{"id":"https://openalex.org/W7224669706","doi":"https://doi.org/10.1007/s10616-026-01095-4","title":"Chitosan nanoparticles functionalised with protocatechuic acid improve colon-targeted pazopanib delivery with multi-pathway therapeutic regulation and pharmacokinetic optimisation in colorectal cancer","display_name":"Chitosan nanoparticles functionalised with protocatechuic acid improve colon-targeted pazopanib delivery with multi-pathway therapeutic regulation and pharmacokinetic optimisation in colorectal cancer","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224669706","doi":"https://doi.org/10.1007/s10616-026-01095-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/42964559","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13719970"},"language":"en","primary_location":{"id":"doi:10.1007/s10616-026-01095-4","doi":"https://doi.org/10.1007/s10616-026-01095-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10616-026-01095-4","pdf_url":null,"source":{"id":"https://openalex.org/S78433294","display_name":"Cytotechnology","issn_l":"0920-9069","issn":["0920-9069","1573-0778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13719970/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033386199","display_name":"Tanvi Maheshwari","orcid":"https://orcid.org/0000-0002-0805-2951","observed_orcids":["https://orcid.org/0000-0002-0805-2951","https://orcid.org/0009-0000-9647-1330"]},"institutions":[{"id":"https://openalex.org/I226983648","display_name":"Narsee Monjee Institute of Management Studies","ror":"https://ror.org/04qksbm30","country_code":"IN","type":"education","lineage":["https://openalex.org/I226983648"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tanvi Maheshwari","raw_affiliation_strings":["School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-Be University, Shirpur, Maharashtra 425405 India"],"raw_orcid":"https://orcid.org/0009-0000-9647-1330","affiliations":[{"raw_affiliation_string":"School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-Be University, Shirpur, Maharashtra 425405 India","institution_ids":["https://openalex.org/I226983648"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078931606","display_name":"Sankha Bhattacharya","orcid":"https://orcid.org/0000-0002-0771-9582","observed_orcids":["https://orcid.org/0000-0002-0771-9582"]},"institutions":[{"id":"https://openalex.org/I226983648","display_name":"Narsee Monjee Institute of Management Studies","ror":"https://ror.org/04qksbm30","country_code":"IN","type":"education","lineage":["https://openalex.org/I226983648"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sankha Bhattacharya","raw_affiliation_strings":["School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-Be University, Shirpur, Maharashtra 425405 India"],"raw_orcid":"https://orcid.org/0000-0002-0771-9582","affiliations":[{"raw_affiliation_string":"School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-Be University, Shirpur, Maharashtra 425405 India","institution_ids":["https://openalex.org/I226983648"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078931606"],"corresponding_institution_ids":["https://openalex.org/I226983648"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66260522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"6","first_page":"223","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6776999831199646,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6776999831199646,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.3140000104904175,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pazopanib","display_name":"pazopanib","score":0.9509999752044678},{"id":"https://openalex.org/keywords/chitosan-nanoparticles","display_name":"chitosan nanoparticles","score":0.9340000152587891},{"id":"https://openalex.org/keywords/protocatechuic-acid","display_name":"protocatechuic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/colon-specific-drug-delivery","display_name":"colon-targeted drug delivery","score":0.9829999804496765},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nanoparticle-functionalization","display_name":"nanoparticle functionalization","score":0.6790000200271606},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hemocompatibility","display_name":"hemocompatibility","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7149999737739563},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5419999957084656},{"id":"https://openalex.org/keywords/glutathione-peroxidase-1","display_name":"glutathione peroxidase 1","score":0.7670000195503235},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9010000228881836},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.6079999804496765},{"id":"https://openalex.org/keywords/morris-water-maze","display_name":"Morris water maze","score":0.6790000200271606},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2778439243","wikidata":"https://www.wikidata.org/wiki/Q7157043","display_name":"Pazopanib","level":4,"score":0.7748000025749207},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7275999784469604},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.703000009059906},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6266999840736389},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5516999959945679},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5397999882698059},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.44589999318122864},{"id":"https://openalex.org/C2781203734","wikidata":"https://www.wikidata.org/wiki/Q418599","display_name":"Protocatechuic