{"id":"https://openalex.org/W7224652465","doi":"https://doi.org/10.3390/ph19111709","title":"Galantamine Ameliorates Doxorubicin-Induced Cognitive Impairment in Female Rats via Modulation of Neuroinflammation, BDNF/TrkB Pathway and Synaptic Plasticity","display_name":"Galantamine Ameliorates Doxorubicin-Induced Cognitive Impairment in Female Rats via Modulation of Neuroinflammation, BDNF/TrkB Pathway and Synaptic Plasticity","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224652465","doi":"https://doi.org/10.3390/ph19111709"},"language":"en","primary_location":{"id":"doi:10.3390/ph19111709","doi":"https://doi.org/10.3390/ph19111709","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph19111709","pdf_url":null,"source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ph19111709","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053329775","display_name":"Sinan Saral","orcid":"https://orcid.org/0000-0002-0961-1903","observed_orcids":["https://orcid.org/0000-0002-0961-1903"]},"institutions":[{"id":"https://openalex.org/I161597582","display_name":"Recep Tayyip Erdo\u011fan University","ror":"https://ror.org/0468j1635","country_code":"TR","type":"education","lineage":["https://openalex.org/I161597582"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Sinan Saral","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-0961-1903","affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye","institution_ids":["https://openalex.org/I161597582"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083485579","display_name":"Ay\u015feg\u00fcl S\u00fcmer","orcid":"https://orcid.org/0000-0003-4918-4368","observed_orcids":["https://orcid.org/0000-0003-4918-4368"]},"institutions":[{"id":"https://openalex.org/I161597582","display_name":"Recep Tayyip Erdo\u011fan University","ror":"https://ror.org/0468j1635","country_code":"TR","type":"education","lineage":["https://openalex.org/I161597582"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ay\u015feg\u00fcl S\u00fcmer","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-4918-4368","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye","institution_ids":["https://openalex.org/I161597582"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044230730","display_name":"Atilla Top\u00e7u","orcid":"https://orcid.org/0000-0003-4730-5015","observed_orcids":["https://orcid.org/0000-0003-4730-5015"]},"institutions":[{"id":"https://openalex.org/I161597582","display_name":"Recep Tayyip Erdo\u011fan University","ror":"https://ror.org/0468j1635","country_code":"TR","type":"education","lineage":["https://openalex.org/I161597582"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Atilla Top\u00e7u","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-4730-5015","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye","institution_ids":["https://openalex.org/I161597582"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086383005","display_name":"Tolga Mercantepe","orcid":"https://orcid.org/0000-0002-8506-1755","observed_orcids":["https://orcid.org/0000-0002-8506-1755"]},"institutions":[{"id":"https://openalex.org/I161597582","display_name":"Recep Tayyip Erdo\u011fan University","ror":"https://ror.org/0468j1635","country_code":"TR","type":"education","lineage":["https://openalex.org/I161597582"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tolga Mercantepe","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-8506-1755","affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye","institution_ids":["https://openalex.org/I161597582"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006093940","display_name":"\u0130hsan Nalk\u0131ran","orcid":"https://orcid.org/0000-0002-7246-2592","observed_orcids":["https://orcid.org/0000-0002-7246-2592"]},"institutions":[{"id":"https://openalex.org/I161597582","display_name":"Recep Tayyip Erdo\u011fan University","ror":"https://ror.org/0468j1635","country_code":"TR","type":"education","lineage":["https://openalex.org/I161597582"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130hsan Nalk\u0131ran","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-7246-2592","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye","institution_ids":["https://openalex.org/I161597582"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009020336","display_name":"\u00d6zlem Saral","orcid":"https://orcid.org/0000-0002-5283-7000","observed_orcids":["https://orcid.org/0000-0002-5283-7000"]},"institutions":[{"id":"https://openalex.org/I161597582","display_name":"Recep Tayyip Erdo\u011fan