https://openalex.org/C2778840127","wikidata":"https://www.wikidata.org/wiki/Q712838","display_name":"Thyroid function tests","level":3,"score":0.25270000100135803},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202610.2902.v1","doi":"https://doi.org/10.20944/preprints202610.2902.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.2902.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202610.2902.v1","doi":"https://doi.org/10.20944/preprints202610.2902.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.2902.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2511351614","https://openalex.org/W2893882901","https://openalex.org/W3027296703","https://openalex.org/W4387163384","https://openalex.org/W3029941333","https://openalex.org/W4411186185","https://openalex.org/W3023131688","https://openalex.org/W7171992457","https://openalex.org/W2951332454","https://openalex.org/W2420866049"],"abstract_inverted_index":{"Autoimmune":[0],"thyroid":[1,39,42,72,78,94,113,120,135,161,191,196,228],"disease":[2],"is":[3],"common,":[4],"and":[5,23,41,58,61,67,74,98,103,118,127,131,172,184],"low-grade":[6],"systemic":[7],"inflammation":[8],"has":[9],"been":[10],"proposed":[11],"as":[12,35],"a":[13,142,174,204],"contributing":[14],"mechanism.":[15],"The":[16,109],"neutrophil-to-lymphocyte":[17],"ratio":[18,21],"(NLR),":[19],"platelet-to-lymphocyte":[20],"(PLR),":[22],"C-reactive":[24],"protein":[25],"(CRP)":[26],"are":[27,186],"inexpen-sive,":[28],"widely":[29],"available":[30],"inflammatory":[31],"markers":[32,159,218],"whose":[33],"value":[34],"risk":[36,224],"indicators":[37],"for":[38,63,153,223],"autoimmunity":[40,73,136,192],"dysfunction":[43],"remains":[44],"incompletely":[45],"defined.":[46],"In":[47,123,181],"the":[48,157,178],"present":[49],"study,":[50],"we":[51],"aimed":[52],"to":[53],"evaluate":[54],"whether":[55],"NLR,":[56],"PLR,":[57],"CRP\u2014alone,":[59],"combined,":[60],"ad-justed":[62],"sociodemographic,":[64],"clinical,":[65],"habit-related,":[66],"laboratory":[68],"covariates\u2014are":[69],"associated":[70,133,169],"with":[71,75,91,134,170,209],"alterations":[76],"in":[77,85,213,226],"status.":[79],"A":[80],"cross-sectional":[81],"analysis":[82],"was":[83,116],"conduced":[84],"3,406":[86],"adults;":[87],"participants":[88],"were":[89,129],"measured":[90],"TSH,":[92],"FT4,":[93],"antibodies":[95],"(TRAb,":[96],"TPOAb,":[97],"TgAb),":[99],"complete":[100],"blood":[101],"count,":[102],"high-sensitivity":[104],"CRP":[105,140,166,202],"values,":[106],"inter":[107],"alia.":[108],"prevalence":[110],"of":[111,119,151,156,190,195],"any":[112],"status":[114,162,197],"alter-ation":[115,163],"52.2%,":[117],"autoimmunity,":[121],"39.2%.":[122],"multivariable":[124],"analysis,":[125],"NLR":[126,147,183],"PLR":[128,185],"strongly":[130],"independently":[132,168],"(both":[137],"p<":[138],"0.001);":[139],"showed":[141,173],"more":[143],"modest":[144,205],"association":[145,208],"(p=0.033).":[146],"achieved":[148],"an":[149],"AUC":[150],"0.752":[152],"autoimmunity.":[154],"None":[155],"three":[158],"discriminated":[160],"overall,":[164],"but":[165,193,206],"remained":[167],"it":[171],"stronger":[175],"effect":[176],"within":[177],"antibody-positive":[179,214],"subgroup.":[180],"conclusion,":[182],"robust,":[187],"independent":[188],"correlates":[189],"not":[194],"al-teration":[198],"per":[199],"se,":[200],"whereas":[201],"shows":[203],"consistent":[207],"both":[210],"out-comes,":[211],"particularly":[212],"patients.":[215],"These":[216],"low-cost":[217],"may":[219],"com-plement":[220],"antibody":[221],"testing":[222],"stratification":[225],"autoimmune":[227],"disease.":[229]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-30T00:00:00"}