acid","level":3,"score":0.4320000112056732},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4147999882698059},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.38339999318122864},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.3553999960422516},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.3431999981403351},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3172999918460846},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.3125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2987000048160553},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.2915000021457672},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.288100004196167},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.2522999942302704}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s10616-026-01095-4","doi":"https://doi.org/10.1007/s10616-026-01095-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10616-026-01095-4","pdf_url":null,"source":{"id":"https://openalex.org/S78433294","display_name":"Cytotechnology","issn_l":"0920-9069","issn":["0920-9069","1573-0778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotechnology","raw_type":"journal-article"},{"id":"pmid:42964559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42964559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13719970","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13719970/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotechnology","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13719970","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13719970/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotechnology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W1637602982","https://openalex.org/W1994580609","https://openalex.org/W2063909696","https://openalex.org/W2074066498","https://openalex.org/W2097147939","https://openalex.org/W2110651692","https://openalex.org/W2124404906","https://openalex.org/W2134904052","https://openalex.org/W2137268781","https://openalex.org/W2745514721","https://openalex.org/W2980264530","https://openalex.org/W2981928697","https://openalex.org/W3002826868","https://openalex.org/W3006658137","https://openalex.org/W3008581288","https://openalex.org/W3033969339","https://openalex.org/W3093333577","https://openalex.org/W3154302066","https://openalex.org/W3190569427","https://openalex.org/W4233435953","https://openalex.org/W4290999205","https://openalex.org/W4297473813","https://openalex.org/W4306403179","https://openalex.org/W4307511331","https://openalex.org/W4318066663","https://openalex.org/W4324377995","https://openalex.org/W4378516306","https://openalex.org/W4389051205","https://openalex.org/W4389737916","https://openalex.org/W4391656695","https://openalex.org/W4399653159","https://openalex.org/W4403405362","https://openalex.org/W4403452698","https://openalex.org/W4403778168","https://openalex.org/W4404862124","https://openalex.org/W4405420441","https://openalex.org/W4405583845","https://openalex.org/W4406083875","https://openalex.org/W4407143176","https://openalex.org/W4407788705","https://openalex.org/W4408118988","https://openalex.org/W4408541357","https://openalex.org/W4409026354","https://openalex.org/W4409169077","https://openalex.org/W4409591646","https://openalex.org/W4409802564","https://openalex.org/W4409888935","https://openalex.org/W4410114736","https://openalex.org/W4410246210","https://openalex.org/W4410415044","https://openalex.org/W4410477777","https://openalex.org/W4411362565","https://openalex.org/W4412519984","https://openalex.org/W4412522714","https://openalex.org/W4412738747","https://openalex.org/W4412814052","https://openalex.org/W4413144018","https://openalex.org/W4413323919","https://openalex.org/W4413739168","https://openalex.org/W4413991164","https://openalex.org/W4414162683","https://openalex.org/W4415213420","https://openalex.org/W4415279331","https://openalex.org/W4415984877","https://openalex.org/W4416124481","https://openalex.org/W4416271995","https://openalex.org/W4416944425","https://openalex.org/W7117370897","https://openalex.org/W7122640677","https://openalex.org/W7123860153","https://openalex.org/W7125130109","https://openalex.org/W7125613664","https://openalex.org/W7125798065","https://openalex.org/W7127584471","https://openalex.org/W7128060488","https://openalex.org/W7128304744","https://openalex.org/W7128925584","https://openalex.org/W7129497747","https://openalex.org/W7129511643","https://openalex.org/W7130472856","https://openalex.org/W7133186571","https://openalex.org/W7133530032","https://openalex.org/W7133543951","https://openalex.org/W7134130657","https://openalex.org/W7135060032","https://openalex.org/W7138910747","https://openalex.org/W7140096785","https://openalex.org/W7151036232","https://openalex.org/W7153639933","https://openalex.org/W7154591711","https://openalex.org/W7154630415","https://openalex.org/W7155877006","https://openalex.org/W7160558199","https://openalex.org/W7160692124","https://openalex.org/W7161380194","https://openalex.org/W7161782953","https://openalex.org/W7162073793","https://openalex.org/W7162257372","https://openalex.org/W7163017326","https://openalex.org/W7163226236","https://openalex.org/W7163911009","https://openalex.org/W7163915933","https://openalex.org/W7166707218","https://openalex.org/W7170143035"],"related_works":["https://openalex.org/W4413289800","https://openalex.org/W7126047004","https://openalex.org/W2988805773","https://openalex.org/W4365515525","https://openalex.org/W2914889799","https://openalex.org/W7159591387","https://openalex.org/W7161907231","https://openalex.org/W4387745697","https://openalex.org/W4415467654","https://openalex.org/W2738661576"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-30T00:00:00"}