University","ror":"https://ror.org/0468j1635","country_code":"TR","type":"education","lineage":["https://openalex.org/I161597582"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00d6zlem Saral","raw_affiliation_strings":["Department of Nutrition and Dietetics, Faculty of Health Sciences, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Recep Tayyip Erdo\u011fan University, Rize 53100, T\u00fcrkiye","institution_ids":["https://openalex.org/I161597582"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053329775"],"corresponding_institution_ids":["https://openalex.org/I161597582"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82019511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"11","first_page":"1709","last_page":"1709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galantamine","display_name":"galantamine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.953000009059906},{"id":"https://openalex.org/keywords/chemotherapy-induced-cognitive-impairment","display_name":"chemotherapy-induced cognitive impairment","score":0.9649999737739563},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bdnf-trkb-signaling","display_name":"BDNF/TrkB signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.8840000033378601},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.7929999828338623},{"id":"https://openalex.org/keywords/recognition-memory","display_name":"recognition memory","score":0.8299999833106995},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8730000257492065},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.5849999785423279},{"id":"https://openalex.org/keywords/synaptophysin","display_name":"synaptophysin","score":0.7680000066757202},{"id":"https://openalex.org/keywords/psd-95","display_name":"PSD-95","score":0.9729999899864197},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2779056891","wikidata":"https://www.wikidata.org/wiki/Q412690","display_name":"Galantamine","level":5,"score":0.9154999852180481},{"id":"https://openalex.org/C2777209535","wikidata":"https://www.wikidata.org/wiki/Q14864388","display_name":"Synaptophysin","level":3,"score":0.7774999737739563},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.5974000096321106},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5763000249862671},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5462999939918518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49939998984336853},{"id":"https://openalex.org/C2777544248","wikidata":"https://www.wikidata.org/wiki/Q2592323","display_name":"Acetylcholinesterase inhibitor","level":4,"score":0.48739999532699585},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.48100000619888306},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.475600004196167},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.46630001068115234},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.4512999951839447},{"id":"https://openalex.org/C97124661","wikidata":"https://www.wikidata.org/wiki/Q14897782","display_name":"Tropomyosin receptor kinase B","level":4,"score":0.4250999987125397},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4212000072002411},{"id":"https://openalex.org/C90770895","wikidata":"https://www.wikidata.org/wiki/Q14906268","display_name":"Gap-43 protein","level":3,"score":0.4041000008583069},{"id":"https://openalex.org/C50493954","wikidata":"https://www.wikidata.org/wiki/Q18031806","display_name":"Synapsin I","level":5,"score":0.39750000834465027},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.3953000009059906},{"id":"https://openalex.org/C2780216858","wikidata":"https://www.wikidata.org/wiki/Q58397","display_name":"Amitriptyline","level":2,"score":0.33719998598098755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3253999948501587},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32339999079704285},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.31349998712539673},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.31029999256134033},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29789999127388},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C2910298800","wikidata":"https://www.wikidata.org/wiki/Q229944","display_name":"P-Chloroamphetamine","level":5,"score":0.2660999894142151},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.25699999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ph19111709","doi":"https://doi.org/10.3390/ph19111709","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph19111709","pdf_url":null,"source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ph19111709","doi":"https://doi.org/10.3390/ph19111709","