{"id":"https://openalex.org/W7224669691","doi":"https://doi.org/10.64898/2026.10.23.761466","title":"AN INTEGRATED HEART-ON-A-CHIP NAM RESOLVES DISTINCT CLINICAL PHENOTYPES OF MYOCARDIAL ISCHEMIA-REPERFUSION INJURY","display_name":"AN INTEGRATED HEART-ON-A-CHIP NAM RESOLVES DISTINCT CLINICAL PHENOTYPES OF MYOCARDIAL ISCHEMIA-REPERFUSION INJURY","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224669691","doi":"https://doi.org/10.64898/2026.10.23.761466"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.23.761466","doi":"https://doi.org/10.64898/2026.10.23.761466","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.23.761466","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.23.761466.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.23.761466.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064903663","display_name":"Khanh Tran","orcid":"https://orcid.org/0000-0001-5396-8806","observed_orcids":["https://orcid.org/0000-0001-5396-8806"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khanh Tran","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, Irvine, California, USA","Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160124741","display_name":"Ashley Roselynn Vincent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Roselynn Vincent","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, Irvine, California, USA","Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160090774","display_name":"Caroline S Whitmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Whitmer","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, Irvine, California, USA","Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031191572","display_name":"Rami Khayat","orcid":"https://orcid.org/0000-0003-4240-5754","observed_orcids":["https://orcid.org/0000-0003-4240-5754"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rami N. Khayat","raw_affiliation_strings":["Department of Medicine, University of California, Irvine, California, USA","Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Penn State College of Medicine and Milton S. Hershey Medical, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Penn State College of Medicine and Milton S. Hershey Medical, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039275570","display_name":"Anna Grosberg","orcid":"https://orcid.org/0000-0002-8878-0843","observed_orcids":["https://orcid.org/0000-0002-8878-0843"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anna Grosberg","raw_affiliation_strings":["Center for Complex Biological Systems, University of California, Irvine, California, USA","Department of Biomedical Engineering, University of California, Irvine, California, USA","Department of Chemical and Biomolecular Engineering, University of California, Irvine, California, USA","Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, California, USA","Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-8878-0843","affiliations":[{"raw_affiliation_string":"Center for Complex Biological Systems, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039275570"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-on-a-chip","display_name":"heart-on-a-chip","score":0.9120000004768372},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiomyocyte-injury","display_name":"cardiomyocyte injury","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cardiomyocyte-viability","display_name":"cardiomyocyte viability","score":0.796999990940094},{"id":"https://openalex.org/keywords/neonatal-rat-ventricular-myocytes","display_name":"neonatal rat ventricular myocytes","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.828000009059906},{"id":"https://openalex.org/keywords/new-approach-methodologies","display_name":"new approach methodologies","score":0.5879999995231628},{"id":"https://openalex.org/keywords/in-vitro-disease-model","display_name":"in vitro disease model","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.6931999921798706},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6546000242233276},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.6057000160217285},{"id":"https://openalex.org/C115725540","wikidata":"https://www.wikidata.org/wiki/Q7846263","display_name":"Troponin I","level":3,"score":0.5967000126838684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5740000009536743},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5674999952316284},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5160999894142151},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5108000040054321},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5076000094413757},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.5056999921798706},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.46389999985694885},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.43309998512268066},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4307999908924103},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.4120999872684479},{"id":"https://openalex.org/C144469398","wikidata":"https://www.wikidata.org/wiki/Q24785650","display_name":"Troponin T","level":3,"score":0.362199991941452},{"id":"https://openalex.org/C2993711000","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell injury","level":3,"score":0.33239999413490295},{"id":"https://openalex.org/C189809214","wikidata":"https://www.wikidata.org/wiki/Q829522","display_name":"Beat (acoustics)","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.3050000071525574},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2784999907016754}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.23.761466","doi":"https://doi.org/10.64898/2026.10.23.761466","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.23.761466","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.23.761466.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.23.761466","doi":"https://doi.org/10.64898/2026.10.23.761466","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.23.761466","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.23.761466.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224669691.pdf","grobid_xml":"https://content.openalex.org/works/W7224669691.