{"id":"https://openalex.org/W7224562200","doi":"https://doi.org/10.64898/2026.10.28.762626","title":"Kinetochore Proteins CENP-B and LIC2 are critical for Episome Persistence and Replication of Kaposi\u2019s Sarcoma-Associated Herpesvirus","display_name":"Kinetochore Proteins CENP-B and LIC2 are critical for Episome Persistence and Replication of Kaposi\u2019s Sarcoma-Associated Herpesvirus","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224562200","doi":"https://doi.org/10.64898/2026.10.28.762626"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.28.762626","doi":"https://doi.org/10.64898/2026.10.28.762626","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.28.762626","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.28.762626.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.28.762626.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059292633","display_name":"Rajnish Kumar Singh","orcid":"https://orcid.org/0000-0001-7414-1170","observed_orcids":["https://orcid.org/0000-0001-7414-1170"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajnish Kumar Singh","raw_affiliation_strings":["Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151764999","display_name":"Shengwei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shengwei Zhang","raw_affiliation_strings":["Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033041410","display_name":"Dipayan Bose","orcid":"https://orcid.org/0000-0003-4789-2838","observed_orcids":["https://orcid.org/0000-0003-4789-2838"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipayan Bose","raw_affiliation_strings":["Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103145025","display_name":"Ning Ma","orcid":"https://orcid.org/0000-0001-5098-152X","observed_orcids":["https://orcid.org/0000-0001-5098-152X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nian Ma","raw_affiliation_strings":["Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160123451","display_name":"Ramakrishna Vangala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramakrishna Vangala","raw_affiliation_strings":["Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126743230","display_name":"Kiran Chunduru","orcid":"https://orcid.org/0000-0001-5823-7252","observed_orcids":["https://orcid.org/0000-0001-5823-7252"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiran Chunduru","raw_affiliation_strings":["Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032066345","display_name":"Erle S. Robertson","orcid":"https://orcid.org/0000-0002-6088-2979","observed_orcids":["https://orcid.org/0000-0002-6088-2979"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erle S. Robertson","raw_affiliation_strings":["Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, the Tumor Virology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA-19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032066345"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0706000030040741,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kaposi-s-sarcoma-associated-herpesvirus","display_name":"Kaposi's sarcoma-associated herpesvirus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/episome-maintenance","display_name":"episome maintenance","score":0.7540000081062317},{"id":"https://openalex.org/keywords/kinetochore-proteins","display_name":"kinetochore proteins","score":0.9139999747276306},{"id":"https://openalex.org/keywords/chromosome-segregation","display_name":"chromosome segregation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/viral-latency","display_name":"viral latency","score":0.7979999780654907},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/gammaherpesviruses","display_name":"gammaherpesvirus","score":0.7979999780654907},{"id":"https://openalex.org/keywords/shrna-screen","display_name":"shRNA screen","score":0.6460000276565552},{"id":"https://openalex.org/keywords/host-dependency-factors","display_name":"host dependency factors","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8137999773025513},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.7305999994277954},{"id":"https://openalex.org/C192838845","wikidata":"https://www.wikidata.org/wiki/Q908912","display_name":"Kinetochore","level":4,"score":0.6396999955177307},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.607200026512146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.545199990272522},{"id":"https://openalex.org/C2778354886","wikidata":"https://www.wikidata.org/wiki/Q5113927","display_name":"Chromosome segregation","level":4,"score":0.5221999883651733},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4693000018596649},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4221000075340271},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3626999855041504},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35269999504089355},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.32820001244544983},{"id":"https://openalex.org/C2778760011","wikidata":"https://www.wikidata.org/wiki/Q21163346","display_name":"CTCF","level":5,"score":0.3057999908924103},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.302700012922287},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.2879999876022339},{"id":"https://openalex.org/C2780091387","wikidata":"https://www.wikidata.org/wiki/Q6865201","display_name":"Minichromosome","level":4,"score":0.27869999408721924},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.26440000534057617},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.2614000141620636},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2603999972343445},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C2989419327","wikidata":"https://www.wikidata.org/wiki/Q322348","display_name":"Arms race","level":2,"score":0.2517000138759613}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.28.762626","doi":"https://doi.org/10.64898/2026.10.28.762626","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.28.762626","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.28.762626.