{"id":"https://openalex.org/W7224676649","doi":"https://doi.org/10.1097/scs.0000000000013531","title":"What is the Success Rate of Alveolar Cleft Bone Grafting in Van der Woude and Popliteal Pterygium Syndrome?","display_name":"What is the Success Rate of Alveolar Cleft Bone Grafting in Van der Woude and Popliteal Pterygium Syndrome?","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224676649","doi":"https://doi.org/10.1097/scs.0000000000013531","pmid":"https://pubmed.ncbi.nlm.nih.gov/42954657"},"language":"en","primary_location":{"id":"doi:10.1097/scs.0000000000013531","doi":"https://doi.org/10.1097/scs.0000000000013531","is_oa":false,"landing_page_url":"https://doi.org/10.1097/scs.0000000000013531","pdf_url":null,"source":{"id":"https://openalex.org/S36642063","display_name":"Journal of Craniofacial Surgery","issn_l":"1049-2275","issn":["1049-2275","1536-3732"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Craniofacial Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062582195","display_name":"David L. Best","orcid":"https://orcid.org/0000-0003-0146-1477","observed_orcids":["https://orcid.org/0000-0003-0146-1477"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Best","raw_affiliation_strings":["Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Oral and Maxillofacial Surgery, Harvard School of Dental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Oral and Maxillofacial Surgery, Harvard School of Dental Medicine","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128213233","display_name":"Jared Cornejo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jared Cornejo","raw_affiliation_strings":["Clinical Research Assistant"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Assistant","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070230593","display_name":"Nathan Ramachandran","orcid":"https://orcid.org/0009-0004-9313-8056","observed_orcids":["https://orcid.org/0009-0004-9313-8056"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Ramachandran","raw_affiliation_strings":["Clinical Research Intern, Boston Children\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Intern, Boston Children\u2019s Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089702357","display_name":"Bonnie L. Padwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie L. Padwa","raw_affiliation_strings":["Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85104533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alveolar-bone-grafting","display_name":"alveolar bone grafting","score":0.8460000157356262},{"id":"https://openalex.org/keywords/van-der-woude-syndrome","display_name":"Van der Woude syndrome","score":0.9599999785423279},{"id":"https://openalex.org/keywords/popliteal-pterygium-syndrome","display_name":"popliteal pterygium syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cleft-lip-and-palate","display_name":"cleft lip and palate","score":0.8289999961853027},{"id":"https://openalex.org/keywords/irf6","display_name":"IRF6","score":0.7850000262260437},{"id":"https://openalex.org/keywords/grafting-success-rate","display_name":"grafting success","score":0.5889999866485596},{"id":"https://openalex.org/keywords/graft-failure","display_name":"graft failure","score":0.546999990940094},{"id":"https://openalex.org/keywords/bilateral-cleft","display_name":"bilateral cleft","score":0.7110000252723694},{"id":"https://openalex.org/keywords/fistula","display_name":"fistula","score":0.6579999923706055},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9860000014305115},{"id":"https://openalex.org/C2776337968","wikidata":"https://www.wikidata.org/wiki/Q3814234","display_name":"Bone grafting","level":2,"score":0.6341000199317932},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.633400022983551},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5062000155448914},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.5024999976158142},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.4424000084400177},{"id":"https://openalex.org/C2775937945","wikidata":"https://www.wikidata.org/wiki/Q222958","display_name":"Grafting","level":3,"score":0.40209999680519104},{"id":"https://openalex.org/C2983394010","wikidata":"https://www.wikidata.org/wiki/Q19885330","display_name":"Continuous variable","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C151279780","wikidata":"https://www.wikidata.org/wiki/Q143588","display_name":"Dental alveolus","level":2,"score":0.3495999872684479},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C2778266423","wikidata":"https://www.wikidata.org/wiki/Q17142318","display_name":"Pterygium","level":2,"score":0.32580000162124634},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.2800000011920929},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C2779561271","wikidata":"https://www.wikidata.org/wiki/Q7243102","display_name":"Primary