{"id":"https://openalex.org/W7224604075","doi":"https://doi.org/10.64898/2026.10.28.762579","title":"Cortical asymmetry and its developmental change have distinct relationships with brain connectivity","display_name":"Cortical asymmetry and its developmental change have distinct relationships with brain connectivity","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224604075","doi":"https://doi.org/10.64898/2026.10.28.762579"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.28.762579","doi":"https://doi.org/10.64898/2026.10.28.762579","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.28.762579","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.28.762579.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.28.762579.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082198754","display_name":"Siva Venkadesh","orcid":"https://orcid.org/0000-0002-8112-0578","observed_orcids":["https://orcid.org/0000-0002-8112-0578"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Siva Venkadesh","raw_affiliation_strings":["Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-8112-0578","affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077227967","display_name":"Fang-Cheng F. Yeh","orcid":"https://orcid.org/0000-0002-7946-2173","observed_orcids":["https://orcid.org/0000-0002-7946-2173"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang-Cheng Yeh","raw_affiliation_strings":["Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-7946-2173","affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073037534","display_name":"Patrick R. Hof","orcid":"https://orcid.org/0000-0002-3208-1154","observed_orcids":["https://orcid.org/0000-0002-3208-1154"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick R. Hof","raw_affiliation_strings":["Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033322421","display_name":"Julie R. Korenberg","orcid":"https://orcid.org/0000-0001-5264-9109","observed_orcids":["https://orcid.org/0000-0001-5264-9109"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie R. Korenberg","raw_affiliation_strings":["Departments of Pediatrics and Neurology, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Neurology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082198754"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12621","display_name":"Hemispheric Asymmetry in Neuroscience","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12621","display_name":"Hemispheric Asymmetry in Neuroscience","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortical-asymmetry","display_name":"cortical asymmetry","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hemispheric-asymmetry","display_name":"hemispheric lateralization","score":0.8939999938011169},{"id":"https://openalex.org/keywords/brain-connectivity","display_name":"brain connectivity","score":0.859000027179718},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.800000011920929},{"id":"https://openalex.org/keywords/association-tracts","display_name":"association tracts","score":0.6069999933242798},{"id":"https://openalex.org/keywords/developmental-changes","display_name":"developmental changes","score":0.6010000109672546},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.382999986410141},{"id":"https://openalex.org/keywords/longitudinal-development","display_name":"longitudinal development","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C38976095","wikidata":"https://www.wikidata.org/wiki/Q752641","display_name":"Asymmetry","level":2,"score":0.7495999932289124},{"id":"https://openalex.org/C2778183499","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Corpus callosum","level":2,"score":0.6434000134468079},{"id":"https://openalex.org/C195650424","wikidata":"https://www.wikidata.org/wiki/Q4955813","display_name":"Brain asymmetry","level":3,"score":0.5489000082015991},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.52920001745224},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5045999884605408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4275999963283539},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.40860000252723694},{"id":"https://openalex.org/C102790218","wikidata":"https://www.wikidata.org/wiki/Q5462619","display_name":"Fluctuating asymmetry","level":2,"score":0.367000013589859},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.36550000309944153},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.3497999906539917},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.3181000053882599},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.28850001096725464},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C171508891","wikidata":"https://www.wikidata.org/wiki/Q10927834","display_name":"Laterality","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.28.762579","doi":"https://doi.org/10.64898/2026.10.28.762579","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.28.762579","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.28.762579.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.28.762579","doi":"https://doi.org/10.64898/2026.10.28.762579","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.28.762579","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.28.762579.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4195843248","display_name":"UNC/UMN Baby Connectome Project","funder_award_id":"U01MH110274","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8029920266","display_name":"Mapping the Human Connectome During Typical Development","funder_award_id":"U01MH109589","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000859789","display_name":"Global studies into the Genetic Architecture of the Brain's White Matter Network through Harmonized and Coordinated Analyses in the ENIGMA-Consortium","funder_award_id":"R01MH134004","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224604075.pdf","grobid_xml":"https://content.openalex.org/works/W7224604075.