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W96597366","https://openalex.org/W1547005412","https://openalex.org/W1592652318","https://openalex.org/W1934994215","https://openalex.org/W1983102904","https://openalex.org/W1986968300","https://openalex.org/W1990224341","https://openalex.org/W1992470234","https://openalex.org/W1997441943","https://openalex.org/W2003203834","https://openalex.org/W2031550744","https://openalex.org/W2042476232","https://openalex.org/W2043355876","https://openalex.org/W2051395985","https://openalex.org/W2057172700","https://openalex.org/W2067024845","https://openalex.org/W2098058049","https://openalex.org/W2098842126","https://openalex.org/W2101274334","https://openalex.org/W2102557050","https://openalex.org/W2110648972","https://openalex.org/W2111151040","https://openalex.org/W2117397508","https://openalex.org/W2117571600","https://openalex.org/W2122872682","https://openalex.org/W2126409739","https://openalex.org/W2126993614","https://openalex.org/W2130150543","https://openalex.org/W2130271956","https://openalex.org/W2139639976","https://openalex.org/W2147750240","https://openalex.org/W2156677237","https://openalex.org/W2200357463","https://openalex.org/W2334701308","https://openalex.org/W2340877636","https://openalex.org/W2519529333","https://openalex.org/W2547458640","https://openalex.org/W2594606767","https://openalex.org/W2599761051","https://openalex.org/W2603649650","https://openalex.org/W2609319132","https://openalex.org/W2743016615","https://openalex.org/W2767629044","https://openalex.org/W2768390797","https://openalex.org/W2779110724","https://openalex.org/W2782933193","https://openalex.org/W2802020264","https://openalex.org/W2908439034","https://openalex.org/W2971692789","https://openalex.org/W2972010323","https://openalex.org/W3010337032","https://openalex.org/W3015284544","https://openalex.org/W3086702296","https://openalex.org/W3093214739","https://openalex.org/W3111521801","https://openalex.org/W3111583227","https://openalex.org/W3127581834","https://openalex.org/W3202877573","https://openalex.org/W3214329902","https://openalex.org/W4200533588","https://openalex.org/W4238277289","https://openalex.org/W4281685300","https://openalex.org/W4283018145","https://openalex.org/W4308361273","https://openalex.org/W4386233889","https://openalex.org/W4388968044","https://openalex.org/W4396546645","https://openalex.org/W4396919618","https://openalex.org/W4403305130","https://openalex.org/W4404414050","https://openalex.org/W4406714960","https://openalex.org/W4407752799","https://openalex.org/W4410002658","https://openalex.org/W4414016843","https://openalex.org/W4417386090","https://openalex.org/W7128591349","https://openalex.org/W7128701647","https://openalex.org/W7163761659","https://openalex.org/W7168137774"],"related_works":["https://openalex.org/W4386247774","https://openalex.org/W4396240285","https://openalex.org/W3172209504","https://openalex.org/W2762510387","https://openalex.org/W2143314128","https://openalex.org/W7223709628","https://openalex.org/W7135050668","https://openalex.org/W2315601829","https://openalex.org/W3184495862","https://openalex.org/W7213267904"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Reperfusion":[2,179],"is":[3],"required":[4],"for":[5,265],"myocardial":[6],"salvage":[7],"yet":[8,191],"itself":[9],"injures":[10],"the":[11,50,136,272],"heart,":[12],"and":[13,46,99,118,129,140,167,186,239],"cardioprotective":[14,269],"interventions":[15,30],"that":[16,242],"reduce":[17],"infarct":[18,36],"size":[19,37],"experimentally":[20],"have":[21],"repeatedly":[22],"failed":[23],"to":[24,93,255],"improve":[25],"outcomes":[26],"in":[27,49,54],"patients.":[28],"These":[29],"are":[31],"evaluated":[32],"against":[33,271],"viability":[34,163],"or":[35],"alone,":[38],"whereas":[39,214],"ischemia-reperfusion":[40],"(I/R)":[41],"injury":[42,114,241,274],"produces":[43],"structural,":[44,237],"biochemical,":[45,238],"contractile":[47,127,169,240],"dysfunction":[48],"same":[51,137],"tissue.":[52],"No":[53],"vitro":[55],"new":[56],"approach":[57],"methodology":[58],"(NAM),":[59],"however,":[60],"resolves":[61],"all":[62],"three":[63],"within":[64,72],"one":[65],"system.":[66],"Methods":[67],"A":[68],"NAM":[69,235],"was":[70,77,109,177,193],"created":[71],"a":[73,203],"heart-on-a-chip":[74,234],"platform,":[75],"which":[76],"constructed":[78],"by":[79,102,111,115],"culturing":[80],"neonatal":[81],"rat":[82],"ventricular":[83],"myocytes":[84],"(NRVMs)":[85],"on":[86,135,202],"muscular":[87],"thin":[88],"films.":[89],"Cardiomyocytes":[90],"were":[91,133,153],"subjected":[92],"normoxia,":[94],"2":[95,103],"hours":[96,104],"of":[97,105,259,268],"ischemia,":[98,146,196],"ischemia":[100],"followed":[101],"reperfusion.":[106],"Sarcomeric":[107],"architecture":[108],"quantified":[110],"immunofluorescence,":[112],"cardiomyocyte":[113,208],"LIVE/DEAD":[116],"staining":[117],"cardiac":[119],"troponin":[120,165,187],"I":[121],"release":[122,188],"into":[123],"conditioned":[124],"media,":[125],"while":[126,150,173],"stress":[128,170,211,216,221],"spontaneous":[130,174],"beat":[131,175],"frequency":[132,176,227],"recorded":[134],"films":[138],"before":[139],"after":[141],"each":[142],"condition.":[143],"Results":[144],"Under":[145],"z-line":[147],"density":[148],"decreased":[149],"architectural":[151],"metrics":[152],"preserved,":[154],"indicating":[155],"cell":[156],"loss":[157],"rather":[158],"than":[159],"sarcomere":[160],"disorganization.":[161],"Furthermore,":[162],"decreased,":[164],"elevated,":[166],"every":[168,198],"component":[171],"declined,":[172],"unchanged.":[178],"fractured":[180],"this":[181,263],"uniform":[182],"depression.":[183],"Cell":[184],"death":[185],"increased":[189,228],"further,":[190],"structure":[192],"unchanged":[194],"from":[195,248],"so":[197],"functional":[199],"change":[200],"occurred":[201],"depleted":[204],"but":[205],"architecturally":[206],"intact":[207],"population.":[209],"Systolic":[210],"recovered":[212],"partially,":[213],"diastolic":[215],"exceeded":[217],"baseline,":[218],"leaving":[219],"active":[220],"suppressed":[222],"despite":[223],"oxygen":[224],"recovery.":[225],"Beat":[226],"with":[229],"pronounced":[230],"variability.":[231],"Conclusions":[232],"This":[233],"resolved":[236],"global":[243],"indices":[244],"conflate,":[245],"distinguishing":[246],"ischemic":[247,260],"reperfusion":[249],"pathophysiology.":[250],"Interestingly,":[251],"individual":[252],"readouts":[253],"corresponded":[254],"distinct":[256],"clinical":[257],"syndromes":[258],"injury,":[261],"positioning":[262],"platform":[264],"future":[266],"testing":[267],"candidates":[270],"full":[273],"phenotype.":[275]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-30T00:00:00"}