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.28.762626","doi":"https://doi.org/10.64898/2026.10.28.762626","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.28.762626","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.28.762626.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000904203","display_name":"Transcription and Replication of Oncogenic Viruses in Hypoxia","funder_award_id":"P01CA281867","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224562200.pdf","grobid_xml":"https://content.openalex.org/works/W7224562200.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1579734686","https://openalex.org/W1732355436","https://openalex.org/W1967696278","https://openalex.org/W1968219054","https://openalex.org/W1978001038","https://openalex.org/W1998359653","https://openalex.org/W2010258747","https://openalex.org/W2010366657","https://openalex.org/W2013166769","https://openalex.org/W2032130254","https://openalex.org/W2045437181","https://openalex.org/W2053825411","https://openalex.org/W2057658002","https://openalex.org/W2058268968","https://openalex.org/W2063766478","https://openalex.org/W2065845491","https://openalex.org/W2066192691","https://openalex.org/W2072047081","https://openalex.org/W2091173646","https://openalex.org/W2093330306","https://openalex.org/W2099785190","https://openalex.org/W2116376484","https://openalex.org/W2132982759","https://openalex.org/W2141707718","https://openalex.org/W2148038204","https://openalex.org/W2159462264","https://openalex.org/W2162975410","https://openalex.org/W2164122861","https://openalex.org/W2166605824","https://openalex.org/W2168005596","https://openalex.org/W2172127536","https://openalex.org/W2193904104","https://openalex.org/W2266716435","https://openalex.org/W2286487592","https://openalex.org/W2323651502","https://openalex.org/W2336241188","https://openalex.org/W2416663937","https://openalex.org/W2424995076","https://openalex.org/W2484453437","https://openalex.org/W2507139912","https://openalex.org/W2622442325","https://openalex.org/W2749881298","https://openalex.org/W2800094920","https://openalex.org/W2800658844","https://openalex.org/W2902505825","https://openalex.org/W2909951631","https://openalex.org/W2917430100","https://openalex.org/W2971994587","https://openalex.org/W3149691654","https://openalex.org/W3163238175","https://openalex.org/W3185903531","https://openalex.org/W4221064448","https://openalex.org/W4228999251","https://openalex.org/W4249951415","https://openalex.org/W4280576475","https://openalex.org/W4308645045","https://openalex.org/W4387086913","https://openalex.org/W4389625584","https://openalex.org/W4391025326","https://openalex.org/W4395112242","https://openalex.org/W4400823747","https://openalex.org/W4404926221","https://openalex.org/W4406845261","https://openalex.org/W7117458370","https://openalex.org/W7172278857"],"related_works":["https://openalex.org/W2057658002","https://openalex.org/W2125907552","https://openalex.org/W2484453437","https://openalex.org/W2123336494","https://openalex.org/W2166605824","https://openalex.org/W2266716435","https://openalex.org/W3156487266","https://openalex.org/W2118507611","https://openalex.org/W2110599787","https://openalex.org/W1991952124"],"abstract_inverted_index":{"Abstract":[0],"Kaposi\u2019s":[1],"sarcoma-associated":[2],"herpesvirus":[3],"(KSHV)":[4],"establishes":[5],"lifelong":[6],"latency":[7],"by":[8,29,160],"maintaining":[9],"its":[10],"genome":[11,44],"as":[12,119,187],"circular":[13],"episomes":[14,173],"tethered":[15],"to":[16,41,88],"host":[17,38,83,150,175,192],"chromatin":[18],"and":[19,56,103,109,165,198],"faithfully":[20],"segregated":[21],"during":[22],"mitosis.":[23],"This":[24],"process":[25],"is":[26],"primarily":[27],"mediated":[28],"the":[30,65,81,115,142,154],"latency-associated":[31],"nuclear":[32],"antigen":[33],"(LANA),":[34],"which":[35],"interacts":[36],"with":[37],"chromosome-associated":[39],"factors":[40,102,151,194],"ensure":[42],"viral":[43,172],"persistence.":[45,127,181],"Several":[46],"kinetochore":[47,69,157,185],"proteins,":[48],"including":[49],"CENP-F,":[50],"Bub1,":[51],"BubR1,":[52],"Aurora":[53],"B,":[54],"Survivin,":[55],"NuMA,":[57],"have":[58],"been":[59],"implicated":[60],"in":[61,92,195],"this":[62],"process,":[63],"yet":[64],"broader":[66,189],"contribution":[67],"of":[68,80,99,114,129,156,191],"components":[70],"remains":[71],"poorly":[72],"defined.":[73],"We":[74,96],"performed":[75],"a":[76,188],"systematic":[77],"shRNA-based":[78],"screen":[79],"37":[82],"genes":[84],"encoding":[85],"kinetochore-associated":[86,121],"proteins":[87,122,131,158,186],"evaluate":[89],"their":[90],"role":[91],"KSHV":[93,125,161],"episome":[94,126,134,163],"maintenance.":[95],"validated":[97],"involvement":[98],"previously":[100,137],"reported":[101],"identified":[104],"Centromere":[105],"Protein":[106],"B":[107],"(CENP-B)":[108],"Light":[110],"Intermediate":[111],"Chain":[112],"2":[113],"dynein":[116],"complex":[117],"(LIC2)":[118],"novel":[120],"critical":[123,149],"for":[124,162,179,203],"Loss":[128],"these":[130],"significantly":[132],"reduced":[133],"stability,":[135],"highlighting":[136],"unrecognized":[138],"host-virus":[139],"interactions":[140],"at":[141],"chromosome":[143,176],"segregation":[144,177],"machinery.":[145],"These":[146],"findings":[147],"identify":[148],"that":[152],"expand":[153],"repertoire":[155],"co-opted":[159],"maintenance":[164],"provide":[166],"new":[167],"mechanistic":[168],"insights":[169],"into":[170],"how":[171],"exploit":[174],"pathways":[178],"long-term":[180],"Our":[182],"work":[183],"underscores":[184],"class":[190],"dependency":[193],"\u01b3-herpesvirus":[196],"biology":[197],"suggests":[199],"potential":[200],"therapeutic":[201],"targets":[202],"KSHV-associated":[204],"malignancies.":[205]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-30T00:00:00"}