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1980007664","https://openalex.org/W1991568270","https://openalex.org/W2007581301","https://openalex.org/W2021077321","https://openalex.org/W2045334960","https://openalex.org/W2058227754","https://openalex.org/W2058637264","https://openalex.org/W2080586470","https://openalex.org/W2105283203","https://openalex.org/W2122410839","https://openalex.org/W2128244716","https://openalex.org/W2145967963","https://openalex.org/W2154480805","https://openalex.org/W2268603221","https://openalex.org/W2766639217","https://openalex.org/W2789530810","https://openalex.org/W2793631099","https://openalex.org/W2805058741","https://openalex.org/W2888149555","https://openalex.org/W2893411620","https://openalex.org/W2929647880","https://openalex.org/W2943751264","https://openalex.org/W2950030754","https://openalex.org/W2982556665","https://openalex.org/W3014819045","https://openalex.org/W3130499904","https://openalex.org/W3136896178","https://openalex.org/W3214743560","https://openalex.org/W4292658370","https://openalex.org/W4327569182","https://openalex.org/W4361220755","https://openalex.org/W4380080237","https://openalex.org/W4410360752","https://openalex.org/W4411065222","https://openalex.org/W4412640250"],"related_works":["https://openalex.org/W2116364097","https://openalex.org/W7100832006","https://openalex.org/W2126023573","https://openalex.org/W2064988592","https://openalex.org/W2084384067","https://openalex.org/W4402042354","https://openalex.org/W7100593353","https://openalex.org/W2309004816","https://openalex.org/W4381189668","https://openalex.org/W2108888752"],"abstract_inverted_index":{"Abstract":[0],"The":[1,59,157,225],"two":[2,122,162,303],"cerebral":[3],"hemispheres":[4,227],"specialize":[5],"while":[6,233],"remaining":[7,234],"interconnected.":[8],"Does":[9,237],"greater":[10,125],"structural":[11],"asymmetry":[12,23,41,63,103,115,127,219,248,287,296],"imply":[13],"less":[14],"connectivity,":[15],"and":[16,81,116,155,167,182,231,323],"does":[17],"connectivity":[18,238],"also":[19],"relate":[20,239],"to":[21,37,79,240,298],"how":[22,217,241,246,293],"changes":[24,220],"during":[25],"development?":[26],"We":[27,252],"addressed":[28],"these":[29,254],"questions":[30,255],"in":[31,49,171,180,229,256,301,330],"three":[32,70,257],"independent":[33],"cohorts":[34,163],"spanning":[35],"birth":[36],"22":[38],"years,":[39],"measuring":[40],"as":[42],"the":[43,46,87,90,94,110,121,161,172,185,191,194,272,275,279,302],"magnitude":[44],"of":[45,62,86,271],"left\u2013right":[47],"difference":[48],"association":[50],"tract":[51],"overlap":[52,151],"across":[53,66,104,160,288],"74":[54],"homotopic":[55],"cortical":[56,80],"region":[57,244],"pairs.":[58],"regional":[60,102,114,218,295],"pattern":[61,158],"was":[64,142],"similar":[65,179],"cohorts.":[67,105,259,289,305],"In":[68,120,184,268],"all":[69],"cohorts,":[71,124],"more":[72,129],"asymmetric":[73,205,242,261],"regions":[74,134,147,188,206,262],"had":[75,263],"lower":[76,208,264],"connectional":[77,210,266],"density":[78],"non-cortical":[82],"targets.":[83],"However,":[84],"involvement":[85,108,214,270],"corpus":[88,273],"callosum,":[89,274],"major":[91,276],"pathway":[92,277],"connecting":[93],"hemispheres,":[95,280],"showed":[96,281],"no":[97,200,282],"consistent":[98,283],"inverse":[99,284],"relationship":[100,111,141,285],"with":[101,135,148,199,221,286],"Instead,":[106,290],"callosal":[107,137,150,202,213],"conditioned":[109],"between":[112],"mean":[113,126,294],"its":[117,247],"age-related":[118,299],"change.":[119],"older":[123,304],"accompanied":[128],"positive":[130],"age":[131],"effects":[132],"among":[133,146],"appreciable":[136],"overlap,":[138],"whereas":[139,212],"this":[140,311],"weak":[143],"or":[144,250],"negative":[145],"little":[149],"(standardized":[152],"interactions":[153],"+0.42":[154],"+0.56).":[156],"replicated":[159],"at":[164],"matched":[165],"ages,":[166],"longitudinal":[168],"region-mean":[169],"estimates":[170],"Adolescent":[173],"Brain":[174],"Cognitive":[175],"Development":[176],"cohort":[177],"were":[178],"direction":[181],"magnitude.":[183],"youngest":[186],"cohort,":[187],"converged":[189],"toward":[190],"mean,":[192],"narrowing":[193],"between-region":[195],"spread":[196],"by":[197],"12%,":[198],"detected":[201],"moderation.":[203],"More":[204,260],"have":[207],"overall":[209,265],"density,":[211],"helps":[215],"explain":[216],"age.":[222],"Significance":[223],"statement":[224],"brain\u2019s":[226],"differ":[228],"structure":[230],"function":[232],"extensively":[235],"connected.":[236],"a":[243,317],"is,":[245],"develops,":[249],"both?":[251],"distinguish":[253],"developmental":[258,312],"density.":[267],"contrast,":[269],"linking":[278],"it":[291],"distinguished":[292],"related":[297],"change":[300],"A":[306],"static":[307],"comparison":[308],"would":[309],"miss":[310],"relationship.":[313],"These":[314],"findings":[315],"provide":[316],"framework":[318],"for":[319],"studying":[320],"hemispheric":[321],"development":[322],"investigating":[324],"whether":[325],"connectivity\u2013asymmetry":[326],"relationships":[327],"are":[328],"altered":[329],"neurodevelopmental":[331],"conditions.":[332]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}