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph19111709","pdf_url":null,"source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W607594986","https://openalex.org/W1963721982","https://openalex.org/W1991798750","https://openalex.org/W2049929625","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2593735181","https://openalex.org/W2754217560","https://openalex.org/W2800531234","https://openalex.org/W2894564965","https://openalex.org/W3009377426","https://openalex.org/W3136074385","https://openalex.org/W4225670844","https://openalex.org/W4361288414","https://openalex.org/W4368358501","https://openalex.org/W4381429871","https://openalex.org/W4388968908","https://openalex.org/W4391069591","https://openalex.org/W4402679266","https://openalex.org/W4404583215","https://openalex.org/W4405505095","https://openalex.org/W4408238947","https://openalex.org/W4410338564","https://openalex.org/W4413009820","https://openalex.org/W4413839969"],"related_works":["https://openalex.org/W4381429871","https://openalex.org/W4285680693","https://openalex.org/W4394740589","https://openalex.org/W4414027521","https://openalex.org/W4389200852","https://openalex.org/W4210332387","https://openalex.org/W4380995312","https://openalex.org/W3119508314","https://openalex.org/W2973204729","https://openalex.org/W4368358501"],"abstract_inverted_index":{"Background:":[0],"Chemotherapy-related":[1],"cognitive":[2,45,60,243,268],"impairment":[3,244],"is":[4],"a":[5,55,262],"debilitating":[6],"neurocognitive":[7],"syndrome":[8],"with":[9],"no":[10],"approved":[11],"treatment.":[12],"Doxorubicin":[13,143,165,203],"induces":[14],"neuroinflammation,":[15,47,247],"disrupts":[16],"neurotrophic":[17],"signaling,":[18],"and":[19,29,41,51,81,94,103,116,135,137,147,149,168,173,181,184,197,219,250,253],"impairs":[20],"synaptic":[21,52],"plasticity.":[22,256],"Galantamine,":[23,157],"an":[24],"acetylcholinesterase":[25],"inhibitor,":[26],"has":[27],"anti-inflammatory":[28],"neuroprotective":[30,239],"properties.":[31],"This":[32],"study":[33],"investigated":[34],"the":[35,48,99,107,154,188,229],"dose-dependent":[36,238],"effects":[37,240],"of":[38,58],"galantamine":[39,77,84,222,260],"(2.5":[40,78],"5":[42,160],"mg/kg)":[43],"on":[44],"behavior,":[46],"BDNF/TrkB":[49],"pathway,":[50],"plasticity":[53],"in":[54,153],"rat":[56],"model":[57],"doxorubicin-induced":[59,242],"impairment.":[61,269],"Methods:":[62],"Female":[63],"Sprague":[64],"Dawley":[65],"rats":[66],"were":[67,96,119,199],"divided":[68],"into":[69],"control,":[70],"doxorubicin":[71,75,82,216],"(4":[72],"mg/kg/week,":[73],"i.p.),":[74],"+":[76,83],"mg/kg/day,":[79,86],"oral),":[80],"(5":[85],"oral)":[87],"groups.":[88],"After":[89],"four":[90],"weeks,":[91],"spatial":[92,145],"learning":[93,146],"memory":[95,105,148],"assessed":[97,125],"using":[98,106],"Morris":[100],"water":[101],"maze,":[102],"recognition":[104,110],"novel":[108],"object":[109],"test.":[111,156],"Hippocampal":[112],"IL-1\u03b2,":[113],"IL-10,":[114],"BDNF,":[115],"AChE":[117,182],"levels":[118],"measured":[120],"by":[121,126,133,139,201,209,245],"ELISA.":[122],"Histopathology":[123],"was":[124,131,207],"H&E":[127],"staining.":[128],"TrkB":[129,251],"expression":[130],"evaluated":[132],"immunohistochemistry,":[134],"PSD-95":[136,218,226],"synaptophysin":[138,230],"Western":[140,212],"blot.":[141],"Results:":[142],"impaired":[144],"reduced":[150],"discrimination":[151],"index":[152],"NOR":[155],"especially":[158],"at":[159,176,232],"mg/kg,":[161],"attenuated":[162],"these":[163],"deficits.":[164],"increased":[166,185,192,217],"IL-1\u03b2":[167,180],"AChE,":[169],"while":[170],"decreasing":[171],"IL-10":[172],"BDNF.":[174],"Galantamine":[175,236],"both":[177],"doses":[178],"reversed":[179,228],"increases":[183],"BDNF;":[186],"only":[187],"2.5":[189],"mg/kg":[190],"dose":[191],"IL-10.":[193],"Doxorubicin-induced":[194],"neuronal":[195],"shrinkage":[196],"apoptosis":[198],"ameliorated":[200],"galantamine.":[202,211],"upregulated":[204],"TrkB,":[205],"which":[206],"normalized":[208],"high-dose":[210],"blot":[213],"showed":[214],"that":[215],"decreased":[220],"synaptophysin;":[221],"did":[223],"not":[224],"alter":[225],"but":[227],"decrease":[231],"low":[233],"dose.":[234],"Conclusions:":[235],"exerts":[237],"against":[241],"reducing":[246],"modulating":[248],"BDNF":[249],"levels,":[252],"preserving":[254],"presynaptic":[255],"These":[257],"findings":[258],"suggest":[259],"as":[261],"potential":[263],"option":[264],"for":[265],"preventing":[266],"chemotherapy-related":[267]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-30T00:00:00"}
