{"id":"https://openalex.org/W7224616918","doi":"https://doi.org/10.1038/s41392-026-03003-w","title":"Primate embryoids: an in vitro model leading from a totipotency-like phase to early organogenesis","display_name":"Primate embryoids: an in vitro model leading from a totipotency-like phase to early organogenesis","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224616918","doi":"https://doi.org/10.1038/s41392-026-03003-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42957669","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13720207"},"language":"en","primary_location":{"id":"doi:10.1038/s41392-026-03003-w","doi":"https://doi.org/10.1038/s41392-026-03003-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-026-03003-w","pdf_url":"https://www.nature.com/articles/s41392-026-03003-w.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41392-026-03003-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5099114666","display_name":"Aseem Tara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Aseem Tara","raw_affiliation_strings":["Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Biotechnology/Stem Cell Unit, Neustadt Rbge, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Biotechnology/Stem Cell Unit, Neustadt Rbge, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056220165","display_name":"Wilfried A. Kues","orcid":"https://orcid.org/0000-0002-0850-8103","observed_orcids":["https://orcid.org/0000-0002-0850-8103"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wilfried A. Kues","raw_affiliation_strings":["Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Biotechnology/Stem Cell Unit, Neustadt Rbge, Germany. wilfried.kues@fli.de"],"raw_orcid":"https://orcid.org/0000-0002-0850-8103","affiliations":[{"raw_affiliation_string":"Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Biotechnology/Stem Cell Unit, Neustadt Rbge, Germany. wilfried.kues@fli.de","institution_ids":["https://openalex.org/I1310048521"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056220165"],"corresponding_institution_ids":["https://openalex.org/I1310048521"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74349023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/totipotency","display_name":"totipotency","score":0.7979999780654907},{"id":"https://openalex.org/keywords/early-organogenesis","display_name":"early organogenesis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/in-vitro-embryo-models","display_name":"in vitro embryo models","score":0.7710000276565552},{"id":"https://openalex.org/keywords/primordial-germ-cells","display_name":"primordial germ cells","score":0.6959999799728394},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C30503417","wikidata":"https://www.wikidata.org/wiki/Q958938","display_name":"Organogenesis","level":3,"score":0.9003000259399414},{"id":"https://openalex.org/C2780509455","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Primate","level":2,"score":0.6848000288009644},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.666100025177002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6111000180244446},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5598000288009644},{"id":"https://openalex.org/C3018809729","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Nonhuman primate","level":2,"score":0.4291999936103821},{"id":"https://openalex.org/C2777470312","wikidata":"https://www.wikidata.org/wiki/Q82261","display_name":"Haplorhini","level":3,"score":0.32580000162124634},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3228999972343445},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.31220000982284546},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25780001282691956},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25130000710487366}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41392-026-03003-w","doi":"https://doi.org/10.1038/s41392-026-03003-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-026-03003-w","pdf_url":"https://www.nature.com/articles/s41392-026-03003-w.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13720207","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720207/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720207/pdf/41392_2026_Article_3003.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduct Target Ther","raw_type":"Text"},{"id":"pmid:42957669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42957669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal transduction and targeted therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:55c57b41a9b649cfb056615f28ae2bbe","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/55c57b41a9b649cfb056615f28ae2bbe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Signal Transduction and Targeted Therapy, Vol 11, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41392-026-03003-w","doi":"https://doi.org/10.1038/s41392-026-03003-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-026-03003-w","pdf_url":"https://www.nature.com/articles/s41392-026-03003-w.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1993974023","display_name":"Indian Council of Agricultural Research - To provide small-scale crop/livestock producers with livestock that can utilize crop byproducts","funder_award_id":"INV-054049","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224616918.pdf","grobid_xml":"https://content.openalex.org/works/W7224616918.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W4382240679","https://openalex.org/W4384938136","https://openalex.org/W4386492442","https://openalex.org/W4416959551","https://openalex.org/W7164130644"],"related_works":["https://openalex.org/W7220955274","https://openalex.org/W3119157022","https://openalex.org/W87643743","https://openalex.org/W2474085381","https://openalex.org/W7117151323","https://openalex.org/W2542554757","https://openalex.org/W7140130536","https://openalex.org/W7115410921","https://openalex.org/W2415842101","https://openalex.org/W7034930805"],"abstract_inverted_index":{"In":[0],"a":[1,14,36,57],"recent":[2],"seminal":[3],"study":[4,22],"published":[5],"in":[6,28,56],"Cell":[7],",":[8],"Zheng":[9],"et":[10],"al.":[11],"1":[12],"demonstrated":[13],"sophisticated":[15],"embryoid":[16,31],"model":[17,32],"for":[18],"primate":[19],"embryogenesis":[20],"to":[21,25,48],"development":[23],"up":[24],"early":[26],"organogenesis":[27],"vitro.":[29],"This":[30],"is":[33],"based":[34],"on":[35],"totipotent-like":[37],"cynomolgus":[38],"blastomere-like":[39],"stem":[40],"cell":[41],"(cTBLC)":[42],"culture,":[43],"which":[44],"can":[45],"be":[46],"triggered":[47],"autonomously":[49],"undergo":[50],"pre-":[51],"and":[52],"post-implantation":[53],"developmental":[54],"features":[55],"sequential":[58],"manner":[59],"reminiscent":[60],"of":[61],"these":[62],"stages":[63],"after":[64],"fertilization.":[65]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}