{"id":"https://openalex.org/W7224636426","doi":"https://doi.org/10.3390/separations13110315","title":"Nutritional, Bioactive, and Therapeutic Potential of Senna alexandrina Leaf Extract: Anti-Inflammatory Effects and Enhanced Anti-Helicobacter pylori Activity in Combination with Omeprazole\u2013Amoxicillin\u2013Rifabutin Therapy","display_name":"Nutritional, Bioactive, and Therapeutic Potential of Senna alexandrina Leaf Extract: Anti-Inflammatory Effects and Enhanced Anti-Helicobacter pylori Activity in Combination with Omeprazole\u2013Amoxicillin\u2013Rifabutin Therapy","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224636426","doi":"https://doi.org/10.3390/separations13110315"},"language":"en","primary_location":{"id":"doi:10.3390/separations13110315","doi":"https://doi.org/10.3390/separations13110315","is_oa":true,"landing_page_url":"https://doi.org/10.3390/separations13110315","pdf_url":null,"source":{"id":"https://openalex.org/S2738502618","display_name":"Separations","issn_l":"2297-8739","issn":["2297-8739"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Separations","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/separations13110315","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093351612","display_name":"Mansour Alblaji","orcid":"https://orcid.org/0009-0004-0824-3848","observed_orcids":["https://orcid.org/0009-0004-0824-3848"]},"institutions":[{"id":"https://openalex.org/I156216236","display_name":"Qassim University","ror":"https://ror.org/01wsfe280","country_code":"SA","type":"education","lineage":["https://openalex.org/I156216236"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Mansour Alblaji","raw_affiliation_strings":["Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia"],"raw_orcid":"https://orcid.org/0009-0004-0824-3848","affiliations":[{"raw_affiliation_string":"Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia","institution_ids":["https://openalex.org/I156216236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5093351612"],"corresponding_institution_ids":["https://openalex.org/I156216236"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8080979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"11","first_page":"315","last_page":"315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.09139999747276306,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.06889999657869339,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senna-alexandrina","display_name":"Senna alexandrina","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.9399999976158142},{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.9559999704360962},{"id":"https://openalex.org/keywords/anti-helicobacter-pylori-activity","display_name":"anti-Helicobacter pylori activity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5979999899864197},{"id":"https://openalex.org/keywords/fractional-inhibitory-concentration-index","display_name":"fractional inhibitory concentration index","score":0.9079999923706055},{"id":"https://openalex.org/keywords/rosmarinic-acid","display_name":"rosmarinic acid","score":0.875},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.8619999885559082},{"id":"https://openalex.org/keywords/butyrylcholinesterase-inhibition","display_name":"butyrylcholinesterase inhibition","score":0.9710000157356262},{"id":"https://openalex.org/keywords/erythrocyte-membrane-stabilization","display_name":"erythrocyte membrane stabilization","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7129999995231628},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6169999837875366},{"id":"https://openalex.org/keywords/methanol-extract","display_name":"methanol extract","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2778771215","wikidata":"https://www.wikidata.org/wiki/Q50380051","display_name":"Rosmarinic acid","level":3,"score":0.7767000198364258},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6974999904632568},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.5644999742507935},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5447999835014343},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5430999994277954},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4848000109195709},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4650000035762787},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4465000033378601},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.43130001425743103},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.4059999883174896},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.3677999973297119},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.3564999997615814},{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.3456999957561493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3402000069618225},{"id":"https://openalex.org/C26381139","wikidata":"https://www.wikidata.org/wiki/Q1158816","display_name":"Minimum bactericidal