{"id":"https://openalex.org/W7224656248","doi":"https://doi.org/10.3390/nu18213573","title":"Protective Effects of Achyranthes bidentata Root Extract Against Benign Prostatic Hyperplasia Induced by Testosterone Propionate in Rats","display_name":"Protective Effects of Achyranthes bidentata Root Extract Against Benign Prostatic Hyperplasia Induced by Testosterone Propionate in Rats","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224656248","doi":"https://doi.org/10.3390/nu18213573"},"language":"en","primary_location":{"id":"doi:10.3390/nu18213573","doi":"https://doi.org/10.3390/nu18213573","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18213573","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/nu18213573","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160120121","display_name":"Han Kyul Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Han Kyul Kim","raw_affiliation_strings":["Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103541925","display_name":"Phuong Van Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Phuong Tran","raw_affiliation_strings":["Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160092478","display_name":"Sunmin Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sunmin Kim","raw_affiliation_strings":["Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071315882","display_name":"Jungbin Song","orcid":"https://orcid.org/0000-0002-3587-9276","observed_orcids":["https://orcid.org/0000-0002-3587-9276"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jungbin Song","raw_affiliation_strings":["Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-3587-9276","affiliations":[{"raw_affiliation_string":"Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071315882"],"corresponding_institution_ids":["https://openalex.org/I35928602"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87674526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"21","first_page":"3573","last_page":"3573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/achyranthes-bidentata","display_name":"Achyranthes bidentata","score":0.9549999833106995},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/testosterone-propionate","display_name":"testosterone propionate","score":0.8489999771118164},{"id":"https://openalex.org/keywords/lower-urinary-tract-symptoms","display_name":"lower urinary tract symptoms","score":0.7799999713897705},{"id":"https://openalex.org/keywords/prostate-enlargement","display_name":"prostate enlargement","score":0.6830000281333923},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.9520000219345093},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/finasteride","display_name":"finasteride","score":0.7509999871253967},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.5389999747276306},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.546999990940094},{"id":"https://openalex.org/keywords/ethanolic-root-extract","display_name":"ethanolic root extract","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2781115071","wikidata":"https://www.wikidata.org/wiki/Q10354588","display_name":"Testosterone propionate","level":4,"score":0.9083999991416931},{"id":"https://openalex.org/C2775874879","wikidata":"https://www.wikidata.org/wiki/Q424167","display_name":"Finasteride","level":4,"score":0.8323000073432922},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.7182000279426575},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.7150999903678894},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.684499979019165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.675000011920929},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6448000073432922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6317999958992004},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.544700026512146},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.5291000008583069},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.4779999852180481},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.4068000018596649},{"id":"https://openalex.org/C2779256933","wikidata":"https://www.wikidata.org/wiki/Q58929","display_name":"Castration","level":3,"score":0.3991999924182892},{"id":"https://openalex.org/C2776390293","wikidata":"https://www.wikidata.org/wiki/Q2035485","display_name":"Subcutaneous injection","level":2,"score":0.35109999775886536},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.323199987411499},{"id":"https://openalex.org/C2779322244","wikidata":"https://www.wikidata.org/wiki/Q574820","display_name":"Antiandrogen","level":4,"score":0.3222000002861023},{"id":"https://openalex.org/C2781440318","wikidata":"https://www.wikidata.org/wiki/Q1806228","display_name":"Orchiectomy","level":2,"score":0.3181999921798706},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C2780435053","wikidata":"https://www.wikidata.org/wiki/Q506659","display_name":"Benign prostatic hyperplasia (BPH)","level":4,"score":0.27320000529289246},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.2678999900817871},{"id":"https://openalex.org/C2779665388","wikidata":"https://www.wikidata.org/wiki/Q5959159","display_name":"Androgen