{"id":"https://openalex.org/W7224672330","doi":"https://doi.org/10.64898/2026.10.27.761579","title":"Expanding the therapeutic window of bacteria for cancer therapy","display_name":"Expanding the therapeutic window of bacteria for cancer therapy","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224672330","doi":"https://doi.org/10.64898/2026.10.27.761579","pmid":"https://pubmed.ncbi.nlm.nih.gov/42990301","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13733996"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.27.761579","doi":"https://doi.org/10.64898/2026.10.27.761579","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.27.761579","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.27.761579.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.27.761579.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043964705","display_name":"Jongwon Im","orcid":"https://orcid.org/0000-0002-3660-2770","observed_orcids":["https://orcid.org/0000-0002-3660-2770"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jongwon Im","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-3660-2770","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088024858","display_name":"Meghna Komaranchath","orcid":"https://orcid.org/0009-0001-0329-7204","observed_orcids":["https://orcid.org/0009-0001-0329-7204"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghna Komaranchath","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092597256","display_name":"Sophia Xi Windemuth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia Windemuth","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003874359","display_name":"Hannah Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Kim","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082719869","display_name":"Xiaoyu Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyu Hu","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047453102","display_name":"Arjun Rohit Adapa","orcid":"https://orcid.org/0000-0003-0569-3718","observed_orcids":["https://orcid.org/0000-0003-0569-3718"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arjun Adapa","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147406856","display_name":"Myra Ashraf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myra Ashraf","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078356188","display_name":"Katherine A. Cummins","orcid":"https://orcid.org/0000-0002-3803-4818","observed_orcids":["https://orcid.org/0000-0002-3803-4818"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine A. Cummins","raw_affiliation_strings":["Penn Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Penn Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037506448","display_name":"Courtney Coker","orcid":"https://orcid.org/0000-0002-8779-133X","observed_orcids":["https://orcid.org/0000-0002-8779-133X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney Coker","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011204133","display_name":"YoungUk Jang","orcid":"https://orcid.org/0009-0008-1479-7432","observed_orcids":["https://orcid.org/0009-0008-1479-7432"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YoungUk Jang","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036793771","display_name":"\uc9c4\ud558\uc601","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hayoung Jin","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050822671","display_name":"Kam W. Leong","orcid":"https://orcid.org/0000-0002-8133-4955","observed_orcids":["https://orcid.org/0000-0002-8133-4955","https://orcid.org/0009-0007-6612-5542"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kam W. Leong","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA","Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160112741","display_name":"Ronny Drapkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronny Drapkin","raw_affiliation_strings":["Basser Center for BRCA, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA","Penn Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basser Center for BRCA, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Penn Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055848888","display_name":"Jeffrey N. Bruce","orcid":"https://orcid.org/0000-0002-6844-0286","observed_orcids":["https://orcid.org/0000-0002-6844-0286"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey N. Bruce","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046673359","display_name":"Peter Canoll","orcid":"https://orcid.org/0000-0002-7001-0226","observed_orcids":["https://orcid.org/0000-0002-7001-0226"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Canoll","raw_affiliation_strings":["Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050429519","display_name":"Tal Danino","orcid":"https://orcid.org/0000-0003-2713-7659","observed_orcids":["https://orcid.org/0000-0003-2713-7659"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tal Danino","raw_affiliation_strings":["Data Science Institute, Columbia University, New York, NY, USA","Department of Biomedical Engineering, Columbia University, New York, NY, USA","Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Science Institute, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5050429519"],"corresponding_institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetically-modified-bacteria","display_name":"engineered bacteria","score":0.8799999952316284},{"id":"https://openalex.org/keywords/bacterial-cancer-therapy","display_name":"bacterial cancer therapy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lipopolysaccharide-modification","display_name":"lipopolysaccharide modification","score":0.8619999885559082},{"id":"https://openalex.org/keywords/immunogenicity-reduction","display_name":"immunogenicity reduction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8669999837875366},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7990000247955322},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/cytokine-delivery","display_name":"cytokine delivery","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6399999856948853},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6044999957084656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5547999739646912},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5206999778747559},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.49219998717308044},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4846999943256378},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46790000796318054},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4634999930858612},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4162999987602234},{"id":"https://openalex.org/C46622094","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic window","level":2,"score":0.3822000026702881},{"id":"https://openalex.org/C134066672","wikidata":"https://www.wikidata.org/wiki/Q1424639","display_name":"Payload (computing)","level":3,"score":0.36079999804496765},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.3562000095844269},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.3547999858856201},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3483999967575073},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3222000002861023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2992999851703644},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.29649999737739563},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.275299996137619},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26930001378059387},{"id":"https://openalex.org/C144464004","wikidata":"https://www.wikidata.org/wiki/Q3077338","display_name":"Lipid A","level":3,"score":0.2605000138282776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2583000063896179}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.27.761579","doi":"https://doi.org/10.64898/2026.10.27.761579","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.27.761579","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.27.761579.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42990301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42990301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13733996","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13733996/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.10.27.761579","doi":"https://doi.org/10.64898/2026.10.27.761579","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.27.761579","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.27.761579.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2587019979","display_name":null,"funder_award_id":"DGE-2036197","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3412795219","display_name":null,"funder_award_id":"CRI 3446","funder_id":"https://openalex.org/F4320306155","funder_display_name":"Cancer Research Institute"},{"id":"https://openalex.org/G5591456886","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"2036197","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000857426","display_name":"Clinical and Translational Science Award","funder_award_id":"UL1TR001873","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F1841689044","display_name":"Herbert Irving Comprehensive Cancer Center, Columbia University","ror":"https://ror.org/051kc1939"},{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320311939","display_name":"Pershing Square Foundation","ror":"https://ror.org/04tce9s05"},{"id":"https://openalex.org/F4320331782","display_name":"Charlie Teo Foundation","ror":"https://ror.org/048zxq081"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224672330.pdf","grobid_xml":"https://content.openalex.org/works/W7224672330.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1979507175","https://openalex.org/W1990520432","https://openalex.org/W2021008733","https://openalex.org/W2047360542","https://openalex.org/W2053668604","https://openalex.org/W2092235636","https://openalex.org/W2120263648","https://openalex.org/W2124662953","https://openalex.org/W2142954961","https://openalex.org/W2150565980","https://openalex.org/W2155264370","https://openalex.org/W2162114403","https://openalex.org/W2330245166","https://openalex.org/W2480697384","https://openalex.org/W2604960328","https://openalex.org/W2613939563","https://openalex.org/W2766903152","https://openalex.org/W2808456923","https://openalex.org/W2886894534","https://openalex.org/W2951096514","https://openalex.org/W2980271388","https://openalex.org/W3016248076","https://openalex.org/W3030942202","https://openalex.org/W3079191246","https://openalex.org/W3206763752","https://openalex.org/W4210628575","https://openalex.org/W4280534378","https://openalex.org/W4309334544","https://openalex.org/W4362458901","https://openalex.org/W4365457270","https://openalex.org/W4375956143","https://openalex.org/W4381989239","https://openalex.org/W4385410034","https://openalex.org/W4385493546","https://openalex.org/W4401047042","https://openalex.org/W4403638656","https://openalex.org/W4409069246","https://openalex.org/W7161109333"],"related_works":["https://openalex.org/W7214122829","https://openalex.org/W7171781015","https://openalex.org/W3098225580","https://openalex.org/W4394753910","https://openalex.org/W2131722151","https://openalex.org/W4404338244","https://openalex.org/W4390847947","https://openalex.org/W7165786148","https://openalex.org/W7170147618","https://openalex.org/W7220861469"],"abstract_inverted_index":{"Engineered":[0],"bacteria":[1],"enable":[2],"self-amplifying":[3],"therapeutic":[4,100],"delivery":[5,104],"and":[6,16,34,58,88,101,133],"immune":[7],"activation,":[8],"yet":[9],"these":[10,26,124],"same":[11],"features":[12],"drive":[13],"systemic":[14],"toxicity":[15],"off-target":[17],"growth.":[18],"Here,":[19],"we":[20,39],"create":[21],"a":[22,54,74,98,120,127],"\"tumorobe\"":[23],"that":[24,43],"overcomes":[25],"limitations":[27],"by":[28,77],"integrating":[29],"reduced":[30],"immunogenicity,":[31],"tumour-restricted":[32],"growth,":[33],"enhanced":[35],"payload":[36,61],"release.":[37],"Specifically,":[38],"identify":[40],"lipopolysaccharide":[41],"modifications":[42],"reduce":[44],"immunogenicity":[45],"while":[46],"preserving":[47],"fitness,":[48],"restrict":[49],"growth":[50],"to":[51,79,112],"tumours":[52,116],"using":[53],"hypoxia-lactate":[55],"\"AND\"":[56],"gate,":[57],"enhance":[59],"extracellular":[60],"release":[62],"via":[63],"lipoprotein":[64],"deletion.":[65],"This":[66],"strain":[67,91],"expands":[68],"the":[69,90],"maximum":[70],"tolerated":[71],"dose":[72],"in":[73,110],"route-dependent":[75],"manner":[76],"up":[78,111],"1,000-fold.":[80],"Across":[81],"multiple":[82],"murine":[83],"models,":[84],"including":[85],"colorectal":[86,115],"cancer":[87,136],"glioblastoma,":[89],"drives":[92],"robust":[93],"antitumour":[94],"efficacy":[95],"as":[96],"both":[97],"standalone":[99],"an":[102],"immunotherapeutic":[103],"platform,":[105],"achieving":[106],"durable":[107],"complete":[108],"responses":[109],"75%":[113],"of":[114],"when":[117],"armed":[118],"with":[119],"cytokine":[121],"payload.":[122],"Together,":[123],"results":[125],"establish":[126],"broadly":[128],"applicable":[129],"platform":[130],"for":[131],"safe":[132],"effective":[134],"bacterial":[135],"therapy.":[137]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-10-30T00:00:00"}