bone","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C178195510","wikidata":"https://www.wikidata.org/wiki/Q17013040","display_name":"Facial symmetry","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C191093355","wikidata":"https://www.wikidata.org/wiki/Q9250577","display_name":"Exact test","level":2,"score":0.2621000111103058}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/scs.0000000000013531","doi":"https://doi.org/10.1097/scs.0000000000013531","is_oa":false,"landing_page_url":"https://doi.org/10.1097/scs.0000000000013531","pdf_url":null,"source":{"id":"https://openalex.org/S36642063","display_name":"Journal of Craniofacial Surgery","issn_l":"1049-2275","issn":["1049-2275","1536-3732"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Craniofacial Surgery","raw_type":"journal-article"},{"id":"pmid:42954657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42954657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of craniofacial surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W126487324","https://openalex.org/W1978131162","https://openalex.org/W2028689768","https://openalex.org/W2042570767","https://openalex.org/W2070705218","https://openalex.org/W2088287802","https://openalex.org/W2131036795","https://openalex.org/W2312435200","https://openalex.org/W2473089482","https://openalex.org/W2808957957","https://openalex.org/W2914442827","https://openalex.org/W2944784792","https://openalex.org/W2984197558","https://openalex.org/W3114644235","https://openalex.org/W4200412069","https://openalex.org/W4385294952","https://openalex.org/W4404495434"],"related_works":["https://openalex.org/W2097424633","https://openalex.org/W2120434581","https://openalex.org/W2053531256","https://openalex.org/W2009868346","https://openalex.org/W2030213870","https://openalex.org/W56449069","https://openalex.org/W1988927594","https://openalex.org/W1978131162","https://openalex.org/W2171149621","https://openalex.org/W4385294952"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patients":[1],"with":[2,5,28,73,141,146,208],"cleft":[3,8,79,213],"lip":[4],"or":[6],"without":[7],"palate":[9],"(CL\u00b1P)":[10],"and":[11,20,58,84,98,116,143,160,181],"IRF6-related":[12],"disorders":[13],"including":[14],"Van":[15],"der":[16],"Woude":[17],"syndrome":[18,23],"(VWS)":[19],"popliteal":[21],"pterygium":[22],"(PPS)":[24],"have":[25],"been":[26],"associated":[27],"worse":[29],"outcomes":[30,219],"following":[31,35],"primary":[32,100],"labiopalatoplasty.":[33],"Outcomes":[34],"secondary":[36,77],"alveolar":[37,51,78,104,216],"bone":[38,52,80,105,192,217],"grafting":[39,81,152],"remain":[40],"unknown.":[41],"The":[42,90,167],"purpose":[43],"of":[44,71,96,134,174],"this":[45],"study":[46,70],"was":[47,66,93,102,127,153],"to":[48,222],"determine":[49],"whether":[50],"graft":[53,106,193,218,238],"success":[54,194],"differs":[55],"between":[56,82,199],"VWS/PPS":[57,142,158,168,209,229],"nonsyndromic":[59,147,165,223],"CL\u00b1P":[60,74],"patients.":[61],"MATERIALS":[62],"AND":[63],"METHODS:":[64],"This":[65],"a":[67,94,171,233],"retrospective":[68],"cohort":[69],"subjects":[72,136],"who":[75],"underwent":[76],"1999":[83],"2025":[85],"at":[86,151],"Boston":[87],"Children's":[88],"Hospital.":[89],"predictor":[91],"variable":[92],"history":[95],"VWS/PPS,":[97],"the":[99,157,164],"outcome":[101],"radiographic":[103],"success.":[107],"Categorical":[108],"variables":[109,118],"were":[110,119,137,220],"analyzed":[111],"using":[112,121],"Fisher":[113],"exact":[114],"tests,":[115],"continuous":[117],"assessed":[120],"Welchs":[122],"2-sample":[123],"t":[124],"tests.":[125],"Significance":[126],"defined":[128],"as":[129],"P<0.05.":[130],"RESULTS:":[131],"A":[132],"total":[133],"720":[135],"included:":[138],"15":[139],"(2.1%)":[140],"705":[144],"(97.9%)":[145],"CL\u00b1P.":[148],"Mean":[149],"age":[150],"10.6\u00b12.8":[154],"years":[155,162],"in":[156,163],"group":[159,169],"10.2\u00b11.2":[161],"group.":[166],"had":[170,210],"greater":[172],"frequency":[173],"bilateral":[175],"clefts":[176],"(53.3%":[177],"versus":[178,186],"32.5%,":[179],"P=0.03)":[180],"preoperative":[182],"visible":[183],"fistulae":[184],"(60.9%":[185],"31.3%,":[187],"P=0.005).":[188],"Despite":[189],"these":[190],"differences,":[191],"rates":[195],"did":[196],"not":[197,231],"differ":[198],"groups":[200],"(VWS/PPS:":[201],"95.7%;":[202],"nonsyndromic:":[203],"95.4%,":[204],"P>0.999).":[205],"CONCLUSIONS:":[206],"Subjects":[207],"more":[211],"severe":[212],"phenotypes;":[214],"however,":[215],"comparable":[221],"subjects.":[224],"These":[225],"findings":[226],"suggest":[227],"that":[228],"may":[230],"be":[232],"significant":[234],"risk":[235],"factor":[236],"for":[237],"failure.":[239]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-30T00:00:00"}