deficiency","level":4,"score":0.26420000195503235},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25279998779296875}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/nu18213573","doi":"https://doi.org/10.3390/nu18213573","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18213573","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/nu18213573","doi":"https://doi.org/10.3390/nu18213573","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18213573","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W198934061","https://openalex.org/W1969736321","https://openalex.org/W1994503497","https://openalex.org/W1997064427","https://openalex.org/W2006457199","https://openalex.org/W2016005125","https://openalex.org/W2020473971","https://openalex.org/W2022960244","https://openalex.org/W2028103181","https://openalex.org/W2038261670","https://openalex.org/W2055654542","https://openalex.org/W2075665929","https://openalex.org/W2082801640","https://openalex.org/W2094475675","https://openalex.org/W2101665942","https://openalex.org/W2131899125","https://openalex.org/W2137070227","https://openalex.org/W2290466312","https://openalex.org/W2338168020","https://openalex.org/W2507869394","https://openalex.org/W2598719015","https://openalex.org/W2733836692","https://openalex.org/W2917375480","https://openalex.org/W2921201708","https://openalex.org/W2981216777","https://openalex.org/W3005238646","https://openalex.org/W3033381068","https://openalex.org/W3041849750","https://openalex.org/W3082805365","https://openalex.org/W3095578761","https://openalex.org/W3117550730","https://openalex.org/W3204225733","https://openalex.org/W3211828995","https://openalex.org/W4206897266","https://openalex.org/W4225709596","https://openalex.org/W4236357753","https://openalex.org/W4292282797","https://openalex.org/W4310137763","https://openalex.org/W4313886208","https://openalex.org/W4315643379","https://openalex.org/W4386725477","https://openalex.org/W4387890344","https://openalex.org/W4394709442"],"related_works":["https://openalex.org/W7140169063","https://openalex.org/W3012882162","https://openalex.org/W7213887158","https://openalex.org/W6958396451","https://openalex.org/W4411890682","https://openalex.org/W7222973154","https://openalex.org/W2965036209","https://openalex.org/W3029689596","https://openalex.org/W4405942232","https://openalex.org/W4404895982"],"abstract_inverted_index":{"Background/Objectives:":[0],"Benign":[1],"prostatic":[2,186,224],"hyperplasia":[3],"(BPH)":[4],"is":[5,11,32],"prevalent":[6],"among":[7],"older":[8],"men":[9],"and":[10,22,41,98,129,153,164,167,184,223,226],"often":[12],"accompanied":[13],"by":[14,115,118],"lower":[15],"urinary":[16],"tract":[17],"symptoms":[18],"(LUTS),":[19],"including":[20],"storage":[21],"voiding":[23],"symptoms.":[24],"Achyranthis":[25,71],"Radix,":[26],"the":[27,112,174,193,199,204],"root":[28],"of":[29,70,78,121,195,206,242],"Achyranthes":[30],"bidentata,":[31],"commonly":[33],"used":[34],"as":[35],"a":[36,75,231],"functional":[37],"food":[38],"in":[39,45,74,108,198,209,219],"Asia":[40],"has":[42],"been":[43,60],"documented":[44],"traditional":[46],"medicine":[47],"for":[48,125,233,244],"conditions":[49],"associated":[50],"with":[51,137,173,214],"LUTS.":[52],"However,":[53],"its":[54],"effects":[55],"on":[56],"BPH":[57,105,245],"have":[58],"not":[59],"experimentally":[61],"investigated.":[62],"Therefore,":[63],"this":[64],"study":[65],"evaluated":[66],"an":[67],"ethanolic":[68],"extract":[69],"Radix":[72],"(ARE)":[73],"rat":[76],"model":[77],"testosterone":[79],"propionate":[80],"(TP)-induced":[81],"BPH.":[82],"Methods:":[83],"Male":[84],"Sprague-Dawley":[85],"rats":[86,210],"were":[87,131,156],"randomly":[88],"assigned":[89],"to":[90],"six":[91],"groups:":[92],"sham,":[93],"control,":[94],"finasteride":[95,130],"(1":[96],"mg/kg),":[97],"ARE":[99,128,159,177,191,202,243],"(30,":[100],"100,":[101],"or":[102],"300":[103],"mg/kg).":[104],"was":[106],"induced":[107],"all":[109],"groups":[110],"except":[111],"sham":[113],"group":[114],"castration":[116],"followed":[117],"subcutaneous":[119],"administration":[120],"TP":[122,138],"(3":[123],"mg/kg/day)":[124],"4":[126],"weeks.":[127],"orally":[132],"administered":[133,212],"once":[134],"daily":[135],"concurrently":[136,213],"treatment.":[139],"Prostate":[140],"weight,":[141],"prostate":[142,162,165,207],"index,":[143],"histological":[144,170],"changes,":[145],"serum":[146,181,220],"androgen":[147,149,221],"levels,":[148],"receptor":[150],"(AR)":[151],"expression,":[152],"apoptosis-related":[154,196,227],"proteins":[155,197],"evaluated.":[157],"Results:":[158],"significantly":[160,179],"reduced":[161,185],"weight":[163],"index":[166],"attenuated":[168,203],"BPH-associated":[169],"changes":[171,218],"compared":[172],"control":[175],"group.":[176],"also":[178],"decreased":[180],"dihydrotestosterone":[182],"levels":[183,222],"AR":[187],"expression.":[188],"In":[189],"addition,":[190],"modulated":[192],"expression":[194,229],"prostate.":[200],"Conclusions:":[201],"development":[205],"enlargement":[208],"when":[211],"TP.":[215],"The":[216],"accompanying":[217],"androgen-related":[225],"protein":[228],"provide":[230],"basis":[232],"further":[234,240],"mechanistic":[235],"investigation.":[236],"These":[237],"findings":[238],"support":[239],"evaluation":[241],"management.":[246]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-30T00:00:00"}