concentration","level":4,"score":0.322299987077713},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.31459999084472656},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.31209999322891235},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.29840001463890076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2831000089645386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27709999680519104},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.2628999948501587}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/separations13110315","doi":"https://doi.org/10.3390/separations13110315","is_oa":true,"landing_page_url":"https://doi.org/10.3390/separations13110315","pdf_url":null,"source":{"id":"https://openalex.org/S2738502618","display_name":"Separations","issn_l":"2297-8739","issn":["2297-8739"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Separations","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/separations13110315","doi":"https://doi.org/10.3390/separations13110315","is_oa":true,"landing_page_url":"https://doi.org/10.3390/separations13110315","pdf_url":null,"source":{"id":"https://openalex.org/S2738502618","display_name":"Separations","issn_l":"2297-8739","issn":["2297-8739"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Separations","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324403","display_name":"Qassim University","ror":"https://ror.org/01wsfe280"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W768800859","https://openalex.org/W1566271574","https://openalex.org/W1971048984","https://openalex.org/W1975589139","https://openalex.org/W1997892364","https://openalex.org/W2029549580","https://openalex.org/W2049748793","https://openalex.org/W2093824204","https://openalex.org/W2096541421","https://openalex.org/W2158901274","https://openalex.org/W3046449864","https://openalex.org/W4213170223","https://openalex.org/W4225285596","https://openalex.org/W4303980936","https://openalex.org/W4365145667","https://openalex.org/W4366525362","https://openalex.org/W4379231720","https://openalex.org/W4394837105","https://openalex.org/W4395053627","https://openalex.org/W4403699985","https://openalex.org/W4403792288","https://openalex.org/W4407389778","https://openalex.org/W4407740417","https://openalex.org/W4408848274","https://openalex.org/W4409344760","https://openalex.org/W4409866063","https://openalex.org/W4411697423","https://openalex.org/W4412351360","https://openalex.org/W4413791479","https://openalex.org/W4413957472","https://openalex.org/W4415834802","https://openalex.org/W4416935985"],"related_works":["https://openalex.org/W4416786720","https://openalex.org/W3135862103","https://openalex.org/W4403588973","https://openalex.org/W4404070969","https://openalex.org/W3212315445","https://openalex.org/W2938425631","https://openalex.org/W2154223133","https://openalex.org/W7213535558","https://openalex.org/W2145109301","https://openalex.org/W1634189433"],"abstract_inverted_index":{"Senna":[0],"alexandrina":[1,37,199],"is":[2,23],"recognized":[3],"for":[4],"its":[5,9],"medicinal":[6],"uses,":[7],"yet":[8],"multi-target":[10],"therapeutic":[11,230],"potential":[12],"remains":[13],"insufficiently":[14],"characterized.":[15],"To":[16],"the":[17,24,29,43,55,58,130],"best":[18],"of":[19,35,61,68,141],"our":[20],"knowledge,":[21],"this":[22,62],"first":[25],"study":[26,51],"to":[27,146],"investigate":[28],"anti-inflammatory":[30],"and":[31,95,110,153,165,184,208,224],"anti-Helicobacter":[32],"pylori":[33,65,115],"activities":[34],"S.":[36,198],"leaf":[38,71,200],"extract":[39,56,72,99,131,152,175,201],"in":[40,204,225],"combination":[41],"with":[42,132],"omeprazole\u2013amoxicillin\u2013rifabutin":[44],"regimen,":[45],"commercially":[46],"known":[47],"as":[48,171],"Talicia.":[49],"The":[50,98,174],"further":[52,220],"evaluates":[53],"whether":[54],"enhances":[57],"antibacterial":[59],"activity":[60,112,213],"established":[63],"H.":[64,114],"treatment.":[66],"Bioactivity":[67],"a":[69,135],"methanolic":[70],"from":[73],"Al-Qassim,":[74],"Saudi":[75],"Arabia,":[76],"was":[77],"evaluated":[78],"using":[79],"membrane":[80],"stabilization,":[81],"broth":[82],"microdilution":[83],"checkerboard":[84],"assays,":[85],"butyrylcholinesterase":[86],"(BChE)":[87],"inhibition,":[88],"MTT":[89],"assays":[90],"on":[91,187],"WI-38":[92,188],"human":[93],"fibroblasts,":[94],"HPLC":[96,157],"profiling.":[97],"exhibited":[100],"protection":[101],"against":[102,113],"hypotonicity-induced":[103],"erythrocyte":[104],"hemolysis":[105],"(IC50":[106,180,193],"=":[107,119,123,127,181,194],"8.44":[108],"\u00b5g/mL)":[109,183],"bactericidal":[111],"ATCC":[116],"43504":[117],"(MIC":[118],"31.25":[120],"\u00b5g/mL;":[121,125],"MBC":[122],"62.50":[124],"MBC/MIC":[126],"2.0).":[128],"Combining":[129],"Talicia":[133,212],"yielded":[134],"Fractional":[136],"Inhibitory":[137],"Concentration":[138],"Index":[139],"(FICI)":[140],"0.75,":[142],"indicating":[143],"an":[144],"additive":[145,215],"weakly":[147],"synergistic":[148],"interaction":[149],"(7.81":[150],"\u00b5g/mL":[151,155],"8.00":[154],"Talicia).":[156],"identified":[158],"rosmarinic":[159],"acid":[160],"(16.05":[161],"mg/g":[162,168],"dry":[163,169],"extract)":[164,170],"quercetin":[166],"(15.90":[167],"primary":[172],"polyphenols.":[173],"showed":[176],"cell-free":[177],"BChE":[178],"inhibition":[179],"31.8":[182],"low":[185],"cytotoxicity":[186],"fibroblasts":[189],"under":[190],"tested":[191],"conditions":[192],"191.1":[195],"\u00b5g/mL).":[196],"Overall,":[197],"displays":[202],"preliminary":[203],"vitro":[205],"membrane-stabilizing,":[206],"antibacterial,":[207],"cholinesterase-inhibitory":[209],"activities,":[210],"enhancing":[211],"via":[214],"interaction.":[216],"These":[217],"findings":[218],"justify":[219],"mechanistic,":[221],"pharmacokinetic,":[222],"toxicological,":[223],"vivo":[226],"investigations":[227],"before":[228],"any":[229],"or":[231],"clinical":[232],"relevance":[233],"can":[234],"be":[235],"proposed.":[236]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-30T00:00